... response. Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome’s microRNAs due to their capacity to fine-tune gene expression, potentially affecting the multicellular repair response. We profiled...

... was enabled by the participation of Liverpool John Moores University in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. circadian clock exosomes keratinocytes microRNA skin wound healing Chronic, non...

...Wenjuan Yu; Honghui Zeng; Junzhe Chen; Sha Fu; Qiuyan Huang; Yanchun Xu; Anping Xu; Hui-yao Lan; Ying Tang Exosomes have been shown to effectively regulate the biological functions of target cells. Here, we investigated the protective effect and mechanism of hypoxia-induced renal tubular epithelial...

... Figure 5 Regulatory effects of the miR-210 regulates on the proangiogenic switch of CAFs ( A ) Increased expression levels of proangiogenic factors and phosphorylation of STAT3 and JAK2 induced by the exosomes from miR-210-mimic-transfected LC cells, and inhibitory effects induced...

...Francesco Mannavola; Gaetano Pezzicoli; Marco Tucci Exosomes (Exo) have emerged as potent amplifiers of pro-tumorigenic signals to distant cells. The knowledge of their role in colorectal cancer (CRC) is continuously up-growing, although their contribution to metastasis remains largely unclear. Liu...

...Junqiang Fan; Guanxin Xu; Zhibo Chang; Ling Zhu; Jie Yao It has been generally believed that cancer-associated fibroblasts (CAFs) have the ability to increase the process of tumor angiogenesis. However, the potential mechanisms by which cancer-derived exosomes in lung cancer (LC) remains...

... for the exosome isolation and enrichment procedure. ( B,C ) Representative size distribution of sEVs in NTA of sEVs isolated from cells cultured at 1% oxygen and 8% oxygen, respectively. ( D ) Representative Western blot for exosome enriched marker CD63 and TSG101. ( E ) Electron micrograph of sEVs-exo; scale...

... serve as a panel of biomarkers. That being said, work is progressing with Maitrias et al., Cipollone et al., and more recently Doltz et al. identifying a small panel of circulating miRNA (from plasma “exosomes”) in asymptomatic carotid disease that were associated with disease progression and increased...

...Shuming Wang; Yilin Hu; Xiurui Lv; Bin Li; Dianhua Gu; Yang Li; Yong Sun; Yang Su Circular RNAs (circRNAs) play a vital role in cancers. Accumulated evidences showed that the physiological condition of cells can be reflected by the circRNAs in the exosomes they secrete, and these exosomal circRNAs...

...Hui Hu; Boshi Wang; Chunyu Jiang; Ruiting Li; Jungong Zhao Background: Our previous studies observed that administration of exosomes from endothelial progenitor cells (EPC) facilitated vascular repair in the rat model of balloon injury. However, the molecular events underlying this process remain...

...Mona Alharbi; Andrew Lai; Dominic Guanzon; Carlos Palma; Felipe Zuñiga; Lewis Perrin; Yaowu He; John D. Hooper; Carlos Salomon Exosomes are small nanovesicles that carry bioactive molecules which can be delivered to neighbouring cells to modify their biological functions. Studies have showed...

..., they can be released within exosomes and can regulate cell functions in other cells/tissues (macrophages, liver, among others). Other ncRNAs such as piRNA (piwi-interacting RNAs), snoRNA (small nucleolar RNA), tRNAs can also be involved in the regulation of specific cell functions. ( B ) MiRNAs involved...

..., which are enriched in nanovesicles called exosomes, are important regulators of gene expression. When compared with normal pregnancies, pregnancies with gestational diabetes mellitus (GDM) are associated with skeletal muscle insulin resistance as well as increased levels of circulating placental...

... attributed to cellular changes in the microenvironment, including increased migration of mesenchymal stem cells (MSCs) and endothelial cells (ECs) to facilitate metastasis. Recently, the ability of exosomes to communicate signals between cells (and promote cancer progression) has been established...

...Satoru Eguchi; Victor Rizzo In addition to organelle-to-organelle communication within the cell, autocrine, paracrine and even endocrine mechanisms can be conveyed through cell-derived vesicles such as microparticles and exosomes. These organelles carry miRNAs, hormonal factors and cell surface...