.... Emerging evidence has demonstrated that absent in melanoma 2 (AIM2)-mediated inflammasome activation and endoplasmic reticulum stress (ERS) play a pivotal role in the renal fibrosis. Here, we investigated whether overexpression or deficiency of AIM2 affects ERS and fibrosis in aldosterone-infused renal...

... binding protein 1 (xbp1s), a key component of endoplasmic reticulum stress (ERS), contributes to the pathogenesis of PH. Forty male SD rats were randomly assigned to four groups: Control, Monocrotaline (MCT), MCT+AAV-CTL (control), and MCT+AAV-xbp1s. The xbp1s protein levels were found to be elevated...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bile acids Endoplasmic reticulum stress Glycoursodeoxycholic acid Metabolic disorders Metabolic disorders including type 2 diabetes mellitus (T2DM) and metabolic associated fatty liver disease...

.... The interface voltage was maintained at 3.5 kV. Nitrogen was used as nebulizing and drying gas at a flow of 1.5 and 15 l/min, respectively. Argon was used as collision gas at 230 kPa. endoplasmic reticulum stress myocardial infarction renal fibrosis Kidneys and heart are linked since the heart...

... that folic acid could protect melanocytes from Hcy-induced apoptosis and melanin synthesis inhibition, indicating folic acid as a potential benefit agent for patients with progressive vitiligo. apoptosis endoplasmic reticulum stress folic acid homocysteine melanocytes Vitiligo Vitiligo...

... endoplasmic reticulum stress in the syncytiotrophoblast in a manner that involved caspase 8 and TNF-α. To avoid accumulation of the associated misfolded proteins and MLKL, the syncytiotrophoblast exports these potentially dangerous proteins in EVs. It is likely that the dangerous proteins that are loaded...

...-mediated nick-end labelling UPR unfolded protein response VLDL-C VLDL-cholesterol VSMC vascular smooth muscle cell XBP-1 X-binding protein 1 7-KC 7-ketocholesterol abdominal aortic aneurysm endoplasmic reticulum stress mitochondrial biogenesis oxysterols...

... renal injury in SLE. Correspondence: Erika I. Boesen ( erika.boesen@unmc.edu ) 25 06 2018 03 01 2019 06 01 2019 07 01 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 endoplasmic reticulum stress kidney...

.... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 C1q/TNF-related protein 3 endoplasmic reticulum stress High-fat diet spermatogenesis silence information regulator 1 Infertility, defined as couples who have regular intercourse...

... Press Limited on behalf of the Biochemical Society 2018 Autophagy Cognitive decline Diabetes Endoplasmic reticulum stress Neuronal apoptosis An increasing body of evidence supports the view that diabetic patients present a high risk of developing cognitive disorders [ 1 , 2 ]. Nowadays...

.... Statistical significance was taken at P < 0.05. abdominal aortic aneurysm angiotensin II endoplasmic reticulum stress hypertension rupture signal transduction • No pharmacological treatment has been established that can inhibit or slow AAA development and rupture. We have shown...

... developing simple steatosis, endoplasmic reticulum stress does not contribute to the pathogenesis of insulin resistance and steatohepatitis in high-fat-diet-fed foz/foz mice, which develop progressive liver disease in the metabolic context seen in human non-alcoholic steatohepatitis. Male foz/foz...

... 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 endoplasmic reticulum stress inflammation mitochondrion obesity pancreatic β-cell Type 2 diabetes T2DM (Type 2 diabetes mellitus) in the United States and around the world has reached epidemic...