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Keywords: Endoplasmic reticulum stress
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Articles
Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
.... Emerging evidence has demonstrated that absent in melanoma 2 (AIM2)-mediated inflammasome activation and endoplasmic reticulum stress (ERS) play a pivotal role in the renal fibrosis. Here, we investigated whether overexpression or deficiency of AIM2 affects ERS and fibrosis in aldosterone-infused renal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (21): 2467–2481.
Published: 01 November 2021
... binding protein 1 (xbp1s), a key component of endoplasmic reticulum stress (ERS), contributes to the pathogenesis of PH. Forty male SD rats were randomly assigned to four groups: Control, Monocrotaline (MCT), MCT+AAV-CTL (control), and MCT+AAV-xbp1s. The xbp1s protein levels were found to be elevated...
Articles
Clin Sci (Lond) (2021) 135 (14): 1689–1706.
Published: 20 July 2021
... ) or Yue Wu ( yue.wu@xjtu.edu.cn ) or Zuyi Yuan ( zuyiyuan@mail.xjtu.edu.cn ) 18 03 2021 30 06 2021 08 07 2021 08 07 2021 Bile acids Endoplasmic reticulum stress Glycoursodeoxycholic acid Metabolic disorders Metabolic disorders including type 2 diabetes mellitus...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
... 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 endoplasmic reticulum stress myocardial infarction renal fibrosis Kidneys and heart are linked since the heart provides nutrients and oxygen to support normal kidney function. Moreover...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (10): 1127–1141.
Published: 21 May 2020
... contributed equally to this work. 01 03 2020 03 05 2020 13 05 2020 13 05 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 apoptosis endoplasmic reticulum stress folic acid homocysteine melanocytes Vitiligo...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (5): 459–472.
Published: 04 March 2020
... endoplasmic reticulum stress in the syncytiotrophoblast in a manner that involved caspase 8 and TNF-α. To avoid accumulation of the associated misfolded proteins and MLKL, the syncytiotrophoblast exports these potentially dangerous proteins in EVs. It is likely that the dangerous proteins that are loaded...
Articles
Clin Sci (Lond) (2019) 133 (13): 1421–1438.
Published: 05 July 2019
... 04 2019 22 06 2019 24 06 2019 24 06 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 abdominal aortic aneurysm endoplasmic reticulum stress mitochondrial biogenesis oxysterols An abdominal aortic aneurysm...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (2): 167–180.
Published: 18 January 2019
...’ was measured by ELISA (Albuwell M, Exocell, Philadelphia, PA) and excretion rate per day calculated. endoplasmic reticulum stress kidney molecular chaperones systemic lupus erythematosis Systemic lupus erythematosus (SLE) is a frequently debilitating autoimmune disease mainly affecting women...
Articles
Clin Sci (Lond) (2018) 132 (8): 883–899.
Published: 30 April 2018
... protein 3 endoplasmic reticulum stress High-fat diet spermatogenesis silence information regulator 1 Both extracellular stimuli, including hypoxia, hypoglycemia, acidosis, and increased levels of free radicals [ 9 ] and intracellular signals, including altered calcium homeostasis and fluctuations...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (1): 111–125.
Published: 11 January 2018
... on behalf of the Biochemical Society 2018 Autophagy Cognitive decline Diabetes Endoplasmic reticulum stress Neuronal apoptosis An increasing body of evidence supports the view that diabetic patients present a high risk of developing cognitive disorders [ 1 , 2 ]. Nowadays, diabetes...
Articles
Clin Sci (Lond) (2015) 128 (9): 559–565.
Published: 11 February 2015
... in humans. In conclusion, EGFR inhibition appears to protect mice from AAA formation induced by Ang II plus BAPN. The mechanism seems to involve suppression of vascular EGFR and ER stress. abdominal aortic aneurysm angiotensin II endoplasmic reticulum stress hypertension rupture signal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 507–518.
Published: 25 June 2014
... developing simple steatosis, endoplasmic reticulum stress does not contribute to the pathogenesis of insulin resistance and steatohepatitis in high-fat-diet-fed foz/foz mice, which develop progressive liver disease in the metabolic context seen in human non-alcoholic steatohepatitis. Male foz/foz...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2009) 116 (2): 99–111.
Published: 15 December 2008
... 6 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 endoplasmic reticulum stress inflammation mitochondrion obesity pancreatic β-cell Type 2 diabetes T2DM (Type 2 diabetes mellitus) in the United States and around the world has reached epidemic...