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Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

Xiaodi Zhang, Jean L.J.M. Scheijen, Coen D.A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk

Clin Sci (Lond) (2023) 137 (8): 697–706.

DOI: https://doi.org/10.1042/CS20220753

Published: 26 April 2023

...Xiaodi Zhang; Jean L.J.M. Scheijen; Coen D.A. Stehouwer; Kristiaan Wouters; Casper G. Schalkwijk The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycation endproducts (AGEs). MGO and AGEs are increased in subjects with diabetes and are associated...

View article titled, Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

Includes: Supplementary data

Articles

Small extracellular vesicles: a new player in GDM pathogenesis

In Collection

Reproductive Physiology and Disease

Agafe Bless Reyes, Dylan Burger

Clin Sci (Lond) (2022) 136 (24): 1873–1875.

DOI: https://doi.org/10.1042/CS20220658

Published: 22 December 2022

... understanding of the role of EVs in pregnancy Correspondence: Dylan Burger ( dburger@uottawa.ca ) 22 11 2022 22 11 2022 07 12 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 Diabetes Exosome Extracellular Vesicles...

View article titled, Small extracellular vesicles: a new player in GDM pathogenesis

Articles

Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia

Raghavendar Chandran, Lianying He, Xingju Nie, Joshua Voltin, Sarah Jamil, Caren Doueiry, Maria Fatima Falangola, Adviye Ergul, Weiguo Li

Clin Sci (Lond) (2022) 136 (21): 1555–1570.

DOI: https://doi.org/10.1042/CS20220465

Published: 10 November 2022

...Raghavendar Chandran; Lianying He; Xingju Nie; Joshua Voltin; Sarah Jamil; Caren Doueiry; Maria Fatima Falangola; Adviye Ergul; Weiguo Li Diabetes doubles the risk of vascular cognitive impairment, but the underlying reasons remain unclear. In the present study, we determined the temporal...

View article titled, Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia

Includes: Supplementary data

Articles

Correction: Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling

Clin Sci (Lond) (2021) 135 (23): 2659.

DOI: https://doi.org/10.1042/CS-2014-0789_COR

Published: 08 December 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . calveolin-3 diabetes myocardial ischaemia/reperfusion injury...

View article titled, Correction: Inhibition of PKCβ2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling

Articles

Phosphate and fibroblast growth factor 23 in diabetes

Amarens van der Vaart, Stanley M.H. Yeung, Peter R. van Dijk, Stephan J.L. Bakker, Martin H. de Borst

Clin Sci (Lond) (2021) 135 (14): 1669–1687.

DOI: https://doi.org/10.1042/CS20201290

Published: 20 July 2021

...Amarens van der Vaart; Stanley M.H. Yeung; Peter R. van Dijk; Stephan J.L. Bakker; Martin H. de Borst Diabetes is associated with a strongly elevated risk of cardiovascular disease, which is even more pronounced in patients with diabetic nephropathy. Currently available guideline-based efforts...

View article titled, Phosphate and fibroblast growth factor 23 in diabetes

Articles

Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Darnel Prakoso, Mitchel Tate, Miles J. De Blasio, Rebecca H. Ritchie

Clin Sci (Lond) (2021) 135 (11): 1369–1387.

DOI: https://doi.org/10.1042/CS20210052

Published: 02 June 2021

...Darnel Prakoso; Mitchel Tate; Miles J. De Blasio; Rebecca H. Ritchie Diabetes increases the prevalence of heart failure by 6–8-fold, independent of other comorbidities such as hypertension and coronary artery disease, a phenomenon termed diabetic cardiomyopathy. Several key signalling pathways have...

View article titled, Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Articles

ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Xi Cao, Li-Ni Song, Jin-Kui Yang

Clin Sci (Lond) (2021) 135 (3): 535–554.

DOI: https://doi.org/10.1042/CS20200752

Published: 03 February 2021

... is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is threating public health worldwide. The main complications of SARS-CoV-2 infected death patients include many energy metabolism-related chronic diseases, such as diabetes. The specific mechanism leading to this phenomenon...

View article titled, ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

Articles

ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34 + cells derived from diabetic older adults

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Shrinidh Joshi, Ildamaris Montes de Oca, Ahmad Maghrabi, Christine Lopez-Yang, Julio Quiroz-Olvera, Charles A. Garcia, Yagna Prasada Rao Jarajapu

Clin Sci (Lond) (2021) 135 (2): 367–385.

DOI: https://doi.org/10.1042/CS20201133

Published: 27 January 2021

...Shrinidh Joshi; Ildamaris Montes de Oca; Ahmad Maghrabi; Christine Lopez-Yang; Julio Quiroz-Olvera; Charles A. Garcia; Yagna Prasada Rao Jarajapu Diabetes increases the risk for ischemic vascular diseases, which is further elevated in older adults. Bone marrow-derived hematopoietic CD34 + stem...

View article titled, ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34 + cells derived from diabetic older adults

Articles

Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases

Mona Elgazzaz, Eric Lazartigues

Clin Sci (Lond) (2021) 135 (1): 127–142.

DOI: https://doi.org/10.1042/CS20201287

Published: 08 January 2021

... by Portland Press Limited on behalf of the Biochemical Society 2021 Cardiometabolic Disease Diabetes Epigenetics Hypertension Renin Angiotensin System Cardiometabolic disease (CMD) refers to coexisting conditions of insulin resistance, dyslipidemia, obesity, elevated blood pressure (BP...

View article titled, Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases

Articles

Have a heart: failure to increase GLP-1 caused by heart failure increases the risk of diabetes

Michael J. Ryan

Clin Sci (Lond) (2020) 134 (23): 3119–3121.

DOI: https://doi.org/10.1042/CS20201029

Published: 03 December 2020

... in the development of diabetes mellitus and blood glucose control. After the seminal work of Paulescu and Banting and Best in the early 1920s that led to the discovery of insulin (Murray I. Paulesco and the isolation of insulin. J. Hist. Med. Allied Sci . (1971) 26 , 150–157; Raju T.N. The Nobel Chronicles. 1923...

View article titled, Have a heart: failure to increase GLP-1 caused by heart failure increases the risk of diabetes

Articles

SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in Type 2 diabetes

Erik J.M. van Bommel, Frank Geurts, Marcel H.A. Muskiet, Adrian Post, Stephan J.L. Bakker, A.H. Jan Danser, Daan J. Touw, Miranda van Berkel, Mark H.H. Kramer, Max Nieuwdorp, Ele Ferrannini, Jaap A. Joles, Ewout J. Hoorn, Daniël H. van Raalte

Clin Sci (Lond) (2020) 134 (23): 3107–3118.

DOI: https://doi.org/10.1042/CS20201274

Published: 02 December 2020

... and sulfonylurea gliclazide on plasma electrolytes, urinary electrolyte excretion, and acid–base balance in people with Type 2 diabetes (T2D). We assessed the effects of dapagliflozin and gliclazide treatment on plasma electrolytes and bicarbonate, 24-hour urinary pH and excretions of electrolytes, ammonium...

View article titled, SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in Type 2 diabetes

Includes: Supplementary data

Articles

Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Frédéric Clarembeau, Georgia Bale, Nicolas Lanthier

Clin Sci (Lond) (2020) 134 (16): 2117–2135.

DOI: https://doi.org/10.1042/CS20200022

Published: 21 August 2020

...Frédéric Clarembeau; Georgia Bale; Nicolas Lanthier End-stage chronic liver diseases are often associated with insulin resistance (IR) and diabetes mellitus (DM). Indeed, to quantify insulin sensitivity the euglycemic clamp technique was utilized, allowing the following to be stated: in small...

View article titled, Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Articles

Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers

Man K.S. Lee, Gopalkrishna Sreejit, Prabhakara R. Nagareddy, Andrew J. Murphy

Clin Sci (Lond) (2020) 134 (12): 1399–1401.

DOI: https://doi.org/10.1042/CS20200240

Published: 18 June 2020

...Man K.S. Lee; Gopalkrishna Sreejit; Prabhakara R. Nagareddy; Andrew J. Murphy In volume 133 issue 4 of Clinical Science , Liu et al. showed that neutrophils release extracellular traps (NETs) in the setting of diabetes which acts as a stimulus for NLRP3 inflammasome activation in macrophages...

View article titled, Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers

Articles

Impaired insulin exocytosis in chronic hepatitis C infection: contributory role of p38δ MAPK–protein kinase D–golgi complex axis

Parimala Narne

Clin Sci (Lond) (2020) 134 (12): 1449–1456.

DOI: https://doi.org/10.1042/CS20200686

Published: 18 June 2020

...Parimala Narne Hepatitis C virus (HCV) infection and chronic hepatitis C (CHC) are associated with a measurable risk of insulin resistance (IR)/impaired glucose tolerance (IGT)/diabetes mellitus (DM). While loss of hepatic endocrine function contributes to liver cirrhosis in diabetic patients...

View article titled, Impaired insulin exocytosis in chronic hepatitis C infection: contributory role of p38δ MAPK–protein kinase D–golgi complex axis

Articles

Correction: Insulin reverses the major portal hypertension-related derangements in rats with liver cirrhosis and diabetes

Clin Sci (Lond) (2020) 134 (11): 1219–1242.

DOI: https://doi.org/10.1042/CS-20180557_COR

Published: 05 June 2020

... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cirrhosis diabetes angiogenesis portosystemic collaterals insulin The authors of the original article “Insulin reverses the major portal hypertension-related derangements in rats...

View article titled, Correction: Insulin reverses the major portal hypertension-related derangements in rats with liver cirrhosis and diabetes

Articles

The ER stress-autophagy axis: implications for cognitive dysfunction in diabetes mellitus

Qingzhang Zhu

Clin Sci (Lond) (2020) 134 (11): 1255–1258.

DOI: https://doi.org/10.1042/CS20200235

Published: 05 June 2020

...Qingzhang Zhu Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong et al. highlighted the critical...

View article titled, The ER stress-autophagy axis: implications for cognitive dysfunction in diabetes mellitus

Articles

Bone marrow fat: friend or foe in people with diabetes mellitus?

In Collection

Adipose biology, cardiovascular and cardiometabolic disease , Celebrating 100 years of insulin research

Marianna Santopaolo, Yue Gu, Gaia Spinetti, Paolo Madeddu

Clin Sci (Lond) (2020) 134 (8): 1031–1048.

DOI: https://doi.org/10.1042/CS20200220

Published: 27 April 2020

... marrow (BM). Specifically, we summarize current knowledge about the origin and function of BM adipose tissue (BMAT), provide evidence for the association of excess BMAT with diabetes and related cardiovascular complications, and discuss potential therapeutic approaches to correct BMAT dysfunction...

View article titled, Bone marrow fat: friend or foe in people with diabetes mellitus?

Articles

Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Rim Rafeh, Anissa Viveiros, Gavin Y. Oudit, Ahmed F. El-Yazbi

Clin Sci (Lond) (2020) 134 (7): 827–851.

DOI: https://doi.org/10.1042/CS20190227

Published: 09 April 2020

...Rim Rafeh; Anissa Viveiros; Gavin Y. Oudit; Ahmed F. El-Yazbi Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food intake triggered steep increase in the incidence of metabolic disorders including obesity and Type 2 diabetes. Patients with metabolic disease...

View article titled, Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease

Articles

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

Jizheng Chen, Fang Wang, Yue Zhou, Jing Jiang, Sulaiman Ksimu, Xu Zhang, John Zhong Li, Junqi Niu, Qian Wang

Clin Sci (Lond) (2020) 134 (5): 529–542.

DOI: https://doi.org/10.1042/CS20190900

Published: 13 March 2020

...Jizheng Chen; Fang Wang; Yue Zhou; Jing Jiang; Sulaiman Ksimu; Xu Zhang; John Zhong Li; Junqi Niu; Qian Wang Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been...

View article titled, Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

Includes: Supplementary data

Articles

Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Rachel Njeim, Theresa Farhat, Sahar Alkhansa, Natalie Youssef, Batoul Dia, Rasha Slika, Radwan Diab, Sami T. Azar, Assaad A. Eid

Clin Sci (Lond) (2020) 134 (4): 403–417.

DOI: https://doi.org/10.1042/CS20190584

Published: 25 February 2020

...Rachel Njeim; Theresa Farhat; Sahar Alkhansa; Natalie Youssef; Batoul Dia; Rasha Slika; Radwan Diab; Sami T. Azar; Assaad A. Eid Diabetic kidney disease is one of the most serious complications of diabetes worldwide and is the leading cause of end-stage renal disease. While research has primarily...

View article titled, Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury

Articles

Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Yujia Yuan, Younan Chen, Tianqing Peng, Lan Li, Wuzheng Zhu, Fei Liu, Shuyun Liu, Xingxing An, Ruixi Luo, Jingqiu Cheng, Jingping Liu, Yanrong Lu

Clin Sci (Lond) (2019) 133 (15): 1759–1777.

DOI: https://doi.org/10.1042/CS20190672

Published: 14 August 2019

...Yujia Yuan; Younan Chen; Tianqing Peng; Lan Li; Wuzheng Zhu; Fei Liu; Shuyun Liu; Xingxing An; Ruixi Luo; Jingqiu Cheng; Jingping Liu; Yanrong Lu Macrophage polarization toward the M1 phenotype and its subsequent inflammatory response have been implicated in the progression of diabetic...

View article titled, Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Includes: Supplementary data

Articles

Impact of obesity-induced type 2 diabetes on long-term outcomes following stroke

Sonu Bhaskar

Clin Sci (Lond) (2019) 133 (14): 1603–1607.

DOI: https://doi.org/10.1042/CS20190492

Published: 22 July 2019

...Sonu Bhaskar Diabetes is associated with poor recovery profiles following stroke. The pathophysiological mechanisms by which diabetes mediates neurological recovery after stroke are debatable. A recent paper published in the Clinical Science by Pintana et al. (Clinical Science (2019) 133 , 1367...

View article titled, Impact of obesity-induced type 2 diabetes on long-term outcomes following stroke

Articles

Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease

Jia Guo, Zhangsuo Liu, Rujun Gong

Clin Sci (Lond) (2019) 133 (12): 1321–1339.

DOI: https://doi.org/10.1042/CS20190372

Published: 20 June 2019

...Jia Guo; Zhangsuo Liu; Rujun Gong Diabetic kidney disease (DKD) is among the most common complications of diabetes mellitus (DM), and remains the leading cause of end-stage renal diseases (ESRDs) in developed countries, with no definitive therapy yet available. It is imperative to decipher...

View article titled, Long noncoding RNA: an emerging player in diabetes and diabetic kidney disease

Articles

NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound

Dan Liu, Peilang Yang, Min Gao, Tianyi Yu, Yan Shi, Meng Zhang, Min Yao, Yan Liu, Xiong Zhang

Clin Sci (Lond) (2019) 133 (4): 565–582.

DOI: https://doi.org/10.1042/CS20180600

Published: 18 February 2019

...Dan Liu; Peilang Yang; Min Gao; Tianyi Yu; Yan Shi; Meng Zhang; Min Yao; Yan Liu; Xiong Zhang Persistent inflammatory response in the diabetic wound impairs the healing process, resulting in significant morbidity and mortality. Mounting evidence indicate that the activation of Nod-like receptor...

View article titled, NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound

Articles

SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice

Catalina Atorrasagasti, Agostina Onorato, María L. Gimeno, Luz Andreone, Mariana Garcia, Mariana Malvicini, Esteban Fiore, Juan Bayo, Marcelo J. Perone, Guillermo D. Mazzolini

Clin Sci (Lond) (2019) 133 (2): 351–365.

DOI: https://doi.org/10.1042/CS20180714

Published: 30 January 2019

...Catalina Atorrasagasti; Agostina Onorato; María L. Gimeno; Luz Andreone; Mariana Garcia; Mariana Malvicini; Esteban Fiore; Juan Bayo; Marcelo J. Perone; Guillermo D. Mazzolini Obesity, metabolic syndrome, and type 2 diabetes, three strongly interrelated diseases, are associated to increased...

View article titled, SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice

Includes: Supplementary data

Articles

Trained immunity and diabetic vascular disease

Kathrin Thiem, Rinke Stienstra, Niels P. Riksen, Samuel T. Keating

Clin Sci (Lond) (2019) 133 (2): 195–203.

DOI: https://doi.org/10.1042/CS20180905

Published: 18 January 2019

... atherosclerosis remains the principal cause of morbidity and premature mortality in patients with diabetes, and the burden of vascular complications is greatly enhanced by prior periods of inadequate control of blood glucose. Recent findings suggest that long-term changes in bone marrow myeloid progenitors...

View article titled, Trained immunity and diabetic vascular disease

Articles

Histamine and diabetic nephropathy: an up-to-date overview

Alessandro Pini, Roberta Verta, Cristina Grange, Maura Gurrieri, Arianna Carolina Rosa

Clin Sci (Lond) (2019) 133 (1): 41–54.

DOI: https://doi.org/10.1042/CS20180839

Published: 03 January 2019

...Alessandro Pini; Roberta Verta; Cristina Grange; Maura Gurrieri; Arianna Carolina Rosa The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties...

View article titled, Histamine and diabetic nephropathy: an up-to-date overview

Articles

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Gargi Mahapatra, S. Carrie Smith, Timothy M. Hughes, Benjamin Wagner, Joseph A. Maldjian, Barry I. Freedman, Anthony J. A. Molina

Clin Sci (Lond) (2018) 132 (23): 2509–2518.

DOI: https://doi.org/10.1042/CS20180690

Published: 05 December 2018

... peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate...

View article titled, Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes

Articles

Gestational diabetes alters microRNA signatures in human feto-placental endothelial cells depending on fetal sex

Jasmin Strutz, Silvija Cvitic, Hubert Hackl, Karl Kashofer, Hannah M. Appel, Andrea Thüringer, Gernot Desoye, Pieter Koolwijk, Ursula Hiden

Clin Sci (Lond) (2018) 132 (22): 2437–2449.

DOI: https://doi.org/10.1042/CS20180825

Published: 22 November 2018

...Jasmin Strutz; Silvija Cvitic; Hubert Hackl; Karl Kashofer; Hannah M. Appel; Andrea Thüringer; Gernot Desoye; Pieter Koolwijk; Ursula Hiden MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important, epigenetic regulators of endothelial function. Metabolic disturbances such as diabetes...

View article titled, Gestational diabetes alters microRNA signatures in human feto-placental endothelial cells depending on fetal sex

Includes: Supplementary data

Articles

Insulin reverses major portal hypertension-related derangements in rats with liver cirrhosis and diabetes

I-Fang Hsin, Hui-Chun Huang, Ching-Chih Chang, Shao-Jung Hsu, Fa-Yauh Lee, Teh-Ia Huo, Chiao-Lin Chuang, Ming-Chih Hou, Shou-Dong Lee

Clin Sci (Lond) (2018) 132 (22): 2391–2405.

DOI: https://doi.org/10.1042/CS20180557

Published: 19 November 2018

...I-Fang Hsin; Hui-Chun Huang; Ching-Chih Chang; Shao-Jung Hsu; Fa-Yauh Lee; Teh-Ia Huo; Chiao-Lin Chuang; Ming-Chih Hou; Shou-Dong Lee Liver cirrhosis is accompanied by increased intrahepatic resistance and angiogenesis-related portosystemic collaterals formation. Diabetic patients suffer from...

View article titled, Insulin reverses major portal hypertension-related derangements in rats with liver cirrhosis and diabetes

Articles

Sodium-glucose transporter 2 inhibition and cardiovascular events in patients with diabetes: information from clinical trials and observational real-world data

Giulia Ferrannini, Lars Rydén

Clin Sci (Lond) (2018) 132 (18): 2003–2012.

DOI: https://doi.org/10.1042/CS20171374

Published: 19 September 2018

...Giulia Ferrannini; Lars Rydén Cardiovascular (CV) disease (CVD) is the main cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Despite optimal glycaemic control, standard antihyperglycaemic therapy failed to impact CV events in intervention trials; therefore, the U.S...

View article titled, Sodium-glucose transporter 2 inhibition and cardiovascular events in patients with diabetes: information from clinical trials and observational real-world data

Articles

Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders

Cynthia Rajani, Wei Jia

Clin Sci (Lond) (2018) 132 (7): 791–811.

DOI: https://doi.org/10.1042/CS20171328

Published: 16 April 2018

... of host metabolic diseases including obesity, cardiovascular, diabetes, and fatty liver disease. This disruption is often referred to as gut dysbiosis. Gut dysbiosis leads to altered metabolic products derived from the microbiota and these in turn, typically shift the homeostatic metabolic balance...

View article titled, Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders

Articles

O-Linked β- N -acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy

Zafer Gurel, Nader Sheibani

Clin Sci (Lond) (2018) 132 (2): 185–198.

DOI: https://doi.org/10.1042/CS20171454

Published: 19 January 2018

...Zafer Gurel; Nader Sheibani The incidence of diabetes continues to rise among all ages and ethnic groups worldwide. Diabetic retinopathy (DR) is a complication of diabetes that affects the retinal neurovasculature causing serious vision problems, including blindness. Its pathogenesis and severity...

View article titled, O-Linked β- N -acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy

Articles

Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice

Fei-Juan Kong, Lei-Lei Ma, Jun-Jie Guo, Lin-Hao Xu, Yun Li, Shen Qu

Clin Sci (Lond) (2018) 132 (1): 111–125.

DOI: https://doi.org/10.1042/CS20171432

Published: 11 January 2018

...Fei-Juan Kong; Lei-Lei Ma; Jun-Jie Guo; Lin-Hao Xu; Yun Li; Shen Qu Diabetes mellitus is a significant global public health problem depicting a rising prevalence worldwide. As a serious complication of diabetes, diabetes-associated cognitive decline is attracting increasing attention. However...

View article titled, Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice

Articles

The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Matthew Kerr, Michael S. Dodd, Lisa C. Heather

Clin Sci (Lond) (2017) 131 (16): 2079–2094.

DOI: https://doi.org/10.1042/CS20160671

Published: 24 July 2017

... involvement of each of these steps has been amassed from genetic mouse models, where forcing the heart to metabolize too much or too little fat was accompanied by cardiac contractile dysfunction and hypertrophy. In cardiac pathologies, such as heart disease and diabetes, aberrations in FA metabolism occur...

View article titled, The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Articles

Thrombosis in diabetes: a shear flow effect?

Erik Westein, Thomas Hoefer, Anna C. Calkin

Clin Sci (Lond) (2017) 131 (12): 1245–1260.

DOI: https://doi.org/10.1042/CS20160391

Published: 07 June 2017

...Erik Westein; Thomas Hoefer; Anna C. Calkin Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes (T2D). This condition is associated with heightened platelet reactivity, contributing to increased atherothrombotic risk. Indeed, individuals with diabetes respond...

View article titled, Thrombosis in diabetes: a shear flow effect?

Articles

Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease

Paola Dongiovanni, Marica Meroni, Guido Alessandro Baselli, Giulia Alessandra Bassani, Raffaela Rametta, Alessandro Pietrelli, Marco Maggioni, Federica Facciotti, Valentina Trunzo, Sara Badiali, Silvia Fargion, Stefano Gatti, Luca Valenti

Clin Sci (Lond) (2017) 131 (12): 1301–1315.

DOI: https://doi.org/10.1042/CS20170175

Published: 07 June 2017

... fibrosis in InsR+/– MCD-fed mice. Loxl2 up-regulation was similarly detected during IR induced by obesity, but not by lipogenic stimuli (fructose feeding). Most importantly, LOXL2 up-regulation was observed in NAFLD patients with type 2 diabetes (T2D) and LOXL2 hepatic and circulating levels correlated...

View article titled, Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease

Includes: Supplementary data

Articles

DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy

Bin Zhou, Shaoqing Lei, Rui Xue, Yan Leng, Zhengyuan Xia, Zhong-Yuan Xia

Clin Sci (Lond) (2017) 131 (11): 1161–1178.

DOI: https://doi.org/10.1042/CS20170052

Published: 22 May 2017

...Bin Zhou; Shaoqing Lei; Rui Xue; Yan Leng; Zhengyuan Xia; Zhong-Yuan Xia IPO (ischaemic post-conditioning) is a promising method of alleviating myocardial IR (ischaemia-reperfusion) injury; however, IPO-mediated cardioprotection is lost in diabetic hearts via mechanisms that remain largely unclear...

View article titled, DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy

Articles

The emerging role of NADPH oxidase NOX5 in vascular disease

Jay C. Jha, Anna M.D. Watson, Geetha Mathew, Lisanne C. de Vos, Karin Jandeleit-Dahm

Clin Sci (Lond) (2017) 131 (10): 981–990.

DOI: https://doi.org/10.1042/CS20160846

Published: 04 May 2017

... and are the common denominator for various diseases including diabetes-associated macro-/micro-vascular complications and hypertension. A range of enzymes are capable of generating ROS, but the pro-oxidant enzyme family, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), are the only enzymes known...

View article titled, The emerging role of NADPH oxidase NOX5 in vascular disease

Articles

Dual actions of Netrin-1 on islet insulin secretion and immune modulation

Shan Gao, Xiuyuan Zhang, Yibo Qin, Shixin Xu, Ju Zhang, Zhihong Wang, Weiwei Wang, Deling Kong, Chen Li

Clin Sci (Lond) (2016) 130 (21): 1901–1911.

DOI: https://doi.org/10.1042/CS20160133

Published: 22 September 2016

... reported in multiple tissues, we have investigated the potential role of Netrin-1 in the endocrine islet and its implication in mice with high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Effects of exogenous Netrin-1 on β-cell [Ca 2+ ] i , cyclic AMP (cAMP) and insulin production were assessed...

View article titled, Dual actions of Netrin-1 on islet insulin secretion and immune modulation

Includes: Supplementary data

Articles

Cerebrovascular complications of diabetes: focus on cognitive dysfunction

Trevor Hardigan, Rebecca Ward, Adviye Ergul

Clin Sci (Lond) (2016) 130 (20): 1807–1822.

DOI: https://doi.org/10.1042/CS20160397

Published: 15 September 2016

...Trevor Hardigan; Rebecca Ward; Adviye Ergul The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients...

View article titled, Cerebrovascular complications of diabetes: focus on cognitive dysfunction

Articles

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

Naila Rabbani, Mingzhan Xue, Paul J. Thornalley

Clin Sci (Lond) (2016) 130 (19): 1677–1696.

DOI: https://doi.org/10.1042/CS20160025

Published: 23 August 2016

... by glyoxalase 1. The GLO1 gene encoding glyoxalase 1 has low prevalence duplication and high prevalence amplification in some tumours. Dicarbonyl stress contributes to aging, disease and activity of cytotoxic chemotherapeutic agents. It is found at a low, moderate and severe level in obesity, diabetes and renal...

View article titled, Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

Articles

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE −/− mice

Elyse Di Marco, Stephen P. Gray, Phyllis Chew, Kit Kennedy, Mark E. Cooper, Harald H.H.W. Schmidt, Karin A.M. Jandeleit-Dahm

Clin Sci (Lond) (2016) 130 (15): 1363–1374.

DOI: https://doi.org/10.1042/CS20160249

Published: 29 June 2016

...Elyse Di Marco; Stephen P. Gray; Phyllis Chew; Kit Kennedy; Mark E. Cooper; Harald H.H.W. Schmidt; Karin A.M. Jandeleit-Dahm Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers...

View article titled, Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE −/− mice

Includes: Supplementary data

Articles

Blood pressure-independent renoprotection in diabetic rats treated with AT 1 receptor–neprilysin inhibition compared with AT 1 receptor blockade alone

Lodi C.W. Roksnoer, Richard van Veghel, Marian C. Clahsen- van Groningen, René de Vries, Ingrid M. Garrelds, Usha M. Bhaggoe, Jeanette M.G. van Gool, Edith C.H. Friesema, Frank P.J. Leijten, Ewout J. Hoorn, A.H. Jan Danser, Wendy W. Batenburg

Clin Sci (Lond) (2016) 130 (14): 1209–1220.

DOI: https://doi.org/10.1042/CS20160197

Published: 01 June 2016

...–neprilysin inhibition] exerts beneficial effects on blood pressure and kidney function in heart failure, compared with ARB (AT 1 receptor blockade) alone. We hypothesized that ARNI improves cardiac and kidney parameters in diabetic TGR(mREN2)27 rats, an angiotensin II-dependent hypertension model. Rats were...

View article titled, Blood pressure-independent renoprotection in diabetic rats treated with AT 1 receptor–neprilysin inhibition compared with AT 1 receptor blockade alone

Includes: Supplementary data

Articles

Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling

Yan Wang, Haobo Li, Huansen Huang, Shiming Liu, Xiaowen Mao, Sheng Wang, Stanley Sau-ching Wong, Zhengyuan Xia, Michael G. Irwin

Clin Sci (Lond) (2016) 130 (10): 801–812.

DOI: https://doi.org/10.1042/CS20150617

Published: 01 April 2016

... in ischaemic postconditioning cardioprotection, which can be regulated by the Brahma-related gene ( Brg1 ) and nuclear factor-erythroid 2-related factor 2 (Nrf2), although they are both reduced in diabetic hearts. We hypothesized that reduced Brg1/Nrf2 and STAT3 activation may jeopardize IsoPostC-mediated...

View article titled, Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling

Includes: Supplementary data

Articles

Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways

Rui Xue, Shaoqing Lei, Zhong-yuan Xia, Yang Wu, Qingtao Meng, Liying Zhan, Wating Su, Huimin Liu, Jinjin Xu, Zhenzhen Liu, Bin Zhou, Zhengyuan Xia

Clin Sci (Lond) (2016) 130 (5): 377–392.

DOI: https://doi.org/10.1042/CS20150496

Published: 26 January 2016

...Rui Xue; Shaoqing Lei; Zhong-yuan Xia; Yang Wu; Qingtao Meng; Liying Zhan; Wating Su; Huimin Liu; Jinjin Xu; Zhenzhen Liu; Bin Zhou; Zhengyuan Xia Patients with diabetes are vulnerable to MI/R (myocardial ischaemia/reperfusion) injury, but are not responsive to IPostC (ischaemic post-conditioning...

View article titled, Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways

Articles

The regulation of function, growth and survival of GLP-1-producing L-cells

Rune E. Kuhre, Jens J. Holst, Camilla Kappe

Clin Sci (Lond) (2016) 130 (2): 79–91.

DOI: https://doi.org/10.1042/CS20150154

Published: 04 December 2015

... effects on various tissues, regulating energy absorption and disposal, as well as cell proliferation and survival. In Type 2 Diabetes (T2D) reduced plasma levels of GLP-1 have been observed, and plasma levels of GLP-1, as well as reduced numbers of GLP-1 producing cells, have been correlated to obesity...

View article titled, The regulation of function, growth and survival of GLP-1-producing L-cells

Articles

Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome

Laurence Poekes, Nicolas Lanthier, Isabelle A. Leclercq

Clin Sci (Lond) (2015) 129 (11): 933–949.

DOI: https://doi.org/10.1042/CS20150339

Published: 10 September 2015

... tissues as well as its potential contribution to fighting obesity and the metabolic syndrome. adrenergic receptor brown adipose tissue browning diabetes obesity white adipose tissue Correspondence: Dr Isabelle Leclercq (email isabelle.leclercq@uclouvain.be ). 8 5 2015 27...

View article titled, Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome

Articles

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

Tong-Yan Liu, Chang-Xiang Shi, Run Gao, Hai-Jian Sun, Xiao-Qing Xiong, Lei Ding, Qi Chen, Yue-Hua Li, Jue-Jin Wang, Yu-Ming Kang, Guo-Qing Zhu

Clin Sci (Lond) (2015) 129 (10): 839–850.

DOI: https://doi.org/10.1042/CS20150009

Published: 19 August 2015

...Tong-Yan Liu; Chang-Xiang Shi; Run Gao; Hai-Jian Sun; Xiao-Qing Xiong; Lei Ding; Qi Chen; Yue-Hua Li; Jue-Jin Wang; Yu-Ming Kang; Guo-Qing Zhu Increased glucose production and reduced hepatic glycogen storage contribute to metabolic abnormalities in diabetes. Irisin, a newly identified myokine...

View article titled, Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

Includes: Supplementary data

Articles

Impaired mitochondrial energy supply coupled to increased H 2 O 2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

Carlo G. Tocchetti, Brian A. Stanley, Vidhya Sivakumaran, Djahida Bedja, Brian O'Rourke, Nazareno Paolocci, Sonia Cortassa, Miguel A. Aon

Clin Sci (Lond) (2015) 129 (7): 561–574.

DOI: https://doi.org/10.1042/CS20150204

Published: 03 July 2015

...Carlo G. Tocchetti; Brian A. Stanley; Vidhya Sivakumaran; Djahida Bedja; Brian O'Rourke; Nazareno Paolocci; Sonia Cortassa; Miguel A. Aon In Type I diabetic (T1DM) patients, both peaks of hyperglycaemia and increased sympathetic tone probably contribute to impair systolic and diastolic function...

View article titled, Impaired mitochondrial energy supply coupled to increased H 2 O 2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

Includes: Supplementary data

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