1-12 of 12
Keywords: DNA methylation
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2022) 136 (7): 473–492.
Published: 06 April 2022
... as modified histone proteins, cytosine DNA methylation, non-coding RNAs, and mRNA modifications, such as N6-methyladenosine (m6A). The different aspects of epigenomic and epitranscriptomic modifications require protein complexes to write, read, and erase these chemical alterations. Reflecting these important...
Articles
Clin Sci (Lond) (2020) 134 (14): 1935–1956.
Published: 23 July 2020
... in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in the present study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated in the 5...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 273–287.
Published: 29 January 2020
... of the Biochemical Society 2020 acute myocardial infarction Atherosclerosis DNA methylation inflammation reverse cholesterol transport SULT2B1b Atherosclerosis (AS) is the most common underlying cause of ischaemic heart disease and continues to be a leading cause of deaths worldwide [ 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 103–122.
Published: 23 January 2020
.... Importantly, both in vivo and in vitro studies showed alcohol treatments decreased Smad7 and activated Smad3. We further determined how the alcohol affected the balance of Smad7 (inhibitory Smad) and Smad3 (regulatory Smad). Genome-wide methylation sequencing showed an increased DNA methylation of many genes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (20): 2085–2105.
Published: 22 October 2019
...: promoting proliferation but inhibiting metastasis. Mechanistic experiments revealed that doublecortin-like kinase 1 (DCLK1) was a downstream target of SETD3. SETD3 could increase the DNA methylation level of DCLK1 promoter to inhibit the transcription of DCLK1. Further study revealed that DCLK1/PI3K/matrix...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (4): 597–609.
Published: 25 February 2019
..., and implication of histone modifications and DNA methylation in I/R injury-induced organ dysfunction. Understandings of I/R-induced epigenetic alterations and regulations will aid in the development of potential therapeutics. Correspondence: Shougang Zhuang ( szhuang@lifespan.org ) 02 06 2018 25...
Articles
Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
... Stenvinkel ( peter.stenvinkel@ki.se ) 09 12 2016 17 04 2017 19 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 chronic kidney disease DNA methylation epigenetics microRNA Chronic kidney disease (CKD...
Articles
Clin Sci (Lond) (2016) 130 (22): 2053–2059.
Published: 11 October 2016
... individuals with high cardiovascular disease risk selected as being carriers of at least one APOA5 SNP (-1131T>C and/or, S19W and/or 724C>G) compared against 34 individuals wild-type (WT) for these SNPs. DNA methylation patterns of three APOA5 regions [promoter, exon 2 and CpG island (CGI) in exon 3...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (9): 733–746.
Published: 18 March 2016
.... In this setting, DNA methylation could also be an important factor influencing this disease. We performed a genome-wide screening for DNA methylation in CD4 + T-cells from IgAN patients and found three regions aberrantly methylated influencing genes involved in the response and proliferation of CD4 + T-cells. Two...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (8): 575–586.
Published: 08 March 2016
... examined whether the reduced level of COX-2 mRNA expression observed in fibrotic lung fibroblasts is regulated epigenetically. The DNA methylation inhibitor, 5-aza-2′-deoxycytidine (5AZA) restored COX-2 mRNA expression by fibrotic lung fibroblasts dose dependently. Functionally, this resulted...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (4): 385–394.
Published: 27 May 2015
... gestational glucose levels would positively correlate with DNA methylation of the PPARGC1A promoter in placental tissue. We undertook a cross-sectional study of 58 mothers who underwent uncomplicated Caesarean delivery in a university hospital. Maternal gestational glucose concentration was determined after...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 118 (7): 451–457.
Published: 23 December 2009
... DNA methylation E-cadherin implantation placentation trophoblast Placentation in human pregnancy involves proliferation, migration and differentiation of the extra-embryonic trophoblast population, and infiltration of the maternal endometrium by invasive EVTs (extravillous cytotrophoblasts...