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Keywords: DNA damage
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Articles
Clin Sci (Lond) (2022) 136 (1): 163–166.
Published: 10 January 2022
...Sarah-Eve Lemay; Sebastien Bonnet; François Potus In this commentary, we discuss new observations stating that spliced X-box-binding protein 1 (Xbp1s)-DNA damage-inducible transcript 3 (Ddit3) promotes monocrotaline (MCT)-induced pulmonary hypertension (Jiang et al., Clinical Science (2021) 135 (21...
Articles
Clin Sci (Lond) (2020) 134 (7): 727–746.
Published: 07 April 2020
... which vascular aging outcomes are due to local endothelial DNA damage, which was accomplished by genetic removal of ERCC1 (excision repair cross-complementation group 1) DNA repair in mice (EC-knockout (EC-KO) mice). EC-KO showed a progressive decrease in microvascular dilation of the skin, increased...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (14): 1269–1284.
Published: 13 June 2016
... levels of oxidative stress and significantly lower levels of antioxidant activity leading to molecular damage, including protein nitration, lipid peroxidation and DNA damage that contribute to tissue dysfunction. Furthermore, we show that elastase is elevated, suggesting that elastin is degraded...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2007) 112 (12): 599–606.
Published: 14 May 2007
... diabetes, to test this hypothesis, we have investigated oxidative stress pathways and DNA damage in patients with IGR and newly diagnosed Type 2 diabetes. The study population consisted of 92 subjects with NGT (normal glucose tolerance), 78 patients with IGR and 113 patients with newly diagnosed diabetes...
Articles
Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
... malexeye@jaguar1.usouthal.edu ). 26 5 2004 22 7 2004 28 7 2004 28 7 2004 The Biochemical Society 2004 aging DNA damage mitochondrial DNA oxidative stress reactive oxygen species repair Aging can be defined as a multifactorial phenomenon characterized by a time...
Articles
Clin Sci (Lond) (2001) 101 (3): 235–241.
Published: 03 August 2001
... The Biochemical Society and the Medical Research Society © 2001 2001 DNA damage paraoxonase -tocopherol Type II diabetes 235Clinical Science (2001) 101, 235 241 (Printed in Great Britain) Increased DNA oxidative susceptibility without increased plasma LDL oxidizability in Type II diabetes: effects...