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Liangliang Xu, Peng Wang, Xinfu Feng, Jianwei Tang, Lian Li, Xiaobo Zheng, Jinfu Zhang, Yitao Hu, Tian Lan, Kefei Yuan, Yanfang Zhang, Shengsheng Ren, Xiangyong Hao, Ming Zhang, Mingqing Xu
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (20): 2085–2105.
Published: 22 October 2019
...: promoting proliferation but inhibiting metastasis. Mechanistic experiments revealed that doublecortin-like kinase 1 (DCLK1) was a downstream target of SETD3. SETD3 could increase the DNA methylation level of DCLK1 promoter to inhibit the transcription of DCLK1. Further study revealed that DCLK1/PI3K/matrix...
Includes: Supplementary data