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Keywords: Compound 21
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Clin Sci (Lond) (2021) 135 (24): 2763–2780.
Published: 17 December 2021
...Raquel González-Blázquez; Martín Alcalá; José Miguel Cárdenas-Rebollo; Marta Viana; Ulrike Muscha Steckelings; William A. Boisvert; Thomas Unger; María S. Fernández-Alfonso; Beatriz Somoza; Marta Gil-Ortega The aim of the present study was to evaluate the effect of Compound 21 (C21), a selective...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
...Raquel González-Blázquez; Martín Alcalá; María S. Fernández-Alfonso; Ulrike Muscha Steckelings; M. Paz Lorenzo; Marta Viana; William A. Boisvert; Thomas Unger; Marta Gil-Ortega; Beatriz Somoza Compound 21 (C21), a selective agonist of angiotensin II type 2 receptor (AT 2 R), induces vasodilation...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (6): 627–640.
Published: 20 March 2018
..., and in APA-adjacent tissue. The effect of Compound 21 (C21), an AT2R agonist, on CYP11B1 (cortisol synthase) and CYP11B2 (aldosterone synthase) gene expression in NCI-H295R and HAC15 cell lines, and in APA and APA-adjacent tissue, was also assessed using the AT1R antagonist irbesartan to ascertain...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (15): 1307–1326.
Published: 29 June 2016
... 6 5 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 AT2 receptor AT2R agonism cardiovascular compound 21 kidney The biological actions of the renin–angiotensin system (RAS) are regarded to be primarily mediated...
Clin Sci (Lond) (2015) 129 (1): 81–92.
Published: 15 April 2015
... pressure responses to stimulation of central AT 2 Rs by the selective agonist Compound 21 in conscious spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKY rats). We also assessed the impact on noradrenaline [norepinephrine (NE)] plasma levels, autonomic function, spontaneous...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (9): 567–578.
Published: 11 February 2015
... II and the AT 1 receptor antagonist, losartan, induces apoptosis but does not affect the rate of cell death. We demonstrate for the first time that the high-affinity, non-peptide AT 2 receptor agonist, Compound 21 (C21), penetrates the cell membrane of quiescent SK-UT-1 cells, activates intracellular...
Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
... of binding affinities of all the major angiotensin peptides. Additionally, we tested the novel AT 2 R agonist Compound 21, as well as the Mas R ( Mas receptor) agonist and antagonist AVE0991 and A-779 respectively, for their ability to bind to AT 1 R or AT 2 R. Candesartan, CGP42214 and PD123319 were used...