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Keywords: Cardiovascular
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Clin Sci (Lond) (2020) 134 (22): 3023–3046.
Published: 24 November 2020
... focuses largely on the developmental programming of cardiovascular function and begins with a brief discussion on the emergence of the ‘Barker hypothesis’, and its subsequent evolution into the more-encompassing DOHaD framework. We then discuss some fundamental pathophysiological processes by which...
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Clin Sci (Lond) (2020) 134 (7): 747–750.
Published: 07 April 2020
... and cardiovascular and renal diseases [ 28 ], it has been suggested that ACE inhibitors and Ang II-receptor blockers (ARBs) may increase the risk of COVID-19 infection by up-regulating ACE2 [ 29 , 30 ]. On the other hand, it has been proposed that inhibitors of the RAS, particularly ARBs, may actually have...
Clin Sci (Lond) (2018) 132 (22): 2387–2389.
Published: 19 November 2018
... play an important role in human health and disease, including cardiovascular and autoimmune diseases. Changes in the composition of gut microbiota (dysbiosis) are linked to chronic inflammation, thrombosis, atherogenesis, chronic heart, and kidney disease, as well as to autoimmune diseases like...
Clin Sci (Lond) (2018) 132 (18): 2003–2012.
Published: 19 September 2018
...Giulia Ferrannini; Lars Rydén Cardiovascular (CV) disease (CVD) is the main cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Despite optimal glycaemic control, standard antihyperglycaemic therapy failed to impact CV events in intervention trials; therefore, the U.S...
Clin Sci (Lond) (2018) 132 (9): 909–923.
Published: 08 May 2018
... markers of acute kidney injury, as it is rapidly released after tubular damage. However, a growing body of evidence highlights an important role for NGAL beyond that of a biomarker of renal dysfunction. Indeed, numerous studies have demonstrated a role for NGAL in both cardiovascular and renal diseases...
Clin Sci (Lond) (2017) 131 (13): 1405–1418.
Published: 23 June 2017
... are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca 2+ mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non...
Clin Sci (Lond) (2017) 131 (4): 329–342.
Published: 03 February 2017
.... In the present review, we consider recent results from pharmacogenomics and the role of sex in studies that are relevant to cardiovascular therapy. We focus on genome-wide analyses, because they have obvious advantages compared with targeted single-candidate gene studies. For instance, genome-wide approaches do...
Clin Sci (Lond) (2016) 130 (15): 1307–1326.
Published: 29 June 2016
... mechanism against AT1R-mediated actions. Thus, this review will focus on providing insights into the biological role of the AT2R, in particular its actions within the renal and cardiovascular system. Correspondence: Terri J. Allen (email terri.allen@bakeridi.edu.au ). 30 3 2016 25 4 2016...
Clin Sci (Lond) (2016) 130 (12): 1005–1016.
Published: 06 May 2016
... cardiovascular GPR30 menopause metabolism reproduction © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 16 2 2016 17 2 2016 2 3 2016 Correspondence: Dr Sarah Lindsey (email lindsey@tulane.edu ). Women have a lower...
Clin Sci (Lond) (2009) 116 (4): 301–314.
Published: 15 January 2009
...Cheng Qian; Regien G. Schoemaker; Wiek H. van Gilst; Anton J. M. Roks Intervention in the RAAS (renin–angiotensin–aldosterone system) is one of the leading pharmacotherapeutic strategies, among others, used for the treatment of cardiovascular disease to improve the prognosis after myocardial...
Clin Sci (Lond) (2000) 98 (1): 103–110.
Published: 06 December 1999
...: Dr D. O'Mahony, Department of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Republic of Ireland. 19 3 1999 29 6 1999 7 9 1999 The Biochemical Society and the Medical Research Society © 2000 2000 aging cardiovascular sympathetic vagus function...
Clin Sci (Lond) (1999) 97 (3): 291–301.
Published: 21 July 1999
... DE Amsterdam, The Netherlands. 12 2 1999 15 4 1999 23 5 1999 The Biochemical Society and the Medical Research Society © 1999 1999 cardiovascular fingers posture thermodilution tilt-table test 291Clinical Science (1999) 97, 291 301 (Printed in Great Britain...
Clin Sci (Lond) (1997) 92 (1): 13–24.
Published: 01 January 1997
...Gerard A. Rongen; John S. Floras; Jacques W. M. Lenders; Theo Thien; Paul Smits 1. This review focuses on the extracellular actions of ATP and adenosine, and in particular their role in cardiovascular regulation. 2. ATP serves as a co-transmitter within the sympathetic nervous system, and is also...
Clin Sci (Lond) (1995) 89 (4): 349–357.
Published: 01 October 1995
... secretion rates were derived using isotope dilution methodology. Heart rate and blood pressure spectral analysis measurements were also made. The relation of sympatho-adrenal activity to thermogenic and cardiovascular events was studied. Sympathetic nervous and thermogenic responses were measured for 120...