... be determined by Drp1 [ 9 ]. During I/R, Bax translocates to the mitochondria and controls permeability of the mitochondrial outer membrane and cytochrome c release. In cardiac myocytes, DNA-dependent protein kinase catalytic subunit (DNA-PKcs) may promote I/R injury by suppressing Bax inhibitor-1 (BI-1...

..., SRF and the ERK pathway and these findings suggest that hypoxia induces hypertrophy via MURC expression. cardiac myocyte hypoxia muscle-restricted coiled-coil protein (MURC) signalling pathway transforming growth factor-β (TGF-β) • The expression of MURC, a hypertrophy-regulated...

... with increased signalling via G-protein-coupled receptors. Three members of the RGS (regulator of G-protein signalling) superfamily RGS2, RGS4 and RGS5 have been implicated in the attenuation of G-protein signalling pathways in vascular and cardiac myocytes, as well as cells of the kidney and autonomic nervous...

..., and autocrine and paracrine functions. Laminar shear stress exerts anti-apoptotic, anti-atherosclerotic and antithrombotic effects on ECs (endothelial cells). Mechanical stretch of cardiac myocytes can modulate growth, apoptosis, electric remodelling, alterations in gene expression, and autocrine and paracrine...