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Keywords: COX-2
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Articles

Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance

Pei-Chi Chan, Ting-Ni Wu, Ying-Chuan Chen, Chieh-Hua Lu, Martin Wabitsch, Yu-Feng Tian, Po-Shiuan Hsieh
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1581–1596.
https://doi.org/10.1042/CS20180041
Published: 31 July 2018
...Pei-Chi Chan; Ting-Ni Wu; Ying-Chuan Chen; Chieh-Hua Lu; Martin Wabitsch; Yu-Feng Tian; Po-Shiuan Hsieh Adipose tissue (AT) inflammation is crucial to the development of obesity-associated insulin resistance. Our aim was to investigate the contribution of cyclooxygenase-2 (COX-2)/macrophage...
View article titled, Targeted inhibition of CD74 attenuates adipose <span class="search-highlight">COX</span>-<span class="search-highlight">2</span>-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance
Open the PDF for Targeted inhibition of CD74 attenuates adipose <span class="search-highlight">COX</span>-<span class="search-highlight">2</span>-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance in another window
Includes: Supplementary data
Articles

Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms

Thiago Bruder-Nascimento, Simone Kennard, Galina Antonova, James D. Mintz, Kendra K. Bence, Eric J. Belin de Chantemèle
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (11): 881–893.
https://doi.org/10.1042/CS20160073
Published: 22 April 2016
... inhibition only partially improved relaxation whereas COX-2 inhibition and thromboxane-A 2 (TXA 2 ) antagonism fully restored relaxation in POMC-Ptp1b−/− mice . Chronic treatment with the soluble TNF-α receptor etanercept decreased body temperature, restored endothelial function and reestablished aortic COX...
View article titled, Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms
Open the PDF for Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms in another window
Includes: Supplementary data