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Clin Sci (Lond) (2022) 136 (13): 1047–1052.
Published: 06 July 2022
...Erin B. Taylor Dysregulation of neutrophil extracellular trap (NET) formation has been shown to mediate disease pathology in multiple viral infections, including SARS-CoV-2. At the beginning of COVID-19 pandemic, Thierry and Roch wrote a perspective on the mechanisms by which severe SARS-CoV-2...
Clin Sci (Lond) (2022) 136 (6): 431–434.
Published: 29 March 2022
...John D. Imig The SARS-CoV-2 virus that results in COVID-19 has been found to damage multiple organs beyond the lung. Interestingly, the SARS-CoV-2 spike (S) protein can be found circulating in the blood of COVID-19 patients. Experimental findings are demonstrating that the circulating S protein can...
Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
Published: 15 December 2021
... cellular stress. We tested this hypothesis in pericytes (PCs), which are reportedly reduced in the heart of patients with severe coronavirus disease-2019 (COVID-19). Here we newly show that the in vitro exposure of primary human cardiac PCs to the SARS-CoV-2 wildtype strain or the α and δ variants caused...
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
...Nayara Azinheira Nobrega Cruz; Danielle Stoll; Dulce Elena Casarini; Mariane Bertagnolli In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme...
Clin Sci (Lond) (2021) 135 (8): 1009–1014.
Published: 21 April 2021
..., and their safety was addressed in COVID-19 patients. Pedrosa et al. ( Clin. Sci. ( Lond. ) (2021), 135 , 465–481) showed in rats that captopril and candesartan up-regulated ACE2 expression and the protective RAS pathway in lung tissue. In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation...
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
... with the manuscript. Correspondence: Jin-Kui Yang ( firstname.lastname@example.org ) * These authors contributed equally to this work. 16 11 2020 19 01 2021 21 01 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 ACE2 COVID-19...
Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
...)-coronavirus (CoV) and SARS-Cov-2, which cause SARS and coronavirus disease-19 (COVID-19) respectively. ACE-2 is thus a double-edged sword: it promotes cardiovascular health while also facilitating the devastations caused by coronaviruses. COVID-19 is associated with cardiovascular disease as a risk factor...
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ACE2 COVID-19 Heart Failure Hypertension Kidney Diseases SARS-CoV-2...
Clin Sci (Lond) (2020) 134 (23): 3229–3232.
Published: 11 December 2020
... – from cardiovascular regulation to coronavirus disease 2019 (COVID-19). Correspondence: Michael Bader ( email@example.com ) 07 12 2020 07 12 2020 07 12 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020...
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
... is hijacked by SARS-CoV-2 as a cellular receptor to gain entry to alveolar epithelial cells, causing COVID-19, a severe respiratory disease in humans. COVID-19 is frequently life-threatening especially in elderly or people with other medical conditions. As an unprecedented number of COVID-19 patients have...
Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... angiotensin converting enzyme 2 angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions...
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
...U. Muscha Steckelings; Colin Sumners The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for the global corona virus disease 2019 (COVID-19) pandemic enters host cells via a mechanism that includes binding to angiotensin converting enzyme (ACE) 2 (ACE2). Membrane...
Clin Sci (Lond) (2020) 134 (21): 2851–2871.
Published: 04 November 2020
... (SARS)-coronavirus (CoV)-2 responsible for the 2020, coronavirus infectious disease 2019 (COVID-19) pandemic. Understanding the interaction between SARS-CoV-2 and ACE2 is crucial for the design of therapies to combat this disease. This review provides a comparative analysis of methodologies and findings...
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... describe the emerging kidney manifestations of COVID-19, namely the frequent development of acute kidney injury. The possibility that binding of SARS-CoV-2 to kidney ACE2 plays a role in the kidney manifestations is also briefly discussed. Correspondence: Daniel Batlle ( firstname.lastname@example.org...
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
... and serendipitously as a viral receptor, mediating the cellular entry of the coronaviruses causing severe acute respiratory syndrome (SARS) and, very recently, COVID-19. Catalytically, ACE2 functions as a monocarboxypeptidase principally converting the vasoconstrictor angiotensin II to the vasodilatory peptide Ang-(1...
Clin Sci (Lond) (2020) 134 (17): 2315–2317.
Published: 09 September 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Coronavirus COVID-19 signaling pathway SARS-CoV-2 The authors...
Clin Sci (Lond) (2020) 134 (17): 2235–2241.
Published: 01 September 2020
... antibody. Trapping SARS-CoV-2 Mpro cysteine protease using cross-class serpin cysteine protease inhibition activity is a novel idea with significant therapeutic potential. APTT activated partial thromboplastin time CoV coronavirus Covid-19 coronavirus disease Mpro main protease...
Daniella S. Battagello, Guilherme Dragunas, Marianne O. Klein, Ana L.P. Ayub, Fernando J. Velloso, Ricardo G. Correa
Clin Sci (Lond) (2020) 134 (16): 2137–2160.
Published: 21 August 2020
...Daniella S. Battagello; Guilherme Dragunas; Marianne O. Klein; Ana L.P. Ayub; Fernando J. Velloso; Ricardo G. Correa The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses – the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – discovered...
Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
...Thiago Gomes Heck; Mirna Stela Ludwig; Matias Nunes Frizzo; Alberto Antonio Rasia-Filho; Paulo Ivo Homem de Bittencourt, Jr The major risk factors to fatal outcome in COVID-19 patients, i.e., elderliness and pre-existing metabolic and cardiovascular diseases (CVD), share in common...
Clin Sci (Lond) (2020) 134 (12): 1301–1304.
Published: 16 June 2020
...Jameel M. Inal The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes uptake, through attachment...
Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
... mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin–angiotensin system (RAS...
Clin Sci (Lond) (2020) 134 (7): 747–750.
Published: 07 April 2020
... (SARS-CoV) was identified as a novel respiratory pathogen leading to a global outbreak of SARS, and in 2012 a new CoV was shown to cause Middle-East respiratory syndrome (MERS) [ 13 ]. In 2019, SARS-CoV-2 was discovered as the cause of Co rona vi rus D isease-19 (COVID-19) [ 13 , 14 ]. SARS CoV-2...