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Keywords: COVID-19
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Clin Sci (Lond) (2023) 137 (8): 633–643.
Published: 21 April 2023
.... Mechanisms of action include inhibition of viral cell entry, inhibition of viral proteases, and stimulation of cellular innate immune responses. The anti-inflammatory properties of cannabinoids are also under investigation for mitigating the cytokine storm of COVID-19 and controlling chronic inflammation...
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Coronavirus
Clin Sci (Lond) (2022) 136 (20): 1439–1447.
Published: 21 October 2022
.... This approach, identifying calpeptin, through large-scale screening studies as a candidate drug to treat COVID-19, however, has not considered the longer term likely benefits of calpain inhibition, post-COVID-19. This perspective will reflect on the capacity of calpeptin for treating long COVID by inhibiting...
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Clin Sci (Lond) (2022) 136 (13): 1047–1052.
Published: 06 July 2022
...Erin B. Taylor Dysregulation of neutrophil extracellular trap (NET) formation has been shown to mediate disease pathology in multiple viral infections, including SARS-CoV-2. At the beginning of COVID-19 pandemic, Thierry and Roch wrote a perspective on the mechanisms by which severe SARS-CoV-2...
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Coronavirus
Clin Sci (Lond) (2022) 136 (6): 431–434.
Published: 29 March 2022
...John D. Imig The SARS-CoV-2 virus that results in COVID-19 has been found to damage multiple organs beyond the lung. Interestingly, the SARS-CoV-2 spike (S) protein can be found circulating in the blood of COVID-19 patients. Experimental findings are demonstrating that the circulating S protein can...
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Coronavirus
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
Published: 15 December 2021
... cellular stress. We tested this hypothesis in pericytes (PCs), which are reportedly reduced in the heart of patients with severe coronavirus disease-2019 (COVID-19). Here we newly show that the in vitro exposure of primary human cardiac PCs to the SARS-CoV-2 wildtype strain or the α and δ variants caused...
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Coronavirus
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
...Nayara Azinheira Nobrega Cruz; Danielle Stoll; Dulce Elena Casarini; Mariane Bertagnolli In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme...
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Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
... is hijacked by SARS-CoV-2 as a cellular receptor to gain entry to alveolar epithelial cells, causing COVID-19, a severe respiratory disease in humans. COVID-19 is frequently life-threatening especially in elderly or people with other medical conditions. As an unprecedented number of COVID-19 patients have...
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Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... the Mas antagonist A779, suggesting that the ACE2 product Ang-(1-7) was not involved in the DIZE-induced effects. angiotensin converting enzyme 2 angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector...
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Clin Sci (Lond) (2020) 134 (21): 2851–2871.
Published: 04 November 2020
... (SARS)-coronavirus (CoV)-2 responsible for the 2020, coronavirus infectious disease 2019 (COVID-19) pandemic. Understanding the interaction between SARS-CoV-2 and ACE2 is crucial for the design of therapies to combat this disease. This review provides a comparative analysis of methodologies and findings...
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Coronavirus
Clin Sci (Lond) (2020) 134 (17): 2235–2241.
Published: 01 September 2020
... the levels of serpin to induce hypercoagulation, as observed in many Covid-19 patients. Most of the efforts to counter Covid-19 are concentrated on developing DNA- and protein-based vaccines or targeting viral spike protein and protease through natural and synthetic small compounds [ 7...
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Coronavirus
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
... mechanisms and pathways of SARS-CoV-2 related to the pathogenesis of Coronavirus Disease 2019 (Covid-19). After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin–angiotensin system (RAS...
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