... = 10), i.p. trametinib ( n = 12). Data are shown as mean ± SEM. In this figure ‘ n ’ equals individual arterial segments. ( B ) Cumulative concentration–response curves to ET-1 (10 −14 to 10 −7 M) of basilar arteries normalized to 60 mM K + from animals treated with SAH + i.p. vehicle ( n = 5...

... responses of basilar arteries to serotonin [5-hydroxytryptamine (5-HT)] [(pD 2 ) 7.0±0.1 compared with 6.7±0.09 CD] and the thromboxane analogue 9,11-dideoxy-9 α ,11 α -methanoepoxy prostaglandin F 2α (U-46619) [(pD 2 ) 7.2±0.1 compared with 6.8±0.09 CD]. Of importance, increased levels of O -GlcNAc...