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Dong Zheng, Yi Zhang, Ming Zheng, Ting Cao, Grace Wang, Lulu Zhang, Rui Ni, Joseph Brockman, Huiting Zhong, Guo-Chang Fan, Tianqing Peng
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1505–1521.
Published: 15 July 2019
... in DOX-injected mice. These protective effects of NR were recapitulated in cultured cardiomyocytes upon DOX treatment. Mechanistically, NR prevented the blockage of autophagic flux, accumulation of autolysosomes, and oxidative stress in DOX-treated cardiomyocytes, the effects of which were associated...
Includes: Supplementary data