1-50 of 176
Keywords: Atherosclerosis
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2024) 138 (1): 1–21.
Published: 05 January 2024
... induce de novo synthesis of bile salts they act as cholesterol-lowering agents and thereby protect against the development of atherosclerosis in hamsters and monkeys [ 169–171 ]. Various ASBT inhibitors such as Volixibat, Odevixibat, Maralixibat, Lopixibat, Elobixibat, Linerixibat, A4250...
Articles
Articles
Articles
Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... associated with a local dysregulated metabolic response. Thus, recent studies show that metabolites are more than just fuels in their metabolic pathways, and they can act as modulators of vascular inflammation and atherosclerosis. In this review article, we describe the most common immunometabolic pathways...
Articles
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
...Kurt Brassington; Stavros Selemidis; Steven Bozinovski; Ross Vlahos Chronic obstructive pulmonary disease (COPD) and atherosclerosis are chronic irreversible diseases, that share a number of common causative factors including cigarette smoking. Atherosclerosis drastically impairs blood flow...
Articles
Articles
Articles
Clin Sci (Lond) (2021) 135 (13): 1557–1561.
Published: 30 June 2021
...: 10.1042/CS20201399). This important work demonstrates that PML, previously unrecognized as a participant in development of atherosclerosis, may represent a novel target for anti-atherosclerotic therapeutic modalities. Correspondence: Michael V. Autieri ( mautieri@temple.edu ) * These authors...
Articles
Clin Sci (Lond) (2021) 135 (9): 1165–1187.
Published: 14 May 2021
...Abdul Waheed Khan; Francesco Paneni; Karin A.M. Jandeleit-Dahm Atherosclerosis is a disease of large and medium arteries that can lead to life-threatening cerebrovascular and cardiovascular consequences such as heart failure and stroke and is a major contributor to cardiovascular-related mortality...
Articles
Articles
Articles
Clin Sci (Lond) (2021) 135 (3): 447–463.
Published: 01 February 2021
...Ling-lin Qian; Jing-jing Ji; Jia-qi Guo; Yan-ping Wu; Gen-shan Ma; Yu-yu Yao Abnormal vascular smooth muscle cell (VSMC) proliferation is a critical step in the development of atherosclerosis. Serpina3c is a serine protease inhibitor (serpin) that plays a key role in metabolic diseases. The present...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
... , 66 ], the opening of endothelial intercellular junctions and the induction of endothelial fenestration [ 67 ]. atherosclerosis cardiac arrhythmia heart failure hypertension Tyrosine kinase inhibitors vascular endothelial growth factor In recent years, survival for patients...
Articles
Clin Sci (Lond) (2020) 134 (13): 1775–1799.
Published: 17 July 2020
...), and liver failure. With the exception of intrahepatic burden, cardiovascular disease (CVD) and especially atherosclerosis (AS) are common complications of NAFLD. Furthermore, CVD is a major cause of death in NAFLD patients. Additionally, AS is a metabolic disorder highly associated with NAFLD...
Articles
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
Published: 18 June 2020
... the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit...
Articles
Articles
Articles
Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
... to ischemia, which is largely due to an occluded artery, or hemorrhagic, due to vessel rupture [ 3 ]. It is important to note that ∼90% of strokes are ischemic in nature, caused by large vessel atherosclerosis, small vessel disease, cardioembolic, or cryptogenic sources [ 4 ]. Neurologic symptoms...
Articles
Clin Sci (Lond) (2020) 134 (1): 3–13.
Published: 03 January 2020
... with the nearby vessel wall to regulate vascular function. Cross-talk between perivascular adipocytes and the cells in the blood vessel wall is vital for normal vascular function and becomes perturbed in diseases such as atherosclerosis. Perivascular adipocytes surrounding coronary arteries may be primed...
Articles
Clin Sci (Lond) (2019) 133 (16): 1779–1796.
Published: 20 August 2019
... inducing apoptosis. In the Apoe −/− mice, a 4-week infusion of chemerin-9 significantly decreased the areas of aortic atherosclerotic lesions by reducing intraplaque macrophage and SMC contents. Our results indicate that chemerin-9 prevents atherosclerosis. Therefore, the development of chemerin analogs...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1581–1585.
Published: 22 July 2019
...B Sumayyah H Sokeechand; Bernardo L Trigatti Atherosclerosis is a chronic inflammatory disease and a major driver of heart attack and stroke. Atherosclerosis development is driven by the infiltration of leukocytes, including monocytes and neutrophils, among other inflammatory cells into the artery...
Articles
Clin Sci (Lond) (2019) 133 (11): 1215–1228.
Published: 03 June 2019
...Yu Sun; Juan Guan; Yunfeng Hou; Fei Xue; Wei Huang; Wencheng Zhang; Yun Zhang; Cheng Zhang; Jianmin Yang Background: Although junctional adhesion molecule-like protein (JAML) has recently been implicated in leukocyte recruitment during inflammation and wound repair, its role in atherosclerosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (6): 763–776.
Published: 19 March 2019
... therapeutic targets. Herein, we briefly review how sphingolipids are implicated in the progression of atherosclerosis and related diseases, and then we discuss the potential therapy options by targetting several key enzymes in sphingolipid metabolism. Table 1 Human studies investigating the role...
Articles
Clin Sci (Lond) (2018) 132 (23): 2493–2507.
Published: 05 December 2018
..., and plasma glucose level in ApoE −/− mice. These results indicate the inhibitory effects of vasostatin-1 against atherogenesis. The present study provided the first evidence that vasostatin-1 may serve as a novel therapeutic target for atherosclerosis. Correspondence: Takuya Watanabe ( watanabe...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2423–2436.
Published: 22 November 2018
... from earlier revascularisation. Nowadays, different biomarkers of plaque instability have been unravelled, among these miRNAs are promising tools for the diagnosis and treatment of atherosclerosis. Inflammation, reactive oxygen species (ROS) and endothelial dysfunction play a key role in unstable...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (17): 1889–1899.
Published: 05 September 2018
..., such as obesity, diabetes, hypercholesteraemia, and rheumatoid arthritis (RA), have been shown to alter myelopoiesis to exacerbate atherosclerosis. Genetic evidence has emerged in humans with the discovery of clonal haematopoiesis of indeterminate potential (CHIP), resulting in a disordered haematopoietic system...
Articles
Clin Sci (Lond) (2018) 132 (17): 1875–1888.
Published: 05 September 2018
... in the cytoplasm or generated de novo upon platelet activation. atherosclerosis microRNA platelet adhesion and activation Platelets play an important role in the control of vascular homeostasis. Indeed, beyond their function in hemostasis, they can transmit inflammatory signals and secrete...
Articles
Clin Sci (Lond) (2018) 132 (17): 1937–1952.
Published: 05 September 2018
...: Edward R. O’Brien ( ermobrie@ucalgary.ca ) 22 01 2018 07 08 2018 10 08 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis biomarkers coronary artery disease imaging menopause women...
Articles
Clin Sci (Lond) (2018) 132 (16): 1811–1836.
Published: 30 August 2018
...), atherosclerosis and diabetic kidney disease (DKD). Persistent hyperglycaemia in diabetes mellitus increases the production of reactive oxygen species (ROS) and activates mediators of inflammation as well as suppresses antioxidant defence mechanisms ultimately contributing to oxidative stress which leads...
Articles
Clin Sci (Lond) (2018) 132 (14): 1509–1512.
Published: 23 July 2018
...Neil MacRitchie; Pasquale Maffia The hallmark features of atherosclerosis include accumulation of low-density lipoprotein (LDL) carrying cholesterol in the vessel wall, formation of lipid-laden foam cells, and the creation of a pro-inflammatory microenvironment. To date, no effective treatments...
Articles
Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
... in specific groups of diseases: cardiovascular, cancer, and neurodegenerative. These results indicate association with the disease states, although not yet clear-cut to yield specific biomarkers. We also highlight mechanisms whereby thiol pools affect atherosclerosis pathophysiology. Overall, it is unlikely...
Articles
Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
...Glaucylara Reis Geovanini; Peter Libby The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis and its complications has gained considerable attention, but has not yet entered clinical practice. Experimental work has elucidated molecular and cellular pathways...
Articles
Clin Sci (Lond) (2018) 132 (11): 1199–1213.
Published: 15 June 2018
... processes, and immune responses. The aim of the present study was to assess whether mindin contributes to the development of atherosclerosis. A significant up-regulation of Mindin expression was observed in the serum, arteries and atheromatous plaques of ApoE −/− mice after high-fat diet treatment. Mindin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (11): 1135–1153.
Published: 09 June 2018
... of the Biochemical Society 2018 atherosclerosis cholesterol hyperlipidemia low-density lipoprotein PCSK9 inhibitor Discovered in 2003, proprotein convertase subtilisin/kexin type 9 (PCSK9) is a positive regulator of plasma low-density lipoprotein (LDL) [ 1 ]. It behaves as a chaperone to increase...
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2017) 131 (20): 2549–2560.
Published: 13 October 2017
... health benefits. Here, we studied the impact of chocolate liquor on vascular lesion development and plaque composition in a mouse model of atherosclerosis. Apolipoprotein E (apoE)-knockout mice were assigned to two groups and fed a Western diet that contained 250 g/kg of either chocolate liquor...
Includes: Supplementary data
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2017) 131 (12): 1215–1224.
Published: 31 May 2017
... in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...
Articles
Clin Sci (Lond) (2016) 130 (22): 2087–2100.
Published: 11 October 2016
...Kelvin H.M. Kwok; Kenneth K.Y. Cheng; Ruby L.C. Hoo; Dewei Ye; Aimin Xu; Karen S.L. Lam Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (22): 2101–2104.
Published: 11 October 2016
... pathway to exacerbate development of atherosclerosis in ApoE-/- mice. They further demonstrate that ApoE-/- mice transplanted with visceral adipose tissue in which JNK has been inactivated display less systemic inflammation and develop significantly less atherosclerosis compared with control mice...
Articles
Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
...Elyse Di Marco; Stephen P. Gray; Phyllis Chew; Kit Kennedy; Mark E. Cooper; Harald H.H.W. Schmidt; Karin A.M. Jandeleit-Dahm Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (14): 1237–1246.
Published: 13 June 2016
...Stacy Robertson; Gonzalo J. Martínez; Cloe A. Payet; Jennifer Y. Barraclough; David S. Celermajer; Christina Bursill; Sanjay Patel Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1065–1074.
Published: 23 May 2016
... β-oestradiol atherosclerosis carotid intima-medial thickness conjugated equine oestrogens coronary artery calcification Over the last decade, perhaps one of the most controversial medical decision facing women and their physicians is the use of sex hormones during menopause...
Articles
Clin Sci (Lond) (2016) 130 (8): 551–563.
Published: 08 March 2016
... in men. Inappropriate sinus tachycardia is also significantly more prevalent in women. Correspondence: Dr Stacy Westerman (email swester@emory.edu ). 18 8 2015 7 12 2015 12 1 2016 © 2016 Authors; published by Portland Press Limited 2016 atherosclerosis heart failure...
Articles
Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
... has revealed the participation of CXCR3 and its ligands in multiple cardiovascular diseases (CVDs) of different aetiologies including atherosclerosis, hypertension, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD). CXCR3...
Articles