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Keywords: Alzheimer’s disease
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Clin Sci (Lond) (2021) 135 (15): 1929–1944.
Published: 10 August 2021
...Ezekiel Gonzalez-Fernandez; Yedan Liu; Alexander P. Auchus; Fan Fan; Richard J. Roman The accumulation of extracellular amyloid-β (Aβ) and intracellular hyperphosphorylated τ proteins in the brain are the hallmarks of Alzheimer’s disease (AD). Much of the research into the pathogenesis of AD has...
Includes: Multimedia, Supplementary data
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke The RAS is of profound physiological...
Clin Sci (Lond) (2017) 131 (9): 799–802.
Published: 19 April 2017
.... Correspondence: Paul B. Wren ( paul-bryan.b.wren@gsk.com ) 7 12 2016 6 2 2017 9 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 Alzheimer's disease cerebrovascular disease dementia drug discovery translational science...
Clin Sci (Lond) (2012) 122 (9): 409–420.
Published: 16 January 2012
... =Δ C t sample−Δ C t reference) as described previously [ 44 , 45 ]. Alzheimer's disease amyloid β-peptide amyloid precursor protein extracellular-signal-regulated kinase (ERK) glycosphingolipid Amyloid plaques are a key pathological feature of AD (Alzheimer's disease) [ 1...
Includes: Supplementary data
Clin Sci (Lond) (2012) 122 (7): 323–328.
Published: 07 December 2011
... reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory...
Clin Sci (Lond) (2011) 121 (9): 367–387.
Published: 12 July 2011
... and neurons express a more limited TLR repertoire in comparison. Alzheimer's disease bacterial meningitis central nervous system learning and memory neurogenesis Toll-like receptor Innate immunity represents the first line of defence against invading microbes. Unlike the T- and B-cell...
Clin Sci (Lond) (2011) 120 (10): 427–440.
Published: 28 January 2011
... in any medium, provided the original work is properly cited. aging Alzheimer's disease atherosclerosis heart failure longevity Parkinson's disease telomerase telomere The 2009 Nobel Prize in Physiology or Medicine was awarded jointly to Dr Elizabeth H. Blackburn, Dr Carol W. Greider...
Clin Sci (Lond) (2010) 119 (10): 407–421.
Published: 05 August 2010
...Robin Altman; John C. Rutledge AD (Alzheimer's disease) is a progressive neurodegenerative disease of unknown origin. Despite questions as to the underlying cause(s) of this disease, shared risk factors for both AD and atherosclerotic cardiovascular disease indicate that vascular mechanisms may...
Clin Sci (Lond) (2007) 113 (11): 427–434.
Published: 01 November 2007
...Christopher C. T. Smith; Lee Stanyer; D. John Betteridge; Michael B. Cooper Cerebrovascular accumulation of Aβ (β-amyloid) occurs in aging and AD (Alzheimer's disease). Hypercholesterolaemia, which is associated with raised plasma LDL (low-density lipoprotein), may predispose to AD. Soluble Aβ...
Clin Sci (Lond) (2006) 110 (2): 175–191.
Published: 17 January 2006
... disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins, BDNF is secreted in an activity-dependent manner that allows the highly...