...Ezekiel Gonzalez-Fernandez; Yedan Liu; Alexander P. Auchus; Fan Fan; Richard J. Roman The accumulation of extracellular amyloid-β (Aβ) and intracellular hyperphosphorylated τ proteins in the brain are the hallmarks of Alzheimer’s disease (AD). Much of the research into the pathogenesis of AD has...

... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke The RAS is of profound physiological...

.... Correspondence: Paul B. Wren ( paul-bryan.b.wren@gsk.com ) 7 12 2016 6 2 2017 9 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 Alzheimer's disease cerebrovascular disease dementia drug discovery translational science...

...H.K. Irundika Dias; Caroline L.R. Brown; M. Cristina Polidori; Gregory Y.H. Lip; Helen R. Griffiths Elevated low-density lipoprotein (LDL) concentration in mid-life increases the risk of developing Alzheimer's disease (AD) in later life. Increased oxidized LDL (oxLDL) modification and nitration...

... =Δ C t sample−Δ C t reference) as described previously [ 44 , 45 ]. Alzheimer's disease amyloid β-peptide amyloid precursor protein extracellular-signal-regulated kinase (ERK) glycosphingolipid Amyloid plaques are a key pathological feature of AD (Alzheimer's disease) [ 1...

... reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory...

... and neurons express a more limited TLR repertoire in comparison. Alzheimer's disease bacterial meningitis central nervous system learning and memory neurogenesis Toll-like receptor Innate immunity represents the first line of defence against invading microbes. Unlike the T- and B-cell...

... in any medium, provided the original work is properly cited. aging Alzheimer's disease atherosclerosis heart failure longevity Parkinson's disease telomerase telomere The 2009 Nobel Prize in Physiology or Medicine was awarded jointly to Dr Elizabeth H. Blackburn, Dr Carol W. Greider...

...Robin Altman; John C. Rutledge AD (Alzheimer's disease) is a progressive neurodegenerative disease of unknown origin. Despite questions as to the underlying cause(s) of this disease, shared risk factors for both AD and atherosclerotic cardiovascular disease indicate that vascular mechanisms may...

...Christopher C. T. Smith; Lee Stanyer; D. John Betteridge; Michael B. Cooper Cerebrovascular accumulation of Aβ (β-amyloid) occurs in aging and AD (Alzheimer's disease). Hypercholesterolaemia, which is associated with raised plasma LDL (low-density lipoprotein), may predispose to AD. Soluble Aβ...

... disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins, BDNF is secreted in an activity-dependent manner that allows the highly...