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Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen
Clin Sci (Lond) (2021) 135 (21): 2483–2502.
Published: 08 November 2021
... (BMP2) and osteocalcin (OCN). These results were further confirmed in aortic rings ex vivo . Moreover, DMY ameliorated vascular calcification in rats with CKD. Additionally, we found that AKT signaling was activated during vascular calcification, whereas significantly inhibited by DMY administration...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (10): 1069–1073.
Published: 25 May 2018
... inhibtion of Akt (protein kinase B, PKB) signaling. We further discuss the mechanisms underlying Akt activation and its effects on CH and review possible mechanisms of leflunomide effects. Despite some caveats, the availability of such a newly repurposed compound to treat CH can be a relevant advance...
Clin Sci (Lond) (2018) 132 (6): 685–699.
Published: 30 March 2018
... of A77 1726 was not dependent on its T lymphocyte-inhibiting property. A77 1726 suppressed the activation of protein kinase B (AKT) signaling pathway, and overexpression of constitutively active AKT completely abolished A77 1726-mediated cardioprotective effects in vivo and in vitro . Pretreatment...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (3): 197–210.
Published: 05 January 2017
... on behalf of the Biochemical Society 2017 AKT phosphatase phosphoinositide 3-kinase (PI3K) prostate cancer Elevated and/or uncontrolled activation of the signalling networks activated by growth factors, in particular signalling through the phosphoinositide 3-kinase (PI3K) group of lipid...
Lijuan Chen, Jia Huang, Yanxiao Ji, Xiaojing Zhang, Pixiao Wang, Keqiong Deng, Xi Jiang, Genshan Ma, Hongliang Li
Clin Sci (Lond) (2016) 130 (10): 813–828.
Published: 01 April 2016
... cardioprotective action by interruption of Akt- but not MAPK (mitogen-dependent protein kinase)-dependent signalling pathways. Additionally, inactivation of Akt by LY294002 offset the exacerbated hypertrophic response induced by AB in TRIM32-deficient mice. In conclusion, the present study indicates that TRIM32...
Clin Sci (Lond) (2015) 129 (12): 1047–1060.
Published: 24 September 2015
..., activation of extracellular signal-related kinase (ERK)-1/2 and protein kinase B (Akt) in seizures in rats is increased by exogenous IGF-1 and diminished by picropodophyllin. A behavioural study reveals that the ERK1/2 or Akt inhibitor attenuates seizure activity. These results indicate that increased IGF-1...
Xiaoxiong Liu, Nian Wan, Xiao-Jing Zhang, Yichao Zhao, Yan Zhang, Gangying Hu, Fengwei Wan, Rui Zhang, Xueyong Zhu, Hao Xia, Hongliang Li
Clin Sci (Lond) (2015) 128 (12): 923–936.
Published: 27 March 2015
... mechanism analyses suggested that Vinexin-β exerted detrimental effects largely dependent on blocking AKT signalling. The effects and mechanisms of Vinexin-β on MI observed in vivo were further confirmed by our in vitro assays. When collected, these data demonstrate for the first time that Vinexin-β...
Lucas Fernández-Campo, María T. Grande, Julia Diego, Isabel Fuentes-Calvo, Juan F. Macías-Núñez, Angel Sánchez-Rodríguez, Jesús Grande, Luis García-Ortiz, José M. López-Novoa, Carlos Martínez-Salgado
Clin Sci (Lond) (2009) 116 (2): 165–173.
Published: 15 December 2008
... [ERK (extracellular-signal-regulated kinase) and Akt] in lymphocytes from patients with hypertension without or with diabetes. ACEi treatment transiently reduced Ras activation in the first month of treatment, but diuretics induced a sustained increase in Ras activation throughout the 3 months...