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Keywords: AMPK
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Articles
Clin Sci (Lond) (2022) 136 (4): 273–289.
Published: 21 February 2022
... by intraperitoneal injection of BF in vivo after LPS stimulation. Results : Inflammation and injury was significantly reduced in BF pretreated mice, and the indexes related to pyroptosis were suppressed. The phosphorylation of AMP-activated protein kinase (AMPK) in lung tissues of mice in the BF and LPS+BF groups...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (1): 121–137.
Published: 07 January 2022
...). Overexpression of BAT CCL5/CCR5 genes by local lentivirus injection in WT mice suppressed cold stress-induced lipolytic processes and thermogenic activities. In contrast, knockdown of BAT CCL5/CCR5 signaling further up-regulated AMPK phosphorylation as well as thermogenic and lipolysis responses to chronic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (20): 2393–2408.
Published: 22 October 2021
...Laura Wilson; Alice E. Pollard; Lucy Penfold; Phillip J. Muckett; Chad Whilding; Mohammad Bohlooly-Y.; Patricia Wilson; David Carling AMP-activated protein kinase (AMPK) plays a key role in the cellular response to low energy stress and has emerged as an attractive therapeutic target for tackling...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (19): 2243–2263.
Published: 08 October 2021
... kinase (AMPK) phosphorylation. Imatinib activated AMPK also in vitro , resulting in decreased ribosomal protein S6 phosphorylation and protection against islet amyloid polypeptide (IAPP)-aggregation, thioredoxin interacting protein (TXNIP) up-regulation and beta-cell death. 5-Aminoimidazole-4-carboxamide...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Published: 25 September 2020
...Zhuo Li; Hua Guo; Jia Li; Tianjiao Ma; Shanshan Zhou; Zhiguo Zhang; Lining Miao; Lu Cai Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase (AMPK) can attenuate...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (17): 2381–2398.
Published: 16 September 2020
... the expression of molecules related to skeletal muscle development, glucose uptake and metabolism in mice of 3- and 8-months old. We found that AMP-activated protein kinase (AMPK) phosphorylation and myocyte enhancer factor 2 (MEF2) A (MEF2A) expression were down-regulated in AKT2 knockout (KO) mice, which can...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1537–1553.
Published: 25 June 2020
... characteristics. According to mRNA-sequencing analysis, UA significantly decreased the expression of leptin in adipocytes, which was closely related to fatty acid metabolism and the AMPK signalling pathway, as indicated by KEGG pathway analysis. Moreover, lowering UA using benzbromarone (a uricosuric agent...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (5): 611–627.
Published: 01 March 2019
... after irisin treatment. Mechanistically, we demonstrated that FNDC5 was cleaved into irisin, at least partially, in a disintegrin and metalloproteinase (ADAM) family-dependent manner. ADAM10 was the candidate enzyme responsible for the cleavage. Further, we found irisin treatment activated AMPK...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (6): 719–738.
Published: 30 March 2018
..., lipid accumulation, expression of scavenger receptors, plasma cytokine levels and AMP-activated protein kinase (AMPK) activity in macrophages. In addition, the effects of metformin on migration of monocytes, reactive oxygen species (ROS) formation, lipid uptake in the presence of cyclophilin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1877–1893.
Published: 07 July 2017
... of high glucose (HG)-induced cardiomyocyte injury. STZ/HFD-induced cardiomyopathy was exacerbated in FGF21 knockout mice, which was accompanied by a significant reduction in cardiac AMP-activated protein kinase (AMPK) activity and paraoxonase 1 (PON1) expression. By contrast, adeno-associated virus (AAV...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (19): 1697–1709.
Published: 23 August 2016
... (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain...