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Keywords: ADAM17
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Clin Sci (Lond) (2021) 135 (8): 1009–1014.
Published: 21 April 2021
... was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry. If confirmed in humans, these results could become the pathophysiological background for justifying RAS inhibitors as cornerstone cardiovascular...
Clin Sci (Lond) (2021) 135 (3): 465–481.
Published: 01 February 2021
..., an increase in levels of a short intracellular ACE2 polypeptide and an increase in ADAM17 activity in cells, together with an increase in levels of soluble ACE2 and major proinflammatory cytokines in the culture medium. Spike protein-induced changes and levels of spike protein internalization in cells were...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (2): 225–238.
Published: 22 January 2019
... with the survival rate of patients with repaired TOF. However, very little is known concerning its genetic etiology. Based on mouse model studies, a disintergrin and metalloprotease 10/17 (ADAM10 and ADAM17) are the key enzymes for the NOTCH and ErbB pathways, which are critical pathways for heart development...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
...), acetylcholine, (ACh), and sodium nitroprusside (SNP). In vitro , TRV027 prevented the Ang-II-induced up-regulation of ADAM17 and in contrast with Ang-II, had no effects on ACE2 activity and expression levels. Furthermore, TRV027 induced lesser interactions between AT 1 R and ACE2 compared with Ang-II. Together...