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Keywords: ACE2
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Articles
Clin Sci (Lond) (2021) 135 (8): 1009–1014.
Published: 21 April 2021
...Fedor Simko; Tomas Baka Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective renin–angiotensin system (RAS) pathway but also the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RAS inhibitors seemed to interfere with the ACE2 receptor...
Articles
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
..., the activation of angiotensin-converting enzyme 2 (ACE2) – angiotensin (1–7) pathway, a novel branch of the RAS, plays an opposite role in the ACE pathway, which could reverse these consequences by improving local microcirculation, inflammation, stress state, structure remolding, and insulin signaling pathway...
Articles
Clin Sci (Lond) (2021) 135 (3): 465–481.
Published: 01 February 2021
...Maria A. Pedrosa; Rita Valenzuela; Pablo Garrido-Gil; Carmen M. Labandeira; Gemma Navarro; Rafael Franco; Jose L. Labandeira-Garcia; Ana I. Rodriguez-Perez The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-converting enzyme 2), which acts as a double-edged sword...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
...Ravindra K. Sharma; Jing Li; Suraj Krishnan; Elaine M. Richards; Mohan K. Raizada; Rajesh Mohandas The rapid spread of the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought into focus the key role of angiotensin-converting enzyme 2 (ACE2), which serves...
Articles
Clin Sci (Lond) (2020) 134 (22): 2929–2941.
Published: 16 November 2020
...Fernando M. Reis; Adelina M. Reis Angiotensin (Ang)-(1-7) is an active peptide formed from Ang I or Ang-(1-9) by multiple proteolytic steps involving angiotensin-converting enzyme (ACE) 1 and other peptidases, or by a single cleavage of Ang II catalyzed chiefly by ACE2. The effects of Ang-(1-7...
Articles
Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
...Qiuhong Li; Maria B. Grant; Elaine M. Richards; Mohan K. Raizada The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance...
Articles
Clin Sci (Lond) (2018) 132 (14): 1513–1527.
Published: 23 July 2018
... performed in HEK293T cells co-transfected with AT 1 R and Ang converting enzyme type 2 (ACE2) treated with TRV027 (100 nM) or Ang-II (100 nM). TRV027 infusion in SH rats (SHR) reduced AP (~20 mmHg, P <0.05), sympathetic vasomotor activity (ΔMAP = −47.2 ± 2.8 compared with −64 ± 5.1 mmHg, P <0.05...