... binding protein 1 (xbp1s), a key component of endoplasmic reticulum stress (ERS), contributes to the pathogenesis of PH. Forty male SD rats were randomly assigned to four groups: Control, Monocrotaline (MCT), MCT+AAV-CTL (control), and MCT+AAV-xbp1s. The xbp1s protein levels were found to be elevated...

... the cardiac damage associated with diabetes. One potential alternative avenue for targeting diabetes-induced heart failure is the use of adeno-associated viral vector (AAV) gene therapy, which has shown great versatility in a multitude of disease settings. AAV gene therapy has the potential to target specific...

... 2018 AAV gene therapy heart failure MCAD physiological hypertrophy pathological hypertrophy Heart failure (HF) is a debilitating condition that affects 1–3% of people in Western society. The incidence of HF is likely to rise over the coming decades due to the aging population, rising...