...Gerald P. MCCANN; Helen CAHILL; Stephen KNIPE; Douglas F. MUIR; Paul D. MACINTYRE; W. Stewart HILLS 5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the perception of exercise-induced fatigue. Sumatriptan is a selective 5-HT 1B/D receptor agonist which does not cross the blood–brain...

...D. BUNTON; A. MACDONALD; T. BROWN; A. TRACEY; J. C. MCGRATH; A. M. SHAW We compared 5-hydroxytryptamine (5-HT)- and U46619-mediated contractions in bovine pulmonary conventional arteries (CA) and supernumerary arteries (SA). The effects of the NO synthase inhibitor N G -nitro- l -arginine methyl...

...Mikael Lördal; Håkan Wallén; Paul Hjemdahl; Olof Beck; Per M. Hellström 1. The influence of circulating 5-hydroxytryptamine (serotonin) on small intestinal motility was investigated in healthy volunteers. 2. Small intestinal motility was studied by means of a constantly perfused multi-channel...

...-over study to investigate whether the administration of one amine precursor affects the renal metabolism of the other and to determine whether dopamine or 5-hydroxytryptamine would be generated preferentially. The overall effect on sodium excretion was also measured when both precursors were...

...V. C. Menys; C. C. T. Smith; P. Lewins; R. D. T. Farmer; M. I. M. Noble 1. In view of the importance of 5-hydroxytryptamine in coronary thrombosis, we wanted to know whether a potentially protective decrease in platelet 5-hydroxytryptamine could be achieved by treatment with an inhibitor of 5...

...Jay D. Coffman; Richard A. Cohen 1. The involvement of plasma 5-hydroxytryptamine in normal subjects during sympathetic stimulation and in patients with Raynaud's phenomenon was studied. 2. Arterial and venous plasma levels of 5-hydroxytryptamine were measured in normal subjects in a warm room...

...T. C. Li Kam Wa; S. Freestone; R. R. Samson; N. R. Johnson; M. R. Lee 1. The effects of 1 h intravenous infusions of equimolar amounts (45 nmol min −1 kg −1 ) of two putative 5-hydroxytryptamine renal prodrugs, 5-hydroxy-L-tryptophan and γ-L-glutamyl-5-hydroxy-L-tryptophan, were investigated...

...A. Graham; E. W. F. W. Alton; D. M. Geddes 1. 5-Hydroxytryptamine has been suggested as a candidate for an endogenous inhibitor of airway sodium transport. Amiloride, an inhibitor of epithelial sodium channels, has therapeutic potential in disorders of airway ion transport such as cystic fibrosis...

...Fumihiro Tomoda; Masanobu Takata; Shinya Oh-Hashi; Hitoshi Ueno; Kotaro Yasumoto; Hiroyuki Iida; Shigetake Sasayama 1. To examine the pathophysiological significance of 5-hydroxytryptamine (serotonin) in essential hypertension, we compared the renal response to intrarenally formed 5...

... levels and low platelet 5-hydroxytryptamine (serotonin) levels during basal periods. After a glucose load, late peaks of dopamine and free 5-hydroxytryptamine, which coincided with the symptoms but not with the nadir of plasma glucose, were observed. Type II showed a low basal plasma noradrenaline...

... ± SEM, P <0.01) and a dose of 15 mg/kg afforded complete protection. 2. Methysergide, a 5-hydroxytryptamine receptor antagonist, produced a dose-dependent increase in the reserpine-induced injury; a significant ( P <0.05) increase was noted with 15 and 20 mg/kg (47.5 ± 2.9 mm 2 and 49.4 ± 2.2 mm 2...

... hypertensive rats. 2. In vitro , muscarinic activation by pilocarpine increased the pineal metabolic production of hydroxyindole derivatives up to 5-hydroxytryptamine and produced a less marked stimulation of melatonin biosynthesis. 3. Electrical field stimulation of pineal gland slices caused similar...

...Richard J. Barrett; David R. Taylor; Kathryn F. Wright 1. Studies were conducted to test the hypothesis that glycerol-induced acute renal failure in rats may be mediated by 5-hydroxytryptamine. 2. The tryptophan hydroxylase inhibitor, β-chlorophenylalanine, or saline was administered for 4 days...

... placebo (3.11 ± 0.13). 5. The data suggest that 5-hydroxytryptamine can have only a small role, if any, in pressure homoeostasis in sodium replete man at rest in recumbency. At moderate and heavy levels of exercise, the results are compatible with a role for 5-hydroxytryptamine in pressure regulation...

...G. J. Wenting; A. J. Man In 'T Veld; A. J. Woittiez; F. Boomsma; M. A. D. H. Schalekamp 1. The new peripherally acting selective 5-hydroxytryptamine receptor blocking agent ketanserin was given (10 mg intravenously) to 17 patients with essential hypertension. 2. Systemic mean systolic arterial...

... remained virtually unchanged during the whole observation period. Systolic time intervals, reflecting cardiac output, did not change during the ketanserin phase, whereas these values deteriorated during the placebo period. 2. Ketanserin, a novel 5-hydroxytryptamine (5HT 2 )-receptor antagonist with a high...