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Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction

Melissa A. Wasilewski, Laurel A. Grisanti, Jianliang Song, Rhonda L. Carter, Ashley A. Repas, Valerie D. Myers, Erhe Gao, Walter J. Koch, Joseph Y. Cheung, Arthur M. Feldman, Douglas G. Tilley
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2017–2027.
DOI: https://doi.org/10.1042/CS20160363
Published: 06 October 2016
...) and contributes to cardiac dysfunction in animal models, in part via reduced β-adrenergic receptor (βAR) responsiveness. Although cardiac V1AR overexpression and V1AR stimulation are each sufficient to decrease βAR activity, it is unknown whether V1AR inhibition conversely augments βAR responsiveness. Further...
View article titled, Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction
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Includes: Supplementary data