.... This may be due to receptor down-regulation, a defect in post-receptor signal transduction or overproduction of vasodilator compounds. This investigation examined the role of these mechanisms in modulating α-adrenoceptor-mediated contraction in hepatic arteries from patients with advanced cirrhosis. 2...

...Steven M. Frank; Nader El-Gamal; Srinivasa N. Raja; Peter K. Wu; Osama Afifi 1. Although α-adrenoceptor antagonists have been shown to induce core hypothermia in animals, it is unclear whether the primary mechanism is increased heat loss or decreased heat production. Furthermore, studies have...

... The Biochemical Society and the Medical Research Society 1970 α-adrenoceptor blood pressure catecholamines ethanol vasoconstriction Clinical Science (1987) 72 , 25 1-254 SHORT COMMUNICATION 251 Effects of ethanol ingestion on blood pressure reactivity G. EISENHOFER*, D. G. LAMBIE AND R. H. JOHNSON...

... prazosin's α-receptor-blocking effects. 6. Although there is no evidence of an age-related increase in the sensitivity of α-adrenoceptor-mediated vasoconstriction, the results are not inconsistent with an age-related reduction in α-adrenoceptor responsiveness. © 1982 The Biochemical Society and the Medical...

... glycoproteins. 2. Phenylephrine, an α-adrenoceptor agonist, increased the rate at which the bronchi secreted radiolabeled glycoproteins. Thymoxamine, an α-adrenoceptor antagonist, blocked this effect but propranolol, a β-adrenoceptor antagonist, did not. 3. Dobutamine, a β 1 -adrenoceptor agonist, increased...

.... Our data do not support the hypothesis than an increased α-adrenergic tone in elderly people may explain the age-dependent decline of renin in uncomplicated essential hypertension. © 1981 The Biochemical Society and the Medical Research Society 1981 α-adrenoceptor age phentolamine renin...