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Screening for in vitro systematic reviews: a comparison of screening methods and training of a machine learning classifier

Emma Wilson, Florenz Cruz, Duncan Maclean, Joly Ghanawi, Sarah K. McCann, Paul M. Brennan, Jing Liao, Emily S. Sena, Malcolm Macleod

Clin Sci (Lond) (2023) 137 (2): 181–193.

DOI: https://doi.org/10.1042/CS20220594

Published: 27 January 2023

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The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

Kyle M. Siemers, Michelle L. Baack

Clin Sci (Lond) (2023) 137 (1): 31–34.

DOI: https://doi.org/10.1042/CS20220657

Published: 03 January 2023

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Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (23): 1759–1772.

DOI: https://doi.org/10.1042/CS20220547

Published: 02 December 2022

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Includes: Supplementary data

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Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery

Lauren T. May, Belinda A. Bartolo, David G. Harrison, Tomasz Guzik, Grant R. Drummond, Gemma A. Figtree, Rebecca H. Ritchie, Kerry-Anne Rye, Judy B. de Haan

Clin Sci (Lond) (2022) 136 (23): 1731–1758.

DOI: https://doi.org/10.1042/CS20210862

Published: 02 December 2022

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Fifty years of impact on treating bone disease: a commentary on Gasser et al.

Elena L. Dent, Michael J. Ryan

Clin Sci (Lond) (2022) 136 (22): 1657–1659.

DOI: https://doi.org/10.1042/CS20220040

Published: 21 November 2022

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Articles

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2022) 136 (22): 1661–1681.

DOI: https://doi.org/10.1042/CS20220607

Published: 21 November 2022

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Quantifying muscle blood flow: a transformative breakthrough in the science of human exercise physiology

Thomas P. Olson, Joshua R. Smith, Timothy B. Curry

Clin Sci (Lond) (2022) 136 (22): 1653–1656.

DOI: https://doi.org/10.1042/CS20220101

Published: 18 November 2022

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Non-invasive prenatal diagnosis (NIPD): how analysis of cell-free DNA in maternal plasma has changed prenatal diagnosis for monogenic disorders

Britt Hanson, Elizabeth Scotchman, Lyn S. Chitty, Natalie J. Chandler

Clin Sci (Lond) (2022) 136 (22): 1615–1629.

DOI: https://doi.org/10.1042/CS20210380

Published: 16 November 2022

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Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia

Raghavendar Chandran, Lianying He, Xingju Nie, Joshua Voltin, Sarah Jamil, Caren Doueiry, Maria Fatima Falangola, Adviye Ergul, Weiguo Li

Clin Sci (Lond) (2022) 136 (21): 1555–1570.

DOI: https://doi.org/10.1042/CS20220465

Published: 10 November 2022

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Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty

Clin Sci (Lond) (2022) 136 (21): 1485–1511.

DOI: https://doi.org/10.1042/CS20220205

Published: 03 November 2022

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New mechanisms for the kidney-protective effect of alkali in chronic kidney disease

Paul M. O’Connor, Elinor C. Mannon

Clin Sci (Lond) (2022) 136 (20): 1433–1437.

DOI: https://doi.org/10.1042/CS20220395

Published: 18 October 2022

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Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver

Clin Sci (Lond) (2022) 136 (19): 1405–1423.

DOI: https://doi.org/10.1042/CS20210889

Published: 14 October 2022

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Measuring muscle protein synthesis in humans and the influence of nutritional state

Philip C. Calder, Nicolaas E.P. Deutz

Clin Sci (Lond) (2022) 136 (19): 1425–1431.

DOI: https://doi.org/10.1042/CS20211171

Published: 14 October 2022

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Articles

Novel mediators of idiopathic pulmonary fibrosis

Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal

Clin Sci (Lond) (2022) 136 (16): 1229–1240.

DOI: https://doi.org/10.1042/CS20210878

Published: 31 August 2022

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Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Pedro Alves Soares Vaz de Castro, Pedro A. Jose, Ana Cristina Simões e Silva

Clin Sci (Lond) (2022) 136 (16): 1205–1227.

DOI: https://doi.org/10.1042/CS20220338

Published: 18 August 2022

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Replacing bar graphs of continuous data with more informative graphics: are we making progress?

In Collection

Translational meta-research

Nico Riedel, Robert Schulz, Vartan Kazezian, Tracey Weissgerber

Clin Sci (Lond) (2022) 136 (15): 1139–1156.

DOI: https://doi.org/10.1042/CS20220287

Published: 10 August 2022

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Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Hager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier

Clin Sci (Lond) (2022) 1117–1137.

DOI: https://doi.org/10.1042/CS20220245

Published: 05 August 2022

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The emerging role of LRRK2 in tauopathies

Susanne Herbst, Patrick A. Lewis, Huw R. Morris

Clin Sci (Lond) (2022) 136 (13): 1071–1079.

DOI: https://doi.org/10.1042/CS20220067

Published: 11 July 2022

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The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol, Frédéric Jaisser

Clin Sci (Lond) (2022) 136 (12): 1005–1017.

DOI: https://doi.org/10.1042/CS20220212

Published: 29 June 2022

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Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction

Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (11): 879–894.

DOI: https://doi.org/10.1042/CS20220117

Published: 06 June 2022

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Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice

Min-Chun Liao, Kana N. Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang

Clin Sci (Lond) (2022) 136 (10): 715–731.

DOI: https://doi.org/10.1042/CS20220188

Published: 20 May 2022

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Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

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A time to heal: microRNA and circadian dynamics in cutaneous wound repair

Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun TL Hughes, Fawaz Ghali, Kehinde Ross

Clin Sci (Lond) (2022) 136 (8): 579–597.

DOI: https://doi.org/10.1042/CS20220011

Published: 21 April 2022

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SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection

In Collection

Coronavirus

John D. Imig

Clin Sci (Lond) (2022) 136 (6): 431–434.

DOI: https://doi.org/10.1042/CS20220028

Published: 29 March 2022

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Articles

Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

DOI: https://doi.org/10.1042/CS20210509

Published: 07 February 2022

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The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

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Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad

Clin Sci (Lond) (2022) 136 (2): 181–196.

DOI: https://doi.org/10.1042/CS20210964

Published: 28 January 2022

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Articles

Mechanisms of immune aging in HIV

Manon Chauvin, Delphine Sauce

Clin Sci (Lond) (2022) 136 (1): 61–80.

DOI: https://doi.org/10.1042/CS20210344

Published: 05 January 2022

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Urocortins as biomarkers in cardiovascular disease

Inês Vasconcelos, Rui Adão, Miriam T. Rademaker, Adelino F. Leite-Moreira, Ana Patrícia Fontes-Sousa, Carmen Brás-Silva

Clin Sci (Lond) (2022) 136 (1): 1–14.

DOI: https://doi.org/10.1042/CS20210732

Published: 23 December 2021

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Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection

In Collection

Coronavirus

Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler

Clin Sci (Lond) (2021) 135 (24): 2781–2791.

DOI: https://doi.org/10.1042/CS20210666

Published: 22 December 2021

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The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

In Collection

Coronavirus

Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu

Clin Sci (Lond) (2021) 135 (24): 2667–2689.

DOI: https://doi.org/10.1042/CS20210735

Published: 15 December 2021

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Early elimination of uremic toxin ameliorates AKI-to-CKD transition

Jia-Huang Chen, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu, Der-Cherng Tarng, Chih-Kang Chiang

Clin Sci (Lond) (2021) 135 (23): 2643–2658.

DOI: https://doi.org/10.1042/CS20210858

Published: 08 December 2021

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Hypoxic preconditioning in renal ischaemia–reperfusion injury: a review in pre-clinical models

Laurie Bruzzese, Gwénaël Lumet, Donato Vairo, Claire Guiol, Régis Guieu, Alice Faure

Clin Sci (Lond) (2021) 135 (23): 2607–2618.

DOI: https://doi.org/10.1042/CS20210615

Published: 08 December 2021

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Accelerating the transition of clinical science to translational medicine

Stephen T. Holgate

Clin Sci (Lond) (2021) 135 (20): 2423–2428.

DOI: https://doi.org/10.1042/CS20210846

Published: 28 October 2021

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The immune niche of the liver

Michael L. Cheng, Diana Nakib, Catia T. Perciani, Sonya A. MacParland

Clin Sci (Lond) (2021) 135 (20): 2445–2466.

DOI: https://doi.org/10.1042/CS20190654

Published: 28 October 2021

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Updates in deep learning research in ophthalmology

Wei Yan Ng, Shihao Zhang, Zhaoran Wang, Charles Jit Teng Ong, Dinesh V. Gunasekeran, Gilbert Yong San Lim, Feihui Zheng, Shaun Chern Yuan Tan, Gavin Siew Wei Tan, Tyler Hyungtaek Rim, Leopold Schmetterer, Daniel Shu Wei Ting

Clin Sci (Lond) (2021) 135 (20): 2357–2376.

DOI: https://doi.org/10.1042/CS20210207

Published: 18 October 2021

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Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello

Clin Sci (Lond) (2021) 135 (19): 2285–2305.

DOI: https://doi.org/10.1042/CS20210183

Published: 13 October 2021

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Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Jan Neckář, Petra Alánová, Veronika Olejníčková, František Papoušek, Lucie Hejnová, Jan Šilhavý, Michal Behuliak, Michal Bencze, Jaroslav Hrdlička, Marek Vecka, Dagmar Jarkovská, Jitka Švíglerová, Eliška Mistrová, Milan Štengl, Jiří Novotný, Bohuslav Ošťádal, Michal Pravenec, František Kolář

Clin Sci (Lond) (2021) 135 (17): 2143–2163.

DOI: https://doi.org/10.1042/CS20210648

Published: 17 September 2021

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Contribution of dipeptidyl peptidase 4 to non-typeable Haemophilus influenzae -induced lung inflammation in COPD

Sudhir Kotnala, Yerin Kim, Charu Rajput, Hymavathi Reddyvari, Sudhir Bolla, Nathaniel T. Marchetti, Beata Kosmider, Karim Bahmed, Umadevi S. Sajjan

Clin Sci (Lond) (2021) 135 (17): 2067–2083.

DOI: https://doi.org/10.1042/CS20210099

Published: 01 September 2021

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Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino

Clin Sci (Lond) (2021) 135 (17): 2035–2048.

DOI: https://doi.org/10.1042/CS20201406

Published: 31 August 2021

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The science of science: Clinical Science launches a new translational meta-research collection

In Collection

Translational meta-research

Tracey L. Weissgerber

Clin Sci (Lond) (2021) 135 (16): 2031–2034.

DOI: https://doi.org/10.1042/CS20210777

Published: 24 August 2021

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Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Ahmed A. Elmarakby, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (15): 1791–1804.

DOI: https://doi.org/10.1042/CS20201017

Published: 02 August 2021

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Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

Clin Sci (Lond) (2021) 135 (14): 1707–1726.

DOI: https://doi.org/10.1042/CS20210100

Published: 22 July 2021

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Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress

Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu

Clin Sci (Lond) (2021) 135 (14): 1689–1706.

DOI: https://doi.org/10.1042/CS20210198

Published: 20 July 2021

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Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?

In Collection

Cardiovascular-Oncology

Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen

Clin Sci (Lond) (2021) 135 (14): 1649–1668.

DOI: https://doi.org/10.1042/CS20200300

Published: 20 July 2021

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Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents

David L. Brautigan, Caroline Farrington, Goutham Narla

Clin Sci (Lond) (2021) 135 (13): 1545–1556.

DOI: https://doi.org/10.1042/CS20201367

Published: 30 June 2021

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Obesity-associated cardiovascular risk in women: hypertension and heart failure

Jessica L. Faulkner

Clin Sci (Lond) (2021) 135 (12): 1523–1544.

DOI: https://doi.org/10.1042/CS20210384

Published: 23 June 2021

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Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?

Crizza Ching, Dakota Gustafson, Paaladinesh Thavendiranathan, Jason E. Fish

Clin Sci (Lond) (2021) 135 (12): 1487–1503.

DOI: https://doi.org/10.1042/CS20210059

Published: 17 June 2021

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Interactions between cardiology and oncology drugs in precision cardio-oncology

In Collection

Cardiovascular-Oncology

Sailaja Kamaraju, Meera Mohan, Svetlana Zaharova, Brianna Wallace, Joseph McGraw, James Lokken, John Tierney, Elizabeth Weil, Olubadewa Fatunde, Sherry-Ann Brown

Clin Sci (Lond) (2021) 135 (11): 1333–1351.

DOI: https://doi.org/10.1042/CS20200309

Published: 02 June 2021

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Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Darnel Prakoso, Mitchel Tate, Miles J. De Blasio, Rebecca H. Ritchie

Clin Sci (Lond) (2021) 135 (11): 1369–1387.

DOI: https://doi.org/10.1042/CS20210052

Published: 02 June 2021

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