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Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction

Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (11): 879–894.

DOI: https://doi.org/10.1042/CS20220117

Published: 06 June 2022

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Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice

Min-Chun Liao, Kana N. Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang

Clin Sci (Lond) (2022) 136 (10): 715–731.

DOI: https://doi.org/10.1042/CS20220188

Published: 20 May 2022

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Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

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A time to heal: microRNA and circadian dynamics in cutaneous wound repair

Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun TL Hughes, Fawaz Ghali, Kehinde Ross

Clin Sci (Lond) (2022) 136 (8): 579–597.

DOI: https://doi.org/10.1042/CS20220011

Published: 21 April 2022

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SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection

John D. Imig

Clin Sci (Lond) (2022) 136 (6): 431–434.

DOI: https://doi.org/10.1042/CS20220028

Published: 29 March 2022

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Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

DOI: https://doi.org/10.1042/CS20210509

Published: 07 February 2022

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The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

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Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad

Clin Sci (Lond) (2022) 136 (2): 181–196.

DOI: https://doi.org/10.1042/CS20210964

Published: 28 January 2022

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Mechanisms of immune aging in HIV

Manon Chauvin, Delphine Sauce

Clin Sci (Lond) (2022) 136 (1): 61–80.

DOI: https://doi.org/10.1042/CS20210344

Published: 05 January 2022

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Urocortins as biomarkers in cardiovascular disease

Inês Vasconcelos, Rui Adão, Miriam T. Rademaker, Adelino F. Leite-Moreira, Ana Patrícia Fontes-Sousa, Carmen Brás-Silva

Clin Sci (Lond) (2022) 136 (1): 1–14.

DOI: https://doi.org/10.1042/CS20210732

Published: 23 December 2021

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Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection

Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler

Clin Sci (Lond) (2021) 135 (24): 2781–2791.

DOI: https://doi.org/10.1042/CS20210666

Published: 22 December 2021

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The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu

Clin Sci (Lond) (2021) 135 (24): 2667–2689.

DOI: https://doi.org/10.1042/CS20210735

Published: 15 December 2021

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Early elimination of uremic toxin ameliorates AKI-to-CKD transition

Jia-Huang Chen, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu, Der-Cherng Tarng, Chih-Kang Chiang

Clin Sci (Lond) (2021) 135 (23): 2643–2658.

DOI: https://doi.org/10.1042/CS20210858

Published: 08 December 2021

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Hypoxic preconditioning in renal ischaemia–reperfusion injury: a review in pre-clinical models

Laurie Bruzzese, Gwénaël Lumet, Donato Vairo, Claire Guiol, Régis Guieu, Alice Faure

Clin Sci (Lond) (2021) 135 (23): 2607–2618.

DOI: https://doi.org/10.1042/CS20210615

Published: 08 December 2021

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The immune niche of the liver

Michael L. Cheng, Diana Nakib, Catia T. Perciani, Sonya A. MacParland

Clin Sci (Lond) (2021) 135 (20): 2445–2466.

DOI: https://doi.org/10.1042/CS20190654

Published: 28 October 2021

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Accelerating the transition of clinical science to translational medicine

Stephen T. Holgate

Clin Sci (Lond) (2021) 135 (20): 2423–2428.

DOI: https://doi.org/10.1042/CS20210846

Published: 28 October 2021

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Updates in deep learning research in ophthalmology

Wei Yan Ng, Shihao Zhang, Zhaoran Wang, Charles Jit Teng Ong, Dinesh V. Gunasekeran, Gilbert Yong San Lim, Feihui Zheng, Shaun Chern Yuan Tan, Gavin Siew Wei Tan, Tyler Hyungtaek Rim, Leopold Schmetterer, Daniel Shu Wei Ting

Clin Sci (Lond) (2021) 135 (20): 2357–2376.

DOI: https://doi.org/10.1042/CS20210207

Published: 18 October 2021

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Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello

Clin Sci (Lond) (2021) 135 (19): 2285–2305.

DOI: https://doi.org/10.1042/CS20210183

Published: 13 October 2021

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Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Jan Neckář, Petra Alánová, Veronika Olejníčková, František Papoušek, Lucie Hejnová, Jan Šilhavý, Michal Behuliak, Michal Bencze, Jaroslav Hrdlička, Marek Vecka, Dagmar Jarkovská, Jitka Švíglerová, Eliška Mistrová, Milan Štengl, Jiří Novotný, Bohuslav Ošťádal, Michal Pravenec, František Kolář

Clin Sci (Lond) (2021) 135 (17): 2143–2163.

DOI: https://doi.org/10.1042/CS20210648

Published: 17 September 2021

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Contribution of dipeptidyl peptidase 4 to non-typeable Haemophilus influenzae -induced lung inflammation in COPD

Sudhir Kotnala, Yerin Kim, Charu Rajput, Hymavathi Reddyvari, Sudhir Bolla, Nathaniel T. Marchetti, Beata Kosmider, Karim Bahmed, Umadevi S. Sajjan

Clin Sci (Lond) (2021) 135 (17): 2067–2083.

DOI: https://doi.org/10.1042/CS20210099

Published: 01 September 2021

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Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino

Clin Sci (Lond) (2021) 135 (17): 2035–2048.

DOI: https://doi.org/10.1042/CS20201406

Published: 31 August 2021

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The science of science: Clinical Science launches a new translational meta-research collection

Tracey L. Weissgerber

Clin Sci (Lond) (2021) 135 (16): 2031–2034.

DOI: https://doi.org/10.1042/CS20210777

Published: 24 August 2021

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Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Ahmed A. Elmarakby, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (15): 1791–1804.

DOI: https://doi.org/10.1042/CS20201017

Published: 02 August 2021

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Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

Clin Sci (Lond) (2021) 135 (14): 1707–1726.

DOI: https://doi.org/10.1042/CS20210100

Published: 22 July 2021

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Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress

Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu

Clin Sci (Lond) (2021) 135 (14): 1689–1706.

DOI: https://doi.org/10.1042/CS20210198

Published: 20 July 2021

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Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?

Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen

Clin Sci (Lond) (2021) 135 (14): 1649–1668.

DOI: https://doi.org/10.1042/CS20200300

Published: 20 July 2021

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Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents

David L. Brautigan, Caroline Farrington, Goutham Narla

Clin Sci (Lond) (2021) 135 (13): 1545–1556.

DOI: https://doi.org/10.1042/CS20201367

Published: 30 June 2021

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Obesity-associated cardiovascular risk in women: hypertension and heart failure

Jessica L. Faulkner

Clin Sci (Lond) (2021) 135 (12): 1523–1544.

DOI: https://doi.org/10.1042/CS20210384

Published: 23 June 2021

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Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?

Crizza Ching, Dakota Gustafson, Paaladinesh Thavendiranathan, Jason E. Fish

Clin Sci (Lond) (2021) 135 (12): 1487–1503.

DOI: https://doi.org/10.1042/CS20210059

Published: 17 June 2021

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Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Darnel Prakoso, Mitchel Tate, Miles J. De Blasio, Rebecca H. Ritchie

Clin Sci (Lond) (2021) 135 (11): 1369–1387.

DOI: https://doi.org/10.1042/CS20210052

Published: 02 June 2021

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Interactions between cardiology and oncology drugs in precision cardio-oncology

Sailaja Kamaraju, Meera Mohan, Svetlana Zaharova, Brianna Wallace, Joseph McGraw, James Lokken, John Tierney, Elizabeth Weil, Olubadewa Fatunde, Sherry-Ann Brown

Clin Sci (Lond) (2021) 135 (11): 1333–1351.

DOI: https://doi.org/10.1042/CS20200309

Published: 02 June 2021

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Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction

Shuhan Ji, Diane Gumina, Kathryn McPeak, Radu Moldovan, Miriam D. Post, Emily J. Su

Clin Sci (Lond) (2021) 135 (9): 1127–1143.

DOI: https://doi.org/10.1042/CS20201533

Published: 11 May 2021

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Murine endometrial-derived mesenchymal stem cells suppress experimental autoimmune encephalomyelitis depending on indoleamine-2,3-dioxygenase expression

Carolina Manganeli Polonio, Carla Longo de Freitas, Marília Garcia de Oliveira, Cristiano Rossato, Wesley Nogueira Brandão, Nágela Ghabdan Zanluqui, Lilian Gomes de Oliveira, Luiza Ayumi Nishiyama Mimura, Maysa Braga Barros Silva, Vera Lúcia Garcia Calich, Marcelo Gil Nisenbaum, Silvio Halpern, Lucila Evangelista, Mariangela Maluf, Paulo Perin, Carlos Eduardo Czeresnia, Jean Pierre Schatzmann Peron

Clin Sci (Lond) (2021) 135 (9): 1065–1082.

DOI: https://doi.org/10.1042/CS20201544

Published: 07 May 2021

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Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

Fedor Simko, Tomas Baka

Clin Sci (Lond) (2021) 135 (8): 1009–1014.

DOI: https://doi.org/10.1042/CS20210182

Published: 21 April 2021

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Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure

Leanne Mooney, Carl S. Goodyear, Tamir Chandra, Kristina Kirschner, Mhairi Copland, Mark C. Petrie, Ninian N. Lang

Clin Sci (Lond) (2021) 135 (7): 991–1007.

DOI: https://doi.org/10.1042/CS20200306

Published: 16 April 2021

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Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Kana N. Miyata, Chao-Sheng Lo, Shuiling Zhao, Min-Chun Liao, Yuchao Pang, Shiao-Ying Chang, Junzheng Peng, Matthias Kretzler, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan

Clin Sci (Lond) (2021) 135 (7): 943–961.

DOI: https://doi.org/10.1042/CS20210094

Published: 14 April 2021

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Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia

Ming Fu, Ledong Tan, Zefeng Lin, Vincent C.H. Lui, Paul K.H. Tam, Jonathan R. Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Chen

Clin Sci (Lond) (2021) 135 (7): 865–884.

DOI: https://doi.org/10.1042/CS20201366

Published: 09 April 2021

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Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Carlos M. Ferrario

Clin Sci (Lond) (2021) 135 (5): 683–686.

DOI: https://doi.org/10.1042/CS20210017

Published: 02 March 2021

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Sympathetic neural responses in heart failure during exercise and after exercise training

Catherine F. Notarius, John S. Floras

Clin Sci (Lond) (2021) 135 (4): 651–669.

DOI: https://doi.org/10.1042/CS20201306

Published: 26 February 2021

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Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19

Maria A. Pedrosa, Rita Valenzuela, Pablo Garrido-Gil, Carmen M. Labandeira, Gemma Navarro, Rafael Franco, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez

Clin Sci (Lond) (2021) 135 (3): 465–481.

DOI: https://doi.org/10.1042/CS20201511

Published: 01 February 2021

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Gastrin, via activation of PPARα, protects the kidney against hypertensive injury

Daqian Gu, Dandong Fang, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Donghai Yang, Xue Zou, Yukai Liu, Wei Eric Wang, Gengze Wu, Pedro A. Jose, Yu Han, Chunyu Zeng

Clin Sci (Lond) (2021) 135 (2): 409–427.

DOI: https://doi.org/10.1042/CS20201340

Published: 29 January 2021

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Cardiotoxic effects of angiogenesis inhibitors

Stephen J.H. Dobbin, Mark C. Petrie, Rachel C. Myles, Rhian M. Touyz, Ninian N. Lang

Clin Sci (Lond) (2021) 135 (1): 71–100.

DOI: https://doi.org/10.1042/CS20200305

Published: 06 January 2021

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Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases

Ravindra K. Sharma, Jing Li, Suraj Krishnan, Elaine M. Richards, Mohan K. Raizada, Rajesh Mohandas

Clin Sci (Lond) (2021) 135 (1): 1–17.

DOI: https://doi.org/10.1042/CS20200482

Published: 05 January 2021

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Potential therapeutic applications of AKAP disrupting peptides

Alessandra Murabito, Sophie Cnudde, Emilio Hirsch, Alessandra Ghigo

Clin Sci (Lond) (2020) 134 (24): 3259–3282.

DOI: https://doi.org/10.1042/CS20201244

Published: 21 December 2020

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Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads

Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Alexandra H. Lopez, Joseph M. Rutkowski, Brett M. Mitchell

Clin Sci (Lond) (2020) 134 (24): 3237–3257.

DOI: https://doi.org/10.1042/CS20201023

Published: 21 December 2020

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Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Sarah L. Walton, Katrina M. Mirabito Colafella, Aneesa Ansari, Siew Yeen Chai, Kate M. Denton

Clin Sci (Lond) (2020) 134 (23): 3213–3228.

DOI: https://doi.org/10.1042/CS20201233

Published: 11 December 2020

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Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice

Zhiyuan Guan, Jialin Jia, Chenggui Zhang, Tiantong Sun, Wang Zhang, Wanqiong Yuan, Huijie Leng, Chunli Song

Clin Sci (Lond) (2020) 134 (23): 3159–3174.

DOI: https://doi.org/10.1042/CS20201224

Published: 09 December 2020

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Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Amy Catherine Kelly, Anita Kramer, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2020) 134 (23): 3123–3136.

DOI: https://doi.org/10.1042/CS20201050

Published: 07 December 2020

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Developmental programming of cardiovascular function: a translational perspective

Stephane L. Bourque, Sandra T. Davidge

Clin Sci (Lond) (2020) 134 (22): 3023–3046.

DOI: https://doi.org/10.1042/CS20191210

Published: 24 November 2020

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Vinpocetine protects against the development of experimental abdominal aortic aneurysms

Chongyang Zhang, Chia George Hsu, Amy Mohan, Hangchuan Shi, Dongmei Li, Chen Yan

Clin Sci (Lond) (2020) 134 (22): 2959–2976.

DOI: https://doi.org/10.1042/CS20201057

Published: 16 November 2020

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Includes: Supplementary data

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