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Articles

Colchicine protects against the development of experimental abdominal aortic aneurysm

Yi Zhao, Qi-Rui Shen, Yu-Xin Chen, Yu Shi, Wen-Bing Wu, Qiao Li, Dong-Jie Li, Fu-Ming Shen, Hui Fu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1533–1545.
https://doi.org/10.1042/CS20230499
Published: 03 October 2023
View article titled, Colchicine protects against the development of experimental abdominal aortic aneurysm
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Includes: Supplementary data
Articles

Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)

Kishore Chittimalli, Jesmin Jahan, Anil Sakamuri, Zachary L. McAdams, Aaron C. Ericsson, Yagna P.R. Jarajapu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (11): 913–930.
https://doi.org/10.1042/CS20220904
Published: 14 June 2023
View article titled, Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1–7)
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Includes: Supplementary data
Articles

Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 823–841.
https://doi.org/10.1042/CS20230433
Published: 31 May 2023
View article titled, Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity
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Includes: Supplementary data
Articles

Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 785–805.
https://doi.org/10.1042/CS20220625
Published: 23 May 2023
View article titled, Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis
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Includes: Supplementary data
Articles

Antiviral activities of hemp cannabinoids

Richard B. van Breemen, Daniel Simchuk
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 633–643.
https://doi.org/10.1042/CS20220193
Published: 21 April 2023
View article titled, Antiviral activities of hemp cannabinoids
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Articles

Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Guochao Song, Fengyi Weng, Bin Zou, Jing Zhao, Jingyi Jin, Dongming Yan, Kai Huang, Xin Sun, Chenghai Liu, Yiyang Hu, Yue Li, Furong Qiu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (7): 561–577.
https://doi.org/10.1042/CS20220674
Published: 13 April 2023
View article titled, Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway
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Includes: Supplementary data
Articles

Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

In Collection
Reproductive Physiology and Disease
Hana Horackova, Veronika Vachalova, Cilia Abad, Rona Karahoda, Frantisek Staud
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (2): 149–161.
https://doi.org/10.1042/CS20220726
Published: 18 January 2023
View article titled, Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport
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Articles

Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3

Jianbo Liu, Kaixuan Liu, Shiquan Chai, Runze Xu, Ying Wang, Yundi Zhang, Shuanglian Wang, Chuanyong Liu, Bing Xue
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 109–127.
https://doi.org/10.1042/CS20220392
Published: 05 January 2023
View article titled, Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3
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Includes: Supplementary data
Articles

Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Kazuhiro Aonuma, DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Yuta Okabe, Zixun Yuan, Siqi Li, Yoshiko Murakata, Kenichi Tominaga, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda, Hiroko Isoda
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1831–1849.
https://doi.org/10.1042/CS20220319
Published: 21 December 2022
View article titled, Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation
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Articles

Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1631–1651.
https://doi.org/10.1042/CS20220404
Published: 16 November 2022
View article titled, Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease
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Articles

CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Yazmin M. Restrepo, Natalia M. Noto, Robert C. Speth
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1513–1533.
https://doi.org/10.1042/CS20220261
Published: 03 November 2022
View article titled, CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood
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Includes: Supplementary data
Articles

Protecting glomerulus: role of angiotensin-II type 2 receptor

Sanket Patel, Kalyani Kulkarni, Tahir Hussain
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1467–1470.
https://doi.org/10.1042/CS20220396
Published: 26 October 2022
View article titled, Protecting glomerulus: role of angiotensin-II type 2 receptor
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Articles

L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Xiao Ma, Dechao Cai, Yakun Zhu, Yao Zhao, Xianbo Shang, Chen Wang, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1053–1069.
https://doi.org/10.1042/CS20220082
Published: 06 July 2022
View article titled, L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway
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Articles

Angiotensin Receptors - Affinity and Beyond

Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 799–802.
https://doi.org/10.1042/CS20220024
Published: 27 May 2022
View article titled, Angiotensin Receptors - Affinity and Beyond
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Articles

Mechanisms underlying immune-related adverse events during checkpoint immunotherapy

Xiao Zhou, Xiang Chen, Leng Han, Hong Liu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 771–785.
https://doi.org/10.1042/CS20210042
Published: 27 May 2022
View article titled, Mechanisms underlying immune-related adverse events during checkpoint immunotherapy
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Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

In Collection
Cardiovascular-Oncology
Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (9): 675–694.
https://doi.org/10.1042/CS20220182
Published: 10 May 2022
View article titled, Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage
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Includes: Supplementary data
Articles

Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (8): 537–555.
https://doi.org/10.1042/CS20211090
Published: 21 April 2022
View article titled, Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice
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Articles

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Xiaoyi Zhang, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (7): 455–471.
https://doi.org/10.1042/CS20211031
Published: 06 April 2022
View article titled, Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis
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Includes: Supplementary data
Articles

Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (6): 405–423.
https://doi.org/10.1042/CS20210835
Published: 23 March 2022
View article titled, Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics
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Articles

The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V. Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 329–343.
https://doi.org/10.1042/CS20211151
Published: 02 March 2022
View article titled, The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype
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Includes: Supplementary data
Articles

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

In Collection
Cardiovascular-Oncology
Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 139–161.
https://doi.org/10.1042/CS20210836
Published: 07 January 2022
View article titled, Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up
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Includes: Supplementary data
Articles

Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice

Bárbara Fernandes Pinto, Lorena Natasha Brito Ribeiro, Gisela Bevilacqua Rolfsen Ferreira da Silva, Camila Simões Freitas, Lucas Kraemer, Fabrício Marcus Silva Oliveira, Marianna Carvalho Clímaco, Flávio Afonso Gonçalves Mourão, Gabryella Soares Pinheiro dos Santos, Samantha Ribeiro Béla, Isabella Luísa da Silva Gurgel, Fábio de Lima Leite, Anselmo Gomes de Oliveira, Maura Regina Silva da Páscoa Vilela, Onésia Cristina Oliveira-Lima, Frederico Marianetti Soriani, Ricardo Toshio Fujiwara, Alexander Birbrair, Remo Castro Russo, Juliana Carvalho-Tavares
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 81–101.
https://doi.org/10.1042/CS20210792
Published: 07 January 2022
View article titled, Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice
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Articles

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (22): 2559–2573.
https://doi.org/10.1042/CS20210713
Published: 26 November 2021
View article titled, Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover
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Includes: Supplementary data
Articles

Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2503–2520.
https://doi.org/10.1042/CS20210719
Published: 09 November 2021
View article titled, Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia
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Articles

Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2483–2502.
https://doi.org/10.1042/CS20210259
Published: 08 November 2021
View article titled, Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling
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Includes: Supplementary data
Articles

Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2409–2422.
https://doi.org/10.1042/CS20210405
Published: 22 October 2021
View article titled, Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats
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Articles

Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
https://doi.org/10.1042/CS20210462
Published: 18 October 2021
View article titled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury
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Articles

Oxytocin: much more than childbirth and milk letdown

Morley D. Hollenberg
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2121–2126.
https://doi.org/10.1042/CS20210180
Published: 10 September 2021
View article titled, Oxytocin: much more than childbirth and milk letdown
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Articles

Eicosanoid receptors as therapeutic targets for asthma

William S. Powell
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1945–1980.
https://doi.org/10.1042/CS20190657
Published: 17 August 2021
View article titled, Eicosanoid receptors as therapeutic targets for asthma
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Articles

Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

In Collection
Cardiovascular-Oncology
Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1897–1914.
https://doi.org/10.1042/CS20210311
Published: 10 August 2021
View article titled, Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo
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Includes: Supplementary data
Articles

Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Ahmed A. Elmarakby, Jennifer C. Sullivan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1791–1804.
https://doi.org/10.1042/CS20201017
Published: 02 August 2021
View article titled, Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)
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Articles

The traditional herbal formulation, Jianpiyifei II , reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice

Xuhua Yu, Tiantian Cai, Long Fan, Ziyao Liang, Qiuling Du, Qi Wang, Zifeng Yang, Ross Vlahos, Lei Wu, Lin Lin
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1733–1750.
https://doi.org/10.1042/CS20210050
Published: 27 July 2021
View article titled, The traditional herbal formulation, Jianpiyifei II , reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice
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Includes: Supplementary data
Articles

A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang, Cheng Yang, Li Yu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1751–1765.
https://doi.org/10.1042/CS20210571
Published: 27 July 2021
View article titled, A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis
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Includes: Supplementary data
Articles

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1707–1726.
https://doi.org/10.1042/CS20210100
Published: 22 July 2021
View article titled, Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
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Includes: Supplementary data
Articles

Fifty years of research on the brain renin–angiotensin system: what have we learned?

Edwyn O. Cruz-López, Estrellita Uijl, A.H. Jan Danser
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1727–1731.
https://doi.org/10.1042/CS20210579
Published: 22 July 2021
View article titled, Fifty years of research on the brain renin–angiotensin system: what have we learned?
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Articles

Unravelling the tangled web of hypertension and cancer

In Collection
Cardiovascular-Oncology
Aristeidis Sionakidis, Linsay McCallum, Sandosh Padmanabhan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1609–1625.
https://doi.org/10.1042/CS20200307
Published: 09 July 2021
View article titled, Unravelling the tangled web of hypertension and cancer
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Articles

Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation

In Collection
Cardiovascular-Oncology
Chenliang Ge, Yang Cheng, Yihao Fan, Yan He
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1409–1426.
https://doi.org/10.1042/CS20210189
Published: 04 June 2021
View article titled, Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation
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Includes: Supplementary data
Articles

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1273–1288.
https://doi.org/10.1042/CS20210061
Published: 26 May 2021
View article titled, Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease
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Articles

Emerging role of carbonic anhydrase inhibitors

Claudiu T. Supuran
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1233–1249.
https://doi.org/10.1042/CS20210040
Published: 20 May 2021
View article titled, Emerging role of carbonic anhydrase inhibitors
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Articles

Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Ying-Yin Sun, Dong-Qing Wu, Na-Na Yin, Lei Yang, Xin Chen, Hai-Di Li, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Hua Wang, Jun Li
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1213–1232.
https://doi.org/10.1042/CS20201363
Published: 20 May 2021
View article titled, Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver
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Includes: Supplementary data
Articles

Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease

Anton J.M. Roks, Caroline Cheng, Catherine M. Shanahan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
https://doi.org/10.1042/CS20210288
Published: 20 May 2021
View article titled, Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease
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Articles

C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
https://doi.org/10.1042/CS20210049
Published: 11 May 2021
View article titled, C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors
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Includes: Supplementary data
Articles

In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system

Antoine M. Snijders, Mi Zhou, Todd P. Whitehead, Briana Fitch, Priyatama Pandey, Aaron Hechmer, Abel Huang, Suzaynn F. Schick, Adam J. de Smith, Adam B. Olshen, Catherine Metayer, Jian-Hua Mao, Joseph L. Wiemels, Scott C. Kogan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1053–1063.
https://doi.org/10.1042/CS20201498
Published: 23 April 2021
View article titled, In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system
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Includes: Supplementary data
Articles

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

In Collection
Coronavirus
Fedor Simko, Tomas Baka
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1009–1014.
https://doi.org/10.1042/CS20210182
Published: 21 April 2021
View article titled, Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?
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Articles

The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting

Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1015–1051.
https://doi.org/10.1042/CS20201445
Published: 21 April 2021
View article titled, The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting
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Articles

Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension

Reda Hmazzou, Yannick Marc, Adrien Flahault, Romain Gerbier, Nadia De Mota, Catherine Llorens-Cortes
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 775–791.
https://doi.org/10.1042/CS20201385
Published: 17 March 2021
View article titled, Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension
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Includes: Supplementary data
Articles

Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Carlos M. Ferrario
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (5): 683–686.
https://doi.org/10.1042/CS20210017
Published: 02 March 2021
View article titled, Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure
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Articles

Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (4): 613–627.
https://doi.org/10.1042/CS20201145
Published: 18 February 2021
View article titled, Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes
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Articles

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
https://doi.org/10.1042/CS20201207
Published: 09 December 2020
View article titled, Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis
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Includes: Supplementary data
Articles

ACE2 in the renin–angiotensin system

In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
https://doi.org/10.1042/CS20200478
Published: 02 December 2020
View article titled, ACE2 in the renin–angiotensin system
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