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Articles

Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu

Clin Sci (Lond) (2023) 137 (10): 785–805.

DOI: https://doi.org/10.1042/CS20220625

Published: 23 May 2023

View article titled, Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Includes: Supplementary data

Articles

NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Lenka Maletinska, Alena Karnošová, Veronika Strnadová, Blanka Zelezna, Jaroslav Kunes, Petr Kašpárek

Clin Sci (Lond) (2023) CS20220880.

DOI: https://doi.org/10.1042/CS20220880

Published: 16 May 2023

View article titled, NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Articles

Antiviral activities of hemp cannabinoids

Richard B. van Breemen, Daniel Simchuk

Clin Sci (Lond) (2023) 137 (8): 633–643.

DOI: https://doi.org/10.1042/CS20220193

Published: 21 April 2023

View article titled, Antiviral activities of hemp cannabinoids

Articles

Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Guochao Song, Fengyi Weng, Bin Zou, Jing Zhao, Jingyi Jin, Dongming Yan, Kai Huang, Xin Sun, Chenghai Liu, Yiyang Hu, Yue Li, Furong Qiu

Clin Sci (Lond) (2023) 137 (7): 561–577.

DOI: https://doi.org/10.1042/CS20220674

Published: 13 April 2023

View article titled, Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Includes: Supplementary data

Articles

Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

In Collection

Reproductive Physiology and Disease

Hana Horackova, Veronika Vachalova, Cilia Abad, Rona Karahoda, Frantisek Staud

Clin Sci (Lond) (2023) 137 (2): 149–161.

DOI: https://doi.org/10.1042/CS20220726

Published: 18 January 2023

View article titled, Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

Articles

Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3

Jianbo Liu, Kaixuan Liu, Shiquan Chai, Runze Xu, Ying Wang, Yundi Zhang, Shuanglian Wang, Chuanyong Liu, Bing Xue

Clin Sci (Lond) (2023) 137 (1): 109–127.

DOI: https://doi.org/10.1042/CS20220392

Published: 05 January 2023

View article titled, Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3

Includes: Supplementary data

Articles

Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Kazuhiro Aonuma, DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Yuta Okabe, Zixun Yuan, Siqi Li, Yoshiko Murakata, Kenichi Tominaga, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda, Hiroko Isoda

Clin Sci (Lond) (2022) 136 (24): 1831–1849.

DOI: https://doi.org/10.1042/CS20220319

Published: 21 December 2022

View article titled, Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Articles

Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi

Clin Sci (Lond) (2022) 136 (22): 1631–1651.

DOI: https://doi.org/10.1042/CS20220404

Published: 16 November 2022

View article titled, Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Articles

CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Yazmin M. Restrepo, Natalia M. Noto, Robert C. Speth

Clin Sci (Lond) (2022) 136 (21): 1513–1533.

DOI: https://doi.org/10.1042/CS20220261

Published: 03 November 2022

View article titled, CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Includes: Supplementary data

Articles

Protecting glomerulus: role of angiotensin-II type 2 receptor

Sanket Patel, Kalyani Kulkarni, Tahir Hussain

Clin Sci (Lond) (2022) 136 (20): 1467–1470.

DOI: https://doi.org/10.1042/CS20220396

Published: 26 October 2022

View article titled, Protecting glomerulus: role of angiotensin-II type 2 receptor

Articles

L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Xiao Ma, Dechao Cai, Yakun Zhu, Yao Zhao, Xianbo Shang, Chen Wang, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng

Clin Sci (Lond) (2022) 136 (13): 1053–1069.

DOI: https://doi.org/10.1042/CS20220082

Published: 06 July 2022

View article titled, L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Articles

Angiotensin Receptors - Affinity and Beyond

Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings

Clin Sci (Lond) (2022) 136 (10): 799–802.

DOI: https://doi.org/10.1042/CS20220024

Published: 27 May 2022

View article titled, Angiotensin Receptors - Affinity and Beyond

Articles

Mechanisms underlying immune-related adverse events during checkpoint immunotherapy

Xiao Zhou, Xiang Chen, Leng Han, Hong Liu

Clin Sci (Lond) (2022) 136 (10): 771–785.

DOI: https://doi.org/10.1042/CS20210042

Published: 27 May 2022

View article titled, Mechanisms underlying immune-related adverse events during checkpoint immunotherapy

Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

In Collection

Cardiovascular-Oncology

Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen

Clin Sci (Lond) (2022) 136 (9): 675–694.

DOI: https://doi.org/10.1042/CS20220182

Published: 10 May 2022

View article titled, Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

Includes: Supplementary data

Articles

Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos

Clin Sci (Lond) (2022) 136 (8): 537–555.

DOI: https://doi.org/10.1042/CS20211090

Published: 21 April 2022

View article titled, Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Articles

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Xiaoyi Zhang, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi

Clin Sci (Lond) (2022) 136 (7): 455–471.

DOI: https://doi.org/10.1042/CS20211031

Published: 06 April 2022

View article titled, Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Includes: Supplementary data

Articles

Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos

Clin Sci (Lond) (2022) 136 (6): 405–423.

DOI: https://doi.org/10.1042/CS20210835

Published: 23 March 2022

View article titled, Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Articles

The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V. Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Clin Sci (Lond) (2022) 136 (5): 329–343.

DOI: https://doi.org/10.1042/CS20211151

Published: 02 March 2022

View article titled, The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Includes: Supplementary data

Articles

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

In Collection

Cardiovascular-Oncology

Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba

Clin Sci (Lond) (2022) 136 (1): 139–161.

DOI: https://doi.org/10.1042/CS20210836

Published: 07 January 2022

View article titled, Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

Includes: Supplementary data

Articles

Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice

Clin Sci (Lond) (2022) 136 (1): 81–101.

DOI: https://doi.org/10.1042/CS20210792

Published: 07 January 2022

View article titled, Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice

Articles

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman

Clin Sci (Lond) (2021) 135 (22): 2559–2573.

DOI: https://doi.org/10.1042/CS20210713

Published: 26 November 2021

View article titled, Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Includes: Supplementary data

Articles

Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi

Clin Sci (Lond) (2021) 135 (21): 2503–2520.

DOI: https://doi.org/10.1042/CS20210719

Published: 09 November 2021

View article titled, Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Articles

Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen

Clin Sci (Lond) (2021) 135 (21): 2483–2502.

DOI: https://doi.org/10.1042/CS20210259

Published: 08 November 2021

View article titled, Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Includes: Supplementary data

Articles

Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda

Clin Sci (Lond) (2021) 135 (20): 2409–2422.

DOI: https://doi.org/10.1042/CS20210405

Published: 22 October 2021

View article titled, Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

Articles

Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy

Clin Sci (Lond) (2021) 135 (20): 2341–2356.

DOI: https://doi.org/10.1042/CS20210462

Published: 18 October 2021

View article titled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Articles

Oxytocin: much more than childbirth and milk letdown

Morley D. Hollenberg

Clin Sci (Lond) (2021) 135 (17): 2121–2126.

DOI: https://doi.org/10.1042/CS20210180

Published: 10 September 2021

View article titled, Oxytocin: much more than childbirth and milk letdown

Articles

Eicosanoid receptors as therapeutic targets for asthma

William S. Powell

Clin Sci (Lond) (2021) 135 (16): 1945–1980.

DOI: https://doi.org/10.1042/CS20190657

Published: 17 August 2021

View article titled, Eicosanoid receptors as therapeutic targets for asthma

Articles

Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

In Collection

Cardiovascular-Oncology

Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba

Clin Sci (Lond) (2021) 135 (15): 1897–1914.

DOI: https://doi.org/10.1042/CS20210311

Published: 10 August 2021

View article titled, Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

Includes: Supplementary data

Articles

Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Ahmed A. Elmarakby, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (15): 1791–1804.

DOI: https://doi.org/10.1042/CS20201017

Published: 02 August 2021

View article titled, Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

Articles

The traditional herbal formulation, Jianpiyifei II , reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice

Xuhua Yu, Tiantian Cai, Long Fan, Ziyao Liang, Qiuling Du, Qi Wang, Zifeng Yang, Ross Vlahos, Lei Wu, Lin Lin

Clin Sci (Lond) (2021) 135 (14): 1733–1750.

DOI: https://doi.org/10.1042/CS20210050

Published: 27 July 2021

View article titled, The traditional herbal formulation, Jianpiyifei II , reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice

Includes: Supplementary data

Articles

A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang, Cheng Yang, Li Yu

Clin Sci (Lond) (2021) 135 (14): 1751–1765.

DOI: https://doi.org/10.1042/CS20210571

Published: 27 July 2021

View article titled, A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Includes: Supplementary data

Articles

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

Clin Sci (Lond) (2021) 135 (14): 1707–1726.

DOI: https://doi.org/10.1042/CS20210100

Published: 22 July 2021

View article titled, Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Includes: Supplementary data

Articles

Fifty years of research on the brain renin–angiotensin system: what have we learned?

Edwyn O. Cruz-López, Estrellita Uijl, A.H. Jan Danser

Clin Sci (Lond) (2021) 135 (14): 1727–1731.

DOI: https://doi.org/10.1042/CS20210579

Published: 22 July 2021

View article titled, Fifty years of research on the brain renin–angiotensin system: what have we learned?

Articles

Unravelling the tangled web of hypertension and cancer

In Collection

Cardiovascular-Oncology

Aristeidis Sionakidis, Linsay McCallum, Sandosh Padmanabhan

Clin Sci (Lond) (2021) 135 (13): 1609–1625.

DOI: https://doi.org/10.1042/CS20200307

Published: 09 July 2021

View article titled, Unravelling the tangled web of hypertension and cancer

Articles

Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation

In Collection

Cardiovascular-Oncology

Chenliang Ge, Yang Cheng, Yihao Fan, Yan He

Clin Sci (Lond) (2021) 135 (11): 1409–1426.

DOI: https://doi.org/10.1042/CS20210189

Published: 04 June 2021

View article titled, Vincristine attenuates cardiac fibrosis through the inhibition of NLRP3 inflammasome activation

Includes: Supplementary data

Articles

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun

Clin Sci (Lond) (2021) 135 (10): 1273–1288.

DOI: https://doi.org/10.1042/CS20210061

Published: 26 May 2021

View article titled, Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Articles

Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Ying-Yin Sun, Dong-Qing Wu, Na-Na Yin, Lei Yang, Xin Chen, Hai-Di Li, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Hua Wang, Jun Li

Clin Sci (Lond) (2021) 135 (10): 1213–1232.

DOI: https://doi.org/10.1042/CS20201363

Published: 20 May 2021

View article titled, Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Includes: Supplementary data

Articles

Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease

Anton J.M. Roks, Caroline Cheng, Catherine M. Shanahan

Clin Sci (Lond) (2021) 135 (10): 1209–1212.

DOI: https://doi.org/10.1042/CS20210288

Published: 20 May 2021

View article titled, Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease

Articles

Emerging role of carbonic anhydrase inhibitors

Claudiu T. Supuran

Clin Sci (Lond) (2021) 135 (10): 1233–1249.

DOI: https://doi.org/10.1042/CS20210040

Published: 20 May 2021

View article titled, Emerging role of carbonic anhydrase inhibitors

Articles

C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza

Clin Sci (Lond) (2021) 135 (9): 1145–1163.

DOI: https://doi.org/10.1042/CS20210049

Published: 11 May 2021

View article titled, C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Includes: Supplementary data

Articles

In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system

Antoine M. Snijders, Mi Zhou, Todd P. Whitehead, Briana Fitch, Priyatama Pandey, Aaron Hechmer, Abel Huang, Suzaynn F. Schick, Adam J. de Smith, Adam B. Olshen, Catherine Metayer, Jian-Hua Mao, Joseph L. Wiemels, Scott C. Kogan

Clin Sci (Lond) (2021) 135 (8): 1053–1063.

DOI: https://doi.org/10.1042/CS20201498

Published: 23 April 2021

View article titled, In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system

Includes: Supplementary data

Articles

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

In Collection

Coronavirus

Fedor Simko, Tomas Baka

Clin Sci (Lond) (2021) 135 (8): 1009–1014.

DOI: https://doi.org/10.1042/CS20210182

Published: 21 April 2021

View article titled, Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

Articles

The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting

Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi

Clin Sci (Lond) (2021) 135 (8): 1015–1051.

DOI: https://doi.org/10.1042/CS20201445

Published: 21 April 2021

View article titled, The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting

Articles

Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension

Reda Hmazzou, Yannick Marc, Adrien Flahault, Romain Gerbier, Nadia De Mota, Catherine Llorens-Cortes

Clin Sci (Lond) (2021) 135 (6): 775–791.

DOI: https://doi.org/10.1042/CS20201385

Published: 17 March 2021

View article titled, Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension

Includes: Supplementary data

Articles

Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Carlos M. Ferrario

Clin Sci (Lond) (2021) 135 (5): 683–686.

DOI: https://doi.org/10.1042/CS20210017

Published: 02 March 2021

View article titled, Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Articles

Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhang

Clin Sci (Lond) (2021) 135 (4): 613–627.

DOI: https://doi.org/10.1042/CS20201145

Published: 18 February 2021

View article titled, Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

Articles

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu

Clin Sci (Lond) (2020) 134 (23): 3175–3193.

DOI: https://doi.org/10.1042/CS20201207

Published: 09 December 2020

View article titled, Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Includes: Supplementary data

Articles

ACE2 in the renin–angiotensin system

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Thiago Verano-Braga, Ana Luiza Valle Martins, Daisy Motta-Santos, Maria José Campagnole-Santos, Robson Augusto Souza Santos

Clin Sci (Lond) (2020) 134 (23): 3063–3078.

DOI: https://doi.org/10.1042/CS20200478

Published: 02 December 2020

View article titled, ACE2 in the renin–angiotensin system

Articles

Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

U. Muscha Steckelings, Colin Sumners

Clin Sci (Lond) (2020) 134 (22): 2987–3006.

DOI: https://doi.org/10.1042/CS20200922

Published: 19 November 2020

View article titled, Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT 2 -receptor agonists

Articles

Vinpocetine protects against the development of experimental abdominal aortic aneurysms

Chongyang Zhang, Chia George Hsu, Amy Mohan, Hangchuan Shi, Dongmei Li, Chen Yan

Clin Sci (Lond) (2020) 134 (22): 2959–2976.

DOI: https://doi.org/10.1042/CS20201057

Published: 16 November 2020

View article titled, Vinpocetine protects against the development of experimental abdominal aortic aneurysms

Includes: Supplementary data

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