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Articles

DsbA-L alleviated tubular injury in diabetic nephropathy via activating mitophagy through maintain MAM integrity

Lin Sun, Ming Yang, Qin Zhang, Shilu Luo, Yachun Han, Hao Zhao, Na Jiang, Yan Liu, Li Li, Chenrui Li, Chongbin Liu, Liyu He, Xuejing Zhu, Yu Liu

Clin Sci (Lond) (2023) CS20220787.

DOI: https://doi.org/10.1042/CS20220787

Published: 25 May 2023

View article titled, DsbA-L alleviated tubular injury in diabetic nephropathy via activating mitophagy through maintain MAM integrity

Articles

TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection

Ildernandes Vieira-Alves, Antonielle Rodrigues Pereira Alves, Natália Muradas Valério Souza, Tales Leonardo de Melo, Leda Maria de Castro Coimbra Campos, Larisse de Souza Barbosa Lacerda, Celso Martins Queiroz-Junior, Ana Cláudia dos Santos Pereira Andrade, Luciola Silva Barcelos, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Steyner F. Cortes, Virginia S. Lemos

Clin Sci (Lond) (2023) 137 (7): 543–559.

DOI: https://doi.org/10.1042/CS20220663

Published: 13 April 2023

View article titled, TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection

Includes: Supplementary data

Articles

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Yvonne Baumer, Mario A. Pita, Andrew S. Baez, Lola R. Ortiz-Whittingham, Manuel A. Cintron, Rebecca R. Rose, Veronica C. Gray, Foster Osei Baah, Tiffany M. Powell-Wiley

Clin Sci (Lond) (2023) 137 (6): 469–494.

DOI: https://doi.org/10.1042/CS20220304

Published: 24 March 2023

View article titled, By what molecular mechanisms do social determinants impact cardiometabolic risk?

Includes: Supplementary data

Articles

Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Zhipeng Tao, Zhiyong Cheng

Clin Sci (Lond) (2023) 137 (6): 415–434.

DOI: https://doi.org/10.1042/CS20210519

Published: 21 March 2023

View article titled, Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Articles

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

In Collection

Reproductive Physiology and Disease

Matthew Kang, Cherie Blenkiron, Lawrence W. Chamley

Clin Sci (Lond) (2023) 137 (5): 385–399.

DOI: https://doi.org/10.1042/CS20220301

Published: 15 March 2023

View article titled, The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

Articles

The role of extracellular vesicles in intercellular communication in human reproduction

In Collection

Reproductive Physiology and Disease

Javier Gonzalez Fernandez, Javier Moncayo Arlandi, Ana Ochando, Carlos Simon, Felipe Vilella

Clin Sci (Lond) (2023) 137 (3): 281–301.

DOI: https://doi.org/10.1042/CS20220793

Published: 10 February 2023

View article titled, The role of extracellular vesicles in intercellular communication in human reproduction

Articles

Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Keitaro Ueda, Chiemi Sakai, Takafumi Ishida, Kosuke Morita, Yusuke Kobayashi, Yasunori Horikoshi, Akiko Baba, Yuma Okazaki, Masao Yoshizumi, Satoshi Tashiro, Mari Ishida

Clin Sci (Lond) (2023) 137 (2): 163–180.

DOI: https://doi.org/10.1042/CS20220525

Published: 24 January 2023

View article titled, Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Includes: Supplementary data

Articles

Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Raffaele Altara, George W. Booz

Clin Sci (Lond) (2023) 137 (2): 143–148.

DOI: https://doi.org/10.1042/CS20220776

Published: 18 January 2023

View article titled, Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Articles

Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways

Sheila Almaraz Postigo, Juan Carlos Montero

Clin Sci (Lond) (2023) 137 (1): 1–15.

DOI: https://doi.org/10.1042/CS20220472

Published: 23 December 2022

View article titled, Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways

Includes: Supplementary data

Articles

Small extracellular vesicles: a new player in GDM pathogenesis

In Collection

Reproductive Physiology and Disease

Agafe Bless Reyes, Dylan Burger

Clin Sci (Lond) (2022) 136 (24): 1873–1875.

DOI: https://doi.org/10.1042/CS20220658

Published: 22 December 2022

View article titled, Small extracellular vesicles: a new player in GDM pathogenesis

Articles

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2022) 136 (22): 1661–1681.

DOI: https://doi.org/10.1042/CS20220607

Published: 21 November 2022

View article titled, Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Includes: Supplementary data

Articles

CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Yazmin M. Restrepo, Natalia M. Noto, Robert C. Speth

Clin Sci (Lond) (2022) 136 (21): 1513–1533.

DOI: https://doi.org/10.1042/CS20220261

Published: 03 November 2022

View article titled, CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Includes: Supplementary data

Articles

Novel mediators of idiopathic pulmonary fibrosis

Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal

Clin Sci (Lond) (2022) 136 (16): 1229–1240.

DOI: https://doi.org/10.1042/CS20210878

Published: 31 August 2022

View article titled, Novel mediators of idiopathic pulmonary fibrosis

Articles

Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma

Zhanzhan Li, Yanyan Li, Na Li, Liangfang Shen, Aibin Liu

Clin Sci (Lond) (2022) 136 (11): 895–909.

DOI: https://doi.org/10.1042/CS20220128

Published: 06 June 2022

View article titled, Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma

Includes: Supplementary data

Articles

ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer

Ting-Yu Chang, Kuo-Cheng Lan, Chen-Yuan Chiu, Meei-Ling Sheu, Shing-Hwa Liu

Clin Sci (Lond) (2022) 136 (9): 657–673.

DOI: https://doi.org/10.1042/CS20220043

Published: 06 May 2022

View article titled, ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer

Includes: Supplementary data

Articles

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Xiaoyi Zhang, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi

Clin Sci (Lond) (2022) 136 (7): 455–471.

DOI: https://doi.org/10.1042/CS20211031

Published: 06 April 2022

View article titled, Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Includes: Supplementary data

Articles

Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?

Nhat-Tu Le, Elizabeth A. Olmsted-Davis, Jun-ichi Abe

Clin Sci (Lond) (2022) 136 (5): 379–382.

DOI: https://doi.org/10.1042/CS20211096

Published: 11 March 2022

View article titled, Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?

Articles

Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression

Natasha Kolesnikoff, Chun-Hsien Chen, Michael Susithiran Samuel

Clin Sci (Lond) (2022) 136 (5): 361–377.

DOI: https://doi.org/10.1042/CS20210679

Published: 09 March 2022

View article titled, Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression

Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

View article titled, The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Articles

Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad

Clin Sci (Lond) (2022) 136 (2): 181–196.

DOI: https://doi.org/10.1042/CS20210964

Published: 28 January 2022

View article titled, Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Includes: Supplementary data

Articles

AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang

Clin Sci (Lond) (2022) 136 (1): 103–120.

DOI: https://doi.org/10.1042/CS20211075

Published: 07 January 2022

View article titled, AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Includes: Supplementary data

Articles

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

In Collection

Coronavirus

Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu

Clin Sci (Lond) (2021) 135 (24): 2667–2689.

DOI: https://doi.org/10.1042/CS20210735

Published: 15 December 2021

View article titled, The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

Articles

Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni

Clin Sci (Lond) (2021) 135 (23): 2625–2641.

DOI: https://doi.org/10.1042/CS20210810

Published: 08 December 2021

View article titled, Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Includes: Supplementary data

Articles

Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen

Clin Sci (Lond) (2021) 135 (21): 2483–2502.

DOI: https://doi.org/10.1042/CS20210259

Published: 08 November 2021

View article titled, Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Includes: Supplementary data

Articles

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

Laura Wilson, Alice E. Pollard, Lucy Penfold, Phillip J. Muckett, Chad Whilding, Mohammad Bohlooly-Y., Patricia Wilson, David Carling

Clin Sci (Lond) (2021) 135 (20): 2393–2408.

DOI: https://doi.org/10.1042/CS20210821

Published: 22 October 2021

View article titled, Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

Includes: Supplementary data

Articles

High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity

Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Oliveira Edilamar Menezes

Clin Sci (Lond) (2021) 135 (20): 2377–2391.

DOI: https://doi.org/10.1042/CS20210739

Published: 19 October 2021

View article titled, High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity

Includes: Supplementary data

Articles

Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy

Clin Sci (Lond) (2021) 135 (20): 2341–2356.

DOI: https://doi.org/10.1042/CS20210462

Published: 18 October 2021

View article titled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Articles

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega

Clin Sci (Lond) (2021) 135 (16): 1999–2029.

DOI: https://doi.org/10.1042/CS20201016

Published: 24 August 2021

View article titled, Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Articles

Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Valter Lubrano, Silvana Balzan

Clin Sci (Lond) (2021) 135 (16): 1981–1997.

DOI: https://doi.org/10.1042/CS20210417

Published: 20 August 2021

View article titled, Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Articles

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long

Clin Sci (Lond) (2021) 135 (15): 1873–1895.

DOI: https://doi.org/10.1042/CS20210447

Published: 06 August 2021

View article titled, Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Includes: Supplementary data

Articles

Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes

Clin Sci (Lond) (2021) 135 (15): 1845–1858.

DOI: https://doi.org/10.1042/CS20210468

Published: 04 August 2021

View article titled, Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Includes: Supplementary data

Articles

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

In Collection

Cardiovascular-Oncology

Daniel N. Meijles, Joshua J. Cull, Susanna T.E. Cooper, Thomais Markou, Michelle A. Hardyman, Stephen J. Fuller, Hajed O. Alharbi, Zoe H.R. Haines, Viridiana Alcantara-Alonso, Peter E. Glennon, Mary N. Sheppard, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2021) 135 (14): 1631–1647.

DOI: https://doi.org/10.1042/CS20210192

Published: 23 July 2021

View article titled, The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

Includes: Supplementary data

Articles

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

Clin Sci (Lond) (2021) 135 (14): 1707–1726.

DOI: https://doi.org/10.1042/CS20210100

Published: 22 July 2021

View article titled, Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Includes: Supplementary data

Articles

Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?

Keiichi Torimoto, Satoru Eguchi

Clin Sci (Lond) (2021) 135 (13): 1627–1630.

DOI: https://doi.org/10.1042/CS20210227

Published: 09 July 2021

View article titled, Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?

Articles

NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia

Jianmin Liu, Daoquan Liu, Xueneng Zhang, Yan Li, Xun Fu, Weixiang He, Mingzhou Li, Ping Chen, Guang Zeng, Michael E. DiSanto, Xinghuan Wang, Xinhua Zhang

Clin Sci (Lond) (2021) 135 (13): 1591–1608.

DOI: https://doi.org/10.1042/CS20210476

Published: 07 July 2021

View article titled, NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia

Includes: Supplementary data

Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt

Clin Sci (Lond) (2021) 135 (13): 1563–1590.

DOI: https://doi.org/10.1042/CS20190768

Published: 07 July 2021

View article titled, Nutrient regulation of inflammatory signalling in obesity and vascular disease

Articles

Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents

David L. Brautigan, Caroline Farrington, Goutham Narla

Clin Sci (Lond) (2021) 135 (13): 1545–1556.

DOI: https://doi.org/10.1042/CS20201367

Published: 30 June 2021

View article titled, Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents

Articles

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun

Clin Sci (Lond) (2021) 135 (10): 1273–1288.

DOI: https://doi.org/10.1042/CS20210061

Published: 26 May 2021

View article titled, Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Articles

Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease

Anton J.M. Roks, Caroline Cheng, Catherine M. Shanahan

Clin Sci (Lond) (2021) 135 (10): 1209–1212.

DOI: https://doi.org/10.1042/CS20210288

Published: 20 May 2021

View article titled, Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease

Articles

Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms

J.C. Ribeiro-Silva, A.A. Miyakawa, Jose E. Krieger

Clin Sci (Lond) (2021) 135 (9): 1189–1207.

DOI: https://doi.org/10.1042/CS20201528

Published: 14 May 2021

View article titled, Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms

Articles

Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia

Ming Fu, Ledong Tan, Zefeng Lin, Vincent C.H. Lui, Paul K.H. Tam, Jonathan R. Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Chen

Clin Sci (Lond) (2021) 135 (7): 865–884.

DOI: https://doi.org/10.1042/CS20201366

Published: 09 April 2021

View article titled, Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia

Includes: Supplementary data

Articles

EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics

Fang-Jing Zhong, Yi-Ming Li, Cong Xu, Bo Sun, Ji-Long Wang, Lian-Yue Yang

Clin Sci (Lond) (2021) 135 (7): 847–864.

DOI: https://doi.org/10.1042/CS20201500

Published: 06 April 2021

View article titled, EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics

Includes: Supplementary data

Articles

Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Ziwei Fu, Fei Wang, Xiyang Liu, Jiajia Hu, Jiahui Su, Xiaohan Lu, Aihua Lu, Jae Min Cho, J. David Symons, Chang-Jiang Zou, Tianxin Yang

Clin Sci (Lond) (2021) 135 (6): 793–810.

DOI: https://doi.org/10.1042/CS20201047

Published: 23 March 2021

View article titled, Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Includes: Supplementary data

Articles

Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz

Clin Sci (Lond) (2021) 135 (6): 753–773.

DOI: https://doi.org/10.1042/CS20201412

Published: 17 March 2021

View article titled, Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Includes: Supplementary data

Articles

P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model

Peter Cuthbertson, Nicholas J. Geraghty, Sam R. Adhikary, Sienna Casolin, Debbie Watson, Ronald Sluyter

Clin Sci (Lond) (2021) 135 (3): 495–513.

DOI: https://doi.org/10.1042/CS20201352

Published: 03 February 2021

View article titled, P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model

Includes: Supplementary data

Articles

Acid sphingomyelinase promotes SGK1-dependent vascular calcification

Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan

Clin Sci (Lond) (2021) 135 (3): 515–534.

DOI: https://doi.org/10.1042/CS20201122

Published: 03 February 2021

View article titled, Acid sphingomyelinase promotes SGK1-dependent vascular calcification

Includes: Supplementary data

Articles

The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling

Xueying Hu, Liang Xiang, Dong He, Rongrong Zhu, Jianing Fang, Zhanwang Wang, Ke Cao

Clin Sci (Lond) (2021) 135 (3): 555–574.

DOI: https://doi.org/10.1042/CS20200908

Published: 03 February 2021

View article titled, The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling

Includes: Supplementary data

Articles

ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Xi Cao, Li-Ni Song, Jin-Kui Yang

Clin Sci (Lond) (2021) 135 (3): 535–554.

DOI: https://doi.org/10.1042/CS20200752

Published: 03 February 2021

View article titled, ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

Articles

Gastrin, via activation of PPARα, protects the kidney against hypertensive injury

Daqian Gu, Dandong Fang, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Donghai Yang, Xue Zou, Yukai Liu, Wei Eric Wang, Gengze Wu, Pedro A. Jose, Yu Han, Chunyu Zeng

Clin Sci (Lond) (2021) 135 (2): 409–427.

DOI: https://doi.org/10.1042/CS20201340

Published: 29 January 2021

View article titled, Gastrin, via activation of PPARα, protects the kidney against hypertensive injury

Includes: Supplementary data

Articles

Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities

Cody C. Gifford, Jiaqi Tang, Angelica Costello, Nidah S. Khakoo, Tri Q. Nguyen, Roel Goldschmeding, Paul J. Higgins, Rohan Samarakoon

Clin Sci (Lond) (2021) 135 (2): 275–303.

DOI: https://doi.org/10.1042/CS20201213

Published: 22 January 2021

View article titled, Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities

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