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Articles

Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model

Carolyn J Wang, Jeremy T Smith, David Lu, Peter B. Noble, Kimberley CW Wang
Journal: Clinical Science
Clin Sci (Lond) (2023) CS20230792.
https://doi.org/10.1042/CS20230792
Published: 21 September 2023
View article titled, Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model
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Articles

Edema and lymphatic clearance: molecular mechanisms and ongoing challenges

Jerome W. Breslin
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (18): 1451–1476.
https://doi.org/10.1042/CS20220314
Published: 21 September 2023
View article titled, Edema and lymphatic clearance: molecular mechanisms and ongoing challenges
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Articles

Polycystic kidneys: interaction of notch and renin

Emily A. Daniel, Nicole A. Sommer, Madhulika Sharma
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1145–1150.
https://doi.org/10.1042/CS20230023
Published: 09 August 2023
View article titled, Polycystic kidneys: interaction of notch and renin
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Articles

DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity

Ming Yang, Qin Zhang, Shilu Luo, Yachun Han, Hao Zhao, Na Jiang, Yan Liu, Li Li, Chenrui Li, Chongbin Liu, Liyu He, Xuejing Zhu, Yu Liu, Lin Sun
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (12): 931–945.
https://doi.org/10.1042/CS20220787
Published: 20 June 2023
View article titled, DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity
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Includes: Supplementary data
Articles

High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro

Aiwen Shen, Yu Wang, Guoxin Ye, Jianping Mao, Qian Zhang, Jing Chen
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (12): 947–962.
https://doi.org/10.1042/CS20220754
Published: 20 June 2023
View article titled, High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro
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Includes: Supplementary data
Articles

TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection

Ildernandes Vieira-Alves, Antonielle Rodrigues Pereira Alves, Natália Muradas Valério Souza, Tales Leonardo de Melo, Leda Maria de Castro Coimbra Campos, Larisse de Souza Barbosa Lacerda, Celso Martins Queiroz-Junior, Ana Cláudia dos Santos Pereira Andrade, Luciola Silva Barcelos, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Steyner F. Cortes, Virginia S. Lemos
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (7): 543–559.
https://doi.org/10.1042/CS20220663
Published: 13 April 2023
View article titled, TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection
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Includes: Supplementary data
Articles

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Yvonne Baumer, Mario A. Pita, Andrew S. Baez, Lola R. Ortiz-Whittingham, Manuel A. Cintron, Rebecca R. Rose, Veronica C. Gray, Foster Osei Baah, Tiffany M. Powell-Wiley
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 469–494.
https://doi.org/10.1042/CS20220304
Published: 24 March 2023
View article titled, By what molecular mechanisms do social determinants impact cardiometabolic risk?
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Includes: Supplementary data
Articles

Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Zhipeng Tao, Zhiyong Cheng
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 415–434.
https://doi.org/10.1042/CS20210519
Published: 21 March 2023
View article titled, Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen
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Articles

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

In Collection
Reproductive Physiology and Disease
Matthew Kang, Cherie Blenkiron, Lawrence W. Chamley
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (5): 385–399.
https://doi.org/10.1042/CS20220301
Published: 15 March 2023
View article titled, The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation
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Articles

The role of extracellular vesicles in intercellular communication in human reproduction

In Collection
Reproductive Physiology and Disease
Javier Gonzalez Fernandez, Javier Moncayo Arlandi, Ana Ochando, Carlos Simon, Felipe Vilella
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (3): 281–301.
https://doi.org/10.1042/CS20220793
Published: 10 February 2023
View article titled, The role of extracellular vesicles in intercellular communication in human reproduction
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Articles

Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Keitaro Ueda, Chiemi Sakai, Takafumi Ishida, Kosuke Morita, Yusuke Kobayashi, Yasunori Horikoshi, Akiko Baba, Yuma Okazaki, Masao Yoshizumi, Satoshi Tashiro, Mari Ishida
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (2): 163–180.
https://doi.org/10.1042/CS20220525
Published: 24 January 2023
View article titled, Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis
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Includes: Supplementary data
Articles

Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Raffaele Altara, George W. Booz
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (2): 143–148.
https://doi.org/10.1042/CS20220776
Published: 18 January 2023
View article titled, Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide
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Articles

Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways

Sheila Almaraz Postigo, Juan Carlos Montero
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 1–15.
https://doi.org/10.1042/CS20220472
Published: 23 December 2022
View article titled, Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways
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Includes: Supplementary data
Articles

Small extracellular vesicles: a new player in GDM pathogenesis

In Collection
Reproductive Physiology and Disease
Agafe Bless Reyes, Dylan Burger
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1873–1875.
https://doi.org/10.1042/CS20220658
Published: 22 December 2022
View article titled, Small extracellular vesicles: a new player in GDM pathogenesis
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Articles

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1661–1681.
https://doi.org/10.1042/CS20220607
Published: 21 November 2022
View article titled, Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice
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Includes: Supplementary data
Articles

CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Yazmin M. Restrepo, Natalia M. Noto, Robert C. Speth
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1513–1533.
https://doi.org/10.1042/CS20220261
Published: 03 November 2022
View article titled, CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood
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Includes: Supplementary data
Articles

Novel mediators of idiopathic pulmonary fibrosis

Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1229–1240.
https://doi.org/10.1042/CS20210878
Published: 31 August 2022
View article titled, Novel mediators of idiopathic pulmonary fibrosis
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Articles

Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma

Zhanzhan Li, Yanyan Li, Na Li, Liangfang Shen, Aibin Liu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 895–909.
https://doi.org/10.1042/CS20220128
Published: 06 June 2022
View article titled, Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma
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Includes: Supplementary data
Articles

ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer

Ting-Yu Chang, Kuo-Cheng Lan, Chen-Yuan Chiu, Meei-Ling Sheu, Shing-Hwa Liu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (9): 657–673.
https://doi.org/10.1042/CS20220043
Published: 06 May 2022
View article titled, ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer
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Includes: Supplementary data
Articles

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Xiaoyi Zhang, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (7): 455–471.
https://doi.org/10.1042/CS20211031
Published: 06 April 2022
View article titled, Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis
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Includes: Supplementary data
Articles

Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?

Nhat-Tu Le, Elizabeth A. Olmsted-Davis, Jun-ichi Abe
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 379–382.
https://doi.org/10.1042/CS20211096
Published: 11 March 2022
View article titled, Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?
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Articles

Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression

Natasha Kolesnikoff, Chun-Hsien Chen, Michael Susithiran Samuel
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 361–377.
https://doi.org/10.1042/CS20210679
Published: 09 March 2022
View article titled, Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression
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Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 197–222.
https://doi.org/10.1042/CS20201474
Published: 04 February 2022
View article titled, The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
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Articles

Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (2): 181–196.
https://doi.org/10.1042/CS20210964
Published: 28 January 2022
View article titled, Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload
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Includes: Supplementary data
Articles

AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 103–120.
https://doi.org/10.1042/CS20211075
Published: 07 January 2022
View article titled, AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress
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Includes: Supplementary data
Articles

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

In Collection
Coronavirus
Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
https://doi.org/10.1042/CS20210735
Published: 15 December 2021
View article titled, The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease
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Articles

Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2625–2641.
https://doi.org/10.1042/CS20210810
Published: 08 December 2021
View article titled, Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress
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Includes: Supplementary data
Articles

Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2483–2502.
https://doi.org/10.1042/CS20210259
Published: 08 November 2021
View article titled, Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling
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Includes: Supplementary data
Articles

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

Laura Wilson, Alice E. Pollard, Lucy Penfold, Phillip J. Muckett, Chad Whilding, Mohammad Bohlooly-Y., Patricia Wilson, David Carling
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2393–2408.
https://doi.org/10.1042/CS20210821
Published: 22 October 2021
View article titled, Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype
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Includes: Supplementary data
Articles

High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity

Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Oliveira Edilamar Menezes
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2377–2391.
https://doi.org/10.1042/CS20210739
Published: 19 October 2021
View article titled, High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity
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Includes: Supplementary data
Articles

Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
https://doi.org/10.1042/CS20210462
Published: 18 October 2021
View article titled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury
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Articles

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1999–2029.
https://doi.org/10.1042/CS20201016
Published: 24 August 2021
View article titled, Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis
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Articles

Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Valter Lubrano, Silvana Balzan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1981–1997.
https://doi.org/10.1042/CS20210417
Published: 20 August 2021
View article titled, Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis
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Articles

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1873–1895.
https://doi.org/10.1042/CS20210447
Published: 06 August 2021
View article titled, Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis
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Includes: Supplementary data
Articles

Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1845–1858.
https://doi.org/10.1042/CS20210468
Published: 04 August 2021
View article titled, Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis
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Includes: Supplementary data
Articles

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

In Collection
Cardiovascular-Oncology
Daniel N. Meijles, Joshua J. Cull, Susanna T.E. Cooper, Thomais Markou, Michelle A. Hardyman, Stephen J. Fuller, Hajed O. Alharbi, Zoe H.R. Haines, Viridiana Alcantara-Alonso, Peter E. Glennon, Mary N. Sheppard, Peter H. Sugden, Angela Clerk
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
https://doi.org/10.1042/CS20210192
Published: 23 July 2021
View article titled, The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension
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Includes: Supplementary data
Articles

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1707–1726.
https://doi.org/10.1042/CS20210100
Published: 22 July 2021
View article titled, Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
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Includes: Supplementary data
Articles

Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?

Keiichi Torimoto, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1627–1630.
https://doi.org/10.1042/CS20210227
Published: 09 July 2021
View article titled, Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?
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Articles

NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia

Jianmin Liu, Daoquan Liu, Xueneng Zhang, Yan Li, Xun Fu, Weixiang He, Mingzhou Li, Ping Chen, Guang Zeng, Michael E. DiSanto, Xinghuan Wang, Xinhua Zhang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1591–1608.
https://doi.org/10.1042/CS20210476
Published: 07 July 2021
View article titled, NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia
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Includes: Supplementary data
Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
https://doi.org/10.1042/CS20190768
Published: 07 July 2021
View article titled, Nutrient regulation of inflammatory signalling in obesity and vascular disease
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Articles

Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents

David L. Brautigan, Caroline Farrington, Goutham Narla
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1545–1556.
https://doi.org/10.1042/CS20201367
Published: 30 June 2021
View article titled, Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents
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Articles

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1273–1288.
https://doi.org/10.1042/CS20210061
Published: 26 May 2021
View article titled, Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease
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Articles

Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease

Anton J.M. Roks, Caroline Cheng, Catherine M. Shanahan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
https://doi.org/10.1042/CS20210288
Published: 20 May 2021
View article titled, Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease
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Articles

Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms

J.C. Ribeiro-Silva, A.A. Miyakawa, Jose E. Krieger
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1189–1207.
https://doi.org/10.1042/CS20201528
Published: 14 May 2021
View article titled, Focal adhesion signaling: vascular smooth muscle cell contractility beyond calcium mechanisms
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Articles

Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia

Ming Fu, Ledong Tan, Zefeng Lin, Vincent C.H. Lui, Paul K.H. Tam, Jonathan R. Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Chen
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 865–884.
https://doi.org/10.1042/CS20201366
Published: 09 April 2021
View article titled, Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia
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Includes: Supplementary data
Articles

EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics

Fang-Jing Zhong, Yi-Ming Li, Cong Xu, Bo Sun, Ji-Long Wang, Lian-Yue Yang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 847–864.
https://doi.org/10.1042/CS20201500
Published: 06 April 2021
View article titled, EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics
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Includes: Supplementary data
Articles

Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Ziwei Fu, Fei Wang, Xiyang Liu, Jiajia Hu, Jiahui Su, Xiaohan Lu, Aihua Lu, Jae Min Cho, J. David Symons, Chang-Jiang Zou, Tianxin Yang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 793–810.
https://doi.org/10.1042/CS20201047
Published: 23 March 2021
View article titled, Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor
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Includes: Supplementary data
Articles

Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 753–773.
https://doi.org/10.1042/CS20201412
Published: 17 March 2021
View article titled, Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway
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Includes: Supplementary data
Articles

P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model

Peter Cuthbertson, Nicholas J. Geraghty, Sam R. Adhikary, Sienna Casolin, Debbie Watson, Ronald Sluyter
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (3): 495–513.
https://doi.org/10.1042/CS20201352
Published: 03 February 2021
View article titled, P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model
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Includes: Supplementary data
Articles

Acid sphingomyelinase promotes SGK1-dependent vascular calcification

Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (3): 515–534.
https://doi.org/10.1042/CS20201122
Published: 03 February 2021
View article titled, Acid sphingomyelinase promotes SGK1-dependent vascular calcification
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Includes: Supplementary data