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Articles

NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Alena Karnošová, Veronika Strnadová, Blanka Železná, Jaroslav Kuneš, Petr Kašpárek, Lenka Maletínská
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 847–862.
DOI: https://doi.org/10.1042/CS20220880
Published: 31 May 2023
View article titled, NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose
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Includes: Supplementary data
Articles

Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by Angiotensin-(1-7)

Kishore Chittimalli, Jesmin Jahan, Anil Sakamuri, Zach L McAdams, Aaron C Ericsson, Yagna P R Jarajapu
Journal: Clinical Science
Clin Sci (Lond) (2023) CS20220904.
DOI: https://doi.org/10.1042/CS20220904
Published: 31 May 2023
View article titled, Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by Angiotensin-(1-7)
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Articles

New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis

Ilja Striz, Kornel Golebski, Zuzana Strizova, Stelios Loukides, Petros Bakakos, Nicola A. Hanania, Milos Jesenak, Zuzana Diamant
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (9): 727–753.
DOI: https://doi.org/10.1042/CS20190281
Published: 18 May 2023
View article titled, New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis
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Articles

Antiviral activities of hemp cannabinoids

Richard B. van Breemen, Daniel Simchuk
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 633–643.
DOI: https://doi.org/10.1042/CS20220193
Published: 21 April 2023
View article titled, Antiviral activities of hemp cannabinoids
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Articles

The leaky gut and the gut microbiome in sepsis – targets in research and treatment

Wiwat Chancharoenthana, Supitcha Kamolratanakul, Marcus J. Schultz, Asada Leelahavanichkul
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 645–662.
DOI: https://doi.org/10.1042/CS20220777
Published: 21 April 2023
View article titled, The leaky gut and the gut microbiome in sepsis – targets in research and treatment
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Articles

TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines

João Moreira, Helena Martins, Margarida Saraiva, Maria João Saraiva
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (5): 355–366.
DOI: https://doi.org/10.1042/CS20220656
Published: 09 March 2023
View article titled, TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines
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Includes: Supplementary data
Articles

Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca 2+ mishandling and atrial fibrosis in active immunization rabbit models

Huaxin Sun, Jie Song, Kai Li, Yao Li, Luxiang Shang, Qina Zhou, Yanmei Lu, Yazhen Zong, Xiuyuan He, Muzappar Kari, Hang Yang, Xianhui Zhou, Ling Zhang, Baopeng Tang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (2): 195–217.
DOI: https://doi.org/10.1042/CS20220654
Published: 27 January 2023
View article titled, Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca 2+ mishandling and atrial fibrosis in active immunization rabbit models
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Includes: Supplementary data
Articles

A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst

In Collection
Reproductive Physiology and Disease
Huajuan Shi, Min Pan, Erteng Jia, Wenxiang Lu, Ying Zhou, Yuqi Sheng, Xiangwei Zhao, Lingbo Cai, Qinyu Ge
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (2): 129.
DOI: https://doi.org/10.1042/CS20220495
Published: 18 January 2023
View article titled, A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst
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Includes: Supplementary data
Articles

Dysregulated haemostasis in thrombo-inflammatory disease

Paula A. Klavina, Gemma Leon, Annie M. Curtis, Roger J.S. Preston
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1809–1829.
DOI: https://doi.org/10.1042/CS20220208
Published: 16 December 2022
View article titled, Dysregulated haemostasis in thrombo-inflammatory disease
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Articles

Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery

Lauren T. May, Belinda A. Bartolo, David G. Harrison, Tomasz Guzik, Grant R. Drummond, Gemma A. Figtree, Rebecca H. Ritchie, Kerry-Anne Rye, Judy B. de Haan
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1731–1758.
DOI: https://doi.org/10.1042/CS20210862
Published: 02 December 2022
View article titled, Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery
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Articles

Fifty years of impact on treating bone disease: a commentary on Gasser et al.

Elena L. Dent, Michael J. Ryan
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1657–1659.
DOI: https://doi.org/10.1042/CS20220040
Published: 21 November 2022
View article titled, Fifty years of impact on treating bone disease: a commentary on Gasser et al.
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Articles

Therapeutic use of calpeptin in COVID-19 infection

In Collection
Coronavirus
Jameel Inal, Ainura Paizuldaeva, Esmeralda Terziu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1439–1447.
DOI: https://doi.org/10.1042/CS20220638
Published: 21 October 2022
View article titled, Therapeutic use of calpeptin in COVID-19 infection
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Articles

New mechanisms for the kidney-protective effect of alkali in chronic kidney disease

Paul M. O’Connor, Elinor C. Mannon
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1433–1437.
DOI: https://doi.org/10.1042/CS20220395
Published: 18 October 2022
View article titled, New mechanisms for the kidney-protective effect of alkali in chronic kidney disease
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Articles

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (19): 1405–1423.
DOI: https://doi.org/10.1042/CS20210889
Published: 14 October 2022
View article titled, Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease
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Includes: Supplementary data
Articles

Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair

Nathalia C. de Almeida Oliveira, Elida A. Neri, Caio M. Silva, Iuri C. Valadão, Miriam H. Fonseca-Alaniz, Camila Zogbi, Débora Levy, Sergio P. Bydlowski, Jose Eduardo Krieger
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1281–1301.
DOI: https://doi.org/10.1042/CS20220216
Published: 05 September 2022
View article titled, Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair
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Includes: Supplementary data
Articles

Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Antonio L. Teixeira, Lais B. Martins, Michael Berk, Moisés E. Bauer
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
DOI: https://doi.org/10.1042/CS20211106
Published: 05 September 2022
View article titled, Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities
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Articles

Novel mediators of idiopathic pulmonary fibrosis

Shigeki Saito, Brian Deskin, Mohammad Rehan, Santosh Yadav, Yasuka Matsunaga, Joseph A. Lasky, Victor J. Thannickal
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1229–1240.
DOI: https://doi.org/10.1042/CS20210878
Published: 31 August 2022
View article titled, Novel mediators of idiopathic pulmonary fibrosis
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Articles

The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases

Denise Busscher, Reinier A. Boon, Rio P. Juni
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (15): 1157–1178.
DOI: https://doi.org/10.1042/CS20210994
Published: 10 August 2022
View article titled, The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases
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Articles

Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection

Erin B. Taylor
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1047–1052.
DOI: https://doi.org/10.1042/CS20220039
Published: 06 July 2022
View article titled, Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection
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Articles

Molecular and cellular regulation of psoriatic inflammation

Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 935–952.
DOI: https://doi.org/10.1042/CS20210916
Published: 22 June 2022
View article titled, Molecular and cellular regulation of psoriatic inflammation
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Articles

Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females

Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 825–840.
DOI: https://doi.org/10.1042/CS20220002
Published: 01 June 2022
View article titled, Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females
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Articles

Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection

Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Apiwan Arinno, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 841–860.
DOI: https://doi.org/10.1042/CS20220074
Published: 01 June 2022
View article titled, Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection
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Articles

Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes

Naila Rabbani
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 819–824.
DOI: https://doi.org/10.1042/CS20220099
Published: 30 May 2022
View article titled, Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes
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Articles

Visualization of regenerating and repairing hearts

Nevan Powers, Guo N. Huang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 787–798.
DOI: https://doi.org/10.1042/CS20211116
Published: 27 May 2022
View article titled, Visualization of regenerating and repairing hearts
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Articles

Angiotensin Receptors - Affinity and Beyond

Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 799–802.
DOI: https://doi.org/10.1042/CS20220024
Published: 27 May 2022
View article titled, Angiotensin Receptors - Affinity and Beyond
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Articles

Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice

Min-Chun Liao, Kana N. Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 715–731.
DOI: https://doi.org/10.1042/CS20220188
Published: 20 May 2022
View article titled, Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice
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Includes: Supplementary data
Articles

The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease

Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L.Y. Cheing, Yaoming Xue, Yijie Jia
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 223–238.
DOI: https://doi.org/10.1042/CS20210470
Published: 07 February 2022
View article titled, The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease
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Includes: Supplementary data
Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 197–222.
DOI: https://doi.org/10.1042/CS20201474
Published: 04 February 2022
View article titled, The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
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Articles

Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension

Sarah-Eve Lemay, Sebastien Bonnet, François Potus
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 163–166.
DOI: https://doi.org/10.1042/CS20211095
Published: 10 January 2022
View article titled, Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension
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Articles

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

In Collection
Cardiovascular-Oncology
Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 139–161.
DOI: https://doi.org/10.1042/CS20210836
Published: 07 January 2022
View article titled, Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up
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Includes: Supplementary data
Articles

Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction

Xiaohong Xiang, Guie Dong, Jiefu Zhu, Gang Zhang, Zheng Dong
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 45–60.
DOI: https://doi.org/10.1042/CS20210823
Published: 05 January 2022
View article titled, Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction
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Includes: Supplementary data
Articles

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

In Collection
Coronavirus
Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
DOI: https://doi.org/10.1042/CS20210735
Published: 15 December 2021
View article titled, The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease
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Articles

Countering the classical renin–angiotensin system

Natalia M. Noto, Yazmin M. Restrepo, Robert C. Speth
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2619–2623.
DOI: https://doi.org/10.1042/CS20211043
Published: 08 December 2021
View article titled, Countering the classical renin–angiotensin system
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Articles

Early elimination of uremic toxin ameliorates AKI-to-CKD transition

Jia-Huang Chen, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu, Der-Cherng Tarng, Chih-Kang Chiang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2643–2658.
DOI: https://doi.org/10.1042/CS20210858
Published: 08 December 2021
View article titled, Early elimination of uremic toxin ameliorates AKI-to-CKD transition
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Includes: Supplementary data
Articles

Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2503–2520.
DOI: https://doi.org/10.1042/CS20210719
Published: 09 November 2021
View article titled, Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia
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Articles

Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension

Hongxia Jiang, Dandan Ding, Yuanzhou He, Xiaochen Li, Yongjian Xu, Xiansheng Liu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2467–2481.
DOI: https://doi.org/10.1042/CS20210612
Published: 01 November 2021
View article titled, Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension
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Articles

Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2409–2422.
DOI: https://doi.org/10.1042/CS20210405
Published: 22 October 2021
View article titled, Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats
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Articles

Key role for EphB2 receptor in kidney fibrosis

Zhimin Huang, Simeng Liu, Anna Tang, Laith Al-Rabadi, Mark Henkemeyer, Patrice N. Mimche, Yufeng Huang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2127–2142.
DOI: https://doi.org/10.1042/CS20210644
Published: 10 September 2021
View article titled, Key role for EphB2 receptor in kidney fibrosis
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Includes: Supplementary data
Articles

Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm

Xianming Zhou, Chao Zhang, Fei Xie, Wei Wei, Rui Li, Qian Xu, Yu Wang, Philip A. Klenotic, Goutham Narla, Nianguo Dong, Zhiyong Lin
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2085–2097.
DOI: https://doi.org/10.1042/CS20210315
Published: 01 September 2021
View article titled, Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm
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Includes: Supplementary data
Articles

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1999–2029.
DOI: https://doi.org/10.1042/CS20201016
Published: 24 August 2021
View article titled, Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis
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Articles

Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Valter Lubrano, Silvana Balzan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1981–1997.
DOI: https://doi.org/10.1042/CS20210417
Published: 20 August 2021
View article titled, Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis
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Articles

Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

In Collection
Cardiovascular-Oncology
Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1897–1914.
DOI: https://doi.org/10.1042/CS20210311
Published: 10 August 2021
View article titled, Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo
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Includes: Supplementary data
Articles

Klotho and calciprotein particles as therapeutic targets against accelerated ageing

Makoto Kuro-o
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1915–1927.
DOI: https://doi.org/10.1042/CS20201453
Published: 10 August 2021
View article titled, Klotho and calciprotein particles as therapeutic targets against accelerated ageing
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Articles

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1873–1895.
DOI: https://doi.org/10.1042/CS20210447
Published: 06 August 2021
View article titled, Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis
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Includes: Supplementary data
Articles

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1707–1726.
DOI: https://doi.org/10.1042/CS20210100
Published: 22 July 2021
View article titled, Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
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Includes: Supplementary data
Articles

Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?

In Collection
Cardiovascular-Oncology
Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
DOI: https://doi.org/10.1042/CS20200300
Published: 20 July 2021
View article titled, Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?
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Articles

Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents

David L. Brautigan, Caroline Farrington, Goutham Narla
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1545–1556.
DOI: https://doi.org/10.1042/CS20201367
Published: 30 June 2021
View article titled, Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents
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Articles

Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?

Crizza Ching, Dakota Gustafson, Paaladinesh Thavendiranathan, Jason E. Fish
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
DOI: https://doi.org/10.1042/CS20210059
Published: 17 June 2021
View article titled, Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?
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Articles

Interactions between cardiology and oncology drugs in precision cardio-oncology

In Collection
Cardiovascular-Oncology
Sailaja Kamaraju, Meera Mohan, Svetlana Zaharova, Brianna Wallace, Joseph McGraw, James Lokken, John Tierney, Elizabeth Weil, Olubadewa Fatunde, Sherry-Ann Brown
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1333–1351.
DOI: https://doi.org/10.1042/CS20200309
Published: 02 June 2021
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Articles

Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Darnel Prakoso, Mitchel Tate, Miles J. De Blasio, Rebecca H. Ritchie
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1369–1387.
DOI: https://doi.org/10.1042/CS20210052
Published: 02 June 2021
View article titled, Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives
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