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Articles

Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 823–841.
DOI: https://doi.org/10.1042/CS20230433
Published: 31 May 2023
View article titled, Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity
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Includes: Supplementary data
Articles

The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Miranda J. Melis, Muska Miller, Vera B.M. Peters, Mervyn Singer
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (9): 707–725.
DOI: https://doi.org/10.1042/CS20220709
Published: 05 May 2023
View article titled, The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction
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Articles

CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p

Jia-Wen Gao, Min-Kai Song, Di-Zheng Wu, Tao Yan, Kai Zhao, Yu-Sheng Huang, Xing-Yu Chen, Chen Tu, Guang-Xu Deng, Zi-Shuo Chen, Ming-Ming Zhang, Jun-Long Huang, Chao Zhang, Zhao-Ming Zhong
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 495–510.
DOI: https://doi.org/10.1042/CS20220833
Published: 24 March 2023
View article titled, CircRBM23 regulates the switch between osteogenesis and adipogenesis of mesenchymal stem cells via sponging miR-338-3p
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Includes: Supplementary data
Articles

The role of extracellular vesicles in intercellular communication in human reproduction

In Collection
Reproductive Physiology and Disease
Javier Gonzalez Fernandez, Javier Moncayo Arlandi, Ana Ochando, Carlos Simon, Felipe Vilella
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (3): 281–301.
DOI: https://doi.org/10.1042/CS20220793
Published: 10 February 2023
View article titled, The role of extracellular vesicles in intercellular communication in human reproduction
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Articles

Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Pedro Alves Soares Vaz de Castro, Pedro A. Jose, Ana Cristina Simões e Silva
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1205–1227.
DOI: https://doi.org/10.1042/CS20220338
Published: 18 August 2022
View article titled, Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure
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Articles

L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Xiao Ma, Dechao Cai, Yakun Zhu, Yao Zhao, Xianbo Shang, Chen Wang, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1053–1069.
DOI: https://doi.org/10.1042/CS20220082
Published: 06 July 2022
View article titled, L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway
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Articles

CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis

Jialei Yang, Wanting He, Lian Gu, Jianxiong Long, Lulu Zhu, Ruirui Zhang, Zhi Zhao, Bingyi Xu, Aruo Nan, Li Su
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 953–971.
DOI: https://doi.org/10.1042/CS20220157
Published: 22 June 2022
View article titled, CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis
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Includes: Supplementary data
Articles

Defining the molecular underpinnings controlling cardiomyocyte proliferation

Donya Mahiny-Shahmohammady, Ludger Hauck, Filio Billia
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 911–934.
DOI: https://doi.org/10.1042/CS20211180
Published: 20 June 2022
View article titled, Defining the molecular underpinnings controlling cardiomyocyte proliferation
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Articles

Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?

Nhat-Tu Le, Elizabeth A. Olmsted-Davis, Jun-ichi Abe
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 379–382.
DOI: https://doi.org/10.1042/CS20211096
Published: 11 March 2022
View article titled, Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?
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Articles

Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension

Hongxia Jiang, Dandan Ding, Yuanzhou He, Xiaochen Li, Yongjian Xu, Xiansheng Liu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (21): 2467–2481.
DOI: https://doi.org/10.1042/CS20210612
Published: 01 November 2021
View article titled, Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension
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Articles

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (16): 1999–2029.
DOI: https://doi.org/10.1042/CS20201016
Published: 24 August 2021
View article titled, Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis
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Articles

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1273–1288.
DOI: https://doi.org/10.1042/CS20210061
Published: 26 May 2021
View article titled, Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease
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Articles

C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
DOI: https://doi.org/10.1042/CS20210049
Published: 11 May 2021
View article titled, C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors
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Includes: Supplementary data
Articles

Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (5): 687–701.
DOI: https://doi.org/10.1042/CS20201419
Published: 09 March 2021
View article titled, Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor
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Articles

Potential therapeutic applications of AKAP disrupting peptides

Alessandra Murabito, Sophie Cnudde, Emilio Hirsch, Alessandra Ghigo
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3259–3282.
DOI: https://doi.org/10.1042/CS20201244
Published: 21 December 2020
View article titled, Potential therapeutic applications of AKAP disrupting peptides
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Articles

Clinical Science Editorial 2020 – a year gone by and the year ahead

Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3233–3235.
DOI: https://doi.org/10.1042/CS20201502
Published: 14 December 2020
View article titled, Clinical Science Editorial 2020 – a year gone by and the year ahead
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Articles

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
DOI: https://doi.org/10.1042/CS20201207
Published: 09 December 2020
View article titled, Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis
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Includes: Supplementary data
Articles

The molecular basis of immune-based platelet disorders

Sarah M. Hicks, Christine S.M. Lee, Sidra A. Ali, Philip Y. Choi, Elizabeth E. Gardiner
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2807–2822.
DOI: https://doi.org/10.1042/CS20191101
Published: 03 November 2020
View article titled, The molecular basis of immune-based platelet disorders
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Articles

Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy

Di Zhao, Yanyan Zhao, Jiao Wang, Lina Wu, Yanling Liu, Shuiying Zhao, Feng Guo, Xiaojun Ma, Haohao Zhang, Zhizhen Li, Dongdong Meng, Lijun Xu, Lixia Zhang, Junqi Liu, Guijun Qin
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2419–2434.
DOI: https://doi.org/10.1042/CS20200694
Published: 18 September 2020
View article titled, Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy
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Includes: Supplementary data
Articles

Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation

Te Li, Lijuan Ding, Yonggang Wang, Ou Yang, Shudong Wang, Jian Kong
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2353–2368.
DOI: https://doi.org/10.1042/CS20191241
Published: 10 September 2020
View article titled, Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation
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Includes: Supplementary data
Articles

Covid-19: the renin–angiotensin system imbalance hypothesis

In Collection
Coronavirus
Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
DOI: https://doi.org/10.1042/CS20200492
Published: 08 June 2020
View article titled, Covid-19: the renin–angiotensin system imbalance hypothesis
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Articles

Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Yun Huang, Yang Li, Anni Lou, Guo zhen Wang, Ye Hu, Yijie Zhang, Weichang Huang, Jun Wang, Yue Li, Xintao Zhu, Tingting Chen, Jiayi Lin, Ying Meng, Xu Li
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 853–869.
DOI: https://doi.org/10.1042/CS20191235
Published: 09 April 2020
View article titled, Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS
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Articles

CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation

Chen-Chen Han, Qian Liu, Yu Zhang, Yi-Fan Li, Dong-Qian Cui, Ting-Ting Luo, Yu-Wen Zhang, Xin-Ming Wang, Chun Wang, Yang Ma, Wei Wei
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (3): 331–347.
DOI: https://doi.org/10.1042/CS20191032
Published: 04 February 2020
View article titled, CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation
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Includes: Supplementary data
Articles

A tangled tale of microRNA and cardiac fibrosis

Mark Chandy
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
DOI: https://doi.org/10.1042/CS20190866
Published: 13 November 2019
View article titled, A tangled tale of microRNA and cardiac fibrosis
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Articles

Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication

Shuming Wang, Yilin Hu, Xiurui Lv, Bin Li, Dianhua Gu, Yang Li, Yong Sun, Yang Su
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (18): 1935–1953.
DOI: https://doi.org/10.1042/CS20190589
Published: 17 September 2019
View article titled, Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication
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Includes: Supplementary data
Articles

Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression

Yiting Geng, Xiao Zheng, Wenwei Hu, Qi Wang, Yanjie Xu, Wenting He, Chen Wu, Danxia Zhu, Changping Wu, Jingting Jiang
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (10): 1197–1213.
DOI: https://doi.org/10.1042/CS20190286
Published: 30 May 2019
View article titled, Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression
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Includes: Supplementary data
Articles

Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis

Tzu-Hao Li, Ying-Ying Yang, Chia-Chang Huang, Chih-Wei Liu, Hung-Cheng Tsai, Ming-Wei Lin, Chang-Youh Tsai, Shiang-Fen Huang, Ying-Wen Wang, Tzung-Yan Lee, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (3): 531–544.
DOI: https://doi.org/10.1042/CS20180873
Published: 13 February 2019
View article titled, Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis
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Articles

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

Phuc N.H. Trinh, Lauren T. May, Katie Leach, Karen J. Gregory
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2323–2338.
DOI: https://doi.org/10.1042/CS20180374
Published: 02 November 2018
View article titled, Biased agonism and allosteric modulation of metabotropic glutamate receptor 5
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Articles

Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration in vitro

Shayna Sharma, Mona Alharbi, Miharu Kobayashi, Andrew Lai, Dominic Guanzon, Felipe Zuñiga, Valeska Ormazabal, Carlos Palma, Katherin Scholz-Romero, Gregory E. Rice, John D. Hooper, Carlos Salomon
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (18): 2029–2044.
DOI: https://doi.org/10.1042/CS20180425
Published: 19 September 2018
View article titled, Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration in vitro
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Includes: Supplementary data
Articles

Platelet communication with the vascular wall: role of platelet-derived microparticles and non-coding RNAs

Voahanginirina Randriamboavonjy, Ingrid Fleming
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1875–1888.
DOI: https://doi.org/10.1042/CS20180580
Published: 05 September 2018
View article titled, Platelet communication with the vascular wall: role of platelet-derived microparticles and non-coding RNAs
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Articles

Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases

Asokan Devarajan
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (6): 615–626.
DOI: https://doi.org/10.1042/CS20171574
Published: 20 March 2018
View article titled, Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases
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Articles

Oxidative stress and reactive oxygen species: a review of their role in ocular disease

Lawson Ung, Ushasree Pattamatta, Nicole Carnt, Jennifer L. Wilkinson-Berka, Gerald Liew, Andrew J.R. White
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
DOI: https://doi.org/10.1042/CS20171246
Published: 04 December 2017
View article titled, Oxidative stress and reactive oxygen species: a review of their role in ocular disease
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Articles

Sulphur dioxide suppresses inflammatory response by sulphenylating NF-κB p65 at Cys 38 in a rat model of acute lung injury

Siyao Chen, Yaqian Huang, Zhiwei Liu, Wen Yu, Heng Zhang, Kun Li, Xiaoqi Yu, Chaoshu Tang, Bin Zhao, Junbao Du, Hongfang Jin
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (21): 2655–2670.
DOI: https://doi.org/10.1042/CS20170274
Published: 27 October 2017
View article titled, Sulphur dioxide suppresses inflammatory response by sulphenylating NF-κB p65 at Cys 38 in a rat model of acute lung injury
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Articles

Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism

Marco D’Agostino, Francesco Martino, Sara Sileno, Francesco Barillà, Sara Beji, Lorenza Marchetti, Fabio Maria Gangi, Luca Persico, Mario Picozza, Anna Montali, Eliana Martino, Cristina Zanoni, Daniele Avitabile, Sandro Parrotto, Maurizio Colognesi Capogrossi, Alessandra Magenta
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (18): 2397–2408.
DOI: https://doi.org/10.1042/CS20171121
Published: 08 September 2017
View article titled, Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism
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Includes: Supplementary data
Articles

Classical activation of macrophages and vardenafil

Richmond Muimo
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1141–1145.
DOI: https://doi.org/10.1042/CS20170137
Published: 22 May 2017
View article titled, Classical activation of macrophages and vardenafil
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Articles

Ubiquitination of nuclear receptors

Jimmy El Hokayem, Celeste Amadei, Jean-Pierre Obeid, Zafar Nawaz
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (10): 917–934.
DOI: https://doi.org/10.1042/CS20160708
Published: 04 May 2017
View article titled, Ubiquitination of nuclear receptors
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Articles

Organelles in health and diseases

Satoru Eguchi, Victor Rizzo
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (1): 1–2.
DOI: https://doi.org/10.1042/CS20160610
Published: 21 November 2016
View article titled, Organelles in health and diseases
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Articles

Epigenetic control of exercise training-induced cardiac hypertrophy by miR-208

Ursula Paula Renó Soci, Tiago Fernandes, Valerio Garrone Barauna, Nara Yumi Hashimoto, Gloria de Fátima Alves Mota, Kaleizu Teodoro Rosa, Maria Claudia Irigoyen, Michael Ian Philips, Edilamar Menezes de Oliveira
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2005–2015.
DOI: https://doi.org/10.1042/CS20160480
Published: 06 October 2016
View article titled, Epigenetic control of exercise training-induced cardiac hypertrophy by miR-208
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Articles

Intracellular cholesterol transport proteins: roles in health and disease

Ugo Soffientini, Annette Graham
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1843–1859.
DOI: https://doi.org/10.1042/CS20160339
Published: 22 September 2016
View article titled, Intracellular cholesterol transport proteins: roles in health and disease
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Articles

Molecular mechanisms for vascular complications of targeted cancer therapies

Srila Gopal, Kenneth B. Miller, Iris Z. Jaffe
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (20): 1763–1779.
DOI: https://doi.org/10.1042/CS20160246
Published: 09 September 2016
View article titled, Molecular mechanisms for vascular complications of targeted cancer therapies
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Articles

Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice

Xia Kang, Along Hou, Rui Wang, Da Liu, Wei Xiang, Qingyun Xie, Bo Zhang, Lixia Gan, Wei Zheng, Hongming Miao
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1257–1268.
DOI: https://doi.org/10.1042/CS20160192
Published: 13 June 2016
View article titled, Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice
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Includes: Supplementary data