Search Results | Clinical Science

1-50 of 339

2 3 4 5

Sort by

Sort Order Select

Articles

The tendency of anemia of inflammation in periodontal diseases

Ye Han, Zhiqiang Luo, Zhao Guo Yue, Li Li Miao, Min Xv, Shu Chang, Yalin Zhan, Jianxia Hou

Clin Sci (Lond) (2023) CS20220524.

DOI: https://doi.org/10.1042/CS20220524

Published: 27 January 2023

View article

Articles

Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Keitaro Ueda, Chiemi Sakai, Takafumi Ishida, Kosuke Morita, Yusuke Kobayashi, Yasunori Horikoshi, Akiko Baba, Yuma Okazaki, Masao Yoshizumi, Satoshi Tashiro, Mari Ishida

Clin Sci (Lond) (2023) 137 (2): 163–180.

DOI: https://doi.org/10.1042/CS20220525

Published: 24 January 2023

View article

Includes: Supplementary data

Articles

Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

Xiaodi Zhang, Jean LJM Scheijen, Coen D.A. Stehouwer, Kristiaan Wouters, Casper Schalkwijk

Clin Sci (Lond) (2023) CS20220753.

DOI: https://doi.org/10.1042/CS20220753

Published: 20 January 2023

View article

Articles

Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

Hana Horackova, Veronika Vachalova, Cilia Abad, Rona Karahoda, Frantisek Staud

Clin Sci (Lond) (2023) 137 (2): 149–161.

DOI: https://doi.org/10.1042/CS20220726

Published: 18 January 2023

View article

Articles

Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Raffaele Altara, George W. Booz

Clin Sci (Lond) (2023) 137 (2): 143–148.

DOI: https://doi.org/10.1042/CS20220776

Published: 18 January 2023

View article

Articles

Targeted bisulfite resequencing of differentially methylated cytosines in pre-eclampsia reveals a skewed dynamic balance in the DNA methylation of enhancers

Xiaoguo Zheng, Weibin Wu, Qian Zhou, Yahan Lian, Yuqian Xiang, Xinzhi Zhao

Clin Sci (Lond) (2023) CS20220644.

DOI: https://doi.org/10.1042/CS20220644

Published: 16 January 2023

View article

Articles

Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein

Clin Sci (Lond) (2023) 137 (1): 47–63.

DOI: https://doi.org/10.1042/CS20220513

Published: 05 January 2023

View article

Includes: Supplementary data

Articles

Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice

Shu-Huei Wang, Feng-Chiao Tsai, Heng-Huei Lin, Tse-Ya Yu, Chun-Heng Kuo, Hung-Yuan Li, Mao-Shin Lin

Clin Sci (Lond) (2023) 137 (1): 17–30.

DOI: https://doi.org/10.1042/CS20220477

Published: 03 January 2023

View article

Articles

Small extracellular vesicles: a new player in GDM pathogenesis

Agafe Bless Reyes, Dylan Burger

Clin Sci (Lond) (2022) 136 (24): 1873–1875.

DOI: https://doi.org/10.1042/CS20220658

Published: 22 December 2022

View article

Articles

Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal

Clin Sci (Lond) (2022) 136 (24): 1851–1871.

DOI: https://doi.org/10.1042/CS20220636

Published: 22 December 2022

View article

Articles

Preeclampsia and syncytiotrophoblast membrane extracellular vesicles (STB-EVs)

Toluwalase Awoyemi, Ana Sofia Cerdeira, Wei Zhang, Shuhan Jiang, Maryam Rahbar, Prassana Logenthiran, Christopher Redman, Manu Vatish

Clin Sci (Lond) (2022) 136 (24): 1793–1807.

DOI: https://doi.org/10.1042/CS20220149

Published: 13 December 2022

View article

Articles

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2022) 136 (22): 1661–1681.

DOI: https://doi.org/10.1042/CS20220607

Published: 21 November 2022

View article

Includes: Supplementary data

Articles

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver

Clin Sci (Lond) (2022) 136 (19): 1405–1423.

DOI: https://doi.org/10.1042/CS20210889

Published: 14 October 2022

View article

Includes: Supplementary data

Articles

Hypertension and renal disease programming: focus on the early postnatal period

Maria Florencia Albertoni Borghese, Lucas Humberto Oronel, Maria Del Carmen Ortiz, Mónica Patricia Majowicz

Clin Sci (Lond) (2022) 136 (17): 1303–1339.

DOI: https://doi.org/10.1042/CS20220293

Published: 08 September 2022

View article

Articles

Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Antonio L. Teixeira, Lais B. Martins, Michael Berk, Moisés E. Bauer

Clin Sci (Lond) (2022) 136 (17): 1257–1280.

DOI: https://doi.org/10.1042/CS20211106

Published: 05 September 2022

View article

Articles

The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease

Adrien Georges, Nabila Bouatia-Naji

Clin Sci (Lond) (2022) 136 (16): 1241–1255.

DOI: https://doi.org/10.1042/CS20210990

Published: 31 August 2022

View article

Articles

Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Pedro Alves Soares Vaz de Castro, Pedro A. Jose, Ana Cristina Simões e Silva

Clin Sci (Lond) (2022) 136 (16): 1205–1227.

DOI: https://doi.org/10.1042/CS20220338

Published: 18 August 2022

View article

Articles

Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Hager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier

Clin Sci (Lond) (2022) 1117–1137.

DOI: https://doi.org/10.1042/CS20220245

Published: 05 August 2022

View article

Includes: Supplementary data

Articles

The emerging role of LRRK2 in tauopathies

Susanne Herbst, Patrick A. Lewis, Huw R. Morris

Clin Sci (Lond) (2022) 136 (13): 1071–1079.

DOI: https://doi.org/10.1042/CS20220067

Published: 11 July 2022

View article

Articles

Cellular and molecular mechanisms of breast cancer susceptibility

Sundus F. Shalabi, Mark A. LaBarge

Clin Sci (Lond) (2022) 136 (13): 1025–1043.

DOI: https://doi.org/10.1042/CS20211158

Published: 04 July 2022

View article

Articles

G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation

Fuwei Zhang, Lifu Lei, Juan Huang, Weiwei Wang, Qian Su, Hongjia Yan, Caiyu Chen, Shuo Zheng, Hongmei Ren, Zhuxin Li, Pedro A. Jose, Yijie Hu, Liangyi Si, Chunyu Zeng, Jian Yang

Clin Sci (Lond) (2022) 136 (12): 989–1003.

DOI: https://doi.org/10.1042/CS20220236

Published: 29 June 2022

View article

Includes: Supplementary data

Articles

Molecular and cellular regulation of psoriatic inflammation

Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann

Clin Sci (Lond) (2022) 136 (12): 935–952.

DOI: https://doi.org/10.1042/CS20210916

Published: 22 June 2022

View article

Articles

Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females

Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2022) 136 (11): 825–840.

DOI: https://doi.org/10.1042/CS20220002

Published: 01 June 2022

View article

Articles

Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang

Clin Sci (Lond) (2022) 136 (11): 803–817.

DOI: https://doi.org/10.1042/CS20220226

Published: 30 May 2022

View article

Includes: Supplementary data

Articles

Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice

Min-Chun Liao, Kana N. Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang

Clin Sci (Lond) (2022) 136 (10): 715–731.

DOI: https://doi.org/10.1042/CS20220188

Published: 20 May 2022

View article

Includes: Supplementary data

Articles

Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis

Laila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti

Clin Sci (Lond) (2022) 136 (9): 643–656.

DOI: https://doi.org/10.1042/CS20211122

Published: 04 May 2022

View article

Includes: Supplementary data

Articles

Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p

Dasom Mun, Hyoeun Kim, Ji-Young Kang, Nuri Yun, Young-Nam Youn, Boyoung Joung

Clin Sci (Lond) (2022) 136 (8): 621–637.

DOI: https://doi.org/10.1042/CS20211141

Published: 27 April 2022

View article

Includes: Supplementary data

Articles

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

View article

Includes: Supplementary data

Articles

A time to heal: microRNA and circadian dynamics in cutaneous wound repair

Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun TL Hughes, Fawaz Ghali, Kehinde Ross

Clin Sci (Lond) (2022) 136 (8): 579–597.

DOI: https://doi.org/10.1042/CS20220011

Published: 21 April 2022

View article

Articles

Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

DOI: https://doi.org/10.1042/CS20210509

Published: 07 February 2022

View article

Articles

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

In Collection

Cardiovascular-Oncology

Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba

Clin Sci (Lond) (2022) 136 (1): 139–161.

DOI: https://doi.org/10.1042/CS20210836

Published: 07 January 2022

View article

Includes: Supplementary data

Articles

AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang

Clin Sci (Lond) (2022) 136 (1): 103–120.

DOI: https://doi.org/10.1042/CS20211075

Published: 07 January 2022

View article

Includes: Supplementary data

Articles

WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway

Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue

Clin Sci (Lond) (2022) 136 (1): 29–44.

DOI: https://doi.org/10.1042/CS20210663

Published: 05 January 2022

View article

Includes: Supplementary data

Articles

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

In Collection

Coronavirus

Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu

Clin Sci (Lond) (2021) 135 (24): 2667–2689.

DOI: https://doi.org/10.1042/CS20210735

Published: 15 December 2021

View article

Articles

Sex differences in white adipose tissue expansion: emerging molecular mechanisms

Simon T. Bond, Anna C. Calkin, Brian G. Drew

Clin Sci (Lond) (2021) 135 (24): 2691–2708.

DOI: https://doi.org/10.1042/CS20210086

Published: 15 December 2021

View article

Articles

Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni

Clin Sci (Lond) (2021) 135 (23): 2625–2641.

DOI: https://doi.org/10.1042/CS20210810

Published: 08 December 2021

View article

Includes: Supplementary data

Articles

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman

Clin Sci (Lond) (2021) 135 (22): 2559–2573.

DOI: https://doi.org/10.1042/CS20210713

Published: 26 November 2021

View article

Includes: Supplementary data

Articles

Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi

Clin Sci (Lond) (2021) 135 (21): 2503–2520.

DOI: https://doi.org/10.1042/CS20210719

Published: 09 November 2021

View article

Articles

Recent advances in understanding ion transport mechanisms in polycystic kidney disease

Anastasia V. Sudarikova, Valeriia Y. Vasileva, Regina F. Sultanova, Daria V. Ilatovskaya

Clin Sci (Lond) (2021) 135 (21): 2521–2540.

DOI: https://doi.org/10.1042/CS20210370

Published: 09 November 2021

View article

Articles

Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Jennifer Leggat, Guillaume Bidault, Antonio Vidal-Puig

Clin Sci (Lond) (2021) 135 (19): 2265–2283.

DOI: https://doi.org/10.1042/CS20210127

Published: 13 October 2021

View article

Articles

Key role for EphB2 receptor in kidney fibrosis

Zhimin Huang, Simeng Liu, Anna Tang, Laith Al-Rabadi, Mark Henkemeyer, Patrice N. Mimche, Yufeng Huang

Clin Sci (Lond) (2021) 135 (17): 2127–2142.

DOI: https://doi.org/10.1042/CS20210644

Published: 10 September 2021

View article

Includes: Supplementary data

Articles

Oxytocin: much more than childbirth and milk letdown

Morley D. Hollenberg

Clin Sci (Lond) (2021) 135 (17): 2121–2126.

DOI: https://doi.org/10.1042/CS20210180

Published: 10 September 2021

View article

Articles

Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm

Xianming Zhou, Chao Zhang, Fei Xie, Wei Wei, Rui Li, Qian Xu, Yu Wang, Philip A. Klenotic, Goutham Narla, Nianguo Dong, Zhiyong Lin

Clin Sci (Lond) (2021) 135 (17): 2085–2097.

DOI: https://doi.org/10.1042/CS20210315

Published: 01 September 2021

View article

Includes: Supplementary data

Articles

Placenta-specific Slc38a2 /SNAT2 knockdown causes fetal growth restriction in mice

Owen R. Vaughan, Katarzyna Maksym, Elena Silva, Kenneth Barentsen, Russel V. Anthony, Thomas L. Brown, Sara L. Hillman, Rebecca Spencer, Anna L. David, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2021) 135 (17): 2049–2066.

DOI: https://doi.org/10.1042/CS20210575

Published: 31 August 2021

View article

Includes: Supplementary data

Articles

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega

Clin Sci (Lond) (2021) 135 (16): 1999–2029.

DOI: https://doi.org/10.1042/CS20201016

Published: 24 August 2021

View article

Articles

Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Valter Lubrano, Silvana Balzan

Clin Sci (Lond) (2021) 135 (16): 1981–1997.

DOI: https://doi.org/10.1042/CS20210417

Published: 20 August 2021

View article

Articles

Eicosanoid receptors as therapeutic targets for asthma

William S. Powell

Clin Sci (Lond) (2021) 135 (16): 1945–1980.

DOI: https://doi.org/10.1042/CS20190657

Published: 17 August 2021

View article

Articles

Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

In Collection

Cardiovascular-Oncology

Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba

Clin Sci (Lond) (2021) 135 (15): 1897–1914.

DOI: https://doi.org/10.1042/CS20210311

Published: 10 August 2021

View article

Includes: Supplementary data

Articles

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long

Clin Sci (Lond) (2021) 135 (15): 1873–1895.

DOI: https://doi.org/10.1042/CS20210447

Published: 06 August 2021

View article

Includes: Supplementary data

Articles

Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes

Clin Sci (Lond) (2021) 135 (15): 1845–1858.

DOI: https://doi.org/10.1042/CS20210468

Published: 04 August 2021

View article

Includes: Supplementary data

2 3 4 5

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only