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G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation

Fuwei Zhang, Lifu Lei, Juan Huang, Weiwei Wang, Qian Su, Hongjia Yan, Caiyu Chen, Shuo Zheng, Hongmei Ren, Zhuxin Li, Pedro A. Jose, Yijie Hu, Liangyi Si, Chunyu Zeng, Jian Yang

Clin Sci (Lond) (2022) 136 (12): 989–1003.

DOI: https://doi.org/10.1042/CS20220236

Published: 29 June 2022

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Molecular and cellular regulation of psoriatic inflammation

Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann

Clin Sci (Lond) (2022) 136 (12): 935–952.

DOI: https://doi.org/10.1042/CS20210916

Published: 22 June 2022

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Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females

Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2022) 136 (11): 825–840.

DOI: https://doi.org/10.1042/CS20220002

Published: 01 June 2022

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Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang

Clin Sci (Lond) (2022) 136 (11): 803–817.

DOI: https://doi.org/10.1042/CS20220226

Published: 30 May 2022

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Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice

Min-Chun Liao, Kana N. Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang

Clin Sci (Lond) (2022) 136 (10): 715–731.

DOI: https://doi.org/10.1042/CS20220188

Published: 20 May 2022

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Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis

Laila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti

Clin Sci (Lond) (2022) 136 (9): 643–656.

DOI: https://doi.org/10.1042/CS20211122

Published: 04 May 2022

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Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p

Dasom Mun, Hyoeun Kim, Ji-Young Kang, Nuri Yun, Young-Nam Youn, Boyoung Joung

Clin Sci (Lond) (2022) 136 (8): 621–637.

DOI: https://doi.org/10.1042/CS20211141

Published: 27 April 2022

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Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

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A time to heal: microRNA and circadian dynamics in cutaneous wound repair

Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun TL Hughes, Fawaz Ghali, Kehinde Ross

Clin Sci (Lond) (2022) 136 (8): 579–597.

DOI: https://doi.org/10.1042/CS20220011

Published: 21 April 2022

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Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

DOI: https://doi.org/10.1042/CS20210509

Published: 07 February 2022

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AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang

Clin Sci (Lond) (2022) 136 (1): 103–120.

DOI: https://doi.org/10.1042/CS20211075

Published: 07 January 2022

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Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba

Clin Sci (Lond) (2022) 136 (1): 139–161.

DOI: https://doi.org/10.1042/CS20210836

Published: 07 January 2022

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WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway

Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue

Clin Sci (Lond) (2022) 136 (1): 29–44.

DOI: https://doi.org/10.1042/CS20210663

Published: 05 January 2022

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Sex differences in white adipose tissue expansion: emerging molecular mechanisms

Simon T. Bond, Anna C. Calkin, Brian G. Drew

Clin Sci (Lond) (2021) 135 (24): 2691–2708.

DOI: https://doi.org/10.1042/CS20210086

Published: 15 December 2021

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The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu

Clin Sci (Lond) (2021) 135 (24): 2667–2689.

DOI: https://doi.org/10.1042/CS20210735

Published: 15 December 2021

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Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni

Clin Sci (Lond) (2021) 135 (23): 2625–2641.

DOI: https://doi.org/10.1042/CS20210810

Published: 08 December 2021

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Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman

Clin Sci (Lond) (2021) 135 (22): 2559–2573.

DOI: https://doi.org/10.1042/CS20210713

Published: 26 November 2021

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Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi

Clin Sci (Lond) (2021) 135 (21): 2503–2520.

DOI: https://doi.org/10.1042/CS20210719

Published: 09 November 2021

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Recent advances in understanding ion transport mechanisms in polycystic kidney disease

Anastasia V. Sudarikova, Valeriia Y. Vasileva, Regina F. Sultanova, Daria V. Ilatovskaya

Clin Sci (Lond) (2021) 135 (21): 2521–2540.

DOI: https://doi.org/10.1042/CS20210370

Published: 09 November 2021

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Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Jennifer Leggat, Guillaume Bidault, Antonio Vidal-Puig

Clin Sci (Lond) (2021) 135 (19): 2265–2283.

DOI: https://doi.org/10.1042/CS20210127

Published: 13 October 2021

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Key role for EphB2 receptor in kidney fibrosis

Zhimin Huang, Simeng Liu, Anna Tang, Laith Al-Rabadi, Mark Henkemeyer, Patrice N. Mimche, Yufeng Huang

Clin Sci (Lond) (2021) 135 (17): 2127–2142.

DOI: https://doi.org/10.1042/CS20210644

Published: 10 September 2021

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Oxytocin: much more than childbirth and milk letdown

Morley D. Hollenberg

Clin Sci (Lond) (2021) 135 (17): 2121–2126.

DOI: https://doi.org/10.1042/CS20210180

Published: 10 September 2021

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Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm

Xianming Zhou, Chao Zhang, Fei Xie, Wei Wei, Rui Li, Qian Xu, Yu Wang, Philip A. Klenotic, Goutham Narla, Nianguo Dong, Zhiyong Lin

Clin Sci (Lond) (2021) 135 (17): 2085–2097.

DOI: https://doi.org/10.1042/CS20210315

Published: 01 September 2021

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Placenta-specific Slc38a2 /SNAT2 knockdown causes fetal growth restriction in mice

Owen R. Vaughan, Katarzyna Maksym, Elena Silva, Kenneth Barentsen, Russel V. Anthony, Thomas L. Brown, Sara L. Hillman, Rebecca Spencer, Anna L. David, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2021) 135 (17): 2049–2066.

DOI: https://doi.org/10.1042/CS20210575

Published: 31 August 2021

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Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

Sandra Rayego-Mateos, Sofia Campillo, Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Laura Marquez-Exposito, Roel Goldschmeding, Diego Rodríguez-Puyol, Laura Calleros, Marta Ruiz-Ortega

Clin Sci (Lond) (2021) 135 (16): 1999–2029.

DOI: https://doi.org/10.1042/CS20201016

Published: 24 August 2021

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Articles

Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Valter Lubrano, Silvana Balzan

Clin Sci (Lond) (2021) 135 (16): 1981–1997.

DOI: https://doi.org/10.1042/CS20210417

Published: 20 August 2021

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Eicosanoid receptors as therapeutic targets for asthma

William S. Powell

Clin Sci (Lond) (2021) 135 (16): 1945–1980.

DOI: https://doi.org/10.1042/CS20190657

Published: 17 August 2021

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Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba

Clin Sci (Lond) (2021) 135 (15): 1897–1914.

DOI: https://doi.org/10.1042/CS20210311

Published: 10 August 2021

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Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long

Clin Sci (Lond) (2021) 135 (15): 1873–1895.

DOI: https://doi.org/10.1042/CS20210447

Published: 06 August 2021

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Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes

Clin Sci (Lond) (2021) 135 (15): 1845–1858.

DOI: https://doi.org/10.1042/CS20210468

Published: 04 August 2021

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Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT 1a receptors in the proximal tubule of the kidney

Ana Paula Oliveira Leite, Xiao C. Li, Rumana Hassan, Xiaowen Zheng, Barbara Alexander, Dulce Elena Casarini, Jia L. Zhuo

Clin Sci (Lond) (2021) 135 (15): 1825–1843.

DOI: https://doi.org/10.1042/CS20201574

Published: 04 August 2021

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Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini, Mariane Bertagnolli

Clin Sci (Lond) (2021) 135 (15): 1805–1824.

DOI: https://doi.org/10.1042/CS20210284

Published: 02 August 2021

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Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

George W. Booz, Gaelle P. Massoud, Raffaele Altara, Fouad A. Zouein

Clin Sci (Lond) (2021) 135 (14): 1767–1772.

DOI: https://doi.org/10.1042/CS20210524

Published: 27 July 2021

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Cholesterol metabolism: a new molecular switch to control inflammation

Diana Cardoso, Esperanza Perucha

Clin Sci (Lond) (2021) 135 (11): 1389–1408.

DOI: https://doi.org/10.1042/CS20201394

Published: 04 June 2021

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Adventitial recruitment of Lyve-1 − macrophages drives aortic aneurysm in an angiotensin-2-based murine model

Antigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne

Clin Sci (Lond) (2021) 135 (10): 1295–1309.

DOI: https://doi.org/10.1042/CS20200963

Published: 28 May 2021

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Molecular mechanisms of anthracycline cardiovascular toxicity

Anna Narezkina, Hari K. Narayan, Alice E. Zemljic-Harpf

Clin Sci (Lond) (2021) 135 (10): 1311–1332.

DOI: https://doi.org/10.1042/CS20200301

Published: 28 May 2021

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A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Lu Dai, Leon Schurgers, Paul G. Shiels, Peter Stenvinkel

Clin Sci (Lond) (2021) 135 (10): 1251–1272.

DOI: https://doi.org/10.1042/CS20201452

Published: 26 May 2021

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Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction

Shuhan Ji, Diane Gumina, Kathryn McPeak, Radu Moldovan, Miriam D. Post, Emily J. Su

Clin Sci (Lond) (2021) 135 (9): 1127–1143.

DOI: https://doi.org/10.1042/CS20201533

Published: 11 May 2021

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Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress

Xiaoguang Sun, Belinda L. Sun, Saad Sammani, Tadeo Bermudez, Steven M. Dudek, Sara M. Camp, Joe G.N. Garcia

Clin Sci (Lond) (2021) 135 (7): 963–977.

DOI: https://doi.org/10.1042/CS20201448

Published: 14 April 2021

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Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Kana N. Miyata, Chao-Sheng Lo, Shuiling Zhao, Min-Chun Liao, Yuchao Pang, Shiao-Ying Chang, Junzheng Peng, Matthias Kretzler, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan

Clin Sci (Lond) (2021) 135 (7): 943–961.

DOI: https://doi.org/10.1042/CS20210094

Published: 14 April 2021

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Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries

Weronika Karle, Samuel Becker, Philipp Stenzel, Christoph Knosalla, Günter Siegel, Oliver Baum, Andreas Zakrzewicz, Janine Berkholz

Clin Sci (Lond) (2021) 135 (7): 887–905.

DOI: https://doi.org/10.1042/CS20201399

Published: 09 April 2021

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Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia

Ming Fu, Ledong Tan, Zefeng Lin, Vincent C.H. Lui, Paul K.H. Tam, Jonathan R. Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Chen

Clin Sci (Lond) (2021) 135 (7): 865–884.

DOI: https://doi.org/10.1042/CS20201366

Published: 09 April 2021

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Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen

Carlos M. Ferrario, Leanne Groban, Hao Wang, Sarfaraz Ahmad

Clin Sci (Lond) (2021) 135 (7): 907–910.

DOI: https://doi.org/10.1042/CS20210163

Published: 09 April 2021

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SOX7 suppresses endothelial-to-mesenchymal transitions by enhancing VE-cadherin expression during outflow tract development

Xuechao Jiang, Tingting Li, Bojian Li, Wei Wei, Fen Li, Sun Chen, Rang Xu, Kun Sun

Clin Sci (Lond) (2021) 135 (6): 829–846.

DOI: https://doi.org/10.1042/CS20201496

Published: 26 March 2021

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Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor

Ziwei Fu, Fei Wang, Xiyang Liu, Jiajia Hu, Jiahui Su, Xiaohan Lu, Aihua Lu, Jae Min Cho, J. David Symons, Chang-Jiang Zou, Tianxin Yang

Clin Sci (Lond) (2021) 135 (6): 793–810.

DOI: https://doi.org/10.1042/CS20201047

Published: 23 March 2021

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Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz

Clin Sci (Lond) (2021) 135 (6): 753–773.

DOI: https://doi.org/10.1042/CS20201412

Published: 17 March 2021

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Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor

Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro

Clin Sci (Lond) (2021) 135 (5): 687–701.

DOI: https://doi.org/10.1042/CS20201419

Published: 09 March 2021

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Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors

Alan H. Baik, Katy K. Tsai, David Y. Oh, Mandar A. Aras

Clin Sci (Lond) (2021) 135 (5): 703–724.

DOI: https://doi.org/10.1042/CS20200331

Published: 09 March 2021

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Protective role of kallistatin in renal fibrosis via modulation of Wnt/β-catenin signaling

Wai Han Yiu, Ye Li, Sarah W.Y. Lok, Kam Wa Chan, Loretta Y.Y. Chan, Joseph C.K. Leung, Kar Neng Lai, James H.L. Tsu, Julie Chao, Xiao-Ru Huang, Hui Yao Lan, Sydney C.W. Tang

Clin Sci (Lond) (2021) 135 (3): 429–446.

DOI: https://doi.org/10.1042/CS20201161

Published: 01 February 2021

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Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19

Maria A. Pedrosa, Rita Valenzuela, Pablo Garrido-Gil, Carmen M. Labandeira, Gemma Navarro, Rafael Franco, Jose L. Labandeira-Garcia, Ana I. Rodriguez-Perez

Clin Sci (Lond) (2021) 135 (3): 465–481.

DOI: https://doi.org/10.1042/CS20201511

Published: 01 February 2021

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