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The tendency of anemia of inflammation in periodontal diseases

Ye Han, Zhiqiang Luo, Zhao Guo Yue, Li Li Miao, Min Xv, Shu Chang, Yalin Zhan, Jianxia Hou

Clin Sci (Lond) (2023) CS20220524.

DOI: https://doi.org/10.1042/CS20220524

Published: 27 January 2023

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Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

Xiaodi Zhang, Jean LJM Scheijen, Coen D.A. Stehouwer, Kristiaan Wouters, Casper Schalkwijk

Clin Sci (Lond) (2023) CS20220753.

DOI: https://doi.org/10.1042/CS20220753

Published: 20 January 2023

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The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler

Clin Sci (Lond) (2023) 137 (1): 87–104.

DOI: https://doi.org/10.1042/CS20220447

Published: 05 January 2023

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Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Justine Gillard, Isabelle A. Leclercq

Clin Sci (Lond) (2023) 137 (1): 65–85.

DOI: https://doi.org/10.1042/CS20220697

Published: 05 January 2023

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The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

Kyle M. Siemers, Michelle L. Baack

Clin Sci (Lond) (2023) 137 (1): 31–34.

DOI: https://doi.org/10.1042/CS20220657

Published: 03 January 2023

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Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal

Clin Sci (Lond) (2022) 136 (24): 1851–1871.

DOI: https://doi.org/10.1042/CS20220636

Published: 22 December 2022

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The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models

Aliye Uc, Birgitta Strandvik, Jianrong Yao, Xiaoming Liu, Yaling Yi, Xingshen Sun, Ruth Welti, John F. Engelhardt, Andrew W. Norris

Clin Sci (Lond) (2022) 136 (24): 1773–1791.

DOI: https://doi.org/10.1042/CS20220450

Published: 13 December 2022

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Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2022) 136 (22): 1711–1730.

DOI: https://doi.org/10.1042/CS20220242

Published: 30 November 2022

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A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

Laura B James-Allan, Frederick J Rosario, Lana Madi, Kelsey Barner, Soumyalekshmi Nair, Andrew Lai, Flavio Carrion, Theresa L Powell, Carlos Salomon, Thomas Jansson

Clin Sci (Lond) (2022) 136 (21): 1535–1549.

DOI: https://doi.org/10.1042/CS20220484

Published: 03 November 2022

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Measuring muscle protein synthesis in humans and the influence of nutritional state

Philip C. Calder, Nicolaas E.P. Deutz

Clin Sci (Lond) (2022) 136 (19): 1425–1431.

DOI: https://doi.org/10.1042/CS20211171

Published: 14 October 2022

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Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation

Katie L. Bidne, Charis Uhlson, Claire Palmer, Karin Zemski-Berry, Theresa L. Powell

Clin Sci (Lond) (2022) 136 (19): 1389–1404.

DOI: https://doi.org/10.1042/CS20220479

Published: 04 October 2022

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Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Antonio L. Teixeira, Lais B. Martins, Michael Berk, Moisés E. Bauer

Clin Sci (Lond) (2022) 136 (17): 1257–1280.

DOI: https://doi.org/10.1042/CS20211106

Published: 05 September 2022

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Targeting skeletal muscle mitochondrial health in obesity

Chantal A. Pileggi, Breana G. Hooks, Ruth McPherson, Robert R.M. Dent, Mary-Ellen Harper

Clin Sci (Lond) (2022) 136 (14): 1081–1110.

DOI: https://doi.org/10.1042/CS20210506

Published: 27 July 2022

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Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Philip C. Calder

Clin Sci (Lond) (2022) 136 (13): 1019–1023.

DOI: https://doi.org/10.1042/CS20220380

Published: 01 July 2022

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Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Arno Téblick, Jan Gunst, Lies Langouche, Greet Van den Berghe

Clin Sci (Lond) (2022) 136 (11): 861–878.

DOI: https://doi.org/10.1042/CS20211003

Published: 01 June 2022

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Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis

Mark Hedley Vickers

Clin Sci (Lond) (2022) 136 (10): 711–714.

DOI: https://doi.org/10.1042/CS20211175

Published: 16 May 2022

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Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

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The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

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Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity

Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh

Clin Sci (Lond) (2022) 136 (1): 121–137.

DOI: https://doi.org/10.1042/CS20210959

Published: 07 January 2022

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Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection

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Coronavirus

Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler

Clin Sci (Lond) (2021) 135 (24): 2781–2791.

DOI: https://doi.org/10.1042/CS20210666

Published: 22 December 2021

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Articles

Asthma and obesity: endotoxin another insult to add to injury?

Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan

Clin Sci (Lond) (2021) 135 (24): 2729–2748.

DOI: https://doi.org/10.1042/CS20210790

Published: 17 December 2021

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Sex differences in white adipose tissue expansion: emerging molecular mechanisms

Simon T. Bond, Anna C. Calkin, Brian G. Drew

Clin Sci (Lond) (2021) 135 (24): 2691–2708.

DOI: https://doi.org/10.1042/CS20210086

Published: 15 December 2021

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Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman

Clin Sci (Lond) (2021) 135 (22): 2559–2573.

DOI: https://doi.org/10.1042/CS20210713

Published: 26 November 2021

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Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

Laura Wilson, Alice E. Pollard, Lucy Penfold, Phillip J. Muckett, Chad Whilding, Mohammad Bohlooly-Y., Patricia Wilson, David Carling

Clin Sci (Lond) (2021) 135 (20): 2393–2408.

DOI: https://doi.org/10.1042/CS20210821

Published: 22 October 2021

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Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello

Clin Sci (Lond) (2021) 135 (19): 2285–2305.

DOI: https://doi.org/10.1042/CS20210183

Published: 13 October 2021

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Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Jennifer Leggat, Guillaume Bidault, Antonio Vidal-Puig

Clin Sci (Lond) (2021) 135 (19): 2265–2283.

DOI: https://doi.org/10.1042/CS20210127

Published: 13 October 2021

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Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2021) 135 (17): 2103–2119.

DOI: https://doi.org/10.1042/CS20210628

Published: 06 September 2021

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Maternal intermittent fasting during pregnancy: a translational research challenge for an important clinical scenario

Dominique Darmaun

Clin Sci (Lond) (2021) 135 (17): 2099–2102.

DOI: https://doi.org/10.1042/CS20210578

Published: 01 September 2021

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Articles

Placenta-specific Slc38a2 /SNAT2 knockdown causes fetal growth restriction in mice

Owen R. Vaughan, Katarzyna Maksym, Elena Silva, Kenneth Barentsen, Russel V. Anthony, Thomas L. Brown, Sara L. Hillman, Rebecca Spencer, Anna L. David, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2021) 135 (17): 2049–2066.

DOI: https://doi.org/10.1042/CS20210575

Published: 31 August 2021

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Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

George W. Booz, Gaelle P. Massoud, Raffaele Altara, Fouad A. Zouein

Clin Sci (Lond) (2021) 135 (14): 1767–1772.

DOI: https://doi.org/10.1042/CS20210524

Published: 27 July 2021

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Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

Clin Sci (Lond) (2021) 135 (14): 1707–1726.

DOI: https://doi.org/10.1042/CS20210100

Published: 22 July 2021

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Phosphate and fibroblast growth factor 23 in diabetes

Amarens van der Vaart, Stanley M.H. Yeung, Peter R. van Dijk, Stephan J.L. Bakker, Martin H. de Borst

Clin Sci (Lond) (2021) 135 (14): 1669–1687.

DOI: https://doi.org/10.1042/CS20201290

Published: 20 July 2021

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Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt

Clin Sci (Lond) (2021) 135 (13): 1563–1590.

DOI: https://doi.org/10.1042/CS20190768

Published: 07 July 2021

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Cholesterol metabolism: a new molecular switch to control inflammation

Diana Cardoso, Esperanza Perucha

Clin Sci (Lond) (2021) 135 (11): 1389–1408.

DOI: https://doi.org/10.1042/CS20201394

Published: 04 June 2021

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A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Lu Dai, Leon Schurgers, Paul G. Shiels, Peter Stenvinkel

Clin Sci (Lond) (2021) 135 (10): 1251–1272.

DOI: https://doi.org/10.1042/CS20201452

Published: 26 May 2021

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Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Ying-Yin Sun, Dong-Qing Wu, Na-Na Yin, Lei Yang, Xin Chen, Hai-Di Li, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Hua Wang, Jun Li

Clin Sci (Lond) (2021) 135 (10): 1213–1232.

DOI: https://doi.org/10.1042/CS20201363

Published: 20 May 2021

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Emerging role of carbonic anhydrase inhibitors

Claudiu T. Supuran

Clin Sci (Lond) (2021) 135 (10): 1233–1249.

DOI: https://doi.org/10.1042/CS20210040

Published: 20 May 2021

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Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira

Clin Sci (Lond) (2021) 135 (9): 1103–1126.

DOI: https://doi.org/10.1042/CS20201339

Published: 11 May 2021

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IGF2 deficiency causes mitochondrial defects in skeletal muscle

Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin

Clin Sci (Lond) (2021) 135 (7): 979–990.

DOI: https://doi.org/10.1042/CS20210128

Published: 16 April 2021

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The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor

Clin Sci (Lond) (2021) 135 (6): 731–752.

DOI: https://doi.org/10.1042/CS20200895

Published: 17 March 2021

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ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Xi Cao, Li-Ni Song, Jin-Kui Yang

Clin Sci (Lond) (2021) 135 (3): 535–554.

DOI: https://doi.org/10.1042/CS20200752

Published: 03 February 2021

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Host cell glutamine metabolism as a potential antiviral target

Sandro Massao Hirabara, Renata Gorjao, Adriana Cristina Levada-Pires, Laureane Nunes Masi, Elaine Hatanaka, Maria Fernanda Cury-Boaventura, Eliane Borges da Silva, Laiane Cristina dos Santos-Oliveira, Vinicius Leonardo Sousa Diniz, Tamires Afonso Duarte Serdan, Vivian Araujo Barbosa de Oliveira, Diego Ribeiro de Souza, Raquel Bragante Gritte, Talita Souza-Siqueira, Raquel Freitas Zambonatto, Tania Cristina Pithon-Curi, Roberto Barbosa Bazotte, Philip Newsholme, Rui Curi

Clin Sci (Lond) (2021) 135 (2): 305–325.

DOI: https://doi.org/10.1042/CS20201042

Published: 22 January 2021

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Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder

Clin Sci (Lond) (2021) 135 (1): 185–200.

DOI: https://doi.org/10.1042/CS20201060

Published: 08 January 2021

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Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid

Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago Andrade Patente, José Alexandre Barbuto, Maria L. Corrêa-Giannella, Mario Lauterbach, Carl Christian Kolbe, Eicke Latz, Niels Olsen Saraiva Camara, Alessandra Pontillo, Rui Curi

Clin Sci (Lond) (2021) 135 (1): 19–34.

DOI: https://doi.org/10.1042/CS20201348

Published: 05 January 2021

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Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Amy Catherine Kelly, Anita Kramer, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2020) 134 (23): 3123–3136.

DOI: https://doi.org/10.1042/CS20201050

Published: 07 December 2020

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Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

Zhuo Li, Hua Guo, Jia Li, Tianjiao Ma, Shanshan Zhou, Zhiguo Zhang, Lining Miao, Lu Cai

Clin Sci (Lond) (2020) 134 (18): 2469–2487.

DOI: https://doi.org/10.1042/CS20191088

Published: 25 September 2020

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Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress

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Celebrating 100 years of insulin research

Joshua A. Beckman, Jiun-Ruey Hu, Shi Huang, Eric Farber-Eger, Quinn S. Wells, Thomas J. Wang, Robert E. Gerszten, Jane F. Ferguson

Clin Sci (Lond) (2020) 134 (17): 2369–2379.

DOI: https://doi.org/10.1042/CS20191227

Published: 16 September 2020

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AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

Miao Chen, Caoyu Ji, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2020) 134 (17): 2381–2398.

DOI: https://doi.org/10.1042/CS20191320

Published: 16 September 2020

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Non-alcoholic fatty liver disease: a metabolic burden promoting atherosclerosis

Lei Zhang, Zhi-Gang She, Hongliang Li, Xiao-Jing Zhang

Clin Sci (Lond) (2020) 134 (13): 1775–1799.

DOI: https://doi.org/10.1042/CS20200446

Published: 17 July 2020

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Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle

Anwar Khan, Sherouk Fouda, Ali Mahzari, Stanley M.H. Chan, Xiu Zhou, Cherubina Ratnam, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2020) 134 (13): 1659–1673.

DOI: https://doi.org/10.1042/CS20200173

Published: 01 July 2020

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