Search Results | Clinical Science

1-50 of 137

2 3

Sort by

Sort Order Select

Articles

Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Arno Téblick, Jan Gunst, Lies Langouche, Greet Van den Berghe

Clin Sci (Lond) (2022) 136 (11): 861–878.

DOI: https://doi.org/10.1042/CS20211003

Published: 01 June 2022

View article

Articles

Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis

Mark Hedley Vickers

Clin Sci (Lond) (2022) 136 (10): 711–714.

DOI: https://doi.org/10.1042/CS20211175

Published: 16 May 2022

View article

Articles

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

View article

Includes: Supplementary data

Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

View article

Articles

Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity

Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh

Clin Sci (Lond) (2022) 136 (1): 121–137.

DOI: https://doi.org/10.1042/CS20210959

Published: 07 January 2022

View article

Includes: Supplementary data

Articles

Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection

Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler

Clin Sci (Lond) (2021) 135 (24): 2781–2791.

DOI: https://doi.org/10.1042/CS20210666

Published: 22 December 2021

View article

Articles

Asthma and obesity: endotoxin another insult to add to injury?

Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan

Clin Sci (Lond) (2021) 135 (24): 2729–2748.

DOI: https://doi.org/10.1042/CS20210790

Published: 17 December 2021

View article

Articles

Sex differences in white adipose tissue expansion: emerging molecular mechanisms

Simon T. Bond, Anna C. Calkin, Brian G. Drew

Clin Sci (Lond) (2021) 135 (24): 2691–2708.

DOI: https://doi.org/10.1042/CS20210086

Published: 15 December 2021

View article

Articles

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover

Dominic J. Corkill, Alan N. Hunt, Mary Jane Hinrichs, Nicholas White, Marlon Rebelatto, Lorin Roskos, Josquin Nys, Alison Scott, Matthew J. Robinson, Patricia Ryan, Anthony D. Postle, Matthew A. Sleeman

Clin Sci (Lond) (2021) 135 (22): 2559–2573.

DOI: https://doi.org/10.1042/CS20210713

Published: 26 November 2021

View article

Includes: Supplementary data

Articles

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

Laura Wilson, Alice E. Pollard, Lucy Penfold, Phillip J. Muckett, Chad Whilding, Mohammad Bohlooly-Y., Patricia Wilson, David Carling

Clin Sci (Lond) (2021) 135 (20): 2393–2408.

DOI: https://doi.org/10.1042/CS20210821

Published: 22 October 2021

View article

Includes: Supplementary data

Articles

Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello

Clin Sci (Lond) (2021) 135 (19): 2285–2305.

DOI: https://doi.org/10.1042/CS20210183

Published: 13 October 2021

View article

Includes: Supplementary data

Articles

Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Jennifer Leggat, Guillaume Bidault, Antonio Vidal-Puig

Clin Sci (Lond) (2021) 135 (19): 2265–2283.

DOI: https://doi.org/10.1042/CS20210127

Published: 13 October 2021

View article

Articles

Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2021) 135 (17): 2103–2119.

DOI: https://doi.org/10.1042/CS20210628

Published: 06 September 2021

View article

Includes: Supplementary data

Articles

Maternal intermittent fasting during pregnancy: a translational research challenge for an important clinical scenario

Dominique Darmaun

Clin Sci (Lond) (2021) 135 (17): 2099–2102.

DOI: https://doi.org/10.1042/CS20210578

Published: 01 September 2021

View article

Articles

Placenta-specific Slc38a2 /SNAT2 knockdown causes fetal growth restriction in mice

Owen R. Vaughan, Katarzyna Maksym, Elena Silva, Kenneth Barentsen, Russel V. Anthony, Thomas L. Brown, Sara L. Hillman, Rebecca Spencer, Anna L. David, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2021) 135 (17): 2049–2066.

DOI: https://doi.org/10.1042/CS20210575

Published: 31 August 2021

View article

Includes: Supplementary data

Articles

Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

George W. Booz, Gaelle P. Massoud, Raffaele Altara, Fouad A. Zouein

Clin Sci (Lond) (2021) 135 (14): 1767–1772.

DOI: https://doi.org/10.1042/CS20210524

Published: 27 July 2021

View article

Articles

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability

Mengqiu Wu, Weiyi Chen, Mengqiu Miao, Qianqian Jin, Shengnan Zhang, Mi Bai, Jiaojiao Fan, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang

Clin Sci (Lond) (2021) 135 (14): 1707–1726.

DOI: https://doi.org/10.1042/CS20210100

Published: 22 July 2021

View article

Includes: Supplementary data

Articles

Phosphate and fibroblast growth factor 23 in diabetes

Amarens van der Vaart, Stanley M.H. Yeung, Peter R. van Dijk, Stephan J.L. Bakker, Martin H. de Borst

Clin Sci (Lond) (2021) 135 (14): 1669–1687.

DOI: https://doi.org/10.1042/CS20201290

Published: 20 July 2021

View article

Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt

Clin Sci (Lond) (2021) 135 (13): 1563–1590.

DOI: https://doi.org/10.1042/CS20190768

Published: 07 July 2021

View article

Articles

Cholesterol metabolism: a new molecular switch to control inflammation

Diana Cardoso, Esperanza Perucha

Clin Sci (Lond) (2021) 135 (11): 1389–1408.

DOI: https://doi.org/10.1042/CS20201394

Published: 04 June 2021

View article

Articles

A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Lu Dai, Leon Schurgers, Paul G. Shiels, Peter Stenvinkel

Clin Sci (Lond) (2021) 135 (10): 1251–1272.

DOI: https://doi.org/10.1042/CS20201452

Published: 26 May 2021

View article

Articles

Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Ying-Yin Sun, Dong-Qing Wu, Na-Na Yin, Lei Yang, Xin Chen, Hai-Di Li, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Hua Wang, Jun Li

Clin Sci (Lond) (2021) 135 (10): 1213–1232.

DOI: https://doi.org/10.1042/CS20201363

Published: 20 May 2021

View article

Includes: Supplementary data

Articles

Emerging role of carbonic anhydrase inhibitors

Claudiu T. Supuran

Clin Sci (Lond) (2021) 135 (10): 1233–1249.

DOI: https://doi.org/10.1042/CS20210040

Published: 20 May 2021

View article

Articles

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira

Clin Sci (Lond) (2021) 135 (9): 1103–1126.

DOI: https://doi.org/10.1042/CS20201339

Published: 11 May 2021

View article

Includes: Supplementary data

Articles

IGF2 deficiency causes mitochondrial defects in skeletal muscle

Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin

Clin Sci (Lond) (2021) 135 (7): 979–990.

DOI: https://doi.org/10.1042/CS20210128

Published: 16 April 2021

View article

Includes: Supplementary data

Articles

The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor

Clin Sci (Lond) (2021) 135 (6): 731–752.

DOI: https://doi.org/10.1042/CS20200895

Published: 17 March 2021

View article

Articles

ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

Xi Cao, Li-Ni Song, Jin-Kui Yang

Clin Sci (Lond) (2021) 135 (3): 535–554.

DOI: https://doi.org/10.1042/CS20200752

Published: 03 February 2021

View article

Articles

Host cell glutamine metabolism as a potential antiviral target

Sandro Massao Hirabara, Renata Gorjao, Adriana Cristina Levada-Pires, Laureane Nunes Masi, Elaine Hatanaka, Maria Fernanda Cury-Boaventura, Eliane Borges da Silva, Laiane Cristina dos Santos-Oliveira, Vinicius Leonardo Sousa Diniz, Tamires Afonso Duarte Serdan, Vivian Araujo Barbosa de Oliveira, Diego Ribeiro de Souza, Raquel Bragante Gritte, Talita Souza-Siqueira, Raquel Freitas Zambonatto, Tania Cristina Pithon-Curi, Roberto Barbosa Bazotte, Philip Newsholme, Rui Curi

Clin Sci (Lond) (2021) 135 (2): 305–325.

DOI: https://doi.org/10.1042/CS20201042

Published: 22 January 2021

View article

Articles

Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder

Clin Sci (Lond) (2021) 135 (1): 185–200.

DOI: https://doi.org/10.1042/CS20201060

Published: 08 January 2021

View article

Includes: Supplementary data

Articles

Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid

Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago Andrade Patente, José Alexandre Barbuto, Maria L. Corrêa-Giannella, Mario Lauterbach, Carl Christian Kolbe, Eicke Latz, Niels Olsen Saraiva Camara, Alessandra Pontillo, Rui Curi

Clin Sci (Lond) (2021) 135 (1): 19–34.

DOI: https://doi.org/10.1042/CS20201348

Published: 05 January 2021

View article

Includes: Supplementary data

Articles

Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Amy Catherine Kelly, Anita Kramer, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2020) 134 (23): 3123–3136.

DOI: https://doi.org/10.1042/CS20201050

Published: 07 December 2020

View article

Includes: Supplementary data

Articles

Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

Zhuo Li, Hua Guo, Jia Li, Tianjiao Ma, Shanshan Zhou, Zhiguo Zhang, Lining Miao, Lu Cai

Clin Sci (Lond) (2020) 134 (18): 2469–2487.

DOI: https://doi.org/10.1042/CS20191088

Published: 25 September 2020

View article

Includes: Supplementary data

Articles

Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress

Joshua A. Beckman, Jiun-Ruey Hu, Shi Huang, Eric Farber-Eger, Quinn S. Wells, Thomas J. Wang, Robert E. Gerszten, Jane F. Ferguson

Clin Sci (Lond) (2020) 134 (17): 2369–2379.

DOI: https://doi.org/10.1042/CS20191227

Published: 16 September 2020

View article

Includes: Supplementary data

Articles

AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

Miao Chen, Caoyu Ji, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2020) 134 (17): 2381–2398.

DOI: https://doi.org/10.1042/CS20191320

Published: 16 September 2020

View article

Includes: Supplementary data

Articles

Non-alcoholic fatty liver disease: a metabolic burden promoting atherosclerosis

Lei Zhang, Zhi-Gang She, Hongliang Li, Xiao-Jing Zhang

Clin Sci (Lond) (2020) 134 (13): 1775–1799.

DOI: https://doi.org/10.1042/CS20200446

Published: 17 July 2020

View article

Articles

Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle

Anwar Khan, Sherouk Fouda, Ali Mahzari, Stanley M.H. Chan, Xiu Zhou, Cherubina Ratnam, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2020) 134 (13): 1659–1673.

DOI: https://doi.org/10.1042/CS20200173

Published: 01 July 2020

View article

Includes: Supplementary data

Articles

Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway

Xiaohong Sun, Kaipeng Huang, Xiao Haiming, Zeyuan Lin, Yan Yang, Meng Zhang, Peiqing Liu, Heqing Huang

Clin Sci (Lond) (2020) 134 (13): 1573–1592.

DOI: https://doi.org/10.1042/CS20200171

Published: 30 June 2020

View article

Articles

Metformin alleviates hyperuricaemia-induced serum FFA elevation and insulin resistance by inhibiting adipocyte hypertrophy and reversing suppressed white adipose tissue beiging

Mengqi Su, Li Sun, Wenpeng Li, He Liu, Yang Liu, Ying Wei, Yue Yuan, Linqun Zheng, Shuangli Yin, Chenguang Dai, Chenyang Zhao, Zhenwei Pan, Yue Li

Clin Sci (Lond) (2020) 134 (12): 1537–1553.

DOI: https://doi.org/10.1042/CS20200580

Published: 25 June 2020

View article

Includes: Supplementary data

Articles

Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats

Jing Cheng, Yi Tan, Jiong Zhou, Linda Xiao, Michael Johnson, Xianqin Qu

Clin Sci (Lond) (2020) 134 (10): 1167–1180.

DOI: https://doi.org/10.1042/CS20200107

Published: 27 May 2020

View article

Articles

Postprandial increase in glucagon-like peptide-1 is blunted in severe heart failure

Daniel F. Arruda-Junior, Flavia L. Martins, Thiago Almeida Salles, Leonardo Jensen, Rafael Dariolli, Ednei L. Antonio, Leonardo dos Santos, Renato O. Crajoinas, Paulo J.F. Tucci, Luís Henrique W. Gowdak, José Eduardo Krieger, Alexandre C. Pereira, Adriana C. Girardi

Clin Sci (Lond) (2020) 134 (9): 1081–1094.

DOI: https://doi.org/10.1042/CS20190946

Published: 07 May 2020

View article

Includes: Supplementary data

Articles

Bone marrow fat: friend or foe in people with diabetes mellitus?

Marianna Santopaolo, Yue Gu, Gaia Spinetti, Paolo Madeddu

Clin Sci (Lond) (2020) 134 (8): 1031–1048.

DOI: https://doi.org/10.1042/CS20200220

Published: 27 April 2020

View article

Articles

Placental function in maternal obesity

Amy C. Kelly, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2020) 134 (8): 961–984.

DOI: https://doi.org/10.1042/CS20190266

Published: 21 April 2020

View article

Articles

Maternal high-fat diet induces long-term obesity with sex-dependent metabolic programming of adipocyte differentiation, hypertrophy and dysfunction in the offspring

Thorsten Litzenburger, Eva-Kristina Huber, Katharina Dinger, Rebecca Wilke, Christina Vohlen, Jaco Selle, Mazlum Kadah, Thorsten Persigehl, Carola Heneweer, Jörg Dötsch, Miguel A. Alejandre Alcazar

Clin Sci (Lond) (2020) 134 (7): 921–939.

DOI: https://doi.org/10.1042/CS20191229

Published: 17 April 2020

View article

Articles

Short-chain fatty acid, acylation and cardiovascular diseases

Xiao-Feng Chen, Xiangqi Chen, Xiaoqiang Tang

Clin Sci (Lond) (2020) 134 (6): 657–676.

DOI: https://doi.org/10.1042/CS20200128

Published: 27 March 2020

View article

Articles

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

Jizheng Chen, Fang Wang, Yue Zhou, Jing Jiang, Sulaiman Ksimu, Xu Zhang, John Zhong Li, Junqi Niu, Qian Wang

Clin Sci (Lond) (2020) 134 (5): 529–542.

DOI: https://doi.org/10.1042/CS20190900

Published: 13 March 2020

View article

Includes: Supplementary data

Articles

Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

Miroslava Kacířová, Anna Zmeškalová, Lucia Kořínková, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská

Clin Sci (Lond) (2020) 134 (5): 547–570.

DOI: https://doi.org/10.1042/CS20191313

Published: 13 March 2020

View article

Articles

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

Ryan P. Ceddia, Sheila Collins

Clin Sci (Lond) (2020) 134 (5): 473–512.

DOI: https://doi.org/10.1042/CS20190579

Published: 09 March 2020

View article

Articles

Myriocin and d-PDMP ameliorate atherosclerosis in ApoE−/− mice via reducing lipid uptake and vascular inflammation

Zemou Yu, Qing Peng, Songyue Li, Hongjun Hao, Jianwen Deng, Lingbing Meng, Zhiyuan Shen, Weiwei Yu, Ding Nan, Yu Bai, Yining Huang

Clin Sci (Lond) (2020) 134 (5): 439–458.

DOI: https://doi.org/10.1042/CS20191028

Published: 04 March 2020

View article

Includes: Supplementary data

Articles

Obesity and adiposity: the culprit of dietary protein efficacy

Carla El-Mallah, Omar Obeid

Clin Sci (Lond) (2020) 134 (4): 389–401.

DOI: https://doi.org/10.1042/CS20190583

Published: 17 February 2020

View article

Articles

The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders

Zhuohao Liu, Kelvin K.L. Wu, Xue Jiang, Aimin Xu, Kenneth K.Y. Cheng

Clin Sci (Lond) (2020) 134 (2): 315–330.

DOI: https://doi.org/10.1042/CS20190966

Published: 30 January 2020

View article

2 3

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only