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Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca 2+ mishandling and atrial fibrosis in active immunization rabbit models

Huaxin Sun, Jie Song, Kai Li, Yao Li, Luxiang Shang, Qina Zhou, Yanmei Lu, Yazhen Zong, Xiuyuan He, Muzappar Kari, Hang Yang, Xianhui Zhou, Ling Zhang, Baopeng Tang

Clin Sci (Lond) (2023) 137 (2): 195–217.

DOI: https://doi.org/10.1042/CS20220654

Published: 27 January 2023

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The long noncoding RNA Meg3 mediates TLR4–induced inflammation in experimental obstructive nephropathy

Wai Han Yiu, Sarah WY Lok, Rui Xue, Jiaoyi Chen, Kar Neng Lai, Hui Yao Lan, Sydney CW Tang

Clin Sci (Lond) (2023) CS20220537.

DOI: https://doi.org/10.1042/CS20220537

Published: 27 January 2023

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The tendency of anemia of inflammation in periodontal diseases

Ye Han, Zhiqiang Luo, Zhao Guo Yue, Li Li Miao, Min Xv, Shu Chang, Yalin Zhan, Jianxia Hou

Clin Sci (Lond) (2023) CS20220524.

DOI: https://doi.org/10.1042/CS20220524

Published: 27 January 2023

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Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Keitaro Ueda, Chiemi Sakai, Takafumi Ishida, Kosuke Morita, Yusuke Kobayashi, Yasunori Horikoshi, Akiko Baba, Yuma Okazaki, Masao Yoshizumi, Satoshi Tashiro, Mari Ishida

Clin Sci (Lond) (2023) 137 (2): 163–180.

DOI: https://doi.org/10.1042/CS20220525

Published: 24 January 2023

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PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Honglin Li, Zhiwen Liu, Ying Wang, Hui Wang, Juan Cai, Chengyuan Tang, Zheng Dong

Clin Sci (Lond) (2022) 136 (24): 1877–1891.

DOI: https://doi.org/10.1042/CS20220493

Published: 22 December 2022

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Articles

Dysregulated haemostasis in thrombo-inflammatory disease

Paula A. Klavina, Gemma Leon, Annie M. Curtis, Roger J.S. Preston

Clin Sci (Lond) (2022) 136 (24): 1809–1829.

DOI: https://doi.org/10.1042/CS20220208

Published: 16 December 2022

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Articles

Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (23): 1759–1772.

DOI: https://doi.org/10.1042/CS20220547

Published: 02 December 2022

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Includes: Supplementary data

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Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi

Clin Sci (Lond) (2022) 136 (22): 1631–1651.

DOI: https://doi.org/10.1042/CS20220404

Published: 16 November 2022

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Therapeutic use of calpeptin in COVID-19 infection

In Collection

Coronavirus

Jameel Inal, Ainura Paizuldaeva, Esmeralda Terziu

Clin Sci (Lond) (2022) 136 (20): 1439–1447.

DOI: https://doi.org/10.1042/CS20220638

Published: 21 October 2022

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Articles

Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Antonio L. Teixeira, Lais B. Martins, Michael Berk, Moisés E. Bauer

Clin Sci (Lond) (2022) 136 (17): 1257–1280.

DOI: https://doi.org/10.1042/CS20211106

Published: 05 September 2022

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Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Hager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier

Clin Sci (Lond) (2022) 1117–1137.

DOI: https://doi.org/10.1042/CS20220245

Published: 05 August 2022

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Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Federico F. De Ponti, Charlotte L. Scott

Clin Sci (Lond) (2022) 136 (15): 1111–1115.

DOI: https://doi.org/10.1042/CS20220258

Published: 01 August 2022

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L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Xiao Ma, Dechao Cai, Yakun Zhu, Yao Zhao, Xianbo Shang, Chen Wang, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng

Clin Sci (Lond) (2022) 136 (13): 1053–1069.

DOI: https://doi.org/10.1042/CS20220082

Published: 06 July 2022

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Casting a wide NET: an update on uncontrolled NETosis in response to COVID-19 infection

Erin B. Taylor

Clin Sci (Lond) (2022) 136 (13): 1047–1052.

DOI: https://doi.org/10.1042/CS20220039

Published: 06 July 2022

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Articles

Molecular and cellular regulation of psoriatic inflammation

Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann

Clin Sci (Lond) (2022) 136 (12): 935–952.

DOI: https://doi.org/10.1042/CS20210916

Published: 22 June 2022

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Articles

Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction

Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (11): 879–894.

DOI: https://doi.org/10.1042/CS20220117

Published: 06 June 2022

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Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Arno Téblick, Jan Gunst, Lies Langouche, Greet Van den Berghe

Clin Sci (Lond) (2022) 136 (11): 861–878.

DOI: https://doi.org/10.1042/CS20211003

Published: 01 June 2022

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Articles

Pathogenesis of pneumonia and acute lung injury

Matthew E. Long, Rama K. Mallampalli, Jeffrey C. Horowitz

Clin Sci (Lond) (2022) 136 (10): 747–769.

DOI: https://doi.org/10.1042/CS20210879

Published: 27 May 2022

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Mechanisms underlying immune-related adverse events during checkpoint immunotherapy

Xiao Zhou, Xiang Chen, Leng Han, Hong Liu

Clin Sci (Lond) (2022) 136 (10): 771–785.

DOI: https://doi.org/10.1042/CS20210042

Published: 27 May 2022

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Articles

Clinical perspectives on vagus nerve stimulation: present and future

Eibhlin Goggins, Shuhei Mitani, Shinji Tanaka

Clin Sci (Lond) (2022) 136 (9): 695–709.

DOI: https://doi.org/10.1042/CS20210507

Published: 10 May 2022

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Articles

Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis

Laila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti

Clin Sci (Lond) (2022) 136 (9): 643–656.

DOI: https://doi.org/10.1042/CS20211122

Published: 04 May 2022

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Includes: Supplementary data

Articles

Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos

Clin Sci (Lond) (2022) 136 (8): 537–555.

DOI: https://doi.org/10.1042/CS20211090

Published: 21 April 2022

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Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

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Includes: Supplementary data

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Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer

Phimmada Hatthakarnkul, Jean A. Quinn, Aula Ammar, Gerard Lynch, Hester Van Wyk, Donald C. McMillan, Chanitra Thuwajit, Joanne Edwards

Clin Sci (Lond) (2022) 136 (8): 521–535.

DOI: https://doi.org/10.1042/CS20210886

Published: 21 April 2022

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Articles

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Xiaoyi Zhang, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi

Clin Sci (Lond) (2022) 136 (7): 455–471.

DOI: https://doi.org/10.1042/CS20211031

Published: 06 April 2022

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Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall

Maria J. Forteza, Daniel F.J. Ketelhuth

Clin Sci (Lond) (2022) 136 (6): 435–454.

DOI: https://doi.org/10.1042/CS20201293

Published: 29 March 2022

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Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos

Clin Sci (Lond) (2022) 136 (6): 405–423.

DOI: https://doi.org/10.1042/CS20210835

Published: 23 March 2022

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Articles

Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway

Liping Liang, Le Liu, Wanyan Zhou, Chenghai Yang, Genghui Mai, Haolin Li, Ye Chen

Clin Sci (Lond) (2022) 136 (4): 291–307.

DOI: https://doi.org/10.1042/CS20210778

Published: 23 February 2022

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The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen

Clin Sci (Lond) (2022) 136 (3): 197–222.

DOI: https://doi.org/10.1042/CS20201474

Published: 04 February 2022

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Articles

Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice

Clin Sci (Lond) (2022) 136 (1): 81–101.

DOI: https://doi.org/10.1042/CS20210792

Published: 07 January 2022

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Articles

AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang

Clin Sci (Lond) (2022) 136 (1): 103–120.

DOI: https://doi.org/10.1042/CS20211075

Published: 07 January 2022

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WNT1-inducible signaling pathway protein 1 regulates kidney inflammation through the NF-κB pathway

Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue

Clin Sci (Lond) (2022) 136 (1): 29–44.

DOI: https://doi.org/10.1042/CS20210663

Published: 05 January 2022

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Mechanisms of immune aging in HIV

Manon Chauvin, Delphine Sauce

Clin Sci (Lond) (2022) 136 (1): 61–80.

DOI: https://doi.org/10.1042/CS20210344

Published: 05 January 2022

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Articles

Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection

In Collection

Coronavirus

Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler

Clin Sci (Lond) (2021) 135 (24): 2781–2791.

DOI: https://doi.org/10.1042/CS20210666

Published: 22 December 2021

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Articles

Asthma and obesity: endotoxin another insult to add to injury?

Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan

Clin Sci (Lond) (2021) 135 (24): 2729–2748.

DOI: https://doi.org/10.1042/CS20210790

Published: 17 December 2021

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Articles

Helicobacter pylori -induced REDD1 modulates Th17 cell responses that contribute to gastritis

Zong-Bao Yan, Jin-Yu Zhang, Yi-Pin Lv, Wen-Qing Tian, Zhi-Guo Shan, Fang-Yuan Mao, Yu-Gang Liu, Wan-Yan Chen, Pan Wang, Yun Yang, Ping Cheng, Liu-Sheng Peng, Ya-Ling Liao, Geng-Yu Yue, Xiao-Lin Xu, Yong-Liang Zhao, Mu-Han Lü, Yuan Zhuang

Clin Sci (Lond) (2021) 135 (22): 2541–2558.

DOI: https://doi.org/10.1042/CS20210753

Published: 26 November 2021

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Articles

The immune niche of the liver

Michael L. Cheng, Diana Nakib, Catia T. Perciani, Sonya A. MacParland

Clin Sci (Lond) (2021) 135 (20): 2445–2466.

DOI: https://doi.org/10.1042/CS20190654

Published: 28 October 2021

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Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats

Ellen E. Gillis, Kasey Belanger, Mahmoud Abdelbary, Riyaz Mohamed, Jingping Sun, Michael W. Brands, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (19): 2329–2339.

DOI: https://doi.org/10.1042/CS20210469

Published: 13 October 2021

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Autoimmune-mediated renal disease and hypertension

Erika I. Boesen, Rahul M. Kakalij

Clin Sci (Lond) (2021) 135 (17): 2165–2196.

DOI: https://doi.org/10.1042/CS20200955

Published: 17 September 2021

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Oxytocin: much more than childbirth and milk letdown

Morley D. Hollenberg

Clin Sci (Lond) (2021) 135 (17): 2121–2126.

DOI: https://doi.org/10.1042/CS20210180

Published: 10 September 2021

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Contribution of dipeptidyl peptidase 4 to non-typeable Haemophilus influenzae -induced lung inflammation in COPD

Sudhir Kotnala, Yerin Kim, Charu Rajput, Hymavathi Reddyvari, Sudhir Bolla, Nathaniel T. Marchetti, Beata Kosmider, Karim Bahmed, Umadevi S. Sajjan

Clin Sci (Lond) (2021) 135 (17): 2067–2083.

DOI: https://doi.org/10.1042/CS20210099

Published: 01 September 2021

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Articles

Blocking of interleukin-1 suppresses angiotensin II-induced renal injury

Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino

Clin Sci (Lond) (2021) 135 (17): 2035–2048.

DOI: https://doi.org/10.1042/CS20201406

Published: 31 August 2021

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Eicosanoid receptors as therapeutic targets for asthma

William S. Powell

Clin Sci (Lond) (2021) 135 (16): 1945–1980.

DOI: https://doi.org/10.1042/CS20190657

Published: 17 August 2021

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Articles

Postnatal inflammation in ApoE −/− mice is associated with immune training and atherosclerosis

Ellesandra C. Noye, Siroon Bekkering, Albert P. Limawan, Maria U. Nguyen, Lisa K. Widiasmoko, Hui Lu, Salvatore Pepe, Michael M. Cheung, Trevelyan R. Menheniott, Megan J. Wallace, Timothy J. Moss, David P. Burgner, Kirsty R. Short

Clin Sci (Lond) (2021) 135 (15): 1859–1871.

DOI: https://doi.org/10.1042/CS20210496

Published: 04 August 2021

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Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed

Clin Sci (Lond) (2021) 135 (14): 1773–1789.

DOI: https://doi.org/10.1042/CS20210549

Published: 30 July 2021

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The traditional herbal formulation, Jianpiyifei II , reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice

Xuhua Yu, Tiantian Cai, Long Fan, Ziyao Liang, Qiuling Du, Qi Wang, Zifeng Yang, Ross Vlahos, Lei Wu, Lin Lin

Clin Sci (Lond) (2021) 135 (14): 1733–1750.

DOI: https://doi.org/10.1042/CS20210050

Published: 27 July 2021

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Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?

In Collection

Cardiovascular-Oncology

Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen

Clin Sci (Lond) (2021) 135 (14): 1649–1668.

DOI: https://doi.org/10.1042/CS20200300

Published: 20 July 2021

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Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt

Clin Sci (Lond) (2021) 135 (13): 1563–1590.

DOI: https://doi.org/10.1042/CS20190768

Published: 07 July 2021

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Articles

Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia

Peerapat Visitchanakun, Wimonrat Panpetch, Wilasinee Saisorn, Piraya Chatthanathon, Dhammika Leshan Wannigama, Arthid Thim-uam, Saovaros Svasti, Suthat Fucharoen, Naraporn Somboonna, Asada Leelahavanichkul

Clin Sci (Lond) (2021) 135 (12): 1467–1486.

DOI: https://doi.org/10.1042/CS20210328

Published: 16 June 2021

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cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7

Lilin Li, Jeonghwan Lee, Ara Cho, Jin Hyuk Kim, Wonmin Ju, Jung Nam An, Jeong Hwan Park, Shi Mao Zhu, Junghun Lee, Seung-Shin Yu, Chun Soo Lim, Dong Ki Kim, Yon Su Kim, Seung Hee Yang, Jung Pyo Lee

Clin Sci (Lond) (2021) 135 (11): 1427–1444.

DOI: https://doi.org/10.1042/CS20210013

Published: 08 June 2021

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Includes: Supplementary data

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