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Articles

G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice

In Collection
Reproductive Physiology and Disease
Renata Lúcia Vieira Pimentel, Janaína Félix Braga, Elizabeth Portugal Pimenta Velloso, Roberto Queiroga Lautner, Marilene Luzia de Oliveira, Mihail Todiras, Natalia Alenina, Michael Bader, Felipe Gaia de Sousa, Suzane Lilian Beier, RAS Santos
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1249–1263.
https://doi.org/10.1042/CS20220819
Published: 22 August 2023
View article titled, G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice
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Articles

Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection

Valerie E. Polcz, Evan L. Barrios, Benjamin Chapin, Catherine C. Price, Ravinder Nagpal, Paramita Chakrabarty, Gemma Casadesus, Thomas Foster, Lyle L. Moldawer, Philip A. Efron
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (12): 963–978.
https://doi.org/10.1042/CS20220555
Published: 20 June 2023
View article titled, Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection
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Articles

Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury

Xiaorui Chen, Di Qi, Shulei Fan, Yirui He, Hekun Jing, Daoxin Wang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (5): 367–383.
https://doi.org/10.1042/CS20220876
Published: 09 March 2023
View article titled, Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury
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Includes: Supplementary data
Articles

Set7 methyltransferase roles in myocardial protection from chronic stressors

James T. Pearson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 105–108.
https://doi.org/10.1042/CS20220773
Published: 05 January 2023
View article titled, Set7 methyltransferase roles in myocardial protection from chronic stressors
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Articles

Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways

Sheila Almaraz Postigo, Juan Carlos Montero
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 1–15.
https://doi.org/10.1042/CS20220472
Published: 23 December 2022
View article titled, Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways
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Includes: Supplementary data
Articles

ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis

Kai Jiang, Haiyan Chen, Kefeng Ding
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (18): 1367–1370.
https://doi.org/10.1042/CS20220394
Published: 26 September 2022
View article titled, ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis
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Articles

Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair

Nathalia C. de Almeida Oliveira, Elida A. Neri, Caio M. Silva, Iuri C. Valadão, Miriam H. Fonseca-Alaniz, Camila Zogbi, Débora Levy, Sergio P. Bydlowski, Jose Eduardo Krieger
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1281–1301.
https://doi.org/10.1042/CS20220216
Published: 05 September 2022
View article titled, Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair
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Includes: Supplementary data
Articles

L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway

Xiao Ma, Dechao Cai, Yakun Zhu, Yao Zhao, Xianbo Shang, Chen Wang, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1053–1069.
https://doi.org/10.1042/CS20220082
Published: 06 July 2022
View article titled, L-Glutamine alleviates osteoarthritis by regulating lncRNA-NKILA expression through the TGF-β1/SMAD2/3 signalling pathway
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Articles

G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation

Fuwei Zhang, Lifu Lei, Juan Huang, Weiwei Wang, Qian Su, Hongjia Yan, Caiyu Chen, Shuo Zheng, Hongmei Ren, Zhuxin Li, Pedro A. Jose, Yijie Hu, Liangyi Si, Chunyu Zeng, Jian Yang
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 989–1003.
https://doi.org/10.1042/CS20220236
Published: 29 June 2022
View article titled, G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation
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Includes: Supplementary data
Articles

Molecular and cellular regulation of psoriatic inflammation

Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 935–952.
https://doi.org/10.1042/CS20210916
Published: 22 June 2022
View article titled, Molecular and cellular regulation of psoriatic inflammation
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Articles

Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma

Zhanzhan Li, Yanyan Li, Na Li, Liangfang Shen, Aibin Liu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 895–909.
https://doi.org/10.1042/CS20220128
Published: 06 June 2022
View article titled, Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma
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Includes: Supplementary data
Articles

Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer

Phimmada Hatthakarnkul, Jean A. Quinn, Aula Ammar, Gerard Lynch, Hester Van Wyk, Donald C. McMillan, Chanitra Thuwajit, Joanne Edwards
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (8): 521–535.
https://doi.org/10.1042/CS20210886
Published: 21 April 2022
View article titled, Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer
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Articles

A time to heal: microRNA and circadian dynamics in cutaneous wound repair

Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun TL Hughes, Fawaz Ghali, Kehinde Ross
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (8): 579–597.
https://doi.org/10.1042/CS20220011
Published: 21 April 2022
View article titled, A time to heal: microRNA and circadian dynamics in cutaneous wound repair
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Articles

The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease

Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L.Y. Cheing, Yaoming Xue, Yijie Jia
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 223–238.
https://doi.org/10.1042/CS20210470
Published: 07 February 2022
View article titled, The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease
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Includes: Supplementary data
Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 197–222.
https://doi.org/10.1042/CS20201474
Published: 04 February 2022
View article titled, The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
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Articles

Countering the classical renin–angiotensin system

Natalia M. Noto, Yazmin M. Restrepo, Robert C. Speth
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2619–2623.
https://doi.org/10.1042/CS20211043
Published: 08 December 2021
View article titled, Countering the classical renin–angiotensin system
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Articles

Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein

Daniele T. Alves, Luiz Felipe Mendes, Walkyria O. Sampaio, Leda M.C. Coimbra-Campos, Maria Aparecida R. Vieira, Anderson J. Ferreira, Almir S. Martins, Elena Popova, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Robson A.S. Santos, Maria Jose Campagnole-Santos
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (18): 2197–2216.
https://doi.org/10.1042/CS20210599
Published: 21 September 2021
View article titled, Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein
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Includes: Supplementary data
Articles

A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang, Cheng Yang, Li Yu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1751–1765.
https://doi.org/10.1042/CS20210571
Published: 27 July 2021
View article titled, A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis
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Includes: Supplementary data
Articles

Promyelocytic leukemia protein: an atherosclerosis suppressor protein?

Cali B. Corbett, Amanda K. St. Paul, Michael V. Autieri
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1557–1561.
https://doi.org/10.1042/CS20210314
Published: 30 June 2021
View article titled, Promyelocytic leukemia protein: an atherosclerosis suppressor protein?
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Articles

Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis

André Felipe Rodrigues, Mihail Todiras, Fatimunnisa Qadri, Maria Jose Campagnole-Santos, Natalia Alenina, Michael Bader
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1353–1367.
https://doi.org/10.1042/CS20210072
Published: 02 June 2021
View article titled, Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis
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Includes: Supplementary data
Articles

Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver

Ying-Yin Sun, Dong-Qing Wu, Na-Na Yin, Lei Yang, Xin Chen, Hai-Di Li, Xiao-Feng Li, Cheng Huang, Xiao-Ming Meng, Hua Wang, Jun Li
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1213–1232.
https://doi.org/10.1042/CS20201363
Published: 20 May 2021
View article titled, Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver
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Includes: Supplementary data
Articles

Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury

Yanjun Liu, Jiacheng Li, Liping Liao, Heming Huang, Shijie Fan, Rong Fu, Jing Huang, Cuicui Shi, Liang Yu, Kai-xian Chen, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 925–941.
https://doi.org/10.1042/CS20201111
Published: 14 April 2021
View article titled, Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury
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Includes: Supplementary data
Articles

Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress

Xiaoguang Sun, Belinda L. Sun, Saad Sammani, Tadeo Bermudez, Steven M. Dudek, Sara M. Camp, Joe G.N. Garcia
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 963–977.
https://doi.org/10.1042/CS20201448
Published: 14 April 2021
View article titled, Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress
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Articles

Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Kana N. Miyata, Chao-Sheng Lo, Shuiling Zhao, Min-Chun Liao, Yuchao Pang, Shiao-Ying Chang, Junzheng Peng, Matthias Kretzler, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 943–961.
https://doi.org/10.1042/CS20210094
Published: 14 April 2021
View article titled, Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice
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Includes: Supplementary data
Articles

CRIP1 expression in monocytes related to hypertension

Olga Schweigert, Julia Adler, Natalie Längst, Dylan Aïssi, Jorge Duque Escobar, Teng Tong, Christian Müller, David-Alexandre Trégouët, Robert Lukowski, Tanja Zeller
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 911–924.
https://doi.org/10.1042/CS20201372
Published: 12 April 2021
View article titled, CRIP1 expression in monocytes related to hypertension
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Includes: Supplementary data
Articles

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries

Weronika Karle, Samuel Becker, Philipp Stenzel, Christoph Knosalla, Günter Siegel, Oliver Baum, Andreas Zakrzewicz, Janine Berkholz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 887–905.
https://doi.org/10.1042/CS20201399
Published: 09 April 2021
View article titled, Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries
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Includes: Supplementary data
Articles

Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen

Carlos M. Ferrario, Leanne Groban, Hao Wang, Sarfaraz Ahmad
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 907–910.
https://doi.org/10.1042/CS20210163
Published: 09 April 2021
View article titled, Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen
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Articles

EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics

Fang-Jing Zhong, Yi-Ming Li, Cong Xu, Bo Sun, Ji-Long Wang, Lian-Yue Yang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 847–864.
https://doi.org/10.1042/CS20201500
Published: 06 April 2021
View article titled, EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics
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Includes: Supplementary data
Articles

KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages

Mu-xing Li, Hang-yan Wang, Chun-hui Yuan, Zhao-lai Ma, Bin Jiang, Lei Li, Li Zhang, Dian-rong Xiu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (4): 629–649.
https://doi.org/10.1042/CS20201259
Published: 22 February 2021
View article titled, KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages
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Includes: Supplementary data
Articles

Acid sphingomyelinase promotes SGK1-dependent vascular calcification

Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (3): 515–534.
https://doi.org/10.1042/CS20201122
Published: 03 February 2021
View article titled, Acid sphingomyelinase promotes SGK1-dependent vascular calcification
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Includes: Supplementary data
Articles

The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling

Xueying Hu, Liang Xiang, Dong He, Rongrong Zhu, Jianing Fang, Zhanwang Wang, Ke Cao
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (3): 555–574.
https://doi.org/10.1042/CS20200908
Published: 03 February 2021
View article titled, The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling
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Includes: Supplementary data
Articles

Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1

Min Gao, Tianyi Yu, Dan Liu, Yan Shi, Peilang Yang, Jie Zhang, Jizhuang Wang, Yan Liu, Xiong Zhang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (2): 347–365.
https://doi.org/10.1042/CS20200573
Published: 27 January 2021
View article titled, Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1
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Articles

Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 185–200.
https://doi.org/10.1042/CS20201060
Published: 08 January 2021
View article titled, Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids
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Includes: Supplementary data
Articles

Mechanisms involved in the adaptation of Escherichia coli O157:H7 to the host intestinal microenvironment

In Collection
Protein structure and function
Romina J. Fernandez-Brando, Sean P. McAteer, Johanna Montañez-Culma, Yennifer Cortés-Araya, Jai Tree, Alan Bernal, Federico Fuentes, Stephen Fitzgerald, Gonzalo E. Pineda, M. Victoria Ramos, David L. Gally, Marina S. Palermo
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3283–3301.
https://doi.org/10.1042/CS20200971
Published: 21 December 2020
View article titled, Mechanisms involved in the adaptation of Escherichia coli O157:H7 to the host intestinal microenvironment
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Includes: Supplementary data
Articles

Epigenetic silencing of miR564 contributes to the leukemogenesis of t(8;21) acute myeloid leukemia

Erna Yang, Wei Guan, Desheng Gong, Xuefeng Gao, Caixia Han, Juan Zhang, Hong Wang, Mengzhen Wang, Yonghui Li, Li Yu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3079–3091.
https://doi.org/10.1042/CS20200786
Published: 02 December 2020
View article titled, Epigenetic silencing of miR564 contributes to the leukemogenesis of t(8;21) acute myeloid leukemia
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Includes: Supplementary data
Articles

Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

Hung-Tsung Wu, Lin Kang, Yu-Chu Su, Horng-Yih Ou, Fu-Yu Chan, Yi-Cheng Chen, Bing-Hua Su, Yi-Shiang Wang, Chao-Liang Wu, Ai-Li Shiau, Pensée Wu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2435–2445.
https://doi.org/10.1042/CS20200147
Published: 25 September 2020
View article titled, Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes
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Articles

Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation

Te Li, Lijuan Ding, Yonggang Wang, Ou Yang, Shudong Wang, Jian Kong
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2353–2368.
https://doi.org/10.1042/CS20191241
Published: 10 September 2020
View article titled, Genetic deficiency of Phactr1 promotes atherosclerosis development via facilitating M1 macrophage polarization and foam cell formation
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Includes: Supplementary data
Articles

The role of protein arginine methyltransferases in kidney diseases

Chunyun Zhang, Shougang Zhuang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
https://doi.org/10.1042/CS20200680
Published: 07 August 2020
View article titled, The role of protein arginine methyltransferases in kidney diseases
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Articles

RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer

Huaiming Wang, Rongkang Huang, Wentai Guo, Xiusen Qin, Zifeng Yang, Zixu Yuan, Yingqi Wei, Chunlin Mo, Zhantao Zeng, Jian Luo, Jian Cai, Hui Wang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1973–1990.
https://doi.org/10.1042/CS20191174
Published: 28 July 2020
View article titled, RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer
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Includes: Supplementary data
Articles

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

Hai-Di Li, Xin Chen, Jie-Jie Xu, Xiao-Sa Du, Yang Yang, Juan-Juan Li, Xiao-Juan Yang, Hui-Min Huang, Xiao-Feng Li, Ming-Fei Wu, Chong Zhang, Chao Zhang, Zeng Li, Hua Wang, Xiao-Ming Meng, Cheng Huang, Jun Li
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1935–1956.
https://doi.org/10.1042/CS20200031
Published: 23 July 2020
View article titled, DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway
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Includes: Supplementary data
Articles

Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury

Jose L. Viñas, Christopher J. Porter, Adrianna Douvris, Matthew Spence, Alex Gutsol, Joseph A. Zimpelmann, Karishma Tailor, Pearl A. Campbell, Kevin D. Burns
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1887–1909.
https://doi.org/10.1042/CS20200168
Published: 23 July 2020
View article titled, Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury
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Includes: Supplementary data
Articles

Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway

Xinglong Dai, Jianjun Liu, Xiong Guo, Anqi Cheng, Xiaoya Deng, Liqun Guo, Ziwei Wang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1821–1839.
https://doi.org/10.1042/CS20191043
Published: 17 July 2020
View article titled, Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway
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Articles

A long noncoding RNA CHAIR protects the heart from pathological stress

Yanxia Qian, Mingming Zhang, Ningtian Zhou, Xiaohan Xu, Jiahui Zhang, Qiang Ding, Junhong Wang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1843–1857.
https://doi.org/10.1042/CS20200149
Published: 17 July 2020
View article titled, A long noncoding RNA CHAIR protects the heart from pathological stress
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Articles

DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways

Chetan P. Hans, Neekun Sharma, Rishabh Dev, Jones M. Blain, Jeff Tonniges, Gunjan Agarwal
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1555–1572.
https://doi.org/10.1042/CS20200456
Published: 25 June 2020
View article titled, DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways
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Includes: Supplementary data
Articles

Deregulation of miRNAs-cMYC circuits is a key event in refractory celiac disease type-2 lymphomagenesis

Valentina Vaira, Gabriella Gaudioso, Maria Antonella Laginestra, Andrea Terrasi, Claudio Agostinelli, Silvano Bosari, Antonio Di Sabatino, Alessandro Vanoli, Marco Paulli, Stefano Ferrero, Leda Roncoroni, Vincenza Lombardo, Liyanage P. Perera, Sonia Fabris, Maurizio Vecchi, Stefano Pileri, Luca Elli
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (10): 1151–1166.
https://doi.org/10.1042/CS20200032
Published: 22 May 2020
View article titled, Deregulation of miRNAs-cMYC circuits is a key event in refractory celiac disease type-2 lymphomagenesis
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Includes: Supplementary data
Articles

From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia

Sonya Frazier, Martin W. McBride, Helen Mulvana, Delyth Graham
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
https://doi.org/10.1042/CS20200023
Published: 27 April 2020
View article titled, From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia
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Articles

Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs

Jinhui Lü, Qian Zhao, Xin Ding, Yuefan Guo, Yuan Li, Zhen Xu, Shujun Li, Zhongrui Wang, Lei Shen, Huang-wen Chen, Zuoren Yu, Richard G. Pestell
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 791–805.
https://doi.org/10.1042/CS20191318
Published: 09 April 2020
View article titled, Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs
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Includes: Supplementary data
Articles

Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats

Suchismita Dutta, Andrew Lai, Katherin Scholz-Romero, Muhammad J. A. Shiddiky, Yusuke Yamauchi, Jay S. Mishra, Gregory E. Rice, Jon Hyett, Sathish Kumar, Carlos Salomon
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (6): 593–607.
https://doi.org/10.1042/CS20191155
Published: 24 March 2020
View article titled, Hypoxia-induced small extracellular vesicle proteins regulate proinflammatory cytokines and systemic blood pressure in pregnant rats
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Includes: Supplementary data
Articles

IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease

Lauretta D. Low, Liangjian Lu, Chang-Yien Chan, Jinmiao Chen, Henry H. Yang, Hanry Yu, Caroline G.L. Lee, Kar-Hui Ng, Hui-Kim Yap
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (2): 225–237.
https://doi.org/10.1042/CS20190961
Published: 27 January 2020
View article titled, IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease
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Includes: Supplementary data
Articles

Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women

In Collection
Clinical and translational research highlights
Kenny Schlosser, Amanpreet Kaur, Natalie Dayan, Duncan J. Stewart, Louise Pilote, Christian Delles
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (2): 87–101.
https://doi.org/10.1042/CS20190920
Published: 21 January 2020
View article titled, Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women
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Includes: Supplementary data