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Articles

Beneficial effects of brief early life angiotensin-converting enzyme inhibition wane with time in sheep with solitary functioning kidney

Zoe McArdle, Reetu R. Singh, Helle Bielefeldt-Ohmann, Karen M. Moritz, Kate M. Denton, Michiel F. Schreuder

Clin Sci (Lond) (2023) 137 (8): 603–615.

DOI: https://doi.org/10.1042/CS20220811

Published: 19 April 2023

View article titled, Beneficial effects of brief early life angiotensin-converting enzyme inhibition wane with time in sheep with solitary functioning kidney

Articles

Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Guochao Song, Fengyi Weng, Bin Zou, Jing Zhao, Jingyi Jin, Dongming Yan, Kai Huang, Xin Sun, Chenghai Liu, Yiyang Hu, Yue Li, Furong Qiu

Clin Sci (Lond) (2023) 137 (7): 561–577.

DOI: https://doi.org/10.1042/CS20220674

Published: 13 April 2023

View article titled, Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Includes: Supplementary data

Articles

Skin-specific mechanisms of body fluid regulation in hypertension

Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M. Touyz, Christian Delles, Giacomo Rossitto

Clin Sci (Lond) (2023) 137 (3): 239–250.

DOI: https://doi.org/10.1042/CS20220609

Published: 07 February 2023

View article titled, Skin-specific mechanisms of body fluid regulation in hypertension

Includes: Supplementary data

Articles

Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype

Brian C. Belyea, Fang Xu, Margaret Wiltsie, Hayes Fountain, Jennifer Charlton, Agnes B. Fogo, Maria Luisa Soledad Sequeira-Lopez, Roberto Ariel Gomez

Clin Sci (Lond) (2023) 137 (1): 35–45.

DOI: https://doi.org/10.1042/CS20220496

Published: 05 January 2023

View article titled, Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype

Includes: Supplementary data

Articles

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Justine Gillard, Isabelle A. Leclercq

Clin Sci (Lond) (2023) 137 (1): 65–85.

DOI: https://doi.org/10.1042/CS20220697

Published: 05 January 2023

View article titled, Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Articles

Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice

Shu-Huei Wang, Feng-Chiao Tsai, Heng-Huei Lin, Tse-Ya Yu, Chun-Heng Kuo, Hung-Yuan Li, Mao-Shin Lin

Clin Sci (Lond) (2023) 137 (1): 17–30.

DOI: https://doi.org/10.1042/CS20220477

Published: 03 January 2023

View article titled, Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice

Articles

The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models

Aliye Uc, Birgitta Strandvik, Jianrong Yao, Xiaoming Liu, Yaling Yi, Xingshen Sun, Ruth Welti, John F. Engelhardt, Andrew W. Norris

Clin Sci (Lond) (2022) 136 (24): 1773–1791.

DOI: https://doi.org/10.1042/CS20220450

Published: 13 December 2022

View article titled, The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models

Includes: Supplementary data

Articles

The nonindustrialised microbiome in a modern world

Fergus Shanahan, Tarini S. Ghosh, Michael G. Molloy, Paul W. O’Toole

Clin Sci (Lond) (2022) 136 (22): 1683–1690.

DOI: https://doi.org/10.1042/CS20220203

Published: 23 November 2022

View article titled, The nonindustrialised microbiome in a modern world

Articles

α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats

Hui-Chun Huang, Ching-Chih Chang, Chon Kit Pun, Ming-Hung Tsai, Chiao-Lin Chuang, Shao-Jung Hsu, Yi-Hsiang Huang, Ming-Chih Hou, Fa-Yauh Lee

Clin Sci (Lond) (2022) 136 (20): 1449–1466.

DOI: https://doi.org/10.1042/CS20220290

Published: 26 October 2022

View article titled, α-Adrenergic blockade prevented environmental temperature reduction-induced transient portal pressure surge in cirrhotic and portal hypertensive rats

Includes: Supplementary data

Articles

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver

Clin Sci (Lond) (2022) 136 (19): 1405–1423.

DOI: https://doi.org/10.1042/CS20210889

Published: 14 October 2022

View article titled, Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Includes: Supplementary data

Articles

Hypertension and renal disease programming: focus on the early postnatal period

Maria Florencia Albertoni Borghese, Lucas Humberto Oronel, Maria Del Carmen Ortiz, Mónica Patricia Majowicz

Clin Sci (Lond) (2022) 136 (17): 1303–1339.

DOI: https://doi.org/10.1042/CS20220293

Published: 08 September 2022

View article titled, Hypertension and renal disease programming: focus on the early postnatal period

Articles

Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Pedro Alves Soares Vaz de Castro, Pedro A. Jose, Ana Cristina Simões e Silva

Clin Sci (Lond) (2022) 136 (16): 1205–1227.

DOI: https://doi.org/10.1042/CS20220338

Published: 18 August 2022

View article titled, Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure

Articles

Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Federico F. De Ponti, Charlotte L. Scott

Clin Sci (Lond) (2022) 136 (15): 1111–1115.

DOI: https://doi.org/10.1042/CS20220258

Published: 01 August 2022

View article titled, Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

In Collection

Cardiovascular-Oncology

Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen

Clin Sci (Lond) (2022) 136 (9): 675–694.

DOI: https://doi.org/10.1042/CS20220182

Published: 10 May 2022

View article titled, Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

Includes: Supplementary data

Articles

ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer

Ting-Yu Chang, Kuo-Cheng Lan, Chen-Yuan Chiu, Meei-Ling Sheu, Shing-Hwa Liu

Clin Sci (Lond) (2022) 136 (9): 657–673.

DOI: https://doi.org/10.1042/CS20220043

Published: 06 May 2022

View article titled, ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer

Includes: Supplementary data

Articles

Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva

Clin Sci (Lond) (2022) 136 (8): 557–577.

DOI: https://doi.org/10.1042/CS20220095

Published: 21 April 2022

View article titled, Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease

Includes: Supplementary data

Articles

Microbiota transplantation in portal hypertension: promises and pitfalls

Emilie K. Mitten, György Baffy

Clin Sci (Lond) (2022) 136 (6): 425–429.

DOI: https://doi.org/10.1042/CS20220029

Published: 25 March 2022

View article titled, Microbiota transplantation in portal hypertension: promises and pitfalls

Articles

MicroRNAs as messengers of liver diseases: has the message finally been decrypted?

Carlos J. Pirola, Silvia Sookoian

Clin Sci (Lond) (2022) 136 (5): 323–328.

DOI: https://doi.org/10.1042/CS20211177

Published: 02 March 2022

View article titled, MicroRNAs as messengers of liver diseases: has the message finally been decrypted?

Articles

The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease

Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L.Y. Cheing, Yaoming Xue, Yijie Jia

Clin Sci (Lond) (2022) 136 (3): 223–238.

DOI: https://doi.org/10.1042/CS20210470

Published: 07 February 2022

View article titled, The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease

Includes: Supplementary data

Articles

AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang

Clin Sci (Lond) (2022) 136 (1): 103–120.

DOI: https://doi.org/10.1042/CS20211075

Published: 07 January 2022

View article titled, AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Includes: Supplementary data

Articles

Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction

Xiaohong Xiang, Guie Dong, Jiefu Zhu, Gang Zhang, Zheng Dong

Clin Sci (Lond) (2022) 136 (1): 45–60.

DOI: https://doi.org/10.1042/CS20210823

Published: 05 January 2022

View article titled, Inhibition of HDAC3 protects against kidney cold storage/transplantation injury and allograft dysfunction

Includes: Supplementary data

Articles

The acute pressure natriuresis response is suppressed by selective ET A receptor blockade

Geoffrey Culshaw, David Binnie, Neeraj Dhaun, Patrick Hadoke, Matthew Bailey, David J Webb

Clin Sci (Lond) (2021) CS20210937.

DOI: https://doi.org/10.1042/CS20210937

Published: 17 December 2021

View article titled, The acute pressure natriuresis response is suppressed by selective ET A receptor blockade

Articles

Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats

Sheon Mary, Philipp Boder, Giacomo Rossitto, Lesley Graham, Kayley Scott, Arun Flynn, David Kipgen, Delyth Graham, Christian Delles

Clin Sci (Lond) (2021) 135 (24): 2749–2761.

DOI: https://doi.org/10.1042/CS20211017

Published: 17 December 2021

View article titled, Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats

Includes: Supplementary data

Articles

Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats

Hui-Chun Huang, Ming-Hung Tsai, Ching-Chih Chang, Chon Kit Pun, Yi-Hsiang Huang, Ming-Chih Hou, Fa-Yauh Lee, Shao-Jung Hsu

Clin Sci (Lond) (2021) 135 (24): 2709–2728.

DOI: https://doi.org/10.1042/CS20210602

Published: 15 December 2021

View article titled, Microbiota transplants from feces or gut content attenuated portal hypertension and portosystemic collaterals in cirrhotic rats

Includes: Supplementary data

Articles

Paternal long-term PM 2.5 exposure causes hypertension via increased renal AT 1 R expression and function in male offspring

Cuimei Hu, Yu Tao, Yi Deng, Qi Cai, Hongmei Ren, Cheng Yu, Shuo Zheng, Jian Yang, Chunyu Zeng

Clin Sci (Lond) (2021) 135 (22): 2575–2588.

DOI: https://doi.org/10.1042/CS20210802

Published: 26 November 2021

View article titled, Paternal long-term PM 2.5 exposure causes hypertension via increased renal AT 1 R expression and function in male offspring

Articles

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

Laura Wilson, Alice E. Pollard, Lucy Penfold, Phillip J. Muckett, Chad Whilding, Mohammad Bohlooly-Y., Patricia Wilson, David Carling

Clin Sci (Lond) (2021) 135 (20): 2393–2408.

DOI: https://doi.org/10.1042/CS20210821

Published: 22 October 2021

View article titled, Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype

Includes: Supplementary data

Articles

Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

Samuele Iesari, Isabelle Leclercq, Nicolas Joudiou, Mina Komuta, Aurélie Daumerie, Jérôme Ambroise, Alexandra Dili, Natacha Feza-Bingi, Daela Xhema, Caroline Bouzin, Bernard Gallez, Francesco Pisani, Eliano Bonaccorsi-Riani, Pierre Gianello

Clin Sci (Lond) (2021) 135 (19): 2285–2305.

DOI: https://doi.org/10.1042/CS20210183

Published: 13 October 2021

View article titled, Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection

Includes: Supplementary data

Articles

Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats

Ellen E. Gillis, Kasey Belanger, Mahmoud Abdelbary, Riyaz Mohamed, Jingping Sun, Michael W. Brands, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (19): 2329–2339.

DOI: https://doi.org/10.1042/CS20210469

Published: 13 October 2021

View article titled, Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats

Articles

Autoimmune-mediated renal disease and hypertension

Erika I. Boesen, Rahul M. Kakalij

Clin Sci (Lond) (2021) 135 (17): 2165–2196.

DOI: https://doi.org/10.1042/CS20200955

Published: 17 September 2021

View article titled, Autoimmune-mediated renal disease and hypertension

Articles

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu, Haibo Long

Clin Sci (Lond) (2021) 135 (15): 1873–1895.

DOI: https://doi.org/10.1042/CS20210447

Published: 06 August 2021

View article titled, Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis

Includes: Supplementary data

Articles

Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT 1a receptors in the proximal tubule of the kidney

Ana Paula Oliveira Leite, Xiao C. Li, Rumana Hassan, Xiaowen Zheng, Barbara Alexander, Dulce Elena Casarini, Jia L. Zhuo

Clin Sci (Lond) (2021) 135 (15): 1825–1843.

DOI: https://doi.org/10.1042/CS20201574

Published: 04 August 2021

View article titled, Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT 1a receptors in the proximal tubule of the kidney

Articles

Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

In Collection

Coronavirus

Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini, Mariane Bertagnolli

Clin Sci (Lond) (2021) 135 (15): 1805–1824.

DOI: https://doi.org/10.1042/CS20210284

Published: 02 August 2021

View article titled, Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

Articles

Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis

André Felipe Rodrigues, Mihail Todiras, Fatimunnisa Qadri, Maria Jose Campagnole-Santos, Natalia Alenina, Michael Bader

Clin Sci (Lond) (2021) 135 (11): 1353–1367.

DOI: https://doi.org/10.1042/CS20210072

Published: 02 June 2021

View article titled, Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis

Includes: Supplementary data

Articles

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu, Lin Sun

Clin Sci (Lond) (2021) 135 (10): 1273–1288.

DOI: https://doi.org/10.1042/CS20210061

Published: 26 May 2021

View article titled, Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

Articles

Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury

Yanjun Liu, Jiacheng Li, Liping Liao, Heming Huang, Shijie Fan, Rong Fu, Jing Huang, Cuicui Shi, Liang Yu, Kai-xian Chen, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li

Clin Sci (Lond) (2021) 135 (7): 925–941.

DOI: https://doi.org/10.1042/CS20201111

Published: 14 April 2021

View article titled, Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury

Includes: Supplementary data

Articles

Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Kana N. Miyata, Chao-Sheng Lo, Shuiling Zhao, Min-Chun Liao, Yuchao Pang, Shiao-Ying Chang, Junzheng Peng, Matthias Kretzler, Janos G. Filep, Julie R. Ingelfinger, Shao-Ling Zhang, John S.D. Chan

Clin Sci (Lond) (2021) 135 (7): 943–961.

DOI: https://doi.org/10.1042/CS20210094

Published: 14 April 2021

View article titled, Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

Includes: Supplementary data

Articles

Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia

Ming Fu, Ledong Tan, Zefeng Lin, Vincent C.H. Lui, Paul K.H. Tam, Jonathan R. Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Chen

Clin Sci (Lond) (2021) 135 (7): 865–884.

DOI: https://doi.org/10.1042/CS20201366

Published: 09 April 2021

View article titled, Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia

Includes: Supplementary data

Articles

EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics

Fang-Jing Zhong, Yi-Ming Li, Cong Xu, Bo Sun, Ji-Long Wang, Lian-Yue Yang

Clin Sci (Lond) (2021) 135 (7): 847–864.

DOI: https://doi.org/10.1042/CS20201500

Published: 06 April 2021

View article titled, EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics

Includes: Supplementary data

Articles

Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis

Dandan Dou, Jinghui Liang, Xiangyu Zhai, Guosheng Li, Hongjuan Wang, Liying Han, Lin Lin, Yifei Ren, Shilian Liu, Chuanyong Liu, Wei Guo, Jingxin Li

Clin Sci (Lond) (2021) 135 (4): 597–611.

DOI: https://doi.org/10.1042/CS20201438

Published: 18 February 2021

View article titled, Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis

Includes: Supplementary data

Articles

Absence of interleukin-10 reduces progression of shiga toxin-induced hemolytic uremic syndrome

Gonzalo Ezequiel Pineda, Bárbara Rearte, María Florencia Todero, Andrea Cecilia Bruballa, Alan Mauro Bernal, Romina Jimena Fernandez-Brando, Martin Amadeo Isturiz, Elsa Zotta, Catalina Dirney Alba-Soto, Marina Sandra Palermo, María Victoria Ramos

Clin Sci (Lond) (2021) 135 (3): 575–588.

DOI: https://doi.org/10.1042/CS20200468

Published: 10 February 2021

View article titled, Absence of interleukin-10 reduces progression of shiga toxin-induced hemolytic uremic syndrome

Articles

Gastrin, via activation of PPARα, protects the kidney against hypertensive injury

Daqian Gu, Dandong Fang, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Donghai Yang, Xue Zou, Yukai Liu, Wei Eric Wang, Gengze Wu, Pedro A. Jose, Yu Han, Chunyu Zeng

Clin Sci (Lond) (2021) 135 (2): 409–427.

DOI: https://doi.org/10.1042/CS20201340

Published: 29 January 2021

View article titled, Gastrin, via activation of PPARα, protects the kidney against hypertensive injury

Includes: Supplementary data

Articles

DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway

Renzo Boldorini, Nausicaa Clemente, Elisa Alchera, Rita Carini

Clin Sci (Lond) (2021) 135 (1): 161–166.

DOI: https://doi.org/10.1042/CS20201091

Published: 08 January 2021

View article titled, DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway

Articles

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Jakob Voelkl, Daniela Egli-Spichtig, Ioana Alesutan, Carsten A. Wagner

Clin Sci (Lond) (2021) 135 (1): 201–227.

DOI: https://doi.org/10.1042/CS20190895

Published: 08 January 2021

View article titled, Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Articles

Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization

Chuanjian Suo, Zeping Gui, Zijie Wang, Jiajun Zhou, Ming Zheng, Hao Chen, Shuang Fei, Min Gu, Ruoyun Tan

Clin Sci (Lond) (2021) 135 (1): 53–69.

DOI: https://doi.org/10.1042/CS20201038

Published: 05 January 2021

View article titled, Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization

Includes: Supplementary data

Articles

Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Ravindra K. Sharma, Jing Li, Suraj Krishnan, Elaine M. Richards, Mohan K. Raizada, Rajesh Mohandas

Clin Sci (Lond) (2021) 135 (1): 1–17.

DOI: https://doi.org/10.1042/CS20200482

Published: 05 January 2021

View article titled, Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases

Articles

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Sarah L. Walton, Katrina M. Mirabito Colafella, Aneesa Ansari, Siew Yeen Chai, Kate M. Denton

Clin Sci (Lond) (2020) 134 (23): 3213–3228.

DOI: https://doi.org/10.1042/CS20201233

Published: 11 December 2020

View article titled, Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

Includes: Supplementary data

Articles

ACE2: from protection of liver disease to propagation of COVID-19

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Fiona J. Warner, Harinda Rajapaksha, Nicholas Shackel, Chandana B. Herath

Clin Sci (Lond) (2020) 134 (23): 3137–3158.

DOI: https://doi.org/10.1042/CS20201268

Published: 07 December 2020

View article titled, ACE2: from protection of liver disease to propagation of COVID-19

Articles

SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in Type 2 diabetes

Erik J.M. van Bommel, Frank Geurts, Marcel H.A. Muskiet, Adrian Post, Stephan J.L. Bakker, A.H. Jan Danser, Daan J. Touw, Miranda van Berkel, Mark H.H. Kramer, Max Nieuwdorp, Ele Ferrannini, Jaap A. Joles, Ewout J. Hoorn, Daniël H. van Raalte

Clin Sci (Lond) (2020) 134 (23): 3107–3118.

DOI: https://doi.org/10.1042/CS20201274

Published: 02 December 2020

View article titled, SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in Type 2 diabetes

Includes: Supplementary data

Articles

ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Tatiane Cristine Silva de Almeida, Katharina Lanza, Roberta da Silva Filha, Leda Maria de Castro C. Campos, Esdras G. Fonseca, Mariana W. Chagas, Natalia Pessoa Rocha, Marcos Augusto de Sá, Maria Aparecida Ribeiro Vieira, Marcelo Vidigal Caliari, Lucas M. Kangussu, Anderson José Ferreira, Ana Cristina Simões e Silva

Clin Sci (Lond) (2020) 134 (23): 3093–3106.

DOI: https://doi.org/10.1042/CS20201022

Published: 02 December 2020

View article titled, ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats

Articles

Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice

Gayathri K. Balasuriya, Mitra Mohsenipour, Kurt Brassington, Aleksandar Dobric, Simone N. De Luca, Kevin Mou, Huei Jiunn Seow, Chalystha Yie Qin Lee, Madushani Herath, Stanley M.H. Chan, Ross Vlahos, Elisa L. Hill-Yardin

Clin Sci (Lond) (2020) 134 (22): 2943–2957.

DOI: https://doi.org/10.1042/CS20200886

Published: 16 November 2020

View article titled, Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice

Includes: Supplementary data

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