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Articles

Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D 1 R expression

Yu Tao, Wenbin Luo, Yue Chen, Caiyu Chen, Shengnan Chen, Xiaoping Li, Ken Chen, Chunyu Zeng

Clin Sci (Lond) (2023) 137 (17): 1391–1407.

https://doi.org/10.1042/CS20230664

Published: 07 September 2023

View article titled, Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D 1 R expression

Includes: Supplementary data

Articles

Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis

Qiaoli Tang, Wanting Shi, Ming Liu, Liqin Tang, Wei Ren, Shaolin Shi

Clin Sci (Lond) (2023) 137 (15): 1195–1208.

https://doi.org/10.1042/CS20230164

Published: 10 August 2023

View article titled, Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis

Includes: Supplementary data

Articles

Regulation of cholesterol homeostasis in osteoporosis mechanisms and therapeutics

Chuncha Bao, Tao Wu, Siyi Zhu, Xiaoyi Wang, Yujia Zhang, Xiangxiu Wang, Lin Yang, Chengqi He

Clin Sci (Lond) (2023) 137 (15): 1131–1143.

https://doi.org/10.1042/CS20220752

Published: 09 August 2023

View article titled, Regulation of cholesterol homeostasis in osteoporosis mechanisms and therapeutics

Articles

DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity

Ming Yang, Qin Zhang, Shilu Luo, Yachun Han, Hao Zhao, Na Jiang, Yan Liu, Li Li, Chenrui Li, Chongbin Liu, Liyu He, Xuejing Zhu, Yu Liu, Lin Sun

Clin Sci (Lond) (2023) 137 (12): 931–945.

https://doi.org/10.1042/CS20220787

Published: 20 June 2023

View article titled, DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity

Includes: Supplementary data

Articles

High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro

Aiwen Shen, Yu Wang, Guoxin Ye, Jianping Mao, Qian Zhang, Jing Chen

Clin Sci (Lond) (2023) 137 (12): 947–962.

https://doi.org/10.1042/CS20220754

Published: 20 June 2023

View article titled, High sodium promotes the secretion and synthesis of PTH through PiT-1-IKKβ pathway in parathyroid gland in vitro

Includes: Supplementary data

Articles

Assessing hypothalamic pituitary gonadal function in reproductive disorders

In Collection

Reproductive Physiology and Disease

Kanyada Koysombat, Waljit S. Dhillo, Ali Abbara

Clin Sci (Lond) (2023) 137 (11): 863–879.

https://doi.org/10.1042/CS20220146

Published: 05 June 2023

View article titled, Assessing hypothalamic pituitary gonadal function in reproductive disorders

Articles

NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Alena Karnošová, Veronika Strnadová, Blanka Železná, Jaroslav Kuneš, Petr Kašpárek, Lenka Maletínská

Clin Sci (Lond) (2023) 137 (10): 847–862.

https://doi.org/10.1042/CS20220880

Published: 31 May 2023

View article titled, NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Includes: Supplementary data

Articles

The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Miranda J. Melis, Muska Miller, Vera B.M. Peters, Mervyn Singer

Clin Sci (Lond) (2023) 137 (9): 707–725.

https://doi.org/10.1042/CS20220709

Published: 05 May 2023

View article titled, The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Articles

Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy

Wenyan Gong, Qibin Jiao, Jinghua Yuan, Hui Luo, Yingying Liu, Yuanyuan Zhang, Zhen Chen, Xiaoling Xu, Lin Bai, Xingwei Zhang

Clin Sci (Lond) (2023) 137 (6): 511–525.

https://doi.org/10.1042/CS20220874

Published: 24 March 2023

View article titled, Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy

Articles

Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome

Jinshan Xing, Gan Qiao, Xin Luo, Shuang Liu, Shaokun Chen, Geng Ye, Chunxiang Zhang, Jingyan Yi

Clin Sci (Lond) (2023) 137 (6): 453–468.

https://doi.org/10.1042/CS20220408

Published: 21 March 2023

View article titled, Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome

Articles

Skin-specific mechanisms of body fluid regulation in hypertension

Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M. Touyz, Christian Delles, Giacomo Rossitto

Clin Sci (Lond) (2023) 137 (3): 239–250.

https://doi.org/10.1042/CS20220609

Published: 07 February 2023

View article titled, Skin-specific mechanisms of body fluid regulation in hypertension

Includes: Supplementary data

Articles

Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

In Collection

Reproductive Physiology and Disease

Hana Horackova, Veronika Vachalova, Cilia Abad, Rona Karahoda, Frantisek Staud

Clin Sci (Lond) (2023) 137 (2): 149–161.

https://doi.org/10.1042/CS20220726

Published: 18 January 2023

View article titled, Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

Articles

The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

In Collection

Reproductive Physiology and Disease

Kyle M. Siemers, Michelle L. Baack

Clin Sci (Lond) (2023) 137 (1): 31–34.

https://doi.org/10.1042/CS20220657

Published: 03 January 2023

View article titled, The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

Articles

Fifty years of impact on treating bone disease: a commentary on Gasser et al.

Elena L. Dent, Michael J. Ryan

Clin Sci (Lond) (2022) 136 (22): 1657–1659.

https://doi.org/10.1042/CS20220040

Published: 21 November 2022

View article titled, Fifty years of impact on treating bone disease: a commentary on Gasser et al.

Articles

Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Philip C. Calder

Clin Sci (Lond) (2022) 136 (13): 1019–1023.

https://doi.org/10.1042/CS20220380

Published: 01 July 2022

View article titled, Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Articles

Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Arno Téblick, Jan Gunst, Lies Langouche, Greet Van den Berghe

Clin Sci (Lond) (2022) 136 (11): 861–878.

https://doi.org/10.1042/CS20211003

Published: 01 June 2022

View article titled, Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Articles

Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis

Mark Hedley Vickers

Clin Sci (Lond) (2022) 136 (10): 711–714.

https://doi.org/10.1042/CS20211175

Published: 16 May 2022

View article titled, Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis

Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

In Collection

Cardiovascular-Oncology

Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen

Clin Sci (Lond) (2022) 136 (9): 675–694.

https://doi.org/10.1042/CS20220182

Published: 10 May 2022

View article titled, Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

Includes: Supplementary data

Articles

There is more to life than serum vitamin D: a lesson from the past

Martin Hewison

Clin Sci (Lond) (2022) 136 (8): 639–642.

https://doi.org/10.1042/CS20211176

Published: 27 April 2022

View article titled, There is more to life than serum vitamin D: a lesson from the past

Articles

Oxytocin: much more than childbirth and milk letdown

Morley D. Hollenberg

Clin Sci (Lond) (2021) 135 (17): 2121–2126.

https://doi.org/10.1042/CS20210180

Published: 10 September 2021

View article titled, Oxytocin: much more than childbirth and milk letdown

Articles

Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2021) 135 (17): 2103–2119.

https://doi.org/10.1042/CS20210628

Published: 06 September 2021

View article titled, Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Includes: Supplementary data

Articles

Klotho and calciprotein particles as therapeutic targets against accelerated ageing

Makoto Kuro-o

Clin Sci (Lond) (2021) 135 (15): 1915–1927.

https://doi.org/10.1042/CS20201453

Published: 10 August 2021

View article titled, Klotho and calciprotein particles as therapeutic targets against accelerated ageing

Articles

Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed

Clin Sci (Lond) (2021) 135 (14): 1773–1789.

https://doi.org/10.1042/CS20210549

Published: 30 July 2021

View article titled, Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Includes: Supplementary data

Articles

Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

George W. Booz, Gaelle P. Massoud, Raffaele Altara, Fouad A. Zouein

Clin Sci (Lond) (2021) 135 (14): 1767–1772.

https://doi.org/10.1042/CS20210524

Published: 27 July 2021

View article titled, Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

Articles

Fifty years of research on the brain renin–angiotensin system: what have we learned?

Edwyn O. Cruz-López, Estrellita Uijl, A.H. Jan Danser

Clin Sci (Lond) (2021) 135 (14): 1727–1731.

https://doi.org/10.1042/CS20210579

Published: 22 July 2021

View article titled, Fifty years of research on the brain renin–angiotensin system: what have we learned?

Articles

Phosphate and fibroblast growth factor 23 in diabetes

Amarens van der Vaart, Stanley M.H. Yeung, Peter R. van Dijk, Stephan J.L. Bakker, Martin H. de Borst

Clin Sci (Lond) (2021) 135 (14): 1669–1687.

https://doi.org/10.1042/CS20201290

Published: 20 July 2021

View article titled, Phosphate and fibroblast growth factor 23 in diabetes

Articles

IGF2 deficiency causes mitochondrial defects in skeletal muscle

Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin

Clin Sci (Lond) (2021) 135 (7): 979–990.

https://doi.org/10.1042/CS20210128

Published: 16 April 2021

View article titled, IGF2 deficiency causes mitochondrial defects in skeletal muscle

Includes: Supplementary data

Articles

Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Carlos M. Ferrario

Clin Sci (Lond) (2021) 135 (5): 683–686.

https://doi.org/10.1042/CS20210017

Published: 02 March 2021

View article titled, Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Articles

ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Xi Cao, Li-Ni Song, Jin-Kui Yang

Clin Sci (Lond) (2021) 135 (3): 535–554.

https://doi.org/10.1042/CS20200752

Published: 03 February 2021

View article titled, ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders

Articles

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Jakob Voelkl, Daniela Egli-Spichtig, Ioana Alesutan, Carsten A. Wagner

Clin Sci (Lond) (2021) 135 (1): 201–227.

https://doi.org/10.1042/CS20190895

Published: 08 January 2021

View article titled, Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Articles

Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Amy Catherine Kelly, Anita Kramer, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2020) 134 (23): 3123–3136.

https://doi.org/10.1042/CS20201050

Published: 07 December 2020

View article titled, Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Includes: Supplementary data

Articles

ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Koichi Yamamoto, Hikari Takeshita, Hiromi Rakugi

Clin Sci (Lond) (2020) 134 (22): 3047–3062.

https://doi.org/10.1042/CS20200486

Published: 24 November 2020

View article titled, ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

Includes: Supplementary data

Articles

Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Fernando M. Reis, Adelina M. Reis

Clin Sci (Lond) (2020) 134 (22): 2929–2941.

https://doi.org/10.1042/CS20200865

Published: 16 November 2020

View article titled, Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions

Articles

Brain angiotensin converting enzyme-2 in central cardiovascular regulation

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Mazher Mohammed, Clara Berdasco, Eric Lazartigues

Clin Sci (Lond) (2020) 134 (19): 2535–2547.

https://doi.org/10.1042/CS20200483

Published: 05 October 2020

View article titled, Brain angiotensin converting enzyme-2 in central cardiovascular regulation

Articles

TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy

Barbara Toffoli, Federica Tonon, Veronica Tisato, Andrea Michelli, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi

Clin Sci (Lond) (2020) 134 (17): 2337–2352.

https://doi.org/10.1042/CS20201004

Published: 10 September 2020

View article titled, TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy

Includes: Supplementary data

Articles

Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Frédéric Clarembeau, Georgia Bale, Nicolas Lanthier

Clin Sci (Lond) (2020) 134 (16): 2117–2135.

https://doi.org/10.1042/CS20200022

Published: 21 August 2020

View article titled, Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Articles

Ctcf is required for renin expression and maintenance of the structural integrity of the kidney

Maria Florencia Martinez, Alexandre G. Martini, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez

Clin Sci (Lond) (2020) 134 (13): 1763–1774.

https://doi.org/10.1042/CS20200184

Published: 10 July 2020

View article titled, Ctcf is required for renin expression and maintenance of the structural integrity of the kidney

Includes: Supplementary data

Articles

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

Lingling Shu, Ling Zhong, Yang Xiao, Xiaoping Wu, Yang Liu, Xue Jiang, Tao Tang, RubyLaiChong Hoo, Zhiguang Zhou, Aimin Xu

Clin Sci (Lond) (2020) 134 (13): 1679–1696.

https://doi.org/10.1042/CS20200021

Published: 07 July 2020

View article titled, Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

Includes: Supplementary data

Articles

Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway

Xiaohong Sun, Kaipeng Huang, Xiao Haiming, Zeyuan Lin, Yan Yang, Meng Zhang, Peiqing Liu, Heqing Huang

Clin Sci (Lond) (2020) 134 (13): 1573–1592.

https://doi.org/10.1042/CS20200171

Published: 30 June 2020

View article titled, Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway

Articles

Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis

Xinhuan Su, Ying Zhao, Yang Li, Shizhan Ma, Zhe Wang

Clin Sci (Lond) (2020) 134 (12): 1521–1535.

https://doi.org/10.1042/CS20200475

Published: 25 June 2020

View article titled, Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis

Includes: Supplementary data

Articles

Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers

Man K.S. Lee, Gopalkrishna Sreejit, Prabhakara R. Nagareddy, Andrew J. Murphy

Clin Sci (Lond) (2020) 134 (12): 1399–1401.

https://doi.org/10.1042/CS20200240

Published: 18 June 2020

View article titled, Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers

Articles

Impaired insulin exocytosis in chronic hepatitis C infection: contributory role of p38δ MAPK–protein kinase D–golgi complex axis

Parimala Narne

Clin Sci (Lond) (2020) 134 (12): 1449–1456.

https://doi.org/10.1042/CS20200686

Published: 18 June 2020

View article titled, Impaired insulin exocytosis in chronic hepatitis C infection: contributory role of p38δ MAPK–protein kinase D–golgi complex axis

Articles

TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Shaojun Li, Wei Cao, Bai Wang, Enbo Zhan, Jian Xu, Shufeng Li

Clin Sci (Lond) (2020) 134 (12): 1319–1331.

https://doi.org/10.1042/CS20200249

Published: 16 June 2020

View article titled, TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling

Includes: Supplementary data

Articles

Resolution of drug-resistant hypertension by adrenal vein sampling-guided adrenalectomy: a proof-of-concept study

Francesca Torresan, Giacomo Rossitto, Valeria Bisogni, Silvia Lerco, Giuseppe Maiolino, Maurizio Cesari, Rui Zhu, Maurizio Iacobone, Teresa Maria Seccia, Gian Paolo Rossi

Clin Sci (Lond) (2020) 134 (11): 1265–1278.

https://doi.org/10.1042/CS20200340

Published: 15 June 2020

View article titled, Resolution of drug-resistant hypertension by adrenal vein sampling-guided adrenalectomy: a proof-of-concept study

Includes: Supplementary data

Articles

Placental function in maternal obesity

Amy C. Kelly, Theresa L. Powell, Thomas Jansson

Clin Sci (Lond) (2020) 134 (8): 961–984.

https://doi.org/10.1042/CS20190266

Published: 21 April 2020

View article titled, Placental function in maternal obesity

Articles

Renal functional effects of the highly selective AT 2 R agonist, β-Pro 7 Ang III, in normotensive rats

Lucinda M. Hilliard Krause, Brandon A. Kemp, Amanda Suan Jui Tan, Emma S. Jones, Mark P. Del Borgo, Marie-Isabel Aguilar, Kate M. Denton, Robert M. Carey, Robert E. Widdop

Clin Sci (Lond) (2020) 134 (7): 871–884.

https://doi.org/10.1042/CS20200153

Published: 14 April 2020

View article titled, Renal functional effects of the highly selective AT 2 R agonist, β-Pro 7 Ang III, in normotensive rats

Articles

Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling

Yingjin Qiao, Pei Wang, Mingyang Chang, Bohan Chen, Yan Ge, Deepak K. Malhotra, Lance D. Dworkin, Rujun Gong

Clin Sci (Lond) (2020) 134 (7): 695–710.

https://doi.org/10.1042/CS20200016

Published: 30 March 2020

View article titled, Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling

Articles

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Lucas F. Almeida, Signe S. Tofteng, Kirsten Madsen, Boye L. Jensen

Clin Sci (Lond) (2020) 134 (6): 641–656.

https://doi.org/10.1042/CS20190765

Published: 27 March 2020

View article titled, Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Articles

Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

Jizheng Chen, Fang Wang, Yue Zhou, Jing Jiang, Sulaiman Ksimu, Xu Zhang, John Zhong Li, Junqi Niu, Qian Wang

Clin Sci (Lond) (2020) 134 (5): 529–542.

https://doi.org/10.1042/CS20190900

Published: 13 March 2020

View article titled, Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells

Includes: Supplementary data

Articles

Endoplasmic reticulum stress occurs in association with the extrusion of toxic extracellular vesicles from human placentae treated with antiphospholipid antibodies

Yunhui Tang, Yan Chen, Yohanes Nursalim, Katie Groom, Anthony Hickey, Larry Chamley, Qi Chen

Clin Sci (Lond) (2020) 134 (5): 459–472.

https://doi.org/10.1042/CS20191245

Published: 04 March 2020

View article titled, Endoplasmic reticulum stress occurs in association with the extrusion of toxic extracellular vesicles from human placentae treated with antiphospholipid antibodies

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