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Articles

NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose

Alena Karnošová, Veronika Strnadová, Blanka Železná, Jaroslav Kuneš, Petr Kašpárek, Lenka Maletínská
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 847–862.
DOI: https://doi.org/10.1042/CS20220880
Published: 31 May 2023
View article titled, NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose
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Includes: Supplementary data
Articles

Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (10): 823–841.
DOI: https://doi.org/10.1042/CS20230433
Published: 31 May 2023
View article titled, Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity
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Includes: Supplementary data
Articles

DsbA-L alleviated tubular injury in diabetic nephropathy via activating mitophagy through maintain MAM integrity

Lin Sun, Ming Yang, Qin Zhang, Shilu Luo, Yachun Han, Hao Zhao, Na Jiang, Yan Liu, Li Li, Chenrui Li, Chongbin Liu, Liyu He, Xuejing Zhu, Yu Liu
Journal: Clinical Science
Clin Sci (Lond) (2023) CS20220787.
DOI: https://doi.org/10.1042/CS20220787
Published: 25 May 2023
View article titled, DsbA-L alleviated tubular injury in diabetic nephropathy via activating mitophagy through maintain MAM integrity
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Articles

Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

Xiaodi Zhang, Jean L.J.M. Scheijen, Coen D.A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 697–706.
DOI: https://doi.org/10.1042/CS20220753
Published: 26 April 2023
View article titled, Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose
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Includes: Supplementary data
Articles

Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity

In Collection
Reproductive Physiology and Disease
Jerad H. Dumolt, Fredrick J. Rosario, Avery C. Kramer, Stacee Horwitz, Theresa L. Powell, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 663–678.
DOI: https://doi.org/10.1042/CS20220890
Published: 21 April 2023
View article titled, Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity
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Articles

Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy

Wenyan Gong, Qibin Jiao, Jinghua Yuan, Hui Luo, Yingying Liu, Yuanyuan Zhang, Zhen Chen, Xiaoling Xu, Lin Bai, Xingwei Zhang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 511–525.
DOI: https://doi.org/10.1042/CS20220874
Published: 24 March 2023
View article titled, Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy
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Articles

Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome

Jinshan Xing, Gan Qiao, Xin Luo, Shuang Liu, Shaokun Chen, Geng Ye, Chunxiang Zhang, Jingyan Yi
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 453–468.
DOI: https://doi.org/10.1042/CS20220408
Published: 21 March 2023
View article titled, Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome
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Articles

Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen

Zhipeng Tao, Zhiyong Cheng
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (6): 415–434.
DOI: https://doi.org/10.1042/CS20210519
Published: 21 March 2023
View article titled, Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen
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Articles

The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 87–104.
DOI: https://doi.org/10.1042/CS20220447
Published: 05 January 2023
View article titled, The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy
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Includes: Supplementary data
Articles

Set7 methyltransferase roles in myocardial protection from chronic stressors

James T. Pearson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 105–108.
DOI: https://doi.org/10.1042/CS20220773
Published: 05 January 2023
View article titled, Set7 methyltransferase roles in myocardial protection from chronic stressors
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Articles

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Justine Gillard, Isabelle A. Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 65–85.
DOI: https://doi.org/10.1042/CS20220697
Published: 05 January 2023
View article titled, Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease
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Articles

Small extracellular vesicles: a new player in GDM pathogenesis

In Collection
Reproductive Physiology and Disease
Agafe Bless Reyes, Dylan Burger
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1873–1875.
DOI: https://doi.org/10.1042/CS20220658
Published: 22 December 2022
View article titled, Small extracellular vesicles: a new player in GDM pathogenesis
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Articles

Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1851–1871.
DOI: https://doi.org/10.1042/CS20220636
Published: 22 December 2022
View article titled, Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases
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Articles

Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1711–1730.
DOI: https://doi.org/10.1042/CS20220242
Published: 30 November 2022
View article titled, Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling
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Includes: Supplementary data
Articles

Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1631–1651.
DOI: https://doi.org/10.1042/CS20220404
Published: 16 November 2022
View article titled, Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease
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Articles

Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia

Raghavendar Chandran, Lianying He, Xingju Nie, Joshua Voltin, Sarah Jamil, Caren Doueiry, Maria Fatima Falangola, Adviye Ergul, Weiguo Li
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1555–1570.
DOI: https://doi.org/10.1042/CS20220465
Published: 10 November 2022
View article titled, Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia
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Includes: Supplementary data
Articles

A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

In Collection
Reproductive Physiology and Disease
Laura B James-Allan, Frederick J Rosario, Lana Madi, Kelsey Barner, Soumyalekshmi Nair, Andrew Lai, Flavio Carrion, Theresa L Powell, Carlos Salomon, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1535–1549.
DOI: https://doi.org/10.1042/CS20220484
Published: 03 November 2022
View article titled, A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice
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Includes: Supplementary data
Articles

Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1485–1511.
DOI: https://doi.org/10.1042/CS20220205
Published: 03 November 2022
View article titled, Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats
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Includes: Supplementary data
Articles

Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms

Kalie L. Tommerdahl, Jessica Kendrick, Robert G. Nelson, Petter Bjornstad
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1471–1483.
DOI: https://doi.org/10.1042/CS20210627
Published: 02 November 2022
View article titled, Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms
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Articles

Measuring muscle protein synthesis in humans and the influence of nutritional state

Philip C. Calder, Nicolaas E.P. Deutz
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (19): 1425–1431.
DOI: https://doi.org/10.1042/CS20211171
Published: 14 October 2022
View article titled, Measuring muscle protein synthesis in humans and the influence of nutritional state
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Articles

Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways

Olufunto O. Badmus, Sarah A. Hillhouse, Christopher D. Anderson, Terry D. Hinds, Jr, David E. Stec
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (18): 1347–1366.
DOI: https://doi.org/10.1042/CS20220572
Published: 23 September 2022
View article titled, Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways
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Articles

Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Federico F. De Ponti, Charlotte L. Scott
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (15): 1111–1115.
DOI: https://doi.org/10.1042/CS20220258
Published: 01 August 2022
View article titled, Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis
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Articles

Targeting skeletal muscle mitochondrial health in obesity

Chantal A. Pileggi, Breana G. Hooks, Ruth McPherson, Robert R.M. Dent, Mary-Ellen Harper
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (14): 1081–1110.
DOI: https://doi.org/10.1042/CS20210506
Published: 27 July 2022
View article titled, Targeting skeletal muscle mitochondrial health in obesity
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Articles

Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Philip C. Calder
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1019–1023.
DOI: https://doi.org/10.1042/CS20220380
Published: 01 July 2022
View article titled, Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease
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Articles

The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol, Frédéric Jaisser
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (12): 1005–1017.
DOI: https://doi.org/10.1042/CS20220212
Published: 29 June 2022
View article titled, The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease
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Articles

Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes

Naila Rabbani
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 819–824.
DOI: https://doi.org/10.1042/CS20220099
Published: 30 May 2022
View article titled, Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes
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Articles

Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis

Laila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (9): 643–656.
DOI: https://doi.org/10.1042/CS20211122
Published: 04 May 2022
View article titled, Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis
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Includes: Supplementary data
Articles

Mechanisms of podocyte injury and implications for diabetic nephropathy

Federica Barutta, Stefania Bellini, Gabriella Gruden
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (7): 493–520.
DOI: https://doi.org/10.1042/CS20210625
Published: 13 April 2022
View article titled, Mechanisms of podocyte injury and implications for diabetic nephropathy
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Articles

Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 345–360.
DOI: https://doi.org/10.1042/CS20210512
Published: 09 March 2022
View article titled, Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs
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Articles

Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms

Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina I. Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian V. Zhang, A.H. Jan Danser, Qing Yang, Xiujun Fan
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (4): 257–272.
DOI: https://doi.org/10.1042/CS20210989
Published: 14 February 2022
View article titled, Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms
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Includes: Supplementary data
Articles

The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease

Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L.Y. Cheing, Yaoming Xue, Yijie Jia
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 223–238.
DOI: https://doi.org/10.1042/CS20210470
Published: 07 February 2022
View article titled, The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease
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Includes: Supplementary data
Articles

Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (2): 167–180.
DOI: https://doi.org/10.1042/CS20210865
Published: 20 January 2022
View article titled, Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease
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Includes: Supplementary data
Articles

Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity

Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (1): 121–137.
DOI: https://doi.org/10.1042/CS20210959
Published: 07 January 2022
View article titled, Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity
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Includes: Supplementary data
Articles

The acute pressure natriuresis response is suppressed by selective ET A receptor blockade

Geoffrey Culshaw, David Binnie, Neeraj Dhaun, Patrick Hadoke, Matthew Bailey, David J Webb
Journal: Clinical Science
Clin Sci (Lond) (2021) CS20210937.
DOI: https://doi.org/10.1042/CS20210937
Published: 17 December 2021
View article titled, The acute pressure natriuresis response is suppressed by selective ET A receptor blockade
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Articles

AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A. Boisvert, Thomas Unger, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2763–2780.
DOI: https://doi.org/10.1042/CS20210971
Published: 17 December 2021
View article titled, AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet
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Includes: Supplementary data
Articles

Asthma and obesity: endotoxin another insult to add to injury?

Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2729–2748.
DOI: https://doi.org/10.1042/CS20210790
Published: 17 December 2021
View article titled, Asthma and obesity: endotoxin another insult to add to injury?
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Articles

Sex differences in white adipose tissue expansion: emerging molecular mechanisms

Simon T. Bond, Anna C. Calkin, Brian G. Drew
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2691–2708.
DOI: https://doi.org/10.1042/CS20210086
Published: 15 December 2021
View article titled, Sex differences in white adipose tissue expansion: emerging molecular mechanisms
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Articles

Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Andris Elksnis, Tomas A Schiffer, Fredrik Palm, Yun Wang, Jing Cen, Kyril Turpaev, Anongnad Ngamjariyawat, Shady Younis, Suling Huang, Yu Shen, Ying Leng, Peter Bergsten, Tony Karlsborn, Nils Welsh, Xuan Wang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2243–2263.
DOI: https://doi.org/10.1042/CS20210604
Published: 08 October 2021
View article titled, Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
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Includes: Supplementary data
Articles

Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2103–2119.
DOI: https://doi.org/10.1042/CS20210628
Published: 06 September 2021
View article titled, Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress
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Includes: Supplementary data
Articles

Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
DOI: https://doi.org/10.1042/CS20210549
Published: 30 July 2021
View article titled, Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice
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Includes: Supplementary data
Articles

Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress

Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1689–1706.
DOI: https://doi.org/10.1042/CS20210198
Published: 20 July 2021
View article titled, Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress
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Includes: Supplementary data
Articles

Phosphate and fibroblast growth factor 23 in diabetes

Amarens van der Vaart, Stanley M.H. Yeung, Peter R. van Dijk, Stephan J.L. Bakker, Martin H. de Borst
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1669–1687.
DOI: https://doi.org/10.1042/CS20201290
Published: 20 July 2021
View article titled, Phosphate and fibroblast growth factor 23 in diabetes
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Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
DOI: https://doi.org/10.1042/CS20190768
Published: 07 July 2021
View article titled, Nutrient regulation of inflammatory signalling in obesity and vascular disease
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Articles

Obesity-associated cardiovascular risk in women: hypertension and heart failure

Jessica L. Faulkner
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
DOI: https://doi.org/10.1042/CS20210384
Published: 23 June 2021
View article titled, Obesity-associated cardiovascular risk in women: hypertension and heart failure
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Articles

Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Darnel Prakoso, Mitchel Tate, Miles J. De Blasio, Rebecca H. Ritchie
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1369–1387.
DOI: https://doi.org/10.1042/CS20210052
Published: 02 June 2021
View article titled, Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives
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Articles

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1103–1126.
DOI: https://doi.org/10.1042/CS20201339
Published: 11 May 2021
View article titled, Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction
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Includes: Supplementary data
Articles

C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
DOI: https://doi.org/10.1042/CS20210049
Published: 11 May 2021
View article titled, C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors
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Includes: Supplementary data
Articles

The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting

Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1015–1051.
DOI: https://doi.org/10.1042/CS20201445
Published: 21 April 2021
View article titled, The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting
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Articles

IGF2 deficiency causes mitochondrial defects in skeletal muscle

Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 979–990.
DOI: https://doi.org/10.1042/CS20210128
Published: 16 April 2021
View article titled, IGF2 deficiency causes mitochondrial defects in skeletal muscle
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Includes: Supplementary data
Articles

The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 731–752.
DOI: https://doi.org/10.1042/CS20200895
Published: 17 March 2021
View article titled, The complex role of adipokines in obesity, inflammation, and autoimmunity
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