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Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

Xiaodi Zhang, Jean LJM Scheijen, Coen D.A. Stehouwer, Kristiaan Wouters, Casper Schalkwijk

Clin Sci (Lond) (2023) CS20220753.

DOI: https://doi.org/10.1042/CS20220753

Published: 20 January 2023

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The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler

Clin Sci (Lond) (2023) 137 (1): 87–104.

DOI: https://doi.org/10.1042/CS20220447

Published: 05 January 2023

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Set7 methyltransferase roles in myocardial protection from chronic stressors

James T. Pearson

Clin Sci (Lond) (2023) 137 (1): 105–108.

DOI: https://doi.org/10.1042/CS20220773

Published: 05 January 2023

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Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Justine Gillard, Isabelle A. Leclercq

Clin Sci (Lond) (2023) 137 (1): 65–85.

DOI: https://doi.org/10.1042/CS20220697

Published: 05 January 2023

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Small extracellular vesicles: a new player in GDM pathogenesis

Agafe Bless Reyes, Dylan Burger

Clin Sci (Lond) (2022) 136 (24): 1873–1875.

DOI: https://doi.org/10.1042/CS20220658

Published: 22 December 2022

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Structural functionality of skeletal muscle mitochondria and its correlation with metabolic diseases

Gourabamani Swalsingh, Punyadhara Pani, Naresh C. Bal

Clin Sci (Lond) (2022) 136 (24): 1851–1871.

DOI: https://doi.org/10.1042/CS20220636

Published: 22 December 2022

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Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2022) 136 (22): 1711–1730.

DOI: https://doi.org/10.1042/CS20220242

Published: 30 November 2022

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Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi

Clin Sci (Lond) (2022) 136 (22): 1631–1651.

DOI: https://doi.org/10.1042/CS20220404

Published: 16 November 2022

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Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia

Raghavendar Chandran, Lianying He, Xingju Nie, Joshua Voltin, Sarah Jamil, Caren Doueiry, Maria Fatima Falangola, Adviye Ergul, Weiguo Li

Clin Sci (Lond) (2022) 136 (21): 1555–1570.

DOI: https://doi.org/10.1042/CS20220465

Published: 10 November 2022

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A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

Laura B James-Allan, Frederick J Rosario, Lana Madi, Kelsey Barner, Soumyalekshmi Nair, Andrew Lai, Flavio Carrion, Theresa L Powell, Carlos Salomon, Thomas Jansson

Clin Sci (Lond) (2022) 136 (21): 1535–1549.

DOI: https://doi.org/10.1042/CS20220484

Published: 03 November 2022

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Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty

Clin Sci (Lond) (2022) 136 (21): 1485–1511.

DOI: https://doi.org/10.1042/CS20220205

Published: 03 November 2022

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Youth versus adult-onset type 2 diabetic kidney disease: Insights into currently known structural differences and the potential underlying mechanisms

Kalie L. Tommerdahl, Jessica Kendrick, Robert G. Nelson, Petter Bjornstad

Clin Sci (Lond) (2022) 136 (21): 1471–1483.

DOI: https://doi.org/10.1042/CS20210627

Published: 02 November 2022

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Measuring muscle protein synthesis in humans and the influence of nutritional state

Philip C. Calder, Nicolaas E.P. Deutz

Clin Sci (Lond) (2022) 136 (19): 1425–1431.

DOI: https://doi.org/10.1042/CS20211171

Published: 14 October 2022

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Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways

Olufunto O. Badmus, Sarah A. Hillhouse, Christopher D. Anderson, Terry D. Hinds, Jr, David E. Stec

Clin Sci (Lond) (2022) 136 (18): 1347–1366.

DOI: https://doi.org/10.1042/CS20220572

Published: 23 September 2022

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Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Federico F. De Ponti, Charlotte L. Scott

Clin Sci (Lond) (2022) 136 (15): 1111–1115.

DOI: https://doi.org/10.1042/CS20220258

Published: 01 August 2022

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Targeting skeletal muscle mitochondrial health in obesity

Chantal A. Pileggi, Breana G. Hooks, Ruth McPherson, Robert R.M. Dent, Mary-Ellen Harper

Clin Sci (Lond) (2022) 136 (14): 1081–1110.

DOI: https://doi.org/10.1042/CS20210506

Published: 27 July 2022

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Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Philip C. Calder

Clin Sci (Lond) (2022) 136 (13): 1019–1023.

DOI: https://doi.org/10.1042/CS20220380

Published: 01 July 2022

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The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol, Frédéric Jaisser

Clin Sci (Lond) (2022) 136 (12): 1005–1017.

DOI: https://doi.org/10.1042/CS20220212

Published: 29 June 2022

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Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes

Naila Rabbani

Clin Sci (Lond) (2022) 136 (11): 819–824.

DOI: https://doi.org/10.1042/CS20220099

Published: 30 May 2022

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Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis

Laila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti

Clin Sci (Lond) (2022) 136 (9): 643–656.

DOI: https://doi.org/10.1042/CS20211122

Published: 04 May 2022

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Mechanisms of podocyte injury and implications for diabetic nephropathy

Federica Barutta, Stefania Bellini, Gabriella Gruden

Clin Sci (Lond) (2022) 136 (7): 493–520.

DOI: https://doi.org/10.1042/CS20210625

Published: 13 April 2022

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Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin

Clin Sci (Lond) (2022) 136 (5): 345–360.

DOI: https://doi.org/10.1042/CS20210512

Published: 09 March 2022

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Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms

Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina I. Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian V. Zhang, A.H. Jan Danser, Qing Yang, Xiujun Fan

Clin Sci (Lond) (2022) 136 (4): 257–272.

DOI: https://doi.org/10.1042/CS20210989

Published: 14 February 2022

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The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease

Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L.Y. Cheing, Yaoming Xue, Yijie Jia

Clin Sci (Lond) (2022) 136 (3): 223–238.

DOI: https://doi.org/10.1042/CS20210470

Published: 07 February 2022

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Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm

Clin Sci (Lond) (2022) 136 (2): 167–180.

DOI: https://doi.org/10.1042/CS20210865

Published: 20 January 2022

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Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity

Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh

Clin Sci (Lond) (2022) 136 (1): 121–137.

DOI: https://doi.org/10.1042/CS20210959

Published: 07 January 2022

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The acute pressure natriuresis response is suppressed by selective ET A receptor blockade

Geoffrey Culshaw, David Binnie, Neeraj Dhaun, Patrick Hadoke, Matthew Bailey, David J Webb

Clin Sci (Lond) (2021) CS20210937.

DOI: https://doi.org/10.1042/CS20210937

Published: 17 December 2021

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AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A. Boisvert, Thomas Unger, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega

Clin Sci (Lond) (2021) 135 (24): 2763–2780.

DOI: https://doi.org/10.1042/CS20210971

Published: 17 December 2021

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Asthma and obesity: endotoxin another insult to add to injury?

Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan

Clin Sci (Lond) (2021) 135 (24): 2729–2748.

DOI: https://doi.org/10.1042/CS20210790

Published: 17 December 2021

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Sex differences in white adipose tissue expansion: emerging molecular mechanisms

Simon T. Bond, Anna C. Calkin, Brian G. Drew

Clin Sci (Lond) (2021) 135 (24): 2691–2708.

DOI: https://doi.org/10.1042/CS20210086

Published: 15 December 2021

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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Andris Elksnis, Tomas A Schiffer, Fredrik Palm, Yun Wang, Jing Cen, Kyril Turpaev, Anongnad Ngamjariyawat, Shady Younis, Suling Huang, Yu Shen, Ying Leng, Peter Bergsten, Tony Karlsborn, Nils Welsh, Xuan Wang

Clin Sci (Lond) (2021) 135 (19): 2243–2263.

DOI: https://doi.org/10.1042/CS20210604

Published: 08 October 2021

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Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2021) 135 (17): 2103–2119.

DOI: https://doi.org/10.1042/CS20210628

Published: 06 September 2021

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Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed

Clin Sci (Lond) (2021) 135 (14): 1773–1789.

DOI: https://doi.org/10.1042/CS20210549

Published: 30 July 2021

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Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress

Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu

Clin Sci (Lond) (2021) 135 (14): 1689–1706.

DOI: https://doi.org/10.1042/CS20210198

Published: 20 July 2021

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Phosphate and fibroblast growth factor 23 in diabetes

Amarens van der Vaart, Stanley M.H. Yeung, Peter R. van Dijk, Stephan J.L. Bakker, Martin H. de Borst

Clin Sci (Lond) (2021) 135 (14): 1669–1687.

DOI: https://doi.org/10.1042/CS20201290

Published: 20 July 2021

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Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt

Clin Sci (Lond) (2021) 135 (13): 1563–1590.

DOI: https://doi.org/10.1042/CS20190768

Published: 07 July 2021

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Obesity-associated cardiovascular risk in women: hypertension and heart failure

Jessica L. Faulkner

Clin Sci (Lond) (2021) 135 (12): 1523–1544.

DOI: https://doi.org/10.1042/CS20210384

Published: 23 June 2021

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Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Darnel Prakoso, Mitchel Tate, Miles J. De Blasio, Rebecca H. Ritchie

Clin Sci (Lond) (2021) 135 (11): 1369–1387.

DOI: https://doi.org/10.1042/CS20210052

Published: 02 June 2021

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Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira

Clin Sci (Lond) (2021) 135 (9): 1103–1126.

DOI: https://doi.org/10.1042/CS20201339

Published: 11 May 2021

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C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza

Clin Sci (Lond) (2021) 135 (9): 1145–1163.

DOI: https://doi.org/10.1042/CS20210049

Published: 11 May 2021

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The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting

Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi

Clin Sci (Lond) (2021) 135 (8): 1015–1051.

DOI: https://doi.org/10.1042/CS20201445

Published: 21 April 2021

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IGF2 deficiency causes mitochondrial defects in skeletal muscle

Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin

Clin Sci (Lond) (2021) 135 (7): 979–990.

DOI: https://doi.org/10.1042/CS20210128

Published: 16 April 2021

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The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor

Clin Sci (Lond) (2021) 135 (6): 731–752.

DOI: https://doi.org/10.1042/CS20200895

Published: 17 March 2021

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Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhang

Clin Sci (Lond) (2021) 135 (4): 613–627.

DOI: https://doi.org/10.1042/CS20201145

Published: 18 February 2021

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Diabetes mellitus: a primary metabolic disturbance. Metabolomics underlying vascular responses to stress and ischemia?

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Celebrating 100 years of insulin research

Evangelos Oikonomou, Costas Tsioufis, Dimitris Tousoulis

Clin Sci (Lond) (2021) 135 (3): 589–591.

DOI: https://doi.org/10.1042/CS20201299

Published: 10 February 2021

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ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34 + cells derived from diabetic older adults

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus

Shrinidh Joshi, Ildamaris Montes de Oca, Ahmad Maghrabi, Christine Lopez-Yang, Julio Quiroz-Olvera, Charles A. Garcia, Yagna Prasada Rao Jarajapu

Clin Sci (Lond) (2021) 135 (2): 367–385.

DOI: https://doi.org/10.1042/CS20201133

Published: 27 January 2021

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β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat

James T. Pearson, Hamish P. Thambyah, Mark T. Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P. Ngo, Connie P.C. Ow, Takashi Sonobe, Yi Ching Chen, Amanda J. Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J. Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Clin Sci (Lond) (2021) 135 (2): 327–346.

DOI: https://doi.org/10.1042/CS20201441

Published: 22 January 2021

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The GCN5: its biological functions and therapeutic potentials

Md. Ezazul Haque, Md. Jakaria, Mahbuba Akther, Duk-Yeon Cho, In-Su Kim, Dong-Kug Choi

Clin Sci (Lond) (2021) 135 (1): 231–257.

DOI: https://doi.org/10.1042/CS20200986

Published: 14 January 2021

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Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder

Clin Sci (Lond) (2021) 135 (1): 185–200.

DOI: https://doi.org/10.1042/CS20201060

Published: 08 January 2021

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Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases

Mona Elgazzaz, Eric Lazartigues

Clin Sci (Lond) (2021) 135 (1): 127–142.

DOI: https://doi.org/10.1042/CS20201287

Published: 08 January 2021

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