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Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes

Naila Rabbani

Clin Sci (Lond) (2022) 136 (11): 819–824.

DOI: https://doi.org/10.1042/CS20220099

Published: 30 May 2022

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Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis

Laila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti

Clin Sci (Lond) (2022) 136 (9): 643–656.

DOI: https://doi.org/10.1042/CS20211122

Published: 04 May 2022

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Mechanisms of podocyte injury and implications for diabetic nephropathy

Federica Barutta, Stefania Bellini, Gabriella Gruden

Clin Sci (Lond) (2022) 136 (7): 493–520.

DOI: https://doi.org/10.1042/CS20210625

Published: 13 April 2022

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Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin

Clin Sci (Lond) (2022) 136 (5): 345–360.

DOI: https://doi.org/10.1042/CS20210512

Published: 09 March 2022

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Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms

Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina I. Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian V. Zhang, A.H. Jan Danser, Qing Yang, Xiujun Fan

Clin Sci (Lond) (2022) 136 (4): 257–272.

DOI: https://doi.org/10.1042/CS20210989

Published: 14 February 2022

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The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease

Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L.Y. Cheing, Yaoming Xue, Yijie Jia

Clin Sci (Lond) (2022) 136 (3): 223–238.

DOI: https://doi.org/10.1042/CS20210470

Published: 07 February 2022

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Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm

Clin Sci (Lond) (2022) 136 (2): 167–180.

DOI: https://doi.org/10.1042/CS20210865

Published: 20 January 2022

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Augmented CCL5/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity

Pei-Chi Chan, Li-Man Hung, Jiung-Pang Huang, Yuan-Ji Day, Chao-Lan Yu, Feng-Chih Kuo, Chieh-Hua Lu, Yu-Feng Tian, Po-Shiuan Hsieh

Clin Sci (Lond) (2022) 136 (1): 121–137.

DOI: https://doi.org/10.1042/CS20210959

Published: 07 January 2022

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The acute pressure natriuresis response is suppressed by selective ET A receptor blockade

Geoffrey Culshaw, David Binnie, Neeraj Dhaun, Patrick Hadoke, Matthew Bailey, David J Webb

Clin Sci (Lond) (2021) CS20210937.

DOI: https://doi.org/10.1042/CS20210937

Published: 17 December 2021

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AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A. Boisvert, Thomas Unger, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega

Clin Sci (Lond) (2021) 135 (24): 2763–2780.

DOI: https://doi.org/10.1042/CS20210971

Published: 17 December 2021

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Asthma and obesity: endotoxin another insult to add to injury?

Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan

Clin Sci (Lond) (2021) 135 (24): 2729–2748.

DOI: https://doi.org/10.1042/CS20210790

Published: 17 December 2021

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Sex differences in white adipose tissue expansion: emerging molecular mechanisms

Simon T. Bond, Anna C. Calkin, Brian G. Drew

Clin Sci (Lond) (2021) 135 (24): 2691–2708.

DOI: https://doi.org/10.1042/CS20210086

Published: 15 December 2021

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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Andris Elksnis, Tomas A Schiffer, Fredrik Palm, Yun Wang, Jing Cen, Kyril Turpaev, Anongnad Ngamjariyawat, Shady Younis, Suling Huang, Yu Shen, Ying Leng, Peter Bergsten, Tony Karlsborn, Nils Welsh, Xuan Wang

Clin Sci (Lond) (2021) 135 (19): 2243–2263.

DOI: https://doi.org/10.1042/CS20210604

Published: 08 October 2021

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Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2021) 135 (17): 2103–2119.

DOI: https://doi.org/10.1042/CS20210628

Published: 06 September 2021

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Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed

Clin Sci (Lond) (2021) 135 (14): 1773–1789.

DOI: https://doi.org/10.1042/CS20210549

Published: 30 July 2021

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Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress

Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu, Junhui Liu

Clin Sci (Lond) (2021) 135 (14): 1689–1706.

DOI: https://doi.org/10.1042/CS20210198

Published: 20 July 2021

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Phosphate and fibroblast growth factor 23 in diabetes

Amarens van der Vaart, Stanley M.H. Yeung, Peter R. van Dijk, Stephan J.L. Bakker, Martin H. de Borst

Clin Sci (Lond) (2021) 135 (14): 1669–1687.

DOI: https://doi.org/10.1042/CS20201290

Published: 20 July 2021

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Nutrient regulation of inflammatory signalling in obesity and vascular disease

Timothy M. Palmer, Ian P. Salt

Clin Sci (Lond) (2021) 135 (13): 1563–1590.

DOI: https://doi.org/10.1042/CS20190768

Published: 07 July 2021

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Obesity-associated cardiovascular risk in women: hypertension and heart failure

Jessica L. Faulkner

Clin Sci (Lond) (2021) 135 (12): 1523–1544.

DOI: https://doi.org/10.1042/CS20210384

Published: 23 June 2021

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Adeno-associated viral (AAV) vector-mediated therapeutics for diabetic cardiomyopathy – current and future perspectives

Darnel Prakoso, Mitchel Tate, Miles J. De Blasio, Rebecca H. Ritchie

Clin Sci (Lond) (2021) 135 (11): 1369–1387.

DOI: https://doi.org/10.1042/CS20210052

Published: 02 June 2021

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C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza

Clin Sci (Lond) (2021) 135 (9): 1145–1163.

DOI: https://doi.org/10.1042/CS20210049

Published: 11 May 2021

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Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira, Ludgero C. Tavares, Ana I. Duarte, Inês Baldeiras, Teresa Cunha-Oliveira, João D. Martins, Maria S. Santos, Alina Maloyan, António J. Moreno, Laura A. Cox, Cun Li, Peter W. Nathanielsz, Mark J. Nijland, Paulo J. Oliveira

Clin Sci (Lond) (2021) 135 (9): 1103–1126.

DOI: https://doi.org/10.1042/CS20201339

Published: 11 May 2021

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The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting

Rana A. Alaaeddine, Ibrahim AlZaim, Safaa H. Hammoud, Aya Arakji, Ali H. Eid, Khaled S. Abd-Elrahman, Ahmed F. El-Yazbi

Clin Sci (Lond) (2021) 135 (8): 1015–1051.

DOI: https://doi.org/10.1042/CS20201445

Published: 21 April 2021

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IGF2 deficiency causes mitochondrial defects in skeletal muscle

Yiyi Zhu, Weiwei Gui, Bowen Tan, Ying Du, Jiaqiang Zhou, Fang Wu, Hong Li, Xihua Lin

Clin Sci (Lond) (2021) 135 (7): 979–990.

DOI: https://doi.org/10.1042/CS20210128

Published: 16 April 2021

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The complex role of adipokines in obesity, inflammation, and autoimmunity

Erin B. Taylor

Clin Sci (Lond) (2021) 135 (6): 731–752.

DOI: https://doi.org/10.1042/CS20200895

Published: 17 March 2021

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Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhang

Clin Sci (Lond) (2021) 135 (4): 613–627.

DOI: https://doi.org/10.1042/CS20201145

Published: 18 February 2021

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Diabetes mellitus: a primary metabolic disturbance. Metabolomics underlying vascular responses to stress and ischemia?

Evangelos Oikonomou, Costas Tsioufis, Dimitris Tousoulis

Clin Sci (Lond) (2021) 135 (3): 589–591.

DOI: https://doi.org/10.1042/CS20201299

Published: 10 February 2021

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ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34 + cells derived from diabetic older adults

Shrinidh Joshi, Ildamaris Montes de Oca, Ahmad Maghrabi, Christine Lopez-Yang, Julio Quiroz-Olvera, Charles A. Garcia, Yagna Prasada Rao Jarajapu

Clin Sci (Lond) (2021) 135 (2): 367–385.

DOI: https://doi.org/10.1042/CS20201133

Published: 27 January 2021

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β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat

James T. Pearson, Hamish P. Thambyah, Mark T. Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P. Ngo, Connie P.C. Ow, Takashi Sonobe, Yi Ching Chen, Amanda J. Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J. Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Clin Sci (Lond) (2021) 135 (2): 327–346.

DOI: https://doi.org/10.1042/CS20201441

Published: 22 January 2021

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The GCN5: its biological functions and therapeutic potentials

Md. Ezazul Haque, Md. Jakaria, Mahbuba Akther, Duk-Yeon Cho, In-Su Kim, Dong-Kug Choi

Clin Sci (Lond) (2021) 135 (1): 231–257.

DOI: https://doi.org/10.1042/CS20200986

Published: 14 January 2021

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Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases

Mona Elgazzaz, Eric Lazartigues

Clin Sci (Lond) (2021) 135 (1): 127–142.

DOI: https://doi.org/10.1042/CS20201287

Published: 08 January 2021

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Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder

Clin Sci (Lond) (2021) 135 (1): 185–200.

DOI: https://doi.org/10.1042/CS20201060

Published: 08 January 2021

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Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid

Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago Andrade Patente, José Alexandre Barbuto, Maria L. Corrêa-Giannella, Mario Lauterbach, Carl Christian Kolbe, Eicke Latz, Niels Olsen Saraiva Camara, Alessandra Pontillo, Rui Curi

Clin Sci (Lond) (2021) 135 (1): 19–34.

DOI: https://doi.org/10.1042/CS20201348

Published: 05 January 2021

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Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases

Ravindra K. Sharma, Jing Li, Suraj Krishnan, Elaine M. Richards, Mohan K. Raizada, Rajesh Mohandas

Clin Sci (Lond) (2021) 135 (1): 1–17.

DOI: https://doi.org/10.1042/CS20200482

Published: 05 January 2021

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Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu

Clin Sci (Lond) (2020) 134 (23): 3175–3193.

DOI: https://doi.org/10.1042/CS20201207

Published: 09 December 2020

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Have a heart: failure to increase GLP-1 caused by heart failure increases the risk of diabetes

Michael J. Ryan

Clin Sci (Lond) (2020) 134 (23): 3119–3121.

DOI: https://doi.org/10.1042/CS20201029

Published: 03 December 2020

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SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in Type 2 diabetes

Erik J.M. van Bommel, Frank Geurts, Marcel H.A. Muskiet, Adrian Post, Stephan J.L. Bakker, A.H. Jan Danser, Daan J. Touw, Miranda van Berkel, Mark H.H. Kramer, Max Nieuwdorp, Ele Ferrannini, Jaap A. Joles, Ewout J. Hoorn, Daniël H. van Raalte

Clin Sci (Lond) (2020) 134 (23): 3107–3118.

DOI: https://doi.org/10.1042/CS20201274

Published: 02 December 2020

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High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease – could extracellular vesicles be at play?

Jack D. Beazer, Patamat Patanapirunhakit, Jason M.R. Gill, Delyth Graham, Helen Karlsson, Stefan Ljunggren, Monique T. Mulder, Dilys J. Freeman

Clin Sci (Lond) (2020) 134 (22): 2977–2986.

DOI: https://doi.org/10.1042/CS20200892

Published: 19 November 2020

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Eicosanoid blood vessel regulation in physiological and pathological states

John D. Imig

Clin Sci (Lond) (2020) 134 (20): 2707–2727.

DOI: https://doi.org/10.1042/CS20191209

Published: 23 October 2020

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Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease

Carlos M. Ferrario, Sarfaraz Ahmad, Leanne Groban

Clin Sci (Lond) (2020) 134 (19): 2645–2664.

DOI: https://doi.org/10.1042/CS20200901

Published: 16 October 2020

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Prothymosin α activates type I collagen to develop a fibrotic placenta in gestational diabetes

Hung-Tsung Wu, Lin Kang, Yu-Chu Su, Horng-Yih Ou, Fu-Yu Chan, Yi-Cheng Chen, Bing-Hua Su, Yi-Shiang Wang, Chao-Liang Wu, Ai-Li Shiau, Pensée Wu

Clin Sci (Lond) (2020) 134 (18): 2435–2445.

DOI: https://doi.org/10.1042/CS20200147

Published: 25 September 2020

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Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

Zhuo Li, Hua Guo, Jia Li, Tianjiao Ma, Shanshan Zhou, Zhiguo Zhang, Lining Miao, Lu Cai

Clin Sci (Lond) (2020) 134 (18): 2469–2487.

DOI: https://doi.org/10.1042/CS20191088

Published: 25 September 2020

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The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

Anissa Viveiros, Gavin Y. Oudit

Clin Sci (Lond) (2020) 134 (18): 2447–2451.

DOI: https://doi.org/10.1042/CS20201028

Published: 25 September 2020

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Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy

Di Zhao, Yanyan Zhao, Jiao Wang, Lina Wu, Yanling Liu, Shuiying Zhao, Feng Guo, Xiaojun Ma, Haohao Zhang, Zhizhen Li, Dongdong Meng, Lijun Xu, Lixia Zhang, Junqi Liu, Guijun Qin

Clin Sci (Lond) (2020) 134 (17): 2419–2434.

DOI: https://doi.org/10.1042/CS20200694

Published: 18 September 2020

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Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress

Joshua A. Beckman, Jiun-Ruey Hu, Shi Huang, Eric Farber-Eger, Quinn S. Wells, Thomas J. Wang, Robert E. Gerszten, Jane F. Ferguson

Clin Sci (Lond) (2020) 134 (17): 2369–2379.

DOI: https://doi.org/10.1042/CS20191227

Published: 16 September 2020

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AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

Miao Chen, Caoyu Ji, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2020) 134 (17): 2381–2398.

DOI: https://doi.org/10.1042/CS20191320

Published: 16 September 2020

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TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy

Barbara Toffoli, Federica Tonon, Veronica Tisato, Andrea Michelli, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi

Clin Sci (Lond) (2020) 134 (17): 2337–2352.

DOI: https://doi.org/10.1042/CS20201004

Published: 10 September 2020

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High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT 1 receptor activation

Tamara Sáez, Floor Spaans, Raven Kirschenman, Tatsuya Sawamura, Sandra T. Davidge

Clin Sci (Lond) (2020) 134 (17): 2295–2313.

DOI: https://doi.org/10.1042/CS20200764

Published: 04 September 2020

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Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang

Clin Sci (Lond) (2020) 134 (16): 2161–2175.

DOI: https://doi.org/10.1042/CS20200530

Published: 24 August 2020

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Cirrhosis and insulin resistance: current knowledge, pathophysiological mechanisms, complications and potential treatments

Frédéric Clarembeau, Georgia Bale, Nicolas Lanthier

Clin Sci (Lond) (2020) 134 (16): 2117–2135.

DOI: https://doi.org/10.1042/CS20200022

Published: 21 August 2020

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