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Articles

Mechanistic insights into the development of severe fetal growth restriction

In Collection
Reproductive Physiology and Disease
Diane L. Gumina, Emily J. Su
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 679–695.
DOI: https://doi.org/10.1042/CS20220284
Published: 26 April 2023
View article titled, Mechanistic insights into the development of severe fetal growth restriction
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Articles

Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity

In Collection
Reproductive Physiology and Disease
Jerad H. Dumolt, Fredrick J. Rosario, Avery C. Kramer, Stacee Horwitz, Theresa L. Powell, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (8): 663–678.
DOI: https://doi.org/10.1042/CS20220890
Published: 21 April 2023
View article titled, Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity
Click here to open pdf in another window PDF for Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity
Articles

Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport

In Collection
Reproductive Physiology and Disease
Hana Horackova, Veronika Vachalova, Cilia Abad, Rona Karahoda, Frantisek Staud
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (2): 149–161.
DOI: https://doi.org/10.1042/CS20220726
Published: 18 January 2023
View article titled, Perfused rat term placenta as a preclinical model to investigate placental dopamine and norepinephrine transport
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Articles

Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype

Brian C. Belyea, Fang Xu, Margaret Wiltsie, Hayes Fountain, Jennifer Charlton, Agnes B. Fogo, Maria Luisa Soledad Sequeira-Lopez, Roberto Ariel Gomez
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 35–45.
DOI: https://doi.org/10.1042/CS20220496
Published: 05 January 2023
View article titled, Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype
Click here to open pdf in another window PDF for Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype
Includes: Supplementary data
Articles

The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

In Collection
Reproductive Physiology and Disease
Kyle M. Siemers, Michelle L. Baack
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 31–34.
DOI: https://doi.org/10.1042/CS20220657
Published: 03 January 2023
View article titled, The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies
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Articles

Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

In Collection
Reproductive Physiology and Disease
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1591–1614.
DOI: https://doi.org/10.1042/CS20220491
Published: 14 November 2022
View article titled, Stress signaler p38 mitogen-activated kinase activation: a cause for concern?
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Includes: Supplementary data
Articles

Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation

In Collection
Reproductive Physiology and Disease
Katie L. Bidne, Charis Uhlson, Claire Palmer, Karin Zemski-Berry, Theresa L. Powell
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (19): 1389–1404.
DOI: https://doi.org/10.1042/CS20220479
Published: 04 October 2022
View article titled, Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation
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Includes: Supplementary data
Articles

Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth

Hager M. Kowash, Harry G. Potter, Rebecca M. Woods, Nick Ashton, Reinmar Hager, Joanna C. Neill, Jocelyn D. Glazier
Journal: Clinical Science
Clin Sci (Lond) (2022) 1117–1137.
DOI: https://doi.org/10.1042/CS20220245
Published: 05 August 2022
View article titled, Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth
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Includes: Supplementary data
Articles

Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis

Mark Hedley Vickers
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 711–714.
DOI: https://doi.org/10.1042/CS20211175
Published: 16 May 2022
View article titled, Utility of preclinical models of altered maternal nutrition to support the developmental origins of health and disease hypothesis
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Articles

Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms

Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina I. Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian V. Zhang, A.H. Jan Danser, Qing Yang, Xiujun Fan
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (4): 257–272.
DOI: https://doi.org/10.1042/CS20210989
Published: 14 February 2022
View article titled, Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms
Click here to open pdf in another window PDF for Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms
Includes: Supplementary data
Articles

Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching

Alyson Deprez, Zakaria Orfi, Alexandra Radu, Ying He, Daniela Ravizzoni Dartora, Junio Dort, Nicolas A. Dumont, Anne Monique Nuyt
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (22): 2589–2605.
DOI: https://doi.org/10.1042/CS20210894
Published: 26 November 2021
View article titled, Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching
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Includes: Supplementary data
Articles

Placenta-specific Slc38a2 /SNAT2 knockdown causes fetal growth restriction in mice

Owen R. Vaughan, Katarzyna Maksym, Elena Silva, Kenneth Barentsen, Russel V. Anthony, Thomas L. Brown, Sara L. Hillman, Rebecca Spencer, Anna L. David, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2049–2066.
DOI: https://doi.org/10.1042/CS20210575
Published: 31 August 2021
View article titled, Placenta-specific Slc38a2 /SNAT2 knockdown causes fetal growth restriction in mice
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Includes: Supplementary data
Articles

Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

In Collection
Coronavirus
Nayara Azinheira Nobrega Cruz, Danielle Stoll, Dulce Elena Casarini, Mariane Bertagnolli
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
DOI: https://doi.org/10.1042/CS20210284
Published: 02 August 2021
View article titled, Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility
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Articles

Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

George W. Booz, Gaelle P. Massoud, Raffaele Altara, Fouad A. Zouein
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1767–1772.
DOI: https://doi.org/10.1042/CS20210524
Published: 27 July 2021
View article titled, Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate
Click here to open pdf in another window PDF for Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate
Articles

Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat

Alaa Alkhalefah, Warwick B. Dunn, James W. Allwood, Kate L. Parry, Franchesca D. Houghton, Nick Ashton, Jocelyn D. Glazier
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1445–1466.
DOI: https://doi.org/10.1042/CS20210137
Published: 11 June 2021
View article titled, Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat
Click here to open pdf in another window PDF for Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat
Includes: Supplementary data
Articles

SOX7 suppresses endothelial-to-mesenchymal transitions by enhancing VE-cadherin expression during outflow tract development

Xuechao Jiang, Tingting Li, Bojian Li, Wei Wei, Fen Li, Sun Chen, Rang Xu, Kun Sun
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 829–846.
DOI: https://doi.org/10.1042/CS20201496
Published: 26 March 2021
View article titled, SOX7 suppresses endothelial-to-mesenchymal transitions by enhancing VE-cadherin expression during outflow tract development
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Includes: Supplementary data
Articles

Developmental programming of cardiovascular function: a translational perspective

Stephane L. Bourque, Sandra T. Davidge
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (22): 3023–3046.
DOI: https://doi.org/10.1042/CS20191210
Published: 24 November 2020
View article titled, Developmental programming of cardiovascular function: a translational perspective
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Articles

The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

Anissa Viveiros, Gavin Y. Oudit
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
DOI: https://doi.org/10.1042/CS20201028
Published: 25 September 2020
View article titled, The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue
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Articles

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Lucas F. Almeida, Signe S. Tofteng, Kirsten Madsen, Boye L. Jensen
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (6): 641–656.
DOI: https://doi.org/10.1042/CS20190765
Published: 27 March 2020
View article titled, Role of the renin–angiotensin system in kidney development and programming of adult blood pressure
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Articles

Adaptive innate immunity or innate adaptive immunity?

Jan Černý, Ilja Stříž
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1549–1565.
DOI: https://doi.org/10.1042/CS20180548
Published: 17 July 2019
View article titled, Adaptive innate immunity or innate adaptive immunity?
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Articles

MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease

Binbin Li, Liwei Yu, Dong Liu, Xueyan Yang, Yufang Zheng, Yonghao Gui, Hongyan Wang
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (23): 2483–2491.
DOI: https://doi.org/10.1042/CS20180732
Published: 05 December 2018
View article titled, MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease
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Includes: Supplementary data
Articles

Investigating the RAS can be a fishy business: interdisciplinary opportunities using Zebrafish

Scott Hoffmann, Linda Mullins, Charlotte Buckley, Sebastien Rider, John Mullins
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (23): 2469–2481.
DOI: https://doi.org/10.1042/CS20180721
Published: 05 December 2018
View article titled, Investigating the RAS can be a fishy business: interdisciplinary opportunities using Zebrafish
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Articles

Prevention of perinatal nicotine-induced bone marrow mesenchymal stem cell myofibroblast differentiation by augmenting the lipofibroblast phenotype

Reiko Sakurai, Jie Liu, Ying Wang, John S. Torday, Virender K. Rehan
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (21): 2357–2368.
DOI: https://doi.org/10.1042/CS20180749
Published: 13 November 2018
View article titled, Prevention of perinatal nicotine-induced bone marrow mesenchymal stem cell myofibroblast differentiation by augmenting the lipofibroblast phenotype
Click here to open pdf in another window PDF for Prevention of perinatal nicotine-induced bone marrow mesenchymal stem cell myofibroblast differentiation by augmenting the lipofibroblast phenotype
Articles

High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice

Xiao Wang, Huarong Wang, Wei Liu, Zhiyuan Zhang, Yanhao Zhang, Wenqiang Zhang, Zijiang Chen, Guoliang Xia, Chao Wang
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (7): 759–776.
DOI: https://doi.org/10.1042/CS20171394
Published: 06 April 2018
View article titled, High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice
Click here to open pdf in another window PDF for High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice
Includes: Supplementary data
Articles

Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction

Stephanie Skuby Chassen, Veronique Ferchaud-Roucher, Madhulika B. Gupta, Thomas Jansson, Theresa L. Powell
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (5): 595–607.
DOI: https://doi.org/10.1042/CS20171340
Published: 15 March 2018
View article titled, Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction
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Includes: Supplementary data
Articles

Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia

Sabrina M. Scroggins, Donna A. Santillan, Jenna M. Lund, Jeremy A. Sandgren, Lindsay K. Krotz, Wendy S. Hamilton, Eric J. Devor, Heather A. Davis, Gary L. Pierce, Katherine N. Gibson-Corley, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (3): 419–436.
DOI: https://doi.org/10.1042/CS20171059
Published: 14 February 2018
View article titled, Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia
Click here to open pdf in another window PDF for Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia
Includes: Supplementary data
Articles

Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner

Kimberley C.W. Wang, Alexander N. Larcombe, Luke J. Berry, Jude S. Morton, Sandra T. Davidge, Alan L. James, Peter B. Noble
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (2): 273–284.
DOI: https://doi.org/10.1042/CS20171554
Published: 25 January 2018
View article titled, Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner
Click here to open pdf in another window PDF for Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner
Articles

Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

Redin A. Spann, William J. Lawson, Gene L. Bidwell, III, C. Austin Zamarripa, Rodrigo O. Maranon, Sibali Bandyopadhyay, Erin R. Taylor, Jane F. Reckelhoff, Michael R. Garrett, Bernadette E. Grayson
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (2): 295–312.
DOI: https://doi.org/10.1042/CS20171416
Published: 25 January 2018
View article titled, Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development
Click here to open pdf in another window PDF for Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development
Includes: Supplementary data
Articles

Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia

Michal Zeman, Monika Okuliarova
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2791–2794.
DOI: https://doi.org/10.1042/CS20171255
Published: 23 November 2017
View article titled, Sex-specific cardiovascular susceptibility to ischaemic myocardial injury following exposure to prenatal hypoxia
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Articles

Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A 165 a, VEGF-A 165 b, PIGF and VE-cadherin

Vincent Pang, David O. Bates, Lopa Leach
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2763–2775.
DOI: https://doi.org/10.1042/CS20171252
Published: 23 November 2017
View article titled, Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A 165 a, VEGF-A 165 b, PIGF and VE-cadherin
Click here to open pdf in another window PDF for Regulation of human feto-placental endothelial barrier integrity by vascular endothelial growth factors: competitive interplay between VEGF-A 165 a, VEGF-A 165 b, PIGF and VE-cadherin
Articles

Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus

Rocio Rojo, Clare Pridans, David Langlais, David A. Hume
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2161–2182.
DOI: https://doi.org/10.1042/CS20170238
Published: 31 July 2017
View article titled, Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus
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Articles

Dynamic response to initial stage blindness in visual system development

Erping Long, Xiayin Zhang, Zhenzhen Liu, Xiaohang Wu, Xuhua Tan, Duoru Lin, Qianzhong Cao, Jingjing Chen, Zhuoling Lin, Dongni Wang, Xiaoyan Li, Jing Li, Jinghui Wang, Wangting Li, Haotian Lin, Weirong Chen, Yizhi Liu
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1515–1527.
DOI: https://doi.org/10.1042/CS20170234
Published: 28 June 2017
View article titled, Dynamic response to initial stage blindness in visual system development
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Includes: Supplementary data
Articles

Long non-coding RNAs (lncRNAs) in skeletal and cardiac muscle: potential therapeutic and diagnostic targets?

Julie R. McMullen, Brian G. Drew
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (24): 2245–2256.
DOI: https://doi.org/10.1042/CS20160244
Published: 04 November 2016
View article titled, Long non-coding RNAs (lncRNAs) in skeletal and cardiac muscle: potential therapeutic and diagnostic targets?
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Articles

Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA

Jeanie B. Tryggestad, Anu Vishwanath, Shaoning Jiang, Ashwini Mallappa, April M. Teague, Yusuke Takahashi, David M. Thompson, Steven D. Chernausek
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1955–1967.
DOI: https://doi.org/10.1042/CS20160305
Published: 22 September 2016
View article titled, Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA
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