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Articles

Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Guochao Song, Fengyi Weng, Bin Zou, Jing Zhao, Jingyi Jin, Dongming Yan, Kai Huang, Xin Sun, Chenghai Liu, Yiyang Hu, Yue Li, Furong Qiu

Clin Sci (Lond) (2023) 137 (7): 561–577.

DOI: https://doi.org/10.1042/CS20220674

Published: 13 April 2023

View article titled, Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway

Includes: Supplementary data

Articles

Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling

Lingling Lu, Weihua Liu, Shumin Li, Mi Bai, Yu Zhou, Zhaohui Jiang, Zhanjun Jia, Songming Huang, Aihua Zhang, Wei Gong

Clin Sci (Lond) (2023) 137 (6): 435–452.

DOI: https://doi.org/10.1042/CS20220728

Published: 21 March 2023

View article titled, Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling

Includes: Supplementary data

Articles

Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury

Xiaorui Chen, Di Qi, Shulei Fan, Yirui He, Hekun Jing, Daoxin Wang

Clin Sci (Lond) (2023) 137 (5): 367–383.

DOI: https://doi.org/10.1042/CS20220876

Published: 09 March 2023

View article titled, Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury

Includes: Supplementary data

Articles

The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy

Wai Han Yiu, Sarah W.Y. Lok, Rui Xue, Jiaoyi Chen, Kar Neng Lai, Hui Yao Lan, Sydney C.W. Tang

Clin Sci (Lond) (2023) 137 (5): 317–331.

DOI: https://doi.org/10.1042/CS20220537

Published: 01 March 2023

View article titled, The long noncoding RNA Meg3 mediates TLR4-induced inflammation in experimental obstructive nephropathy

Includes: Supplementary data

Articles

Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein

Clin Sci (Lond) (2023) 137 (1): 47–63.

DOI: https://doi.org/10.1042/CS20220513

Published: 05 January 2023

View article titled, Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Includes: Supplementary data

Articles

PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Honglin Li, Zhiwen Liu, Ying Wang, Hui Wang, Juan Cai, Chengyuan Tang, Zheng Dong

Clin Sci (Lond) (2022) 136 (24): 1877–1891.

DOI: https://doi.org/10.1042/CS20220493

Published: 22 December 2022

View article titled, PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Articles

CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis

Jialei Yang, Wanting He, Lian Gu, Jianxiong Long, Lulu Zhu, Ruirui Zhang, Zhi Zhao, Bingyi Xu, Aruo Nan, Li Su

Clin Sci (Lond) (2022) 136 (12): 953–971.

DOI: https://doi.org/10.1042/CS20220157

Published: 22 June 2022

View article titled, CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis

Includes: Supplementary data

Articles

Visualization of regenerating and repairing hearts

Nevan Powers, Guo N. Huang

Clin Sci (Lond) (2022) 136 (10): 787–798.

DOI: https://doi.org/10.1042/CS20211116

Published: 27 May 2022

View article titled, Visualization of regenerating and repairing hearts

Articles

Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice

Min-Chun Liao, Kana N. Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang

Clin Sci (Lond) (2022) 136 (10): 715–731.

DOI: https://doi.org/10.1042/CS20220188

Published: 20 May 2022

View article titled, Angiotensin II type-2-receptor stimulation ameliorates focal and segmental glomerulosclerosis in mice

Includes: Supplementary data

Articles

Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Ning Hu, Xiaoyi Zhang, Xuanzhe Zhang, Yongjun Guan, Ruyuan He, Enfu Xue, Xiaoyi Zhang, Wenhong Deng, Jia Yu, Weixing Wang, Qiao Shi

Clin Sci (Lond) (2022) 136 (7): 455–471.

DOI: https://doi.org/10.1042/CS20211031

Published: 06 April 2022

View article titled, Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis

Includes: Supplementary data

Articles

Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway

Bohao Liu, Zhong Wang, Ruyuan He, Rui Xiong, Guorui Li, Lin Zhang, Tinglv Fu, Chenyuan Li, Ning Li, Qing Geng

Clin Sci (Lond) (2022) 136 (4): 273–289.

DOI: https://doi.org/10.1042/CS20211156

Published: 21 February 2022

View article titled, Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway

Includes: Supplementary data

Articles

AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang

Clin Sci (Lond) (2022) 136 (1): 103–120.

DOI: https://doi.org/10.1042/CS20211075

Published: 07 January 2022

View article titled, AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress

Includes: Supplementary data

Articles

Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension

Hongxia Jiang, Dandan Ding, Yuanzhou He, Xiaochen Li, Yongjian Xu, Xiansheng Liu

Clin Sci (Lond) (2021) 135 (21): 2467–2481.

DOI: https://doi.org/10.1042/CS20210612

Published: 01 November 2021

View article titled, Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension

Articles

Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Andris Elksnis, Tomas A Schiffer, Fredrik Palm, Yun Wang, Jing Cen, Kyril Turpaev, Anongnad Ngamjariyawat, Shady Younis, Suling Huang, Yu Shen, Ying Leng, Peter Bergsten, Tony Karlsborn, Nils Welsh, Xuan Wang

Clin Sci (Lond) (2021) 135 (19): 2243–2263.

DOI: https://doi.org/10.1042/CS20210604

Published: 08 October 2021

View article titled, Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Includes: Supplementary data

Articles

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Jan Neckář, Petra Alánová, Veronika Olejníčková, František Papoušek, Lucie Hejnová, Jan Šilhavý, Michal Behuliak, Michal Bencze, Jaroslav Hrdlička, Marek Vecka, Dagmar Jarkovská, Jitka Švíglerová, Eliška Mistrová, Milan Štengl, Jiří Novotný, Bohuslav Ošťádal, Michal Pravenec, František Kolář

Clin Sci (Lond) (2021) 135 (17): 2143–2163.

DOI: https://doi.org/10.1042/CS20210648

Published: 17 September 2021

View article titled, Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Includes: Supplementary data

Articles

NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia

Jianmin Liu, Daoquan Liu, Xueneng Zhang, Yan Li, Xun Fu, Weixiang He, Mingzhou Li, Ping Chen, Guang Zeng, Michael E. DiSanto, Xinghuan Wang, Xinhua Zhang

Clin Sci (Lond) (2021) 135 (13): 1591–1608.

DOI: https://doi.org/10.1042/CS20210476

Published: 07 July 2021

View article titled, NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia

Includes: Supplementary data

Articles

Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?

Crizza Ching, Dakota Gustafson, Paaladinesh Thavendiranathan, Jason E. Fish

Clin Sci (Lond) (2021) 135 (12): 1487–1503.

DOI: https://doi.org/10.1042/CS20210059

Published: 17 June 2021

View article titled, Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?

Articles

Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia

Peerapat Visitchanakun, Wimonrat Panpetch, Wilasinee Saisorn, Piraya Chatthanathon, Dhammika Leshan Wannigama, Arthid Thim-uam, Saovaros Svasti, Suthat Fucharoen, Naraporn Somboonna, Asada Leelahavanichkul

Clin Sci (Lond) (2021) 135 (12): 1467–1486.

DOI: https://doi.org/10.1042/CS20210328

Published: 16 June 2021

View article titled, Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia

Includes: Supplementary data

Articles

cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7

Lilin Li, Jeonghwan Lee, Ara Cho, Jin Hyuk Kim, Wonmin Ju, Jung Nam An, Jeong Hwan Park, Shi Mao Zhu, Junghun Lee, Seung-Shin Yu, Chun Soo Lim, Dong Ki Kim, Yon Su Kim, Seung Hee Yang, Jung Pyo Lee

Clin Sci (Lond) (2021) 135 (11): 1427–1444.

DOI: https://doi.org/10.1042/CS20210013

Published: 08 June 2021

View article titled, cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7

Includes: Supplementary data

Articles

Brain angiotensin system: a new promise in the management of epilepsy?

Alberto Javier Ramos

Clin Sci (Lond) (2021) 135 (6): 725–730.

DOI: https://doi.org/10.1042/CS20201296

Published: 17 March 2021

View article titled, Brain angiotensin system: a new promise in the management of epilepsy?

Articles

Acid sphingomyelinase promotes SGK1-dependent vascular calcification

Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan

Clin Sci (Lond) (2021) 135 (3): 515–534.

DOI: https://doi.org/10.1042/CS20201122

Published: 03 February 2021

View article titled, Acid sphingomyelinase promotes SGK1-dependent vascular calcification

Includes: Supplementary data

Articles

DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway

Renzo Boldorini, Nausicaa Clemente, Elisa Alchera, Rita Carini

Clin Sci (Lond) (2021) 135 (1): 161–166.

DOI: https://doi.org/10.1042/CS20201091

Published: 08 January 2021

View article titled, DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway

Articles

Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy

Di Zhao, Yanyan Zhao, Jiao Wang, Lina Wu, Yanling Liu, Shuiying Zhao, Feng Guo, Xiaojun Ma, Haohao Zhang, Zhizhen Li, Dongdong Meng, Lijun Xu, Lixia Zhang, Junqi Liu, Guijun Qin

Clin Sci (Lond) (2020) 134 (17): 2419–2434.

DOI: https://doi.org/10.1042/CS20200694

Published: 18 September 2020

View article titled, Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy

Includes: Supplementary data

Articles

DUSP12 protects against hepatic ischemia–reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo

Tao Qiu, Tianyu Wang, Jiangqiao Zhou, Zhongbao Chen, Jilin Zou, Long Zhang, Xiaoxiong Ma

Clin Sci (Lond) (2020) 134 (17): 2279–2294.

DOI: https://doi.org/10.1042/CS20191272

Published: 03 September 2020

View article titled, DUSP12 protects against hepatic ischemia–reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo

Includes: Supplementary data

Articles

miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute tubular injury

Wenjuan Yu, Honghui Zeng, Junzhe Chen, Sha Fu, Qiuyan Huang, Yanchun Xu, Anping Xu, Hui-yao Lan, Ying Tang

Clin Sci (Lond) (2020) 134 (16): 2223–2234.

DOI: https://doi.org/10.1042/CS20200288

Published: 28 August 2020

View article titled, miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute tubular injury

Includes: Supplementary data

Articles

Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury

Jose L. Viñas, Christopher J. Porter, Adrianna Douvris, Matthew Spence, Alex Gutsol, Joseph A. Zimpelmann, Karishma Tailor, Pearl A. Campbell, Kevin D. Burns

Clin Sci (Lond) (2020) 134 (14): 1887–1909.

DOI: https://doi.org/10.1042/CS20200168

Published: 23 July 2020

View article titled, Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury

Includes: Supplementary data

Articles

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

Hai-Di Li, Xin Chen, Jie-Jie Xu, Xiao-Sa Du, Yang Yang, Juan-Juan Li, Xiao-Juan Yang, Hui-Min Huang, Xiao-Feng Li, Ming-Fei Wu, Chong Zhang, Chao Zhang, Zeng Li, Hua Wang, Xiao-Ming Meng, Cheng Huang, Jun Li

Clin Sci (Lond) (2020) 134 (14): 1935–1956.

DOI: https://doi.org/10.1042/CS20200031

Published: 23 July 2020

View article titled, DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

Includes: Supplementary data

Articles

Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Riyaz Mohamed, Olga Rafikova, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2020) 134 (13): 1751–1762.

DOI: https://doi.org/10.1042/CS20200575

Published: 10 July 2020

View article titled, Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia–reperfusion injury

Articles

Tubular transcriptional co-activator with PDZ-binding motif protects against ischemic acute kidney injury

Chia-Lin Wu, Chia-Chu Chang, Tao-Hsiang Yang, Alexander Charng-Dar Tsai, Jui-Lin Wang, Chung-Ho Chang, Der-Cherng Tarng

Clin Sci (Lond) (2020) 134 (13): 1593–1612.

DOI: https://doi.org/10.1042/CS20200223

Published: 30 June 2020

View article titled, Tubular transcriptional co-activator with PDZ-binding motif protects against ischemic acute kidney injury

Includes: Supplementary data

Articles

The Krüppel-like factor 15-NFATc1 axis ameliorates podocyte injury: a novel rationale for using glucocorticoids in proteinuria diseases

Caoshuai Dou, Hong Zhang, Guibao Ke, Li Zhang, Zhiwen Lian, Xueqin Chen, Xingchen Zhao, Yuanhan Chen, Ruizhao Li, Jianchao Ma, Zhuo Li, Ting Lin, Wenjian Wang, Zhi ming Ye, Xinling Liang, Wei Shi, Bin Zhang, Shuangxin Liu

Clin Sci (Lond) (2020) 134 (12): 1305–1318.

DOI: https://doi.org/10.1042/CS20200075

Published: 16 June 2020

View article titled, The Krüppel-like factor 15-NFATc1 axis ameliorates podocyte injury: a novel rationale for using glucocorticoids in proteinuria diseases

Includes: Supplementary data

Articles

IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture

Rana Ghali, Nada J. Habeichi, Abdullah Kaplan, Cynthia Tannous, Emna Abidi, Amira Bekdash, Rima Farhat, Hana Itani, Abdo Jurjus, George W. Booz, Ziad Mallat, Fouad A. Zouein

Clin Sci (Lond) (2020) 134 (11): 1191–1218.

DOI: https://doi.org/10.1042/CS20200402

Published: 03 June 2020

View article titled, IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture

Includes: Supplementary data

Articles

Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo

Jiaxi Chen, Tongtian Zhuang, Jianru Chen, Yangzi Tian, Xiuli Yi, Qingrong Ni, Weigang Zhang, Pu Song, Zhe Jian, Ling Liu, Tingting Cui, Kai Li, Tianwen Gao, Chunying Li, Shuli Li

Clin Sci (Lond) (2020) 134 (10): 1127–1141.

DOI: https://doi.org/10.1042/CS20200218

Published: 21 May 2020

View article titled, Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo

Includes: Supplementary data

Articles

Targeting mitochondria to protect the heart: a matter of balance?

Fouad A. Zouein, George W. Booz

Clin Sci (Lond) (2020) 134 (7): 885–888.

DOI: https://doi.org/10.1042/CS20200236

Published: 14 April 2020

View article titled, Targeting mitochondria to protect the heart: a matter of balance?

Articles

Endoplasmic reticulum stress occurs in association with the extrusion of toxic extracellular vesicles from human placentae treated with antiphospholipid antibodies

Yunhui Tang, Yan Chen, Yohanes Nursalim, Katie Groom, Anthony Hickey, Larry Chamley, Qi Chen

Clin Sci (Lond) (2020) 134 (5): 459–472.

DOI: https://doi.org/10.1042/CS20191245

Published: 04 March 2020

View article titled, Endoplasmic reticulum stress occurs in association with the extrusion of toxic extracellular vesicles from human placentae treated with antiphospholipid antibodies

Articles

Double-stranded RNA and Toll-like receptor activation: a novel mechanism for blood pressure regulation

Vanessa Dela Justina, Fernanda R. Giachini, Fernanda Priviero, R. Clinton Webb

Clin Sci (Lond) (2020) 134 (2): 303–313.

DOI: https://doi.org/10.1042/CS20190913

Published: 30 January 2020

View article titled, Double-stranded RNA and Toll-like receptor activation: a novel mechanism for blood pressure regulation

Articles

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Runa S.J. Lindblom, Gavin C. Higgins, Tuong-Vi Nguyen, Maryann Arnstein, Darren C. Henstridge, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Mark E. Cooper, Josephine M. Forbes, Melinda T. Coughlan

Clin Sci (Lond) (2020) 134 (2): 239–259.

DOI: https://doi.org/10.1042/CS20190787

Published: 29 January 2020

View article titled, Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Includes: Supplementary data

Articles

SPZ1 promotes deregulation of Bim to boost apoptosis resistance in colorectal cancer

Xiao-Yu Liu, Chang-Bo Zheng, Teng Wang, Jian Xu, Meng Zhang, Ling-Shan Gou, Linfang Jin, Xiaowei Qi, Xianhai Zeng, Hongwen Li, Shuqi Qiu, Peng Zhang

Clin Sci (Lond) (2020) 134 (2): 155–167.

DOI: https://doi.org/10.1042/CS20190865

Published: 23 January 2020

View article titled, SPZ1 promotes deregulation of Bim to boost apoptosis resistance in colorectal cancer

Includes: Supplementary data

Articles

Processes exacerbating apoptosis in non-alcoholic steatohepatitis

Marta B. Afonso, Rui E. Castro, Cecília M. P. Rodrigues

Clin Sci (Lond) (2019) 133 (22): 2245–2264.

DOI: https://doi.org/10.1042/CS20190068

Published: 19 November 2019

View article titled, Processes exacerbating apoptosis in non-alcoholic steatohepatitis

Articles

Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Yujia Yuan, Younan Chen, Tianqing Peng, Lan Li, Wuzheng Zhu, Fei Liu, Shuyun Liu, Xingxing An, Ruixi Luo, Jingqiu Cheng, Jingping Liu, Yanrong Lu

Clin Sci (Lond) (2019) 133 (15): 1759–1777.

DOI: https://doi.org/10.1042/CS20190672

Published: 14 August 2019

View article titled, Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Includes: Supplementary data

Articles

RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress

Jia-nan Wang, Ming-ming Liu, Fang Wang, Biao Wei, Qin Yang, Yu-ting Cai, Xin Chen, Xue-qi Liu, Ling Jiang, Chao Li, Xiao-wei Hu, Ju-tao Yu, Tao-tao Ma, Juan Jin, Yong-gui Wu, Jun Li, Xiao-ming Meng

Clin Sci (Lond) (2019) 133 (14): 1609–1627.

DOI: https://doi.org/10.1042/CS20190599

Published: 25 July 2019

View article titled, RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress

Includes: Supplementary data

Articles

PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice

Jean-François Thibodeau, Jean-Christophe Simard, Chet E. Holterman, Amélie Blais, Marie-Pier Cloutier, Thalia Medeiros, Martin Leduc, Brigitte Grouix, François A. Leblond, Dylan Burger, Richard L. Hébert, Christopher R.J. Kennedy, Lyne Gagnon

Clin Sci (Lond) (2019) 133 (14): 1587–1602.

DOI: https://doi.org/10.1042/CS20190479

Published: 22 July 2019

View article titled, PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice

Articles

Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity

Dong Zheng, Yi Zhang, Ming Zheng, Ting Cao, Grace Wang, Lulu Zhang, Rui Ni, Joseph Brockman, Huiting Zhong, Guo-Chang Fan, Tianqing Peng

Clin Sci (Lond) (2019) 133 (13): 1505–1521.

DOI: https://doi.org/10.1042/CS20181022

Published: 15 July 2019

View article titled, Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity

Includes: Supplementary data

Articles

Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons

Hiranya Pintana, Grazyna Lietzau, Ingrid Lovise Augestad, Fausto Chiazza, Thomas Nyström, Cesare Patrone, Vladimer Darsalia

Clin Sci (Lond) (2019) 133 (13): 1367–1386.

DOI: https://doi.org/10.1042/CS20190180

Published: 01 July 2019

View article titled, Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons

Includes: Supplementary data

Articles

Advances in heart regeneration based on cardiomyocyte proliferation and regenerative potential of binucleated cardiomyocytes and polyploidization

Marina Leone, Felix B. Engel

Clin Sci (Lond) (2019) 133 (11): 1229–1253.

DOI: https://doi.org/10.1042/CS20180560

Published: 07 June 2019

View article titled, Advances in heart regeneration based on cardiomyocyte proliferation and regenerative potential of binucleated cardiomyocytes and polyploidization

Articles

Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress

Lynn H.H. Aung, Yu-Zhen Li, Hua Yu, Xiatian Chen, Zhongjie Yu, Jinning Gao, Peifeng Li

Clin Sci (Lond) (2019) 133 (9): 1067–1084.

DOI: https://doi.org/10.1042/CS20190125

Published: 09 May 2019

View article titled, Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress

Includes: Supplementary data

Articles

Pharmacological inhibition of TRPV4 channels protects against ischemia–reperfusion-induced renal insufficiency in neonatal pigs

Hitesh Soni, Dieniffer Peixoto-Neves, Michael A. Olushoga, Adebowale Adebiyi

Clin Sci (Lond) (2019) 133 (9): 1031–1047.

DOI: https://doi.org/10.1042/CS20180815

Published: 02 May 2019

View article titled, Pharmacological inhibition of TRPV4 channels protects against ischemia–reperfusion-induced renal insufficiency in neonatal pigs

Includes: Supplementary data

Articles

A pan-RAF inhibitor LY3009120 inhibits necroptosis by preventing phosphorylation of RIPK1 and alleviates dextran sulfate sodium-induced colitis

Chong Zhang, Yiqin Luo, Qiaoling He, Shuai Liu, Andong He, Jie Yan

Clin Sci (Lond) (2019) 133 (8): 919–932.

DOI: https://doi.org/10.1042/CS20181081

Published: 16 April 2019

View article titled, A pan-RAF inhibitor LY3009120 inhibits necroptosis by preventing phosphorylation of RIPK1 and alleviates dextran sulfate sodium-induced colitis

Includes: Supplementary data

Articles

Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice

Yunlong Lei, Kui Wang, Xuefeng Li, Yi Li, Xuping Feng, Jing Zhou, Zhe Zhang, Canhua Huang, Tao Zhang

Clin Sci (Lond) (2019) 133 (7): 789–804.

DOI: https://doi.org/10.1042/CS20180687

Published: 02 April 2019

View article titled, Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice

Includes: Supplementary data

Articles

NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound

Dan Liu, Peilang Yang, Min Gao, Tianyi Yu, Yan Shi, Meng Zhang, Min Yao, Yan Liu, Xiong Zhang

Clin Sci (Lond) (2019) 133 (4): 565–582.

DOI: https://doi.org/10.1042/CS20180600

Published: 18 February 2019

View article titled, NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound

Articles

Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis

Tzu-Hao Li, Ying-Ying Yang, Chia-Chang Huang, Chih-Wei Liu, Hung-Cheng Tsai, Ming-Wei Lin, Chang-Youh Tsai, Shiang-Fen Huang, Ying-Wen Wang, Tzung-Yan Lee, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin

Clin Sci (Lond) (2019) 133 (3): 531–544.

DOI: https://doi.org/10.1042/CS20180873

Published: 13 February 2019

View article titled, Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis

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