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Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca 2+ mishandling and atrial fibrosis in active immunization rabbit models

Huaxin Sun, Jie Song, Kai Li, Yao Li, Luxiang Shang, Qina Zhou, Yanmei Lu, Yazhen Zong, Xiuyuan He, Muzappar Kari, Hang Yang, Xianhui Zhou, Ling Zhang, Baopeng Tang

Clin Sci (Lond) (2023) 137 (2): 195–217.

DOI: https://doi.org/10.1042/CS20220654

Published: 27 January 2023

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Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Keitaro Ueda, Chiemi Sakai, Takafumi Ishida, Kosuke Morita, Yusuke Kobayashi, Yasunori Horikoshi, Akiko Baba, Yuma Okazaki, Masao Yoshizumi, Satoshi Tashiro, Mari Ishida

Clin Sci (Lond) (2023) 137 (2): 163–180.

DOI: https://doi.org/10.1042/CS20220525

Published: 24 January 2023

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Central role for BRAF in cardiac hypertrophy: rethinking the pathological–physiological divide

Raffaele Altara, George W. Booz

Clin Sci (Lond) (2023) 137 (2): 143–148.

DOI: https://doi.org/10.1042/CS20220776

Published: 18 January 2023

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Skin-specific mechanisms of body fluid regulation in hypertension

Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M Touyz, Christian Delles, Giacomo Rossitto

Clin Sci (Lond) (2023) CS20220609.

DOI: https://doi.org/10.1042/CS20220609

Published: 17 January 2023

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Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein

Clin Sci (Lond) (2023) 137 (1): 47–63.

DOI: https://doi.org/10.1042/CS20220513

Published: 05 January 2023

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Set7 methyltransferase roles in myocardial protection from chronic stressors

James T. Pearson

Clin Sci (Lond) (2023) 137 (1): 105–108.

DOI: https://doi.org/10.1042/CS20220773

Published: 05 January 2023

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Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice

Shu-Huei Wang, Feng-Chiao Tsai, Heng-Huei Lin, Tse-Ya Yu, Chun-Heng Kuo, Hung-Yuan Li, Mao-Shin Lin

Clin Sci (Lond) (2023) 137 (1): 17–30.

DOI: https://doi.org/10.1042/CS20220477

Published: 03 January 2023

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Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation

Kazuhiro Aonuma, DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Yuta Okabe, Zixun Yuan, Siqi Li, Yoshiko Murakata, Kenichi Tominaga, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda, Hiroko Isoda

Clin Sci (Lond) (2022) 136 (24): 1831–1849.

DOI: https://doi.org/10.1042/CS20220319

Published: 21 December 2022

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Dysregulated haemostasis in thrombo-inflammatory disease

Paula A. Klavina, Gemma Leon, Annie M. Curtis, Roger J.S. Preston

Clin Sci (Lond) (2022) 136 (24): 1809–1829.

DOI: https://doi.org/10.1042/CS20220208

Published: 16 December 2022

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Genetically inducing renal lymphangiogenesis attenuates hypertension in mice

Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (23): 1759–1772.

DOI: https://doi.org/10.1042/CS20220547

Published: 02 December 2022

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Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery

Lauren T. May, Belinda A. Bartolo, David G. Harrison, Tomasz Guzik, Grant R. Drummond, Gemma A. Figtree, Rebecca H. Ritchie, Kerry-Anne Rye, Judy B. de Haan

Clin Sci (Lond) (2022) 136 (23): 1731–1758.

DOI: https://doi.org/10.1042/CS20210862

Published: 02 December 2022

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Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2022) 136 (22): 1661–1681.

DOI: https://doi.org/10.1042/CS20220607

Published: 21 November 2022

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Quantifying muscle blood flow: a transformative breakthrough in the science of human exercise physiology

Thomas P. Olson, Joshua R. Smith, Timothy B. Curry

Clin Sci (Lond) (2022) 136 (22): 1653–1656.

DOI: https://doi.org/10.1042/CS20220101

Published: 18 November 2022

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Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease

Nour-Mounira Z. Bakkar, Ibrahim AlZaim, Ahmed F. El-Yazbi

Clin Sci (Lond) (2022) 136 (22): 1631–1651.

DOI: https://doi.org/10.1042/CS20220404

Published: 16 November 2022

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Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs

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Coronavirus

Jaroslav Pelisek, Benedikt Reutersberg, Urs F Greber, Alexander Zimmermann

Clin Sci (Lond) (2022) 136 (21): 1571–1590.

DOI: https://doi.org/10.1042/CS20220235

Published: 11 November 2022

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Articles

Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction

Guilherme Lunardon, Tábatha de Oliveira Silva, Caroline A. Lino, Yao Wei Lu, Juliane B. Miranda, Paula F. Asprino, Amanda de Almeida Silva, Gabrielle T. Nepomuceno, Maria Cláudia Costa Irigoyen, Marcela S. Carneiro-Ramos, Ana Paula C. Takano, Herculano da Silva Martinho, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

Clin Sci (Lond) (2022) 136 (21): 1537–1554.

DOI: https://doi.org/10.1042/CS20220466

Published: 10 November 2022

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Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia

Raghavendar Chandran, Lianying He, Xingju Nie, Joshua Voltin, Sarah Jamil, Caren Doueiry, Maria Fatima Falangola, Adviye Ergul, Weiguo Li

Clin Sci (Lond) (2022) 136 (21): 1555–1570.

DOI: https://doi.org/10.1042/CS20220465

Published: 10 November 2022

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CGP42112: the full AT 2 receptor agonist and its role in the renin–angiotensin–aldosterone system: no longer misunderstood

Yazmin M. Restrepo, Natalia M. Noto, Robert C. Speth

Clin Sci (Lond) (2022) 136 (21): 1513–1533.

DOI: https://doi.org/10.1042/CS20220261

Published: 03 November 2022

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Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension

Jessica L. Faulkner, Jennifer C. Sullivan

Clin Sci (Lond) (2022) 136 (18): 1341–1346.

DOI: https://doi.org/10.1042/CS20220056

Published: 21 September 2022

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Hypertension and renal disease programming: focus on the early postnatal period

Maria Florencia Albertoni Borghese, Lucas Humberto Oronel, Maria Del Carmen Ortiz, Mónica Patricia Majowicz

Clin Sci (Lond) (2022) 136 (17): 1303–1339.

DOI: https://doi.org/10.1042/CS20220293

Published: 08 September 2022

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Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair

Nathalia C. de Almeida Oliveira, Elida A. Neri, Caio M. Silva, Iuri C. Valadão, Miriam H. Fonseca-Alaniz, Camila Zogbi, Débora Levy, Sergio P. Bydlowski, Jose Eduardo Krieger

Clin Sci (Lond) (2022) 136 (17): 1281–1301.

DOI: https://doi.org/10.1042/CS20220216

Published: 05 September 2022

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The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease

Adrien Georges, Nabila Bouatia-Naji

Clin Sci (Lond) (2022) 136 (16): 1241–1255.

DOI: https://doi.org/10.1042/CS20210990

Published: 31 August 2022

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The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation

Eleonora Cianflone, Mariangela Scalise, Fabiola Marino, Luca Salerno, Nadia Salerno, Konrad Urbanek, Daniele Torella

Clin Sci (Lond) (2022) 136 (16): 1179–1203.

DOI: https://doi.org/10.1042/CS20220391

Published: 18 August 2022

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The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases

Denise Busscher, Reinier A. Boon, Rio P. Juni

Clin Sci (Lond) (2022) 136 (15): 1157–1178.

DOI: https://doi.org/10.1042/CS20210994

Published: 10 August 2022

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G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation

Fuwei Zhang, Lifu Lei, Juan Huang, Weiwei Wang, Qian Su, Hongjia Yan, Caiyu Chen, Shuo Zheng, Hongmei Ren, Zhuxin Li, Pedro A. Jose, Yijie Hu, Liangyi Si, Chunyu Zeng, Jian Yang

Clin Sci (Lond) (2022) 136 (12): 989–1003.

DOI: https://doi.org/10.1042/CS20220236

Published: 29 June 2022

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The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease

Jonatan Barrera-Chimal, Casimiro Gerarduzzi, Patrick Rossignol, Frédéric Jaisser

Clin Sci (Lond) (2022) 136 (12): 1005–1017.

DOI: https://doi.org/10.1042/CS20220212

Published: 29 June 2022

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Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction

Anna K. Whitehead, Nicholas D. Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S. Pearson, Kyle B. LaPenna, Thomas E. Sharp, David J. Lefer, Eric Lazartigues, Jason D. Gardner, Xinping Yue

Clin Sci (Lond) (2022) 136 (12): 973–987.

DOI: https://doi.org/10.1042/CS20220083

Published: 22 June 2022

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Defining the molecular underpinnings controlling cardiomyocyte proliferation

Donya Mahiny-Shahmohammady, Ludger Hauck, Filio Billia

Clin Sci (Lond) (2022) 136 (12): 911–934.

DOI: https://doi.org/10.1042/CS20211180

Published: 20 June 2022

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Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction

Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (11): 879–894.

DOI: https://doi.org/10.1042/CS20220117

Published: 06 June 2022

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Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females

Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2022) 136 (11): 825–840.

DOI: https://doi.org/10.1042/CS20220002

Published: 01 June 2022

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Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection

Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Apiwan Arinno, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn

Clin Sci (Lond) (2022) 136 (11): 841–860.

DOI: https://doi.org/10.1042/CS20220074

Published: 01 June 2022

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Articles

Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang

Clin Sci (Lond) (2022) 136 (11): 803–817.

DOI: https://doi.org/10.1042/CS20220226

Published: 30 May 2022

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Angiotensin Receptors - Affinity and Beyond

Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings

Clin Sci (Lond) (2022) 136 (10): 799–802.

DOI: https://doi.org/10.1042/CS20220024

Published: 27 May 2022

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Visualization of regenerating and repairing hearts

Nevan Powers, Guo N. Huang

Clin Sci (Lond) (2022) 136 (10): 787–798.

DOI: https://doi.org/10.1042/CS20211116

Published: 27 May 2022

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Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

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Cardiovascular-Oncology

Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen

Clin Sci (Lond) (2022) 136 (9): 675–694.

DOI: https://doi.org/10.1042/CS20220182

Published: 10 May 2022

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Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p

Dasom Mun, Hyoeun Kim, Ji-Young Kang, Nuri Yun, Young-Nam Youn, Boyoung Joung

Clin Sci (Lond) (2022) 136 (8): 621–637.

DOI: https://doi.org/10.1042/CS20211141

Published: 27 April 2022

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Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension

Theodore W. Kurtz, Michal Pravenec, Stephen E. DiCarlo

Clin Sci (Lond) (2022) 136 (8): 599–620.

DOI: https://doi.org/10.1042/CS20210566

Published: 22 April 2022

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Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos

Clin Sci (Lond) (2022) 136 (8): 537–555.

DOI: https://doi.org/10.1042/CS20211090

Published: 21 April 2022

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SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection

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Coronavirus

John D. Imig

Clin Sci (Lond) (2022) 136 (6): 431–434.

DOI: https://doi.org/10.1042/CS20220028

Published: 29 March 2022

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Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall

Maria J. Forteza, Daniel F.J. Ketelhuth

Clin Sci (Lond) (2022) 136 (6): 435–454.

DOI: https://doi.org/10.1042/CS20201293

Published: 29 March 2022

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Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos

Clin Sci (Lond) (2022) 136 (6): 405–423.

DOI: https://doi.org/10.1042/CS20210835

Published: 23 March 2022

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Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?

Nhat-Tu Le, Elizabeth A. Olmsted-Davis, Jun-ichi Abe

Clin Sci (Lond) (2022) 136 (5): 379–382.

DOI: https://doi.org/10.1042/CS20211096

Published: 11 March 2022

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Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin

Clin Sci (Lond) (2022) 136 (5): 345–360.

DOI: https://doi.org/10.1042/CS20210512

Published: 09 March 2022

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Role of prostaglandin D 2 receptors in the pathogenesis of abdominal aortic aneurysm formation

Neal L. Weintraub, Andra L. Blomkalns, Mourad Ogbi, Tetsuo Horimatsu, Tyler W. Benson, Yuqing Huo, David J. Fulton, Gautam Agarwal, Richard Lee, Michael A. Winkler, Lufei Young, Ken Fujise, Avirup Guha, Tohru Fukai, Masuko Ushio-Fukai, Xiaochun Long, Brian H. Annex, Ha Won Kim

Clin Sci (Lond) (2022) 136 (5): 309–321.

DOI: https://doi.org/10.1042/CS20220031

Published: 02 March 2022

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The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V. Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Clin Sci (Lond) (2022) 136 (5): 329–343.

DOI: https://doi.org/10.1042/CS20211151

Published: 02 March 2022

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Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms

Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina I. Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian V. Zhang, A.H. Jan Danser, Qing Yang, Xiujun Fan

Clin Sci (Lond) (2022) 136 (4): 257–272.

DOI: https://doi.org/10.1042/CS20210989

Published: 14 February 2022

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Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

DOI: https://doi.org/10.1042/CS20210509

Published: 07 February 2022

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Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad

Clin Sci (Lond) (2022) 136 (2): 181–196.

DOI: https://doi.org/10.1042/CS20210964

Published: 28 January 2022

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Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension

Sarah-Eve Lemay, Sebastien Bonnet, François Potus

Clin Sci (Lond) (2022) 136 (1): 163–166.

DOI: https://doi.org/10.1042/CS20211095

Published: 10 January 2022

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Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

In Collection

Cardiovascular-Oncology

Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba

Clin Sci (Lond) (2022) 136 (1): 139–161.

DOI: https://doi.org/10.1042/CS20210836

Published: 07 January 2022

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