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Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction

Anna K. Whitehead, Nicholas D. Fried, Zhen Li, Kandasamy Neelamegam, Charlotte S. Pearson, Kyle B. LaPenna, Thomas E. Sharp, David J. Lefer, Eric Lazartigues, Jason D. Gardner, Xinping Yue

Clin Sci (Lond) (2022) 136 (12): 973–987.

DOI: https://doi.org/10.1042/CS20220083

Published: 22 June 2022

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Defining the molecular underpinnings controlling cardiomyocyte proliferation

Donya Mahiny-Shahmohammady, Ludger Hauck, Filio Billia

Clin Sci (Lond) (2022) 136 (12): 911–934.

DOI: https://doi.org/10.1042/CS20211180

Published: 20 June 2022

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G protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation

Fuwei Zhang, Lifu Lei, Juan Huang, Weiwei Wang, Qian Su, Hongjia Yan, Caiyu Chen, Shuo Zheng, Hongmei Ren, Zhuxin Li, Pedro A. Jose, Yijie Hu, Liangyi Si, Chunyu Zeng, Jian Yang

Clin Sci (Lond) (2022) CS20220236.

DOI: https://doi.org/10.1042/CS20220236

Published: 13 June 2022

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Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction

Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell

Clin Sci (Lond) (2022) 136 (11): 879–894.

DOI: https://doi.org/10.1042/CS20220117

Published: 06 June 2022

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Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females

Riyaz Mohamed, Gene R. Crislip, Sarah McLarnon, Qingqing Wei, Paul M. O’Connor, Jennifer C. Sullivan

Clin Sci (Lond) (2022) 136 (11): 825–840.

DOI: https://doi.org/10.1042/CS20220002

Published: 01 June 2022

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Promoting mitochondrial fusion in doxorubicin-induced cardiotoxicity: a novel therapeutic target for cardioprotection

Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Apiwan Arinno, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn

Clin Sci (Lond) (2022) 136 (11): 841–860.

DOI: https://doi.org/10.1042/CS20220074

Published: 01 June 2022

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Articles

Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of Ca V 1.2 calcium channel in hypertension

Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang

Clin Sci (Lond) (2022) 136 (11): 803–817.

DOI: https://doi.org/10.1042/CS20220226

Published: 30 May 2022

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Visualization of regenerating and repairing hearts

Nevan Powers, Guo N. Huang

Clin Sci (Lond) (2022) 136 (10): 787–798.

DOI: https://doi.org/10.1042/CS20211116

Published: 27 May 2022

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Angiotensin Receptors - Affinity and Beyond

Colin Sumners, Igor Maciel Souza Silva, U. Muscha Steckelings

Clin Sci (Lond) (2022) 136 (10): 799–802.

DOI: https://doi.org/10.1042/CS20220024

Published: 27 May 2022

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Articles

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage

Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen

Clin Sci (Lond) (2022) 136 (9): 675–694.

DOI: https://doi.org/10.1042/CS20220182

Published: 10 May 2022

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Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p

Dasom Mun, Hyoeun Kim, Ji-Young Kang, Nuri Yun, Young-Nam Youn, Boyoung Joung

Clin Sci (Lond) (2022) 136 (8): 621–637.

DOI: https://doi.org/10.1042/CS20211141

Published: 27 April 2022

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Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension

Theodore W. Kurtz, Michal Pravenec, Stephen E. DiCarlo

Clin Sci (Lond) (2022) 136 (8): 599–620.

DOI: https://doi.org/10.1042/CS20210566

Published: 22 April 2022

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Ebselen abolishes vascular dysfunction in influenza A virus-induced exacerbations of cigarette smoke-induced lung inflammation in mice

Kurt Brassington, Stanley M.H. Chan, Simone N. De Luca, Aleksandar Dobric, Suleman A. Almerdasi, Kevin Mou, Huei Jiunn Seow, Osezua Oseghale, Steven Bozinovski, Stavros Selemidis, Ross Vlahos

Clin Sci (Lond) (2022) 136 (8): 537–555.

DOI: https://doi.org/10.1042/CS20211090

Published: 21 April 2022

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Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall

Maria J. Forteza, Daniel F.J. Ketelhuth

Clin Sci (Lond) (2022) 136 (6): 435–454.

DOI: https://doi.org/10.1042/CS20201293

Published: 29 March 2022

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SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection

John D. Imig

Clin Sci (Lond) (2022) 136 (6): 431–434.

DOI: https://doi.org/10.1042/CS20220028

Published: 29 March 2022

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Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos

Clin Sci (Lond) (2022) 136 (6): 405–423.

DOI: https://doi.org/10.1042/CS20210835

Published: 23 March 2022

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Articles

Paradoxical effects of osteoprotegerin on vascular function: inhibiting inflammation while promoting oxidative stress?

Nhat-Tu Le, Elizabeth A. Olmsted-Davis, Jun-ichi Abe

Clin Sci (Lond) (2022) 136 (5): 379–382.

DOI: https://doi.org/10.1042/CS20211096

Published: 11 March 2022

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Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin

Clin Sci (Lond) (2022) 136 (5): 345–360.

DOI: https://doi.org/10.1042/CS20210512

Published: 09 March 2022

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Role of prostaglandin D 2 receptors in the pathogenesis of abdominal aortic aneurysm formation

Neal L. Weintraub, Andra L. Blomkalns, Mourad Ogbi, Tetsuo Horimatsu, Tyler W. Benson, Yuqing Huo, David J. Fulton, Gautam Agarwal, Richard Lee, Michael A. Winkler, Lufei Young, Ken Fujise, Avirup Guha, Tohru Fukai, Masuko Ushio-Fukai, Xiaochun Long, Brian H. Annex, Ha Won Kim

Clin Sci (Lond) (2022) 136 (5): 309–321.

DOI: https://doi.org/10.1042/CS20220031

Published: 02 March 2022

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The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Maria Vitoria da Silva, Artur Santos-Miranda, Julliane V. Joviano-Santos, Diego Santos Souza, Leisiane Pereira Marques, Jaqueline Oliveira Sarmento, Samuel Santos Beserra, Danilo Roman-Campos

Clin Sci (Lond) (2022) 136 (5): 329–343.

DOI: https://doi.org/10.1042/CS20211151

Published: 02 March 2022

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Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms

Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina I. Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian V. Zhang, A.H. Jan Danser, Qing Yang, Xiujun Fan

Clin Sci (Lond) (2022) 136 (4): 257–272.

DOI: https://doi.org/10.1042/CS20210989

Published: 14 February 2022

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Emergent players in renovascular disease

Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman

Clin Sci (Lond) (2022) 136 (3): 239–256.

DOI: https://doi.org/10.1042/CS20210509

Published: 07 February 2022

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Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad

Clin Sci (Lond) (2022) 136 (2): 181–196.

DOI: https://doi.org/10.1042/CS20210964

Published: 28 January 2022

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Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension

Sarah-Eve Lemay, Sebastien Bonnet, François Potus

Clin Sci (Lond) (2022) 136 (1): 163–166.

DOI: https://doi.org/10.1042/CS20211095

Published: 10 January 2022

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Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba

Clin Sci (Lond) (2022) 136 (1): 139–161.

DOI: https://doi.org/10.1042/CS20210836

Published: 07 January 2022

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Urocortins as biomarkers in cardiovascular disease

Inês Vasconcelos, Rui Adão, Miriam T. Rademaker, Adelino F. Leite-Moreira, Ana Patrícia Fontes-Sousa, Carmen Brás-Silva

Clin Sci (Lond) (2022) 136 (1): 1–14.

DOI: https://doi.org/10.1042/CS20210732

Published: 23 December 2021

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Articles

The acute pressure natriuresis response is suppressed by selective ET A receptor blockade

Geoffrey Culshaw, David Binnie, Neeraj Dhaun, Patrick Hadoke, Matthew Bailey, David J Webb

Clin Sci (Lond) (2021) CS20210937.

DOI: https://doi.org/10.1042/CS20210937

Published: 17 December 2021

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AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A. Boisvert, Thomas Unger, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega

Clin Sci (Lond) (2021) 135 (24): 2763–2780.

DOI: https://doi.org/10.1042/CS20210971

Published: 17 December 2021

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Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats

Sheon Mary, Philipp Boder, Giacomo Rossitto, Lesley Graham, Kayley Scott, Arun Flynn, David Kipgen, Delyth Graham, Christian Delles

Clin Sci (Lond) (2021) 135 (24): 2749–2761.

DOI: https://doi.org/10.1042/CS20211017

Published: 17 December 2021

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The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

Elisa Avolio, Michele Carrabba, Rachel Milligan, Maia Kavanagh Williamson, Antonio P. Beltrami, Kapil Gupta, Karen T. Elvers, Monica Gamez, Rebecca R. Foster, Kathleen Gillespie, Fergus Hamilton, David Arnold, Imre Berger, Andrew D. Davidson, Darryl Hill, Massimo Caputo, Paolo Madeddu

Clin Sci (Lond) (2021) 135 (24): 2667–2689.

DOI: https://doi.org/10.1042/CS20210735

Published: 15 December 2021

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Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity

Ninian N. Lang, Rhian M. Touyz

Clin Sci (Lond) (2021) 135 (23): 2661–2663.

DOI: https://doi.org/10.1042/CS20210986

Published: 09 December 2021

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Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni

Clin Sci (Lond) (2021) 135 (23): 2625–2641.

DOI: https://doi.org/10.1042/CS20210810

Published: 08 December 2021

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Countering the classical renin–angiotensin system

Natalia M. Noto, Yazmin M. Restrepo, Robert C. Speth

Clin Sci (Lond) (2021) 135 (23): 2619–2623.

DOI: https://doi.org/10.1042/CS20211043

Published: 08 December 2021

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Paternal long-term PM 2.5 exposure causes hypertension via increased renal AT 1 R expression and function in male offspring

Cuimei Hu, Yu Tao, Yi Deng, Qi Cai, Hongmei Ren, Cheng Yu, Shuo Zheng, Jian Yang, Chunyu Zeng

Clin Sci (Lond) (2021) 135 (22): 2575–2588.

DOI: https://doi.org/10.1042/CS20210802

Published: 26 November 2021

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Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia

Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi

Clin Sci (Lond) (2021) 135 (21): 2503–2520.

DOI: https://doi.org/10.1042/CS20210719

Published: 09 November 2021

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Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Liyun Feng, Dongdong Que, Zehua Li, Xinglong Zhong, Jing Yan, Jintao Wei, Xiuli Zhang, Pingzhen Yang, Caiwen Ou, Minsheng Chen

Clin Sci (Lond) (2021) 135 (21): 2483–2502.

DOI: https://doi.org/10.1042/CS20210259

Published: 08 November 2021

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Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension

Hongxia Jiang, Dandan Ding, Yuanzhou He, Xiaochen Li, Yongjian Xu, Xiansheng Liu

Clin Sci (Lond) (2021) 135 (21): 2467–2481.

DOI: https://doi.org/10.1042/CS20210612

Published: 01 November 2021

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Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species

Rhéure Alves-Lopes, Karla Bianca Neves, Anastasiya Strembitska, Adam P. Harvey, Katie Y. Harvey, Hiba Yusuf, Susan Haniford, Ross T. Hepburn, Jennifer Dyet, Wendy Beattie, Laura Haddow, John McAbney, Delyth Graham, Augusto C. Montezano

Clin Sci (Lond) (2021) 135 (20): 2429–2444.

DOI: https://doi.org/10.1042/CS20210643

Published: 28 October 2021

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Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda

Clin Sci (Lond) (2021) 135 (20): 2409–2422.

DOI: https://doi.org/10.1042/CS20210405

Published: 22 October 2021

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High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH 2 -terminal activity

Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Oliveira Edilamar Menezes

Clin Sci (Lond) (2021) 135 (20): 2377–2391.

DOI: https://doi.org/10.1042/CS20210739

Published: 19 October 2021

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Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy

Clin Sci (Lond) (2021) 135 (20): 2341–2356.

DOI: https://doi.org/10.1042/CS20210462

Published: 18 October 2021

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Splenectomy increases blood pressure and abolishes sex differences in renal T-regulatory cells in spontaneously hypertensive rats

Ellen E. Gillis, Kasey Belanger, Mahmoud Abdelbary, Riyaz Mohamed, Jingping Sun, Michael W. Brands, Jennifer C. Sullivan

Clin Sci (Lond) (2021) 135 (19): 2329–2339.

DOI: https://doi.org/10.1042/CS20210469

Published: 13 October 2021

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Epigenetic processes during preeclampsia and effects on fetal development and chronic health

Usman M. Ashraf, Dalton L. Hall, Adam Z. Rawls, Barbara T. Alexander

Clin Sci (Lond) (2021) 135 (19): 2307–2327.

DOI: https://doi.org/10.1042/CS20190070

Published: 13 October 2021

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Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Jennifer Leggat, Guillaume Bidault, Antonio Vidal-Puig

Clin Sci (Lond) (2021) 135 (19): 2265–2283.

DOI: https://doi.org/10.1042/CS20210127

Published: 13 October 2021

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Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein

Daniele T. Alves, Luiz Felipe Mendes, Walkyria O. Sampaio, Leda M.C. Coimbra-Campos, Maria Aparecida R. Vieira, Anderson J. Ferreira, Almir S. Martins, Elena Popova, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Robson A.S. Santos, Maria Jose Campagnole-Santos

Clin Sci (Lond) (2021) 135 (18): 2197–2216.

DOI: https://doi.org/10.1042/CS20210599

Published: 21 September 2021

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Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Jan Neckář, Petra Alánová, Veronika Olejníčková, František Papoušek, Lucie Hejnová, Jan Šilhavý, Michal Behuliak, Michal Bencze, Jaroslav Hrdlička, Marek Vecka, Dagmar Jarkovská, Jitka Švíglerová, Eliška Mistrová, Milan Štengl, Jiří Novotný, Bohuslav Ošťádal, Michal Pravenec, František Kolář

Clin Sci (Lond) (2021) 135 (17): 2143–2163.

DOI: https://doi.org/10.1042/CS20210648

Published: 17 September 2021

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Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm

Xianming Zhou, Chao Zhang, Fei Xie, Wei Wei, Rui Li, Qian Xu, Yu Wang, Philip A. Klenotic, Goutham Narla, Nianguo Dong, Zhiyong Lin

Clin Sci (Lond) (2021) 135 (17): 2085–2097.

DOI: https://doi.org/10.1042/CS20210315

Published: 01 September 2021

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Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Valter Lubrano, Silvana Balzan

Clin Sci (Lond) (2021) 135 (16): 1981–1997.

DOI: https://doi.org/10.1042/CS20210417

Published: 20 August 2021

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Vascular contributions to cognitive impairment and dementia: the emerging role of 20-HETE

Ezekiel Gonzalez-Fernandez, Yedan Liu, Alexander P. Auchus, Fan Fan, Richard J. Roman

Clin Sci (Lond) (2021) 135 (15): 1929–1944.

DOI: https://doi.org/10.1042/CS20201033

Published: 10 August 2021

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Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba

Clin Sci (Lond) (2021) 135 (15): 1897–1914.

DOI: https://doi.org/10.1042/CS20210311

Published: 10 August 2021

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