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Articles

Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization

Jing-Xuan Xu, Shui-Lin Qin, Hao-Wen Wei, Yuan-Yuan Chen, Yu-Chong Peng, Lu-Nan Qi
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (4): 303–316.
DOI: https://doi.org/10.1042/CS20220661
Published: 17 February 2023
View article titled, Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization
Click here to open pdf in another window PDF for Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization
Includes: Supplementary data
Articles

Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways

Sheila Almaraz Postigo, Juan Carlos Montero
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 1–15.
DOI: https://doi.org/10.1042/CS20220472
Published: 23 December 2022
View article titled, Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways
Click here to open pdf in another window PDF for Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways
Includes: Supplementary data
Articles

CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2

Xudong Wang, Yanshi Li, Min Pan, Tao Lu, Min Wang, Zhihai Wang, Chuan Liu, Guohua Hu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1691–1710.
DOI: https://doi.org/10.1042/CS20220581
Published: 25 November 2022
View article titled, CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2
Click here to open pdf in another window PDF for CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial–mesenchymal transition via inhibiting MDM2
Includes: Supplementary data
Articles

ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis

Kai Jiang, Haiyan Chen, Kefeng Ding
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (18): 1367–1370.
DOI: https://doi.org/10.1042/CS20220394
Published: 26 September 2022
View article titled, ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis
Click here to open pdf in another window PDF for ANGPTL1, Foxo3a-Sox2, and colorectal cancer metastasis
Articles

Cellular and molecular mechanisms of breast cancer susceptibility

Sundus F. Shalabi, Mark A. LaBarge
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1025–1043.
DOI: https://doi.org/10.1042/CS20211158
Published: 04 July 2022
View article titled, Cellular and molecular mechanisms of breast cancer susceptibility
Click here to open pdf in another window PDF for Cellular and molecular mechanisms of breast cancer susceptibility
Articles

Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma

Zhanzhan Li, Yanyan Li, Na Li, Liangfang Shen, Aibin Liu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 895–909.
DOI: https://doi.org/10.1042/CS20220128
Published: 06 June 2022
View article titled, Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma
Click here to open pdf in another window PDF for Silencing GOLGA8B inhibits cell invasion and metastasis by suppressing STAT3 signaling pathway in lung squamous cell carcinoma
Includes: Supplementary data
Articles

Mechanisms underlying immune-related adverse events during checkpoint immunotherapy

Xiao Zhou, Xiang Chen, Leng Han, Hong Liu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (10): 771–785.
DOI: https://doi.org/10.1042/CS20210042
Published: 27 May 2022
View article titled, Mechanisms underlying immune-related adverse events during checkpoint immunotherapy
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Articles

ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer

Ting-Yu Chang, Kuo-Cheng Lan, Chen-Yuan Chiu, Meei-Ling Sheu, Shing-Hwa Liu
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (9): 657–673.
DOI: https://doi.org/10.1042/CS20220043
Published: 06 May 2022
View article titled, ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer
Click here to open pdf in another window PDF for ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer
Includes: Supplementary data
Articles

Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer

Phimmada Hatthakarnkul, Jean A. Quinn, Aula Ammar, Gerard Lynch, Hester Van Wyk, Donald C. McMillan, Chanitra Thuwajit, Joanne Edwards
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (8): 521–535.
DOI: https://doi.org/10.1042/CS20210886
Published: 21 April 2022
View article titled, Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer
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Articles

Epigenomic alterations in cancer: mechanisms and therapeutic potential

Jaimie S. Gray, Sajad A. Wani, Moray J. Campbell
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (7): 473–492.
DOI: https://doi.org/10.1042/CS20210449
Published: 06 April 2022
View article titled, Epigenomic alterations in cancer: mechanisms and therapeutic potential
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Articles

Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy

David Mas-Ponte, Marcel McCullough, Fran Supek
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 383–404.
DOI: https://doi.org/10.1042/CS20210682
Published: 11 March 2022
View article titled, Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy
Click here to open pdf in another window PDF for Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy
Includes: Supplementary data
Articles

Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression

Natasha Kolesnikoff, Chun-Hsien Chen, Michael Susithiran Samuel
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 361–377.
DOI: https://doi.org/10.1042/CS20210679
Published: 09 March 2022
View article titled, Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression
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Articles

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham, Carsten Gram Hansen
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (3): 197–222.
DOI: https://doi.org/10.1042/CS20201474
Published: 04 February 2022
View article titled, The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
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Articles

Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity

In Collection
Cardiovascular-Oncology
Ninian N. Lang, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2661–2663.
DOI: https://doi.org/10.1042/CS20210986
Published: 09 December 2021
View article titled, Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity
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Articles

A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang, Cheng Yang, Li Yu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1751–1765.
DOI: https://doi.org/10.1042/CS20210571
Published: 27 July 2021
View article titled, A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis
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Includes: Supplementary data
Articles

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension

In Collection
Cardiovascular-Oncology
Daniel N. Meijles, Joshua J. Cull, Susanna T.E. Cooper, Thomais Markou, Michelle A. Hardyman, Stephen J. Fuller, Hajed O. Alharbi, Zoe H.R. Haines, Viridiana Alcantara-Alonso, Peter E. Glennon, Mary N. Sheppard, Peter H. Sugden, Angela Clerk
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
DOI: https://doi.org/10.1042/CS20210192
Published: 23 July 2021
View article titled, The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension
Click here to open pdf in another window PDF for The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension
Includes: Supplementary data
Articles

Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?

In Collection
Cardiovascular-Oncology
Daan C.H. van Dorst, Leni van Doorn, Katrina M. Mirabito Colafella, Olivier C. Manintveld, H. Carlijne Hassing, A.H. Jan Danser, Ron H.J. Mathijssen, Jorie Versmissen
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
DOI: https://doi.org/10.1042/CS20200300
Published: 20 July 2021
View article titled, Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?
Click here to open pdf in another window PDF for Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?
Articles

Unravelling the tangled web of hypertension and cancer

In Collection
Cardiovascular-Oncology
Aristeidis Sionakidis, Linsay McCallum, Sandosh Padmanabhan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1609–1625.
DOI: https://doi.org/10.1042/CS20200307
Published: 09 July 2021
View article titled, Unravelling the tangled web of hypertension and cancer
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Articles

Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents

David L. Brautigan, Caroline Farrington, Goutham Narla
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1545–1556.
DOI: https://doi.org/10.1042/CS20201367
Published: 30 June 2021
View article titled, Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents
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Articles

Interactions between cardiology and oncology drugs in precision cardio-oncology

In Collection
Cardiovascular-Oncology
Sailaja Kamaraju, Meera Mohan, Svetlana Zaharova, Brianna Wallace, Joseph McGraw, James Lokken, John Tierney, Elizabeth Weil, Olubadewa Fatunde, Sherry-Ann Brown
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1333–1351.
DOI: https://doi.org/10.1042/CS20200309
Published: 02 June 2021
View article titled, Interactions between cardiology and oncology drugs in precision cardio-oncology
Click here to open pdf in another window PDF for Interactions between cardiology and oncology drugs in precision cardio-oncology
Articles

Missing links — epigenetic regulators of the pancreatic cancer–associated inflammation

Gregor Werba, Tamas A. Gonda
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1289–1293.
DOI: https://doi.org/10.1042/CS20210181
Published: 28 May 2021
View article titled, Missing links — epigenetic regulators of the pancreatic cancer–associated inflammation
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Articles

Emerging role of carbonic anhydrase inhibitors

Claudiu T. Supuran
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1233–1249.
DOI: https://doi.org/10.1042/CS20210040
Published: 20 May 2021
View article titled, Emerging role of carbonic anhydrase inhibitors
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Articles

In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system

Antoine M. Snijders, Mi Zhou, Todd P. Whitehead, Briana Fitch, Priyatama Pandey, Aaron Hechmer, Abel Huang, Suzaynn F. Schick, Adam J. de Smith, Adam B. Olshen, Catherine Metayer, Jian-Hua Mao, Joseph L. Wiemels, Scott C. Kogan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (8): 1053–1063.
DOI: https://doi.org/10.1042/CS20201498
Published: 23 April 2021
View article titled, In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system
Click here to open pdf in another window PDF for In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system
Includes: Supplementary data
Articles

Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure

In Collection
Cardiovascular-Oncology
Leanne Mooney, Carl S. Goodyear, Tamir Chandra, Kristina Kirschner, Mhairi Copland, Mark C. Petrie, Ninian N. Lang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 991–1007.
DOI: https://doi.org/10.1042/CS20200306
Published: 16 April 2021
View article titled, Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure
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Articles

EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics

Fang-Jing Zhong, Yi-Ming Li, Cong Xu, Bo Sun, Ji-Long Wang, Lian-Yue Yang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (7): 847–864.
DOI: https://doi.org/10.1042/CS20201500
Published: 06 April 2021
View article titled, EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics
Click here to open pdf in another window PDF for EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics
Includes: Supplementary data
Articles

KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages

Mu-xing Li, Hang-yan Wang, Chun-hui Yuan, Zhao-lai Ma, Bin Jiang, Lei Li, Li Zhang, Dian-rong Xiu
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (4): 629–649.
DOI: https://doi.org/10.1042/CS20201259
Published: 22 February 2021
View article titled, KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages
Click here to open pdf in another window PDF for KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages
Includes: Supplementary data
Articles

P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model

Peter Cuthbertson, Nicholas J. Geraghty, Sam R. Adhikary, Sienna Casolin, Debbie Watson, Ronald Sluyter
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (3): 495–513.
DOI: https://doi.org/10.1042/CS20201352
Published: 03 February 2021
View article titled, P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model
Click here to open pdf in another window PDF for P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model
Includes: Supplementary data
Articles

The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling

Xueying Hu, Liang Xiang, Dong He, Rongrong Zhu, Jianing Fang, Zhanwang Wang, Ke Cao
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (3): 555–574.
DOI: https://doi.org/10.1042/CS20200908
Published: 03 February 2021
View article titled, The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling
Click here to open pdf in another window PDF for The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis -activation and the consequent initiation of Rho GTPase-mediated signaling
Includes: Supplementary data
Articles

Cardiotoxic effects of angiogenesis inhibitors

In Collection
Cardiovascular-Oncology
Stephen J.H. Dobbin, Mark C. Petrie, Rachel C. Myles, Rhian M. Touyz, Ninian N. Lang
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 71–100.
DOI: https://doi.org/10.1042/CS20200305
Published: 06 January 2021
View article titled, Cardiotoxic effects of angiogenesis inhibitors
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Articles

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

Jitske van den Bulk, Noel F.C.C. de Miranda, Peter ten Dijke
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 35–52.
DOI: https://doi.org/10.1042/CS20201236
Published: 05 January 2021
View article titled, Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression
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Articles

Epigenetic silencing of miR564 contributes to the leukemogenesis of t(8;21) acute myeloid leukemia

Erna Yang, Wei Guan, Desheng Gong, Xuefeng Gao, Caixia Han, Juan Zhang, Hong Wang, Mengzhen Wang, Yonghui Li, Li Yu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3079–3091.
DOI: https://doi.org/10.1042/CS20200786
Published: 02 December 2020
View article titled, Epigenetic silencing of miR564 contributes to the leukemogenesis of t(8;21) acute myeloid leukemia
Click here to open pdf in another window PDF for Epigenetic silencing of miR564 contributes to the leukemogenesis of t(8;21) acute myeloid leukemia
Includes: Supplementary data
Articles

CYP1B1 as a therapeutic target in cardio-oncology

In Collection
Cardiovascular-Oncology
Alexa N. Carrera, Marianne K.O. Grant, Beshay N. Zordoky
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2897–2927.
DOI: https://doi.org/10.1042/CS20200310
Published: 13 November 2020
View article titled, CYP1B1 as a therapeutic target in cardio-oncology
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Articles

Cardiovascular toxicity of PI3Kα inhibitors

In Collection
Cardiovascular-Oncology
Chandu Sadasivan, Pavel Zhabyeyev, Dina Labib, James A. White, D. Ian Paterson, Gavin Y. Oudit
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2595–2622.
DOI: https://doi.org/10.1042/CS20200302
Published: 14 October 2020
View article titled, Cardiovascular toxicity of PI3Kα inhibitors
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Articles

Vascular toxicity associated with anti-angiogenic drugs

In Collection
Cardiovascular-Oncology
Karla B. Neves, Augusto C. Montezano, Ninian N. Lang, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
DOI: https://doi.org/10.1042/CS20200308
Published: 29 September 2020
View article titled, Vascular toxicity associated with anti-angiogenic drugs
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Articles

Emerging roles for the IL-6 family of cytokines in pancreatic cancer

Gemma van Duijneveldt, Michael D.W. Griffin, Tracy L. Putoczki
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2091–2115.
DOI: https://doi.org/10.1042/CS20191211
Published: 18 August 2020
View article titled, Emerging roles for the IL-6 family of cytokines in pancreatic cancer
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Articles

RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer

Huaiming Wang, Rongkang Huang, Wentai Guo, Xiusen Qin, Zifeng Yang, Zixu Yuan, Yingqi Wei, Chunlin Mo, Zhantao Zeng, Jian Luo, Jian Cai, Hui Wang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1973–1990.
DOI: https://doi.org/10.1042/CS20191174
Published: 28 July 2020
View article titled, RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer
Click here to open pdf in another window PDF for RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer
Includes: Supplementary data
Articles

Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway

Xinglong Dai, Jianjun Liu, Xiong Guo, Anqi Cheng, Xiaoya Deng, Liqun Guo, Ziwei Wang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1821–1839.
DOI: https://doi.org/10.1042/CS20191043
Published: 17 July 2020
View article titled, Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway
Click here to open pdf in another window PDF for Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway
Articles

Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway

Yongjie Zhou, Qing Xu, Lv Tao, Yuwei Chen, Yuke Shu, Zhenru Wu, Changli Lu, Yujun Shi, Hong Bu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1457–1472.
DOI: https://doi.org/10.1042/CS20200244
Published: 18 June 2020
View article titled, Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway
Click here to open pdf in another window PDF for Enhanced SMARCD1, a subunit of the SWI/SNF complex, promotes liver cancer growth through the mTOR pathway
Includes: Supplementary data
Articles

p110δ PI3K as a therapeutic target of solid tumours

Lydia Xenou, Evangelia A. Papakonstanti
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1377–1397.
DOI: https://doi.org/10.1042/CS20190772
Published: 18 June 2020
View article titled, p110δ PI3K as a therapeutic target of solid tumours
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Articles

LOC101928834, a novel lncRNA in Wnt/β-catenin signaling pathway, promotes cell proliferation and predicts poor clinical outcome in myelodysplastic syndromes

Nianyi Li, Yan Ma, Wei Wang, C. Cameron Yin, Wanling Wu, Ruichen Sun, Guangjie Zhao, Shuang Li, Xiaoqin Wang
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1279–1293.
DOI: https://doi.org/10.1042/CS20200439
Published: 15 June 2020
View article titled, LOC101928834, a novel lncRNA in Wnt/β-catenin signaling pathway, promotes cell proliferation and predicts poor clinical outcome in myelodysplastic syndromes
Click here to open pdf in another window PDF for LOC101928834, a novel lncRNA in Wnt/β-catenin signaling pathway, promotes cell proliferation and predicts poor clinical outcome in myelodysplastic syndromes
Includes: Supplementary data
Articles

Deregulation of miRNAs-cMYC circuits is a key event in refractory celiac disease type-2 lymphomagenesis

Valentina Vaira, Gabriella Gaudioso, Maria Antonella Laginestra, Andrea Terrasi, Claudio Agostinelli, Silvano Bosari, Antonio Di Sabatino, Alessandro Vanoli, Marco Paulli, Stefano Ferrero, Leda Roncoroni, Vincenza Lombardo, Liyanage P. Perera, Sonia Fabris, Maurizio Vecchi, Stefano Pileri, Luca Elli
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (10): 1151–1166.
DOI: https://doi.org/10.1042/CS20200032
Published: 22 May 2020
View article titled, Deregulation of miRNAs-cMYC circuits is a key event in refractory celiac disease type-2 lymphomagenesis
Click here to open pdf in another window PDF for Deregulation of miRNAs-cMYC circuits is a key event in refractory celiac disease type-2 lymphomagenesis
Includes: Supplementary data
Articles

DLC-1 down-regulation via exosomal miR-106b-3p exchange promotes CRC metastasis by the epithelial-to-mesenchymal transition

Francesco Mannavola, Gaetano Pezzicoli, Marco Tucci
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (8): 955–959.
DOI: https://doi.org/10.1042/CS20200181
Published: 21 April 2020
View article titled, DLC-1 down-regulation via exosomal miR-106b-3p exchange promotes CRC metastasis by the epithelial-to-mesenchymal transition
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Articles

miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway

Junqiang Fan, Guanxin Xu, Zhibo Chang, Ling Zhu, Jie Yao
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 807–825.
DOI: https://doi.org/10.1042/CS20200039
Published: 09 April 2020
View article titled, miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway
Click here to open pdf in another window PDF for miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway
Includes: Supplementary data
Articles

Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs

Jinhui Lü, Qian Zhao, Xin Ding, Yuefan Guo, Yuan Li, Zhen Xu, Shujun Li, Zhongrui Wang, Lei Shen, Huang-wen Chen, Zuoren Yu, Richard G. Pestell
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 791–805.
DOI: https://doi.org/10.1042/CS20191318
Published: 09 April 2020
View article titled, Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs
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Includes: Supplementary data
Articles

Tumoral PD-1 hi CD8 + T cells are partially exhausted and predict favorable outcome in triple-negative breast cancer

Liang Guo, Chunmei Cao, Shyamal Goswami, Xiaoyan Huang, Linxiaoxi Ma, Yicheng Guo, Benlong Yang, Teng Li, Yayun Chi, Xiaoming Zhang, Jiong Wu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 711–726.
DOI: https://doi.org/10.1042/CS20191261
Published: 03 April 2020
View article titled, Tumoral PD-1 hi CD8 + T cells are partially exhausted and predict favorable outcome in triple-negative breast cancer
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Includes: Supplementary data
Articles

Clinical Science : translating molecular bioscience and experimental research into medical insights

Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (4): 435–437.
DOI: https://doi.org/10.1042/CS20200182
Published: 28 February 2020
View article titled, Clinical Science : translating molecular bioscience and experimental research into medical insights
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Articles

Colorectal cancer-derived exosomal miR-106b-3p promotes metastasis by down-regulating DLC-1 expression

He Liu, Yanlong Liu, Ping Sun, Kaiming Leng, Yi Xu, Liqi Mei, Peng Han, Bomiao Zhang, Kefei Yao, Chunbo Li, Junge Bai, Binbin Cui
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (4): 419–434.
DOI: https://doi.org/10.1042/CS20191087
Published: 27 February 2020
View article titled, Colorectal cancer-derived exosomal miR-106b-3p promotes metastasis by down-regulating DLC-1 expression
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Includes: Supplementary data
Articles

Acute myeloid leukemia immune escape by epigenetic CD48 silencing

Zhiding Wang, Yang Xiao, Wei Guan, Mengzhen Wang, Jinghong Chen, Linlin Zhang, Yan Li, Qian Xiong, Hong Wang, Maoquan Wang, Yuyan Li, Na Lv, Yonghui Li, Lixin Wang, Li Yu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (2): 261–271.
DOI: https://doi.org/10.1042/CS20191170
Published: 29 January 2020
View article titled, Acute myeloid leukemia immune escape by epigenetic CD48 silencing
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Includes: Supplementary data
Articles

Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease

Peter Cuthbertson, Sam R. Adhikary, Nicholas J. Geraghty, Thomas V. Guy, Amirazin Hadjiashrafi, Stephen J. Fuller, Diane Ly, Debbie Watson, Ronald Sluyter
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (2): 207–223.
DOI: https://doi.org/10.1042/CS20191086
Published: 27 January 2020
View article titled, Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease
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Articles

The TERT copy number gain is sensitive to telomerase inhibitors in human melanoma

Jinyu Yu, Jiayi Yu, Xiaowen Wu, Qian Guo, Ting Yin, Zhiyuan Cheng, Jie Dai, Yan Kong, Jun Guo
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (2): 193–205.
DOI: https://doi.org/10.1042/CS20190890
Published: 23 January 2020
View article titled, The TERT copy number gain is sensitive to telomerase inhibitors in human melanoma
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Includes: Supplementary data