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Cover ImageThe cover of this issue of Clinical Science (vol 137, iss 1) features a Hematoxylin and Eosin staining of mouse kidney from the study by Belyea et al. In their paper, they found that overexpression of Notch signaling specifically within renin-expressing cells of the kidney leads to the development of a polycystic kidney phenotype. Shown here is a kidney from a mutant mouse at 9 months of age. Photo taken by Fang Xu.Close Modal
In this Issue
Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease
Clin Sci (Lond) (2023) 137 (1): 65–85.
Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways
Clin Sci (Lond) (2023) 137 (1): 1–15.
Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice
Clin Sci (Lond) (2023) 137 (1): 17–30.
Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype
Brian C. Belyea; Fang Xu; Margaret Wiltsie; Hayes Fountain; Jennifer Charlton; Agnes B. Fogo; Maria Luisa Soledad Sequeira-Lopez; Roberto Ariel Gomez
Clin Sci (Lond) (2023) 137 (1): 35–45.
Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice
Nada J. Habeichi; Rana Ghali; Ali Mroueh; Abdullah Kaplan; Cynthia Tannous; Abdo Jurjus; Ghadir Amin; Mathias Mericskay; George W. Booz; Ahmed El-Yazbi; Fouad A. Zouein
Clin Sci (Lond) (2023) 137 (1): 47–63.
The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy
Ander Vergara; Carmen Llorens-Cebrià; Nerea Martos; Irene Martínez-Díaz; Frank Stein; Pamela Domínguez-Báez; Mireia Molina-Van den Bosch; Mandy Rettel; Begoña Benito; Sheila Bermejo; Michael Paul Pieper; Conxita Jacobs-Cachá; Maria José Soler
Clin Sci (Lond) (2023) 137 (1): 87–104.
Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell–derived Wnt3
Jianbo Liu; Kaixuan Liu; Shiquan Chai; Runze Xu; Ying Wang; Yundi Zhang; Shuanglian Wang; Chuanyong Liu; Bing Xue
Clin Sci (Lond) (2023) 137 (1): 109–127.
The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies
Clin Sci (Lond) (2023) 137 (1): 31–34.