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Cover ImageThe cover of this issue of Clinical Science (volume 135, issue 14) features an immunofluorescence staining of neural epidermal growth factor-like like 2 (NELL2) in human hyperplastic prostate cells. In their study, Liu et al. found that NELL2 is upregulated in human hyperplastic prostate and localized in the stroma and the epithelium compartments of human prostate tissues.
In this Issue
Cardiovascular toxicity of angiogenesis inhibitors and immune checkpoint inhibitors: synergistic anti-tumour effects at the cost of increased cardiovascular risk?
Daan C.H. van Dorst; Leni van Doorn; Katrina M. Mirabito Colafella; Olivier C. Manintveld; H. Carlijne Hassing; A.H. Jan Danser; Ron H.J. Mathijssen; Jorie Versmissen
Clin Sci (Lond) (2021) 135 (14): 1649–1668.
Phosphate and fibroblast growth factor 23 in diabetes
Amarens van der Vaart; Stanley M.H. Yeung; Peter R. van Dijk; Stephan J.L. Bakker; Martin H. de Borst
Clin Sci (Lond) (2021) 135 (14): 1669–1687.
Fifty years of research on the brain renin–angiotensin system: what have we learned?
Clin Sci (Lond) (2021) 135 (14): 1727–1731.
Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate
Clin Sci (Lond) (2021) 135 (14): 1767–1772.
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension
Daniel N. Meijles; Joshua J. Cull; Susanna T.E. Cooper; Thomais Markou; Michelle A. Hardyman; Stephen J. Fuller; Hajed O. Alharbi; Zoe H.R. Haines; Viridiana Alcantara-Alonso; Peter E. Glennon; Mary N. Sheppard; Peter H. Sugden; Angela Clerk
Clin Sci (Lond) (2021) 135 (14): 1631–1647.
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress
Lele Cheng; Tao Chen; Manyun Guo; Peining Liu; Xiangrui Qiao; Yuanyuan Wei; Jianqing She; Bolin Li; Wen Xi; Juan Zhou; Zuyi Yuan; Yue Wu; Junhui Liu
Clin Sci (Lond) (2021) 135 (14): 1689–1706.
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability
Mengqiu Wu; Weiyi Chen; Mengqiu Miao; Qianqian Jin; Shengnan Zhang; Mi Bai; Jiaojiao Fan; Yue Zhang; Aihua Zhang; Zhanjun Jia; Songming Huang
Clin Sci (Lond) (2021) 135 (14): 1707–1726.
The traditional herbal formulation, Jianpiyifei II, reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice
Xuhua Yu; Tiantian Cai; Long Fan; Ziyao Liang; Qiuling Du; Qi Wang; Zifeng Yang; Ross Vlahos; Lei Wu; Lin Lin
Clin Sci (Lond) (2021) 135 (14): 1733–1750.
A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis
Clin Sci (Lond) (2021) 135 (14): 1751–1765.
Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice
Clin Sci (Lond) (2021) 135 (14): 1773–1789.