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Volume 135, Issue 1
January 2021
Issue Cover
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  • Cover Image

    Cover Image

    issue cover
    The cover of this issue of Clinical Science (volume 135, issue 1) features an image from Elgazzaz and Lazartigues' study on epigenetic modifications of the renin-angiotensin system in cardiometabolic diseases. It depicts protein interactions within the renin-angiotensin system components and their functional partners. (Figure created using STRING database v.11 accessed on 12/24/2020).
ISSN 0143-5221
EISSN 1470-8736
In this Issue

Review Articles

Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases
Ravindra K. Sharma; Jing Li; Suraj Krishnan; Elaine M. Richards; Mohan K. Raizada; Rajesh Mohandas
Clin Sci (Lond) (2021) 135 (1): 1–17.
View Articletitled, Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases
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Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression
Jitske van den Bulk; Noel F.C.C. de Miranda; Peter ten Dijke
Clin Sci (Lond) (2021) 135 (1): 35–52.
View Articletitled, Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression
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Cardiotoxic effects of angiogenesis inhibitors
Stephen J.H. Dobbin; Mark C. Petrie; Rachel C. Myles; Rhian M. Touyz; Ninian N. Lang
Clin Sci (Lond) (2021) 135 (1): 71–100.
View Articletitled, Cardiotoxic effects of angiogenesis inhibitors
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Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease
Weiwei Yu; Haiqiang Jin; Yining Huang
Clin Sci (Lond) (2021) 135 (1): 109–126.
View Articletitled, Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease
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Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases
Mona Elgazzaz; Eric Lazartigues
Clin Sci (Lond) (2021) 135 (1): 127–142.
View Articletitled, Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases
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Inflammation: a putative link between phosphate metabolism and cardiovascular disease
Jakob Voelkl; Daniela Egli-Spichtig; Ioana Alesutan; Carsten A. Wagner
Clin Sci (Lond) (2021) 135 (1): 201–227.
View Articletitled, Inflammation: a putative link between phosphate metabolism and cardiovascular disease
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The GCN5: its biological functions and therapeutic potentials
Md. Ezazul Haque; Md. Jakaria; Mahbuba Akther; Duk-Yeon Cho; In-Su Kim; Dong-Kug Choi
Clin Sci (Lond) (2021) 135 (1): 231–257.
View Articletitled, The GCN5: its biological functions and therapeutic potentials
Supplementary data
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Commentaries

Time to fiddle with your unpublished data
Michael J. Ryan; Rhian M. Touyz
Clin Sci (Lond) (2021) 135 (1): 101–103.
View Articletitled, Time to <em>fiddle</em> with your unpublished data
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The CAT-1 is out of the bag: endothelial Cationic Amino Acid Transporter-1 is a critical player in cardiorenal syndrome type 2
Michael P. Hutchens; Carmen De Miguel
Clin Sci (Lond) (2021) 135 (1): 105–108.
View Articletitled, The CAT-1 is out of the bag: endothelial Cationic Amino Acid Transporter-1 is a critical player in cardiorenal syndrome type 2
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DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway
Renzo Boldorini; Nausicaa Clemente; Elisa Alchera; Rita Carini
Clin Sci (Lond) (2021) 135 (1): 161–166.
View Articletitled, DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway
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Research Articles

Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Mariana Rodrigues Davanso; Amanda Rabello Crisma; Tárcio Teodoro Braga; Laureane Nunes Masi; Cátia Lira do Amaral; Vinícius Nunes Cordeiro Leal; Dhêmerson Souza de Lima; Thiago Andrade Patente; José Alexandre Barbuto; Maria L. Corrêa-Giannella; Mario Lauterbach; Carl Christian Kolbe; Eicke Latz; Niels Olsen Saraiva Camara; Alessandra Pontillo; Rui Curi
Clin Sci (Lond) (2021) 135 (1): 19–34.
View Articletitled, Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Supplementary data
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Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization
Chuanjian Suo; Zeping Gui; Zijie Wang; Jiajun Zhou; Ming Zheng; Hao Chen; Shuang Fei; Min Gu; Ruoyun Tan
Clin Sci (Lond) (2021) 135 (1): 53–69.
View Articletitled, Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization
Supplementary data
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Role of endoplasmic reticulum stress in renal damage after myocardial infarction
Beatriz Delgado-Valero; Lucía de la Fuente-Chávez; Ana Romero-Miranda; María Visitación Bartolomé; Bunty Ramchandani; Fabián Islas; María Luaces; Victoria Cachofeiro; Ernesto Martínez-Martínez
Clin Sci (Lond) (2021) 135 (1): 143–159.
View Articletitled, Role of endoplasmic reticulum stress in renal damage after myocardial infarction
Supplementary data
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Changes in the expression and functional activities of Myosin II isoforms in human hyperplastic prostate
Weixiang He; Xiao Wang; Daxing Zhan; Mingzhou Li; Qian Wang; Jianmin Liu; Daoquan Liu; Xun Fu; Qiaofeng Qian; Yan Li; Ping Chen; Guang Zeng; Xinghuan Wang; Michael E. DiSanto; Xinhua Zhang
Clin Sci (Lond) (2021) 135 (1): 167–183.
View Articletitled, Changes in the expression and functional activities of Myosin II isoforms in human hyperplastic prostate
Supplementary data
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Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids
Helena L. Fisk; Caroline E. Childs; Elizabeth A. Miles; Robert Ayres; Paul S. Noakes; Carolina Paras-Chavez; Ondrej Kuda; Jan Kopecký; Elie Antoun; Karen A. Lillycrop; Philip C. Calder
Clin Sci (Lond) (2021) 135 (1): 185–200.
View Articletitled, Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids
Supplementary data
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Retractions

Retraction: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling
Clin Sci (Lond) (2021) 135 (1): 229.
View Articletitled, Retraction: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling
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Submit your work
Participation of the spleen in the neuroinflammation after pilocarpine-induced status epilepticus: Implications for epileptogenesis and epilepsy
Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury
Correction: The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease
Inflammatory liver diseases and susceptibility to sepsis
Cardiotoxic effects of common and emerging drugs: role of cannabinoid receptors
  • Online ISSN 1470-8736
  • Print ISSN 0143-5221

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