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Issues
April 2020
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Cover Image
Cover Image
In this issue of Clinical Science (volume 134, issue 7), Gao et al. highlight the role of DsbA-L on mitochondrial dysfunction of tubular cells in diabetic kidney and provide a novel therapeutic insight to alleviate diabetic tubulopathy via targeting mitochondrial dynamics. The cover image features an immunofluorescence staining of DsbA-L and mitochondria in human proximal tubular cells (DsbA-L, green; mitochondria, red; DAPI, blue; Colocalization: white).
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Maternal high-fat diet induces long-term obesity with sex-dependent metabolic programming of adipocyte differentiation, hypertrophy and dysfunction in the offspring
Thorsten Litzenburger; Eva-Kristina Huber; Katharina Dinger; Rebecca Wilke; Christina Vohlen; Jaco Selle; Mazlum Kadah; Thorsten Persigehl; Carola Heneweer; Jörg Dötsch; Miguel A. Alejandre Alcazar
Clin Sci (Lond) (2020) 134 (7): 921–939.
Editorial
ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19
Clin Sci (Lond) (2020) 134 (7): 747–750.
Review Articles
Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease
Clin Sci (Lond) (2020) 134 (7): 827–851.
Commentaries
Research Articles
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease
Clin Sci (Lond) (2020) 134 (7): 677–694.
Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling
Yingjin Qiao; Pei Wang; Mingyang Chang; Bohan Chen; Yan Ge; Deepak K. Malhotra; Lance D. Dworkin; Rujun Gong
Clin Sci (Lond) (2020) 134 (7): 695–710.
Tumoral PD-1hiCD8+ T cells are partially exhausted and predict favorable outcome in triple-negative breast cancer
Liang Guo; Chunmei Cao; Shyamal Goswami; Xiaoyan Huang; Linxiaoxi Ma; Yicheng Guo; Benlong Yang; Teng Li; Yayun Chi; Xiaoming Zhang; Jiong Wu
Clin Sci (Lond) (2020) 134 (7): 711–726.
Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction
Paula K. Bautista-Niño; Eliana Portilla-Fernandez; Eloisa Rubio-Beltrán; Janette J. van der Linden; René de Vries; Richard van Veghel; Martine de Boer; Matej Durik; Yanto Ridwan; Renata Brandt; Jeroen Essers; Robert I. Menzies; Rachel Thomas; Alain de Bruin; Dirk J. Duncker; Heleen M.M. van Beusekom; Mohsen Ghanbari; Jan H.J. Hoeijmakers; Radislav Sedlacek; Rhian M. Touyz; Augusto C. Montezano; Ingrid van der Pluijm; A.H. Jan Danser; Kristian A. Haanes; Anton J.M. Roks
Clin Sci (Lond) (2020) 134 (7): 727–746.
Effects of corticosteroids on COPD lung macrophage phenotype and function
Andrew Higham; Tom Scott; Jian Li; Rosemary Gaskell; Aisha Baba Dikwa; Rajesh Shah; M. Angeles Montero-Fernandez; Simon Lea; Dave Singh
Clin Sci (Lond) (2020) 134 (7): 751–763.
Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis
Monique Michels; Mariane Abatti; Andriele Vieira; Pricila Ávila; Amanda Indalécio Goulart; Heloisa Borges; Emily Córneo; Diogo Dominguini; Tatiana Barichello; Felipe Dal-Pizzol
Clin Sci (Lond) (2020) 134 (7): 765–776.
Effects of circulating extracellular microvesicles from spinal cord-injured adults on endothelial cell function
L. Madden Brewster; Geoff B. Coombs; Vinicius P. Garcia; Jamie G. Hijmans; Noah M. DeSouza; Kelly A. Stockelman; Otto F. Barak; Tanja Mijacika; Zeljko Dujic; Jared J. Greiner; Aaron A. Phillips; Philip N. Ainslie; Christopher A. DeSouza
Clin Sci (Lond) (2020) 134 (7): 777–789.
Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs
Jinhui Lü; Qian Zhao; Xin Ding; Yuefan Guo; Yuan Li; Zhen Xu; Shujun Li; Zhongrui Wang; Lei Shen; Huang-wen Chen; Zuoren Yu; Richard G. Pestell
Clin Sci (Lond) (2020) 134 (7): 791–805.
miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway
Clin Sci (Lond) (2020) 134 (7): 807–825.
Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS
Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li
Clin Sci (Lond) (2020) 134 (7): 853–869.
Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats
Lucinda M. Hilliard Krause; Brandon A. Kemp; Amanda Suan Jui Tan; Emma S. Jones; Mark P. Del Borgo; Marie-Isabel Aguilar; Kate M. Denton; Robert M. Carey; Robert E. Widdop
Clin Sci (Lond) (2020) 134 (7): 871–884.
Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner
Michael Schuliga; Jane Read; Kaj E.C. Blokland; David W. Waters; Janette Burgess; Cecilia Prêle; Steven E. Mutsaers; Jade Jaffar; Glen Westall; Andrew Reid; Allen James; Christopher Grainge; Darryl A. Knight
Clin Sci (Lond) (2020) 134 (7): 889–905.
Albendazole negatively regulates keratinocyte proliferation
Davide Di Fusco; Carmine Stolfi; Antonio Di Grazia; Vincenzo Dinallo; Federica Laudisi; Irene Marafini; Alfredo Colantoni; Ivan Monteleone; Giovanni Monteleone
Clin Sci (Lond) (2020) 134 (7): 907–920.
