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Issues
December 2020
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Cover Image
Cover Image
This cover features a Safranin-O/Fast Green staining of knee in a control mouse. In this issue of Clinical Science (volume 134, issue 23), Guan et al. investigate that gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Editorial
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Clin Sci (Lond) (2020) 134 (23): 3229–3232.
Review Articles
ACE2 in the renin–angiotensin system
Thiago Verano-Braga; Ana Luiza Valle Martins; Daisy Motta-Santos; Maria José Campagnole-Santos; Robson Augusto Souza Santos
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
ACE2: from protection of liver disease to propagation of COVID-19
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Commentaries
Have a heart: failure to increase GLP-1 caused by heart failure increases the risk of diabetes
Clin Sci (Lond) (2020) 134 (23): 3119–3121.
Research Articles
Epigenetic silencing of miR564 contributes to the leukemogenesis of t(8;21) acute myeloid leukemia
Erna Yang; Wei Guan; Desheng Gong; Xuefeng Gao; Caixia Han; Juan Zhang; Hong Wang; Mengzhen Wang; Yonghui Li; Li Yu
Clin Sci (Lond) (2020) 134 (23): 3079–3091.
ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats
Tatiane Cristine Silva de Almeida; Katharina Lanza; Roberta da Silva Filha; Leda Maria de Castro C. Campos; Esdras G. Fonseca; Mariana W. Chagas; Natalia Pessoa Rocha; Marcos Augusto de Sá; Maria Aparecida Ribeiro Vieira; Marcelo Vidigal Caliari; Lucas M. Kangussu; Anderson José Ferreira; Ana Cristina Simões e Silva
Clin Sci (Lond) (2020) 134 (23): 3093–3106.
SGLT2 inhibition versus sulfonylurea treatment effects on electrolyte and acid–base balance: secondary analysis of a clinical trial reaching glycemic equipoise: Tubular effects of SGLT2 inhibition in Type 2 diabetes
Erik J.M. van Bommel; Frank Geurts; Marcel H.A. Muskiet; Adrian Post; Stephan J.L. Bakker; A.H. Jan Danser; Daan J. Touw; Miranda van Berkel; Mark H.H. Kramer; Max Nieuwdorp; Ele Ferrannini; Jaap A. Joles; Ewout J. Hoorn; Daniël H. van Raalte
Clin Sci (Lond) (2020) 134 (23): 3107–3118.
Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta
Clin Sci (Lond) (2020) 134 (23): 3123–3136.
Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice
Zhiyuan Guan; Jialin Jia; Chenggui Zhang; Tiantong Sun; Wang Zhang; Wanqiong Yuan; Huijie Leng; Chunli Song
Clin Sci (Lond) (2020) 134 (23): 3159–3174.
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis
Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure
Milene Tavares Fontes; Suliana Mesquita Paula; Caroline Antunes Lino; Nathalia Senger; Gisele Kruger Couto; Maria Luiza de Morais Barreto-Chaves; José Geraldo Mill; Luciana Venturini Rossoni
Clin Sci (Lond) (2020) 134 (23): 3195–3211.
Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
