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Cover ImageIn the latest issue of Clinical Science (volume 133, issue 2), Chen et al. investigate the biological function and regulatory mechanisms of long non-coding RNA DCST1-AS1 in hepatocellular carcinoma (HCC), and discuss the clinical significance of their findings. This issue's cover features their colony formation assay, in which up-regulation of DCST1-AS1 expression (top right and bottom right dishes) significantly increased proliferation of HepG2 and Bel-7404 HCC cell lines compared to the control (top left and bottom left dishes).Close Modal
In this Issue
Immunotherapy: enhancing the efficacy of this promising therapeutic in multiple cancers
Clin Sci (Lond) (2019) 133 (2): 181–193.
Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)
Clin Sci (Lond) (2019) 133 (2): 269–286.
Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)
Clin Sci (Lond) (2019) 133 (2): 287–313.
Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies
Clin Sci (Lond) (2019) 133 (2): 315–319.
Sodium 4-phenylbutyrate treatment protects against renal injury in NZBWF1 mice
Clin Sci (Lond) (2019) 133 (2): 167–180.
Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling
Yifang Xie; Anyun Ma; Boshi Wang; Rui Peng; Yingchun Jing; Deqian Wang; Richard H. Finnell; Bin Qiao; Yongming Wang; Hongyan Wang; Yufang Zheng
Clin Sci (Lond) (2019) 133 (2): 225–238.
Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation
Roel Bijkerk; Marina A. Aleksinskaya; Jacques M.G.J. Duijs; Jennifer Veth; Bettina Husen; Dania Reiche; Cornelia Prehn; Jerzy Adamski; Ton J. Rabelink; Jo G.R. De Mey; Anton Jan van Zonneveld
Clin Sci (Lond) (2019) 133 (2): 239–252.
MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S-adenosylmethionine and de novo purine synthesis
Yi-Cheng Wang; Ming-Tsung Wu; Feng-Yao Tang; Der-Yuan Chen; Hsin-An Ko; Barry Shane; Wen-Nan Huang; En-Pei Isabel Chiang
Clin Sci (Lond) (2019) 133 (2): 253–267.
Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome
Steven J. Forrester; Qian Xu; Daniel S. Kikuchi; Derick Okwan-Duodu; Ana Carolina Campos; Elizabeth A. Faidley; Guogang Zhang; Bernard Lassègue; Ruxana T. Sadikot; Kathy K. Griendling; Marina S. Hernandes
Clin Sci (Lond) (2019) 133 (2): 321–334.
USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling
Clin Sci (Lond) (2019) 133 (2): 335–349.
SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice
Catalina Atorrasagasti; Agostina Onorato; María L. Gimeno; Luz Andreone; Mariana Garcia; Mariana Malvicini; Esteban Fiore; Juan Bayo; Marcelo J. Perone; Guillermo D. Mazzolini
Clin Sci (Lond) (2019) 133 (2): 351–365.
LncRNA DCST1-AS1 functions as a competing endogenous RNA to regulate FAIM2 expression by sponging miR-1254 in hepatocellular carcinoma
Clin Sci (Lond) (2019) 133 (2): 367–379.
ZEB1-AS1 is associated with poor prognosis in non-small-cell lung cancer and influences cell migration and apoptosis by repressing ID1
Clin Sci (Lond) (2019) 133 (2): 381–392.