Issues

In the latest issue of Clinical Science (volume 133, issue 16), Pokorna et al. investigate the cardiotoxicity associated with anthracycline anticancer drugs in a rabbit model. Their observations using this well-established model corresponds with the cardiomyopathy in patients treated with high cumulative doses of anthracycline anticancer drugs such as daunorubicin, doxorubicin, idarubicin or epirubicin. The cover image depicts degenerating cardiomyocytes. The profound loss of myofibrils is accompanied by vacuolization of the cytoplasm as necrotic cells are gradually replaced by fibrotic scar tissue (blue-stained collagen fibers).