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Issues
July 2018
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Cover Image
Cover Image
The 3D structure of recombinant human deoxyribonuclease I. The N-terminal leucine shown in yellow at the top of the structure was selected for PEGylation of the protein. The amino acids shown in yellow towards the bottom of the protein are those interacting with globular actin, a potent inhibitor of human deoxyribonuclease I; for details, see pages 1439–1452.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control
Clin Sci (Lond) (2018) 132 (13): 1383–1401.
Hypotheses
Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis
Clin Sci (Lond) (2018) 132 (13): 1433–1438.
Research Articles
The preventive and therapeutic implication for renal fibrosis by targetting TGF-β/Smad3 signaling
Clin Sci (Lond) (2018) 132 (13): 1403–1415.
Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction
Ping Chen; Jian-Nong Wu; Yang Shu; He-Guo Jiang; Xiao-Hui Zhao; Hai Qian; Kang Chen; Ting Lan; Chen-Guo Chen; Jian Li
Clin Sci (Lond) (2018) 132 (13): 1417–1433.
Impact of PEGylation on the mucolytic activity of recombinant human deoxyribonuclease I in cystic fibrosis sputum
Marie-Julie Guichard; David Kinoo; Anne-Sophie Aubriot; Nathalie Bauwens; Jordane Gougué; François Vermeulen; Patrick Lebecque; Teresinha Leal; Rita Vanbever
Clin Sci (Lond) (2018) 132 (13): 1439–1452.
Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice
Naomi C. Boisvert; Chet E. Holterman; Jean-François Thibodeau; Rania Nasrallah; Eldjonai Kamto; Cesar H. Comin; Luciano da F. Costa; Anthony Carter; Richard L. Hébert; Alex Gutsol; Gregory O. Cron; Baptiste Lacoste; Douglas A. Gray; Chris R. Kennedy
Clin Sci (Lond) (2018) 132 (13): 1453–1470.
Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage
Jaime Ibarrola; Vanessa Arrieta; Rafael Sádaba; Ernesto Martinez-Martinez; Amaia Garcia-Peña; Virginia Alvarez; Amaya Fernández-Celis; Alicia Gainza; Enrique Santamaría; Joaquin Fernández-Irigoyen; Victoria Cachofeiro; Guillermo Zalba; Renaud Fay; Patrick Rossignol; Natalia López-Andrés
Clin Sci (Lond) (2018) 132 (13): 1471–1485.
