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Cover ImageOleic-acid-treated HepG2 cells immunostained for PGC-1α (PPARγ co-activator-1 α). In Clinical Science volume 132, issue 1, the results of work by Bernardi et al. include reporting that the protein TRAIL (TNF-related apoptosis inducing ligand) increases the expression of PGC-1α in HepG2 cells cultured with oleic acid. Overall, the article points to a potential therapeutic role for TRAIL against impaired glucose tolerance and non-alcoholic fatty liver disease; for details see pages 69–83.Close Modal
In this Issue
The molecular basis of immune regulation in autoimmunity
Shu-Han Yang; Cai-yue Gao; Liang Li; Christopher Chang; Patrick S.C. Leung; M. Eric Gershwin; Zhe-Xiong Lian
Clin Sci (Lond) (2018) 132 (1): 43–67.
Endothelin type B (ETB) receptors: friend or foe in the pathogenesis of pre-eclampsia and future cardiovascular disease (CVD) risk?
Clin Sci (Lond) (2018) 132 (1): 33–36.
Autoantibodies against angiotensin and adrenergic receptors: more than a biomarker?
Clin Sci (Lond) (2018) 132 (1): 127–130.
Does sympathetic dysfunction occur before denervation in pure autonomic failure?
Ling Guo; Murray D. Esler; Carolina Sari; Sarah Phillips; Elisabeth A. Lambert; Nora E. Straznicky; Gavin W. Lambert; Susan J. Corcoran
Clin Sci (Lond) (2018) 132 (1): 1–16.
A critical evaluation of the anabolic response after bolus or continuous feeding in COPD and healthy older adults
Renate Jonker; Nicolaas E.P. Deutz; Rajesh Harrykissoon; Anthony J. Zachria; Eugene A. Veley; Mariëlle P.K.J. Engelen
Clin Sci (Lond) (2018) 132 (1): 17–31.
TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse
Stella Bernardi; Barbara Toffoli; Veronica Tisato; Fleur Bossi; Stefania Biffi; Andrea Lorenzon; Giorgio Zauli; Paola Secchiero; Bruno Fabris
Clin Sci (Lond) (2018) 132 (1): 69–83.
Hypertrophied myocardium is vulnerable to ischemia/reperfusion injury and refractory to rapamycin-induced protection due to increased oxidative/nitrative stress
Lei-Lei Ma; Yang Li; Pei-Pei Yin; Fei-Juan Kong; Jun-Jie Guo; Hong-Tao Shi; Jian-Bing Zhu; Yun-Zeng Zou; Jun-Bo Ge
Clin Sci (Lond) (2018) 132 (1): 93–110.
Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice
Clin Sci (Lond) (2018) 132 (1): 111–125.
Vascular dysfunction in the stroke-prone spontaneously hypertensive rat is dependent on constrictor prostanoid activity and Y chromosome lineage
Shanzana I. Khan; Karen L. Andrews; Ann-Maree Jefferis; Garry L. Jennings; Amanda K. Sampson; Jaye P.F. Chin-Dusting
Clin Sci (Lond) (2018) 132 (1): 131–143.
Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels
Clin Sci (Lond) (2018) 132 (1): 145–156.
Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review
Clin Sci (Lond) (2018) 132 (1): 157–171.
Comment on ‘Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR−/− mouse model of atherosclerosis’
Clin Sci (Lond) (2018) 132 (1): 37–38.
Response to comment by Moxon et al.
Dawn Thompson; Nicola Morrice; Louise Grant; Samantha Le Sommer; Emma K. Lees; Nimesh Mody; Heather M. Wilson; Mirela Delibegovic
Clin Sci (Lond) (2018) 132 (1): 39–41.