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August 2017
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Human vascular smooth muscle cell derived from a skin precursor. Subjects with type-2 diabetes have fewer skin-derived precursors in their skin. Vascular smooth muscle cells derived from skin-derived precursors from subjects with type-2 diabetes carry persistent signatures of disease even weeks after being removed from the patient. Thus, skin-derived precursors may be a promising platform to study type-2 diabetes associated vascular disease in a dish. In Clinical Science volume 131, issue 15, Steinbach et al. describe new approach to studying human vascular smooth muscle cell (VSMC) pathophysiology by examining VSMCs differentiated from progenitors found in skin (see pages 1801-1814).
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
Negative regulators of angiogenesis: important targets for treatment of exudative AMD
Mitra Farnoodian; Shoujian Wang; Joel Dietz; Robert W. Nickells; Christine M. Sorenson; Nader Sheibani
Clin Sci (Lond) (2017) 131 (15): 1763–1780.
Curcumin mediates anticancer effects by modulating multiple cell signaling pathways
Ajaikumar B. Kunnumakkara; Devivasha Bordoloi; Choudhary Harsha; Kishore Banik; Subash C. Gupta; Bharat B. Aggarwal
Clin Sci (Lond) (2017) 131 (15): 1781–1799.
MicroRNAs in the skin: role in development, homoeostasis and regeneration
Steven Horsburgh; Nicola Fullard; Mathilde Roger; Abbie Degnan; Stephen Todryk; Stefan Przyborski; Steven O’Reilly
Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Commentaries
Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease
Clin Sci (Lond) (2017) 131 (15): 1919–1922.
Dysregulation of miR-223 constitutes a promising biomarker that informs about clinical outcomes of acute liver failure
Clin Sci (Lond) (2017) 131 (15): 2059–2062.
Research Articles
Skin-derived precursors from human subjects with Type 2 diabetes yield dysfunctional vascular smooth muscle cells
Sarah K. Steinbach; Terrence M. Yau; Maral Ouzounian; Husam Abdel-Qadir; Mark Chandy; Thomas K. Waddell; Mansoor Husain
Clin Sci (Lond) (2017) 131 (15): 1801–1814.
Urinary glycated uromodulin in diabetic kidney disease
Chia-Chu Chang; Chen-Yu Chen; Ching-Hui Huang; Chia-Lin Wu; Hung-Ming Wu; Ping-Fang Chiu; Chew-Teng Kor; Ting-Huan Chen; Geen-Dong Chang; Cheng-Chin Kuo; Hui-Chin Wen; Chih-Yang Huang; Chung-Ho Chang
Clin Sci (Lond) (2017) 131 (15): 1815–1829.
ABCB1 gene polymorphism associated with clinical factors can predict drug-resistant tuberculosis
Yasmin Pontual; Vanessa S.S. Pacheco; Sérgio P. Monteiro; Marcel S.B. Quintana; Marli J.M. Costa; Valeria C. Rolla; Liane de Castro
Clin Sci (Lond) (2017) 131 (15): 1831–1840.
Inhibition of HDAC3 prevents diabetic cardiomyopathy in OVE26 mice via epigenetic regulation of DUSP5-ERK1/2 pathway
Zheng Xu; Qian Tong; Zhiguo Zhang; Shudong Wang; Yang Zheng; Qiuju Liu; Ling-bo Qian; Shao-yu Chen; Jian Sun; Lu Cai
Clin Sci (Lond) (2017) 131 (15): 1841–1857.
Mycobacterium tuberculosis Rv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy
Clin Sci (Lond) (2017) 131 (15): 1859–1876.
FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice
Fan Wu; Baile Wang; Saisai Zhang; Lihua Shi; Yanfang Wang; Rongrong Xiong; Xuebo Pan; Fanghua Gong; Xiaokun Li; Zhuofeng Lin
Clin Sci (Lond) (2017) 131 (15): 1877–1893.
Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function
Rungong Yang; Shuhong Fu; Liang Zhao; Bei Zhen; Ling Ye; Xiaolu Niu; Xiaoxia Li; Pumin Zhang; Jie Bai
Clin Sci (Lond) (2017) 131 (15): 1895–1904.
Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes
Bram Brouwers; Vera B. Schrauwen-Hinderling; Tomas Jelenik; Anne Gemmink; Bas Havekes; Yvonne Bruls; Dennis Dahlmans; Michael Roden; Matthijs K.C. Hesselink; Patrick Schrauwen
Clin Sci (Lond) (2017) 131 (15): 1905–1917.
Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/− mice
Haiyan Wu; Bibi S. van Thiel; Paula K. Bautista-Niño; Erwin Reiling; Matej Durik; Frank P.J. Leijten; Yanto Ridwan; Renata M.C. Brandt; Harry van Steeg; Martijn E.T. Dollé; Wilbert P. Vermeij; Jan H.J. Hoeijmakers; Jeroen Essers; Ingrid van der Pluijm; A.H. Jan Danser; Anton J.M. Roks
Clin Sci (Lond) (2017) 131 (15): 1941–1953.
Smad7 protects against acute kidney injury by rescuing tubular epithelial cells from the G1 cell cycle arrest
Clin Sci (Lond) (2017) 131 (15): 1955–1969.
miR-223 represents a biomarker in acute and chronic liver injury
Florian Schueller; Sanchari Roy; Sven Heiko Loosen; Jan Alder; Christiane Koppe; Anne Theres Schneider; Franziska Wandrer; Heike Bantel; Mihael Vucur; Qing-Sheng Mi; Christian Trautwein; Tom Luedde; Christoph Roderburg
Clin Sci (Lond) (2017) 131 (15): 1971–1987.
AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice
Friedrich Krueger; Kai Kappert; Anna Foryst-Ludwig; Frederike Kramer; Markus Clemenz; Aleksandra Grzesiak; Manuela Sommerfeld; Jan Paul Frese; Andreas Greiner; Ulrich Kintscher; Thomas Unger; Elena Kaschina
Clin Sci (Lond) (2017) 131 (15): 1989–2005.
Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation
Imad Al Ghouleh; Sanghamitra Sahoo; Daniel N. Meijles; Jefferson H. Amaral; Daniel S. de Jesus; John Sembrat; Mauricio Rojas; Dmitry A. Goncharov; Elena A. Goncharova; Patrick J. Pagano
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
Improvement in exercise duration, lung function and well-being in G551D-cystic fibrosis patients: a double-blind, placebo-controlled, randomized, cross-over study with ivacaftor treatment
Deirdre Edgeworth; Dominic Keating; Matthew Ellis; Brenda Button; Elyssa Williams; Denise Clark; Audrey Tierney; Stephane Heritier; Tom Kotsimbos; John Wilson
Clin Sci (Lond) (2017) 131 (15): 2037–2045.
Depletion of MHC class II invariant chain peptide or γ–δ T-cells ameliorates experimental preeclampsia
Piyali Chatterjee; Valorie L. Chiasson; Geetha Seerangan; Eugene De Guzman; Moheb Milad; Kelsey R. Bounds; Olga Gasheva; Richard P. Tobin; Mohamad Hatahet; Shelley Kopriva; Kathleen A. Jones; M. Karen Newell-Rogers; Brett M. Mitchell
Clin Sci (Lond) (2017) 131 (15): 2047–2058.
