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November 2023
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Cover Image
Cover Image
The nine classic hallmarks of ageing (the inner pink circle) and five potential new hallmarks (the outer blue circle) were evaluated for their involvement in skeletal muscle ageing and sarcopenia in women and men. Strong evidence was found for epigenetic alteration, mitochondrial dysfunction, neural dysfunction, and moderate evidence for inflammation, deregulated nutrient sensing, immunoaging, extracellular matrix dysfunction, and reduced vascular perfusion as hallmarks for skeletal muscle ageing. Evidence for the relevance of these hallmarks to human sarcopenia is limited but emerging. For further information, see the review by Granic and colleagues (pp. 1721–1751) in this issue. Created with BioRender.com. The image is provided by Antoneta Granic.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Review Articles
The O-GlcNAc dichotomy: when does adaptation become pathological?
Tiago J. Costa; Emily W. Wilson; Milene T. Fontes; Laena Pernomian; Rita C. Tostes; Camilla F. Wenceslau; Cameron G. McCarthy
Clin Sci (Lond) (2023) 137 (22): 1683–1697.
Endothelial progenitor cells in pregnancy-related diseases
Clin Sci (Lond) (2023) 137 (22): 1699–1719.
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men
Clin Sci (Lond) (2023) 137 (22): 1721–1751.
Research Articles
PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway
Clin Sci (Lond) (2023) 137 (22): 1753–1769.